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Protein

Anaerobic glycerol-3-phosphate dehydrogenase subunit B

Gene

glpB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor.

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route).
Proteins known to be involved in this subpathway in this organism are:
  1. Anaerobic glycerol-3-phosphate dehydrogenase subunit B (glpB), Anaerobic glycerol-3-phosphate dehydrogenase subunit A (glpA), Anaerobic glycerol-3-phosphate dehydrogenase subunit C (glpC)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route), the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

  • anaerobic respiration Source: EcoCyc
  • glycerol-3-phosphate catabolic process Source: EcoCyc
  • glycerol catabolic process Source: UniProtKB-UniPathway

Keywordsi

Molecular functionOxidoreductase
LigandFlavoprotein, FMN

Enzyme and pathway databases

BioCyciEcoCyc:ANGLYC3PDEHYDROGSUBUNITB-MONOMER
MetaCyc:ANGLYC3PDEHYDROGSUBUNITB-MONOMER
UniPathwayiUPA00618; UER00673

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic glycerol-3-phosphate dehydrogenase subunit B (EC:1.1.5.3)
Short name:
Anaerobic G-3-P dehydrogenase subunit B
Short name:
Anaerobic G3Pdhase B
Gene namesi
Name:glpB
Ordered Locus Names:b2242, JW2236
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi

Organism-specific databases

EcoGeneiEG10392 glpB

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • plasma membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002045591 – 419Anaerobic glycerol-3-phosphate dehydrogenase subunit BAdd BLAST419

Proteomic databases

PaxDbiP13033
PRIDEiP13033

Interactioni

Subunit structurei

Composed of a catalytic GlpA/B dimer and of membrane bound GlpC.

Protein-protein interaction databases

BioGridi4260490, 447 interactors
DIPiDIP-9791N
IntActiP13033, 5 interactors
STRINGi316385.ECDH10B_2401

Structurei

3D structure databases

ProteinModelPortaliP13033
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108KJ0 Bacteria
COG3075 LUCA
HOGENOMiHOG000278489
InParanoidiP13033
KOiK00112
OMAiVAINAQC
PhylomeDBiP13033

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00753 Glycerol3P_GlpB, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR009158 G3P_DH_GlpB_su
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PIRSFiPIRSF000141 Anaerobic_G3P_dh, 1 hit
SUPFAMiSSF51905 SSF51905, 4 hits
TIGRFAMsiTIGR03378 glycerol3P_GlpB, 1 hit

Sequencei

Sequence statusi: Complete.

P13033-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFDTVIMGG GLAGLLCGLQ LQKHGLRCAI VTRGQSALHF SSGSLDLLSH
60 70 80 90 100
LPDGQPVTDI HSGLESLRQQ APAHPYSLLE PQRVLDLACQ AQALIAESGA
110 120 130 140 150
QLQGSVELAH QRVTPLGTLR STWLSSPEVP VWPLPAKKIC VVGISGLMDF
160 170 180 190 200
QAHLAAASLR ELGLAVETAE IELPELDVLR NNATEFRAVN IARFLDNEEN
210 220 230 240 250
WPLLLDALIP VANTCEMILM PACFGLADDK LWRWLNEKLP CSLMLLPTLP
260 270 280 290 300
PSVLGIRLQN QLQRQFVRQG GVWMPGDEVK KVTCKNGVVN EIWTRNHADI
310 320 330 340 350
PLRPRFAVLA SGSFFSGGLV AERNGIREPI LGLDVLQTAT RGEWYKGDFF
360 370 380 390 400
APQPWQQFGV TTDETLRPSQ AGQTIENLFA IGSVLGGFDP IAQGCGGGVC
410
AVSALHAAQQ IAQRAGGQQ
Length:419
Mass (Da):45,357
Last modified:January 1, 1990 - v1
Checksum:iC8A2285AD09F4F55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20938 Genomic DNA Translation: AAA83865.1
U00096 Genomic DNA Translation: AAC75302.1
AP009048 Genomic DNA Translation: BAA16061.1
PIRiB32006 DEECNB
RefSeqiNP_416745.1, NC_000913.3
WP_001209927.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75302; AAC75302; b2242
BAA16061; BAA16061; BAA16061
GeneIDi946733
KEGGiecj:JW2236
eco:b2242
PATRICifig|511145.12.peg.2331

Entry informationi

Entry nameiGLPB_ECOLI
AccessioniPrimary (citable) accession number: P13033
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: March 28, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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