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P13011

- ACOD2_MOUSE

UniProt

P13011 - ACOD2_MOUSE

Protein

Acyl-CoA desaturase 2

Gene

Scd2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O2 and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.

    Catalytic activityi

    Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.

    Cofactori

    Iron.

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. stearoyl-CoA 9-desaturase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    Iron

    Enzyme and pathway databases

    BRENDAi1.14.19.1. 3474.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl-CoA desaturase 2 (EC:1.14.19.1)
    Alternative name(s):
    Delta(9)-desaturase 2
    Short name:
    Delta-9 desaturase 2
    Fatty acid desaturase 2
    Stearoyl-CoA desaturase 2
    Gene namesi
    Name:Scd2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:98240. Scd2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: MGI
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 358358Acyl-CoA desaturase 2PRO_0000185398Add
    BLAST

    Proteomic databases

    PaxDbiP13011.
    PRIDEiP13011.

    PTM databases

    PhosphoSiteiP13011.

    Expressioni

    Gene expression databases

    BgeeiP13011.
    CleanExiMM_SCD2.
    GenevestigatoriP13011.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000026221.

    Structurei

    3D structure databases

    ProteinModelPortaliP13011.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 7069CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini93 – 1019LumenalSequence Analysis
    Topological domaini119 – 21597CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini235 – 24915LumenalSequence AnalysisAdd
    BLAST
    Topological domaini273 – 35886CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei71 – 9222HelicalSequence AnalysisAdd
    BLAST
    Transmembranei102 – 11817HelicalSequence AnalysisAdd
    BLAST
    Transmembranei216 – 23419HelicalSequence AnalysisAdd
    BLAST
    Transmembranei250 – 27223HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi119 – 1246Histidine box-1
    Motifi156 – 1605Histidine box-2
    Motifi297 – 3015Histidine box-3

    Domaini

    The histidine box domains may contain the active site and/or be involved in metal ion binding.

    Sequence similaritiesi

    Belongs to the fatty acid desaturase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1398.
    GeneTreeiENSGT00530000063158.
    HOGENOMiHOG000270352.
    HOVERGENiHBG003367.
    InParanoidiQ8BH96.
    KOiK00507.
    OMAiRRENSIT.
    OrthoDBiEOG7ZPNKS.
    TreeFamiTF313251.

    Family and domain databases

    InterProiIPR005804. Fatty_acid_desaturase-1.
    IPR001522. Fatty_acid_desaturase-1_C.
    IPR015876. Fatty_acid_desaturase-1_core.
    [Graphical view]
    PfamiPF00487. FA_desaturase. 1 hit.
    [Graphical view]
    PRINTSiPR00075. FACDDSATRASE.
    PROSITEiPS00476. FATTY_ACID_DESATUR_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P13011-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAHILQEIS GAYSATTTIT APPSGGQQNG GEKFEKSSHH WGADVRPELK    50
    DDLYDPTYQD DEGPPPKLEY VWRNIILMAL LHLGALYGIT LVPSCKLYTC 100
    LFAYLYYVIS ALGITAGAHR LWSHRTYKAR LPLRLFLIIA NTMAFQNDVY 150
    EWARDHRAHH KFSETHADPH NSRRGFFFSH VGWLLVRKHP AVKEKGGKLD 200
    MSDLKAEKLV MFQRRYYKPG LLLMCFVLPT LVPWYCWGET FVNSLCVSTF 250
    LRYAVVLNAT WLVNSAAHLY GYRPYDKNIS SRENILVSMG AVGEGFHNYH 300
    HAFPYDYSAS EYRWHINFTT FFIDCMALLG LAYDRKRVSR AAVLARIKRT 350
    GDGSCKSG 358
    Length:358
    Mass (Da):40,916
    Last modified:July 27, 2011 - v2
    Checksum:i3E04893F12E92A9A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti220 – 2201G → D in AAA40094. (PubMed:2570068)Curated
    Sequence conflicti295 – 2951G → R in AAA40094. (PubMed:2570068)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26270 mRNA. Translation: AAA40094.1.
    AK083922 mRNA. Translation: BAC39066.1.
    AK147406 mRNA. Translation: BAE27893.1.
    CH466534 Genomic DNA. Translation: EDL41928.1.
    BC040384 mRNA. Translation: AAH40384.1.
    CCDSiCCDS29848.1.
    PIRiA36507.
    RefSeqiNP_033154.2. NM_009128.2.
    UniGeneiMm.487021.

    Genome annotation databases

    EnsembliENSMUST00000026221; ENSMUSP00000026221; ENSMUSG00000025203.
    GeneIDi20250.
    KEGGimmu:20250.
    UCSCiuc008hpp.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M26270 mRNA. Translation: AAA40094.1 .
    AK083922 mRNA. Translation: BAC39066.1 .
    AK147406 mRNA. Translation: BAE27893.1 .
    CH466534 Genomic DNA. Translation: EDL41928.1 .
    BC040384 mRNA. Translation: AAH40384.1 .
    CCDSi CCDS29848.1.
    PIRi A36507.
    RefSeqi NP_033154.2. NM_009128.2.
    UniGenei Mm.487021.

    3D structure databases

    ProteinModelPortali P13011.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000026221.

    PTM databases

    PhosphoSitei P13011.

    Proteomic databases

    PaxDbi P13011.
    PRIDEi P13011.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026221 ; ENSMUSP00000026221 ; ENSMUSG00000025203 .
    GeneIDi 20250.
    KEGGi mmu:20250.
    UCSCi uc008hpp.2. mouse.

    Organism-specific databases

    CTDi 20250.
    MGIi MGI:98240. Scd2.

    Phylogenomic databases

    eggNOGi COG1398.
    GeneTreei ENSGT00530000063158.
    HOGENOMi HOG000270352.
    HOVERGENi HBG003367.
    InParanoidi Q8BH96.
    KOi K00507.
    OMAi RRENSIT.
    OrthoDBi EOG7ZPNKS.
    TreeFami TF313251.

    Enzyme and pathway databases

    BRENDAi 1.14.19.1. 3474.

    Miscellaneous databases

    ChiTaRSi Scd2. mouse.
    NextBioi 297901.
    PROi P13011.
    SOURCEi Search...

    Gene expression databases

    Bgeei P13011.
    CleanExi MM_SCD2.
    Genevestigatori P13011.

    Family and domain databases

    InterProi IPR005804. Fatty_acid_desaturase-1.
    IPR001522. Fatty_acid_desaturase-1_C.
    IPR015876. Fatty_acid_desaturase-1_core.
    [Graphical view ]
    Pfami PF00487. FA_desaturase. 1 hit.
    [Graphical view ]
    PRINTSi PR00075. FACDDSATRASE.
    PROSITEi PS00476. FATTY_ACID_DESATUR_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase."
      Kaestner K.H., Ntambi J.M., Kelly T.J. Jr., Lane M.D.
      J. Biol. Chem. 264:14755-14761(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Adipocyte.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and C57BL/6J.
      Tissue: Brain and Spinal ganglion.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: 129.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiACOD2_MOUSE
    AccessioniPrimary (citable) accession number: P13011
    Secondary accession number(s): Q8BH96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3