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Protein

Methyl-coenzyme M reductase subunit gamma

Gene

mcrG

Organism
Methanothermus fervidus
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.

Pathwayi: methyl-coenzyme M reduction

This protein is involved in step 1 of the subpathway that synthesizes methane from methyl-coenzyme M.
Proteins known to be involved in this subpathway in this organism are:
  1. Methyl-coenzyme M reductase subunit gamma (mcrG), Methyl-coenzyme M reductase subunit beta (mcrB), Methyl-coenzyme M reductase subunit alpha (mcrA)
This subpathway is part of the pathway methyl-coenzyme M reduction, which is itself part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes methane from methyl-coenzyme M, the pathway methyl-coenzyme M reduction and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMethanogenesis

Enzyme and pathway databases

UniPathwayiUPA00646; UER00699

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase subunit gamma (EC:2.8.4.1)
Alternative name(s):
Coenzyme-B sulfoethylthiotransferase gamma
Gene namesi
Name:mcrG
OrganismiMethanothermus fervidus
Taxonomic identifieri2180 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanothermaceaeMethanothermus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001474741 – 249Methyl-coenzyme M reductase subunit gammaAdd BLAST249

Proteomic databases

PRIDEiP12973

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains.

Structurei

3D structure databases

ProteinModelPortaliP12973
SMRiP12973
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiarCOG04858 Archaea
COG4057 LUCA

Family and domain databases

CDDicd00539 MCR_gamma, 1 hit
Gene3Di3.90.320.20, 1 hit
InterProiView protein in InterPro
IPR009024 Me_CoM_Rdtase_Fd-like_fold
IPR003178 Me_CoM_Rdtase_gsu
IPR036994 Me_CoM_Rdtase_gsu_sf
PfamiView protein in Pfam
PF02240 MCR_gamma, 1 hit
PIRSFiPIRSF000264 Meth_CoM_rd_gama, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005845 Me_CoM_Rdtase_gsu, 1 hit
SUPFAMiSSF55088 SSF55088, 1 hit
TIGRFAMsiTIGR03259 met_CoM_red_gam, 1 hit

Sequencei

Sequence statusi: Complete.

P12973-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQFYPGSTK IAENRRKFMN PDAELEKLRE ISDEDVVRIL GHRAPGEEYP
60 70 80 90 100
SVHPPLEELD EPEDPIKDIV EPTEGAKAGD RVRYVQFTDS VYFAPAQPYI
110 120 130 140 150
RSRAYLWRYR GADAGTLSGR QIIEARERDV EKIAKELIET EFFDPARTGI
160 170 180 190 200
RGKSVHGHSL RLDENGMMFD MLRRQVYDEE TGRVKMVKNQ IGDEFDEPID
210 220 230 240
LGEPLDEETL KEKTTIYRID NIPYREDKDL LEIVQRIHQL RSEAGFSPE
Length:249
Mass (Da):28,856
Last modified:October 1, 1989 - v1
Checksum:i9EBC01D15018300F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03375 Genomic DNA Translation: AAA72196.1

Genome annotation databases

GeneIDi9962515

Similar proteinsi

Entry informationi

Entry nameiMCRG_METFE
AccessioniPrimary (citable) accession number: P12973
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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