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P12980 (LYL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 146. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein lyl-1
Alternative name(s):
Class A basic helix-loop-helix protein 18
Short name=bHLHa18
Lymphoblastic leukemia-derived sequence 1
Gene names
Name:LYL1
Synonyms:BHLHA18
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein.

Subcellular location

Nucleus Potential.

Involvement in disease

A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Sequence caution

The sequence AAA88084.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAA88085.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAA92488.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 280280Protein lyl-1
PRO_0000127262

Regions

Domain150 – 20253bHLH

Experimental info

Sequence conflict2351A → P in AAA88084. Ref.1
Sequence conflict2351A → P in AAA88085. Ref.1
Sequence conflict2351A → P in AAA92488. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P12980 [UniParc].

Last modified April 14, 2009. Version 3.
Checksum: 4A9D795FF74C59F8

FASTA28029,938
        10         20         30         40         50         60 
MCPPQAQAEV GPTMTEKAEM VCAPSPAPAP PPKPASPGPP QVEEVGHRGG SSPPRLPPGV 

        70         80         90        100        110        120 
PVISLGHSRP PGVAMPTTEL GTLRPPLLQL STLGTAPPTL ALHYHPHPFL NSVYIGPAGP 

       130        140        150        160        170        180 
FSIFPSSRLK RRPSHCELDL AEGHQPQKVA RRVFTNSRER WRQQNVNGAF AELRKLLPTH 

       190        200        210        220        230        240 
PPDRKLSKNE VLRLAMKYIG FLVRLLRDQA AALAAGPTPP GPRKRPVHRV PDDGARRGSG 

       250        260        270        280 
RRAEAAARSQ PAPPADPDGS PGGAARPIKM EQTALSPEVR 

« Hide

References

« Hide 'large scale' references
[1]"lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif."
Mellentin J.D., Smith S.D., Cleary M.L.
Cell 58:77-83(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lymph.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M22637 mRNA. Translation: AAA88084.1. Different initiation.
M22637 mRNA. Translation: AAA88085.1. Different initiation.
M22638 Genomic DNA. Translation: AAA92488.1. Different initiation.
AC005546 Genomic DNA. Translation: AAC33149.1.
AC007787 Genomic DNA. No translation available.
BC002796 mRNA. Translation: AAH02796.2.
CCDSCCDS12292.1.
PIRA30988.
RefSeqNP_005574.2. NM_005583.4.
UniGeneHs.46446.
Hs.728534.

3D structure databases

ProteinModelPortalP12980.
SMRP12980. Positions 148-209.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110244. 8 interactions.
DIPDIP-40885N.
IntActP12980. 1 interaction.
MINTMINT-85715.
STRING9606.ENSP00000264824.

PTM databases

PhosphoSiteP12980.

Polymorphism databases

DMDM226694149.

Proteomic databases

PaxDbP12980.
PRIDEP12980.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264824; ENSP00000264824; ENSG00000104903.
GeneID4066.
KEGGhsa:4066.
UCSCuc002mwi.3. human.

Organism-specific databases

CTD4066.
GeneCardsGC19M013209.
H-InvDBHIX0014818.
HGNCHGNC:6734. LYL1.
MIM151440. gene+phenotype.
neXtProtNX_P12980.
PharmGKBPA30497.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG307510.
HOGENOMHOG000113414.
HOVERGENHBG094957.
InParanoidP12980.
KOK15604.
OMAIKMEQTA.
OrthoDBEOG7SN8DF.
PhylomeDBP12980.
TreeFamTF315153.

Gene expression databases

ArrayExpressP12980.
BgeeP12980.
CleanExHS_LYL1.
GenevestigatorP12980.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiLYL1.
GenomeRNAi4066.
NextBio15940.
PROP12980.
SOURCESearch...

Entry information

Entry nameLYL1_HUMAN
AccessionPrimary (citable) accession number: P12980
Secondary accession number(s): O76102
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 14, 2009
Last modified: July 9, 2014
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM