Reviewed, UniProtKB/Swiss-Prot P13011 (ACOD2_MOUSE)

Names and origin

Protein names

Recommended name:
    Acyl-CoA desaturase 2
    EC=1.14.19.1
Alternative name(s):
    Stearoyl-CoA desaturase 2
    Fatty acid desaturase 2
    Delta(9)-desaturase 2

Gene names

Name:

Scd2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O2 and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.
Catalytic activity	Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.
Cofactor	Iron.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein Probable.
Domain	The histidine box domains may contain the active site and/or be involved in metal ion binding.
Sequence similarities	Belongs to the fatty acid desaturase family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane
Ligand	Iron
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW stearoyl-CoA 9-desaturase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Acyl-CoA desaturase 2		PRO_0000185398
Regions
	Transmembrane	75 – 95	21	Potential
	Transmembrane	97 – 117	21	Potential
	Transmembrane	222 – 242	21	Potential
	Transmembrane	314 – 334	21	Potential
	Motif	119 – 124	6	Histidine box-1
	Motif	156 – 160	5	Histidine box-2
	Motif	297 – 301	5	Histidine box-3

Sequences

	Sequence		Length	Mass (Da)
	P13011-1 [UniParc]. Last modified January 1, 1990. Version 1. Checksum: 201904F1F1262A8F	FASTA	358	41,073
	10 20 30 40 50 60 MPAHILQEIS GAYSATTTIT APPSGGQQNG GEKFEKSSHH WGADVRPELK DDLYDPTYQD 70 80 90 100 110 120 DEGPPPKLEY VWRNIILMAL LHLGALYGIT LVPSCKLYTC LFAYLYYVIS ALGITAGAHR 130 140 150 160 170 180 LWSHRTYKAR LPLRLFLIIA NTMAFQNDVY EWARDHRAHH KFSETHADPH NSRRGFFFSH 190 200 210 220 230 240 VGWLLVRKHP AVKEKGGKLD MSDLKAEKLV MFQRRYYKPD LLLMCFVLPT LVPWYCWGET 250 260 270 280 290 300 FVNSLCVSTF LRYAVVLNAT WLVNSAAHLY GYRPYDKNIS SRENILVSMG AVGERFHNYH 310 320 330 340 350 HAFPYDYSAS EYRWHINFTT FFIDCMALLG LAYDRKRVSR AAVLARIKRT GDGSCKSG

References

[1]	"Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase." Kaestner K.H., Ntambi J.M., Kelly T.J. Jr., Lane M.D. J. Biol. Chem. 264:14755-14761(1989) [PubMed: 2570068] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Adipocyte.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M26270 mRNA. Translation: AAA40094.1.
IPI	IPI00117142.
PIR	A36507.
UniGene	Mm.193096
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P13011.
Genome annotation databases
Ensembl	ENSMUSG00000025203. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:98240. Scd2.
Phylogenomic databases
HOGENOM	P13011.
HOVERGEN	P13011.
Enzyme and pathway databases
BRENDA	1.14.19.1. 244.
Gene expression databases
ArrayExpress	P13011.
Bgee	P13011.
CleanEx	MM_SCD2.
GermOnline	ENSMUSG00000025203. Mus musculus.
Family and domain databases
InterPro	IPR005804. Fatty_acid_desaturase-1. IPR001522. Fatty_acid_desaturase-1_C. IPR015876. Fatty_acid_desaturase-1_core. [Graphical view]
Pfam	PF00487. FA_desaturase. 1 hit. [Graphical view]
PRINTS	PR00075. FACDDSATRASE.
ProDom	PD002221. Desaturase. 1 hit. PD001081. FA_desat_sub. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00476. FATTY_ACID_DESATUR_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

ACOD2_MOUSE

Accession

Primary (citable) accession number: P13011

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
Last sequence update:	January 1, 1990
Last modified:	June 16, 2009
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)