P13011 (ACOD2_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 108.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Acyl-CoA desaturase 2 EC=1.14.19.1 Alternative name(s): Delta(9)-desaturase 2 Short name=Delta-9 desaturase 2 Fatty acid desaturase 2 Stearoyl-CoA desaturase 2 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 358 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O2 and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. |
| Catalytic activity | Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O. |
| Cofactor | Iron. |
| Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein Probable. |
| Domain | The histidine box domains may contain the active site and/or be involved in metal ion binding. |
| Sequence similarities | Belongs to the fatty acid desaturase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Fatty acid biosynthesis Lipid synthesis |
| Cellular component | Endoplasmic reticulum Membrane |
| Domain | Transmembrane Transmembrane helix |
| Ligand | Iron |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | iron ion binding Inferred from electronic annotation. Source: InterPro stearoyl-CoA 9-desaturase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 358 | 358 | Acyl-CoA desaturase 2 | PRO_0000185398 | |||||
Regions | |||||||||
| Topological domain | 2 – 70 | 69 | Cytoplasmic Potential | ||||||
| Transmembrane | 71 – 92 | 22 | Helical; Potential | ||||||
| Topological domain | 93 – 101 | 9 | Lumenal Potential | ||||||
| Transmembrane | 102 – 118 | 17 | Helical; Potential | ||||||
| Topological domain | 119 – 215 | 97 | Cytoplasmic Potential | ||||||
| Transmembrane | 216 – 234 | 19 | Helical; Potential | ||||||
| Topological domain | 235 – 249 | 15 | Lumenal Potential | ||||||
| Transmembrane | 250 – 272 | 23 | Helical; Potential | ||||||
| Topological domain | 273 – 358 | 86 | Cytoplasmic Potential | ||||||
| Motif | 119 – 124 | 6 | Histidine box-1 | ||||||
| Motif | 156 – 160 | 5 | Histidine box-2 | ||||||
| Motif | 297 – 301 | 5 | Histidine box-3 | ||||||
Experimental info | |||||||||
| Sequence conflict | 220 | 1 | G → D in AAA40094. Ref.1 | ||||||
| Sequence conflict | 295 | 1 | G → R in AAA40094. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase." Kaestner K.H., Ntambi J.M., Kelly T.J. Jr., Lane M.D. J. Biol. Chem. 264:14755-14761(1989) [PubMed: 2570068] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Adipocyte. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6 and C57BL/6J. Tissue: Brain and Spinal ganglion. |
| [3] | Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: 129. Tissue: Mammary tumor. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M26270 mRNA. Translation: AAA40094.1. AK083922 mRNA. Translation: BAC39066.1. AK147406 mRNA. Translation: BAE27893.1. CH466534 Genomic DNA. Translation: EDL41928.1. BC040384 mRNA. Translation: AAH40384.1. |
| IPI | IPI00117142. |
| PIR | A36507. |
| RefSeq | NP_033154.2. NM_009128.2. |
| UniGene | Mm.485035. |
3D structure databases | |
| ProteinModelPortal | P13011. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | P13011. |
Proteomic databases | |
| PRIDE | P13011. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000026221; ENSMUSP00000026221; ENSMUSG00000025203. |
| GeneID | 20250. |
| KEGG | mmu:20250. |
| NMPDR | fig|10090.3.peg.5128. |
Organism-specific databases | |
| CTD | 20250. |
| MGI | MGI:98240. Scd2. |
Phylogenomic databases | |
| eggNOG | roNOG13436. |
| HOGENOM | HBG380611. |
| HOVERGEN | HBG003367. |
| InParanoid | P13011. |
| OrthoDB | EOG4W9J41. |
Enzyme and pathway databases | |
| BRENDA | 1.14.19.1. 3474. |
Gene expression databases | |
| ArrayExpress | P13011. |
| Bgee | P13011. |
| CleanEx | MM_SCD2. |
| Genevestigator | P13011. |
| GermOnline | ENSMUSG00000025203. Mus musculus. |
Family and domain databases | |
| InterPro | IPR005804. Fatty_acid_desaturase-1. IPR001522. Fatty_acid_desaturase-1_C. IPR015876. Fatty_acid_desaturase-1_core. [Graphical view] |
| KO | K00507. |
| Pfam | PF00487. FA_desaturase. 1 hit. [Graphical view] |
| PRINTS | PR00075. FACDDSATRASE. |
| PROSITE | PS00476. FATTY_ACID_DESATUR_1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| SOURCE | Search... |
Entry information
| Entry name | ACOD2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P13011 Secondary accession number(s): Q8BH96 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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