Reviewed,
UniProtKB/Swiss-Prot P12980 (LYL1_HUMAN)
Last modified
June 16, 2009.
Version 92.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Protein lyl-1 Alternative name(s): Lymphoblastic leukemia-derived sequence 1 | ||
| Gene names |
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| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 280 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Subunit structure | Efficient DNA binding requires dimerization with another bHLH protein. |
| Subcellular location | Nucleus Potential. |
| Involvement in disease | A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB. |
| Sequence similarities | Contains 1 basic helix-loop-helix (bHLH) domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Coding sequence diversity | Chromosomal rearrangement |
| Disease | Proto-oncogene |
| Ligand | DNA-binding |
| Gene Ontology (GO) | |
| Biological process | regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | DNA binding Ref.1 Traceable author statement. Source: ProtInc transcription regulator activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 280 | 280 | Protein lyl-1 | PRO_0000127262 | |||||
Regions | |||||||||
| Domain | 163 – 203 | 41 | Helix-loop-helix motif | ||||||
| DNA binding | 150 – 162 | 13 | Basic motif | ||||||
Experimental info | |||||||||
| Sequence conflict | 235 | 1 | A → P in AAA88084. Ref.1 | ||||||
| Sequence conflict | 235 | 1 | A → P in AAA88085. Ref.1 | ||||||
| Sequence conflict | 235 | 1 | A → P in AAA92488. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif." Mellentin J.D., Smith S.D., Cleary M.L. Cell 58:77-83(1989) [PubMed: 2752424] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. |
| [2] | "The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M.Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lymph. |
Cross-references
Sequence databases | |
|---|---|
| M22637 mRNA. Translation: AAA88084.1. Different initiation. M22637 mRNA. Translation: AAA88085.1. Different initiation. M22638 Genomic DNA. Translation: AAA92488.1. Different initiation. AC005546 Genomic DNA. Translation: AAC33149.1. AC007787 Genomic DNA. No translation available. BC002796 mRNA. Translation: AAH02796.2. | |
| IPI | IPI00218258. |
| PIR | A30988. |
| RefSeq | NP_005574.2. |
| UniGene | Hs.46446 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | P12980. |
Genome annotation databases | |
| Ensembl | ENSG00000104903. Homo sapiens. [Contig view] |
| GeneID | 4066. |
| KEGG | hsa:4066. |
Organism-specific databases | |
| GeneCards | GC19M013070. |
| H-InvDB | HIX0014818. |
| HGNC | HGNC:6734. LYL1. |
| MIM | 151440. gene+phenotype. |
| Orphanet | 513. Leukemia, lymphoblastic, acute. |
| PharmGKB | PA30497. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | P12980. |
| HOVERGEN | P12980. |
| OMA | P12980. AMPTTEL. |
Gene expression databases | |
| Bgee | P12980. |
| CleanEx | HS_LYL1. |
| GermOnline | ENSG00000104903. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001092. HLH_basic. IPR011598. HLH_DNA_bd. [Graphical view] |
| Gene3D | G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit. |
| Pfam | PF00010. HLH. 1 hit. [Graphical view] |
| SMART | SM00353. HLH. 1 hit. [Graphical view] |
| PROSITE | PS50888. HLH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 15940. |
| SOURCE | Search... |
Entry information
| Entry name | LYL1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P12980 Secondary accession number(s): O76102 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


