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Protein

Protein lyl-1

Gene

LYL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • B cell differentiation Source: UniProtKB
  • blood vessel maturation Source: UniProtKB
  • definitive hemopoiesis Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiP12980

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lyl-1
Alternative name(s):
Class A basic helix-loop-helix protein 18
Short name:
bHLHa18
Lymphoblastic leukemia-derived sequence 1
Gene namesi
Name:LYL1
Synonyms:BHLHA18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104903.4
HGNCiHGNC:6734 LYL1
MIMi151440 gene+phenotype
neXtProtiNX_P12980

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi4066
MIMi151440 gene+phenotype
OpenTargetsiENSG00000104903
PharmGKBiPA30497

Polymorphism and mutation databases

BioMutaiLYL1
DMDMi226694149

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272621 – 280Protein lyl-1Add BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei260PhosphoserineCombined sources1
Modified residuei276PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP12980
MaxQBiP12980
PaxDbiP12980
PeptideAtlasiP12980
PRIDEiP12980

PTM databases

iPTMnetiP12980
PhosphoSitePlusiP12980

Expressioni

Gene expression databases

BgeeiENSG00000104903
CleanExiHS_LYL1
ExpressionAtlasiP12980 baseline and differential
GenevisibleiP12980 HS

Organism-specific databases

HPAiHPA075004

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110244, 9 interactors
DIPiDIP-40885N
IntActiP12980, 2 interactors
STRINGi9606.ENSP00000264824

Structurei

3D structure databases

ProteinModelPortaliP12980
SMRiP12980
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini150 – 202bHLHPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000113414
HOVERGENiHBG094957
InParanoidiP12980
KOiK15604
OMAiIKMEQTA
OrthoDBiEOG091G0ESI
PhylomeDBiP12980
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P12980-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPPQAQAEV GPTMTEKAEM VCAPSPAPAP PPKPASPGPP QVEEVGHRGG
60 70 80 90 100
SSPPRLPPGV PVISLGHSRP PGVAMPTTEL GTLRPPLLQL STLGTAPPTL
110 120 130 140 150
ALHYHPHPFL NSVYIGPAGP FSIFPSSRLK RRPSHCELDL AEGHQPQKVA
160 170 180 190 200
RRVFTNSRER WRQQNVNGAF AELRKLLPTH PPDRKLSKNE VLRLAMKYIG
210 220 230 240 250
FLVRLLRDQA AALAAGPTPP GPRKRPVHRV PDDGARRGSG RRAEAAARSQ
260 270 280
PAPPADPDGS PGGAARPIKM EQTALSPEVR
Length:280
Mass (Da):29,938
Last modified:April 14, 2009 - v3
Checksum:i4A9D795FF74C59F8
GO

Sequence cautioni

The sequence AAA88084 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAA88085 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAA92488 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti235A → P in AAA88084 (PubMed:2752424).Curated1
Sequence conflicti235A → P in AAA88085 (PubMed:2752424).Curated1
Sequence conflicti235A → P in AAA92488 (PubMed:2752424).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22637 mRNA Translation: AAA88084.1 Different initiation.
M22637 mRNA Translation: AAA88085.1 Different initiation.
M22638 Genomic DNA Translation: AAA92488.1 Different initiation.
AC005546 Genomic DNA Translation: AAC33149.1
AC007787 Genomic DNA No translation available.
BC002796 mRNA Translation: AAH02796.2
CCDSiCCDS12292.1
PIRiA30988
RefSeqiNP_005574.2, NM_005583.4
UniGeneiHs.46446
Hs.728534

Genome annotation databases

EnsembliENST00000264824; ENSP00000264824; ENSG00000104903
GeneIDi4066
KEGGihsa:4066
UCSCiuc002mwi.4 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Entry informationi

Entry nameiLYL1_HUMAN
AccessioniPrimary (citable) accession number: P12980
Secondary accession number(s): O76102
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 14, 2009
Last modified: May 23, 2018
This is version 173 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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