Reviewed,
UniProtKB/Swiss-Prot P13011 (ACOD2_MOUSE)
Last modified
June 16, 2009.
Version 81.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Acyl-CoA desaturase 2 EC=1.14.19.1 Alternative name(s): Stearoyl-CoA desaturase 2 Fatty acid desaturase 2 Delta(9)-desaturase 2 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 358 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O2 and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. |
| Catalytic activity | Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O. |
| Cofactor | Iron. |
| Subcellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein Probable. |
| Domain | The histidine box domains may contain the active site and/or be involved in metal ion binding. |
| Sequence similarities | Belongs to the fatty acid desaturase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Fatty acid biosynthesis Lipid synthesis |
| Cellular component | Endoplasmic reticulum Membrane |
| Domain | Transmembrane |
| Ligand | Iron |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW stearoyl-CoA 9-desaturase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 358 | 358 | Acyl-CoA desaturase 2 | PRO_0000185398 | |||||
Regions | |||||||||
| Transmembrane | 75 – 95 | 21 | Potential | ||||||
| Transmembrane | 97 – 117 | 21 | Potential | ||||||
| Transmembrane | 222 – 242 | 21 | Potential | ||||||
| Transmembrane | 314 – 334 | 21 | Potential | ||||||
| Motif | 119 – 124 | 6 | Histidine box-1 | ||||||
| Motif | 156 – 160 | 5 | Histidine box-2 | ||||||
| Motif | 297 – 301 | 5 | Histidine box-3 | ||||||
Sequences
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References
| [1] | "Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase." Kaestner K.H., Ntambi J.M., Kelly T.J. Jr., Lane M.D. J. Biol. Chem. 264:14755-14761(1989) [PubMed: 2570068] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Adipocyte. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M26270 mRNA. Translation: AAA40094.1. | |
| IPI | IPI00117142. |
| PIR | A36507. |
| UniGene | Mm.193096 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | P13011. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000025203. Mus musculus. [Contig view] |
Organism-specific databases | |
| MGI | MGI:98240. Scd2. |
Phylogenomic databases | |
| HOGENOM | P13011. |
| HOVERGEN | P13011. |
Enzyme and pathway databases | |
| BRENDA | 1.14.19.1. 244. |
Gene expression databases | |
| ArrayExpress | P13011. |
| Bgee | P13011. |
| CleanEx | MM_SCD2. |
| GermOnline | ENSMUSG00000025203. Mus musculus. |
Family and domain databases | |
| InterPro | IPR005804. Fatty_acid_desaturase-1. IPR001522. Fatty_acid_desaturase-1_C. IPR015876. Fatty_acid_desaturase-1_core. [Graphical view] |
| Pfam | PF00487. FA_desaturase. 1 hit. [Graphical view] |
| PRINTS | PR00075. FACDDSATRASE. |
| ProDom | PD002221. Desaturase. 1 hit. PD001081. FA_desat_sub. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00476. FATTY_ACID_DESATUR_1. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | ACOD2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P13011 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


