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Protein

60S ribosomal protein L7a

Gene

Rpl7a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-MMU-72689. Formation of a pool of free 40S subunits.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L7a
Alternative name(s):
Surfeit locus protein 3
Gene namesi
Name:Rpl7a
Synonyms:Surf-3, Surf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1353472. Rpl7a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367481 – 26660S ribosomal protein L7aAdd BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki20Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei34N6-acetyllysineBy similarity1
Cross-linki48Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei97N6-acetyllysine; alternateBy similarity1
Cross-linki97Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei217N6-acetyllysineBy similarity1
Cross-linki245Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP12970.
PaxDbiP12970.
PeptideAtlasiP12970.
PRIDEiP12970.

PTM databases

iPTMnetiP12970.
PhosphoSitePlusiP12970.
SwissPalmiP12970.

Expressioni

Gene expression databases

BgeeiENSMUSG00000062647.
CleanExiMM_RPL7A.
ExpressionAtlasiP12970. baseline and differential.
GenevisibleiP12970. MM.

Interactioni

Subunit structurei

Interacts with CRY1 (By similarity). Interacts with DICER1, AGO2, TARBP2, MOV10 and EIF6; they form a large RNA-induced silencing complex (RISC) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205125. 4 interactors.
CORUMiP12970.
IntActiP12970. 8 interactors.
MINTiMINT-4132646.
STRINGi10090.ENSMUSP00000135914.

Structurei

3D structure databases

ProteinModelPortaliP12970.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3166. Eukaryota.
COG1358. LUCA.
GeneTreeiENSGT00390000004753.
HOVERGENiHBG002936.
InParanoidiP12970.
KOiK02936.
OMAiRQRSILY.
OrthoDBiEOG091G0HPD.
PhylomeDBiP12970.
TreeFamiTF300788.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiView protein in InterPro
IPR029064. L30e-like.
IPR001921. Ribosomal_L7A/L8.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR018492. Ribosomal_L7Ae/L8/Nhp2.
IPR004037. Ribosomal_L7Ae_CS.
PfamiView protein in Pfam
PF01248. Ribosomal_L7Ae. 1 hit.
PRINTSiPR00881. L7ARS6FAMILY.
PR00882. RIBOSOMALL7A.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiView protein in PROSITE
PS01082. RIBOSOMAL_L7AE. 1 hit.

Sequencei

Sequence statusi: Complete.

P12970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKGKKAKGK KVAPAPAVVK KQEAKKVVNP LFEKRPKNFG IGQDIQPKRD
60 70 80 90 100
LTRFVKWPRY IRLQRQRAIL YKRLKVPPAI NQFTQALDRQ TATQLLKLAH
110 120 130 140 150
KYRPETKQEK KQRLLARAEK KAAGKGDVPT KRPPVLRAGV NTVTTLVENK
160 170 180 190 200
KAQLVVIAHD VDPIELVVFL PALCRKMGVP YCIIKGKARL GHLVHRKTCT
210 220 230 240 250
TVAFTQVNSE DKGALAKLVE AIRTNYNDRY DEIRRHWGGN VLGPKSVARI
260
AKLEKAKAKE LATKLG
Length:266
Mass (Da):29,977
Last modified:January 23, 2007 - v2
Checksum:i54EF5F1CD3C519F6
GO

Sequence cautioni

The sequence AAH16489 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14689
, M21455, M21456, M21457, M21458, M21459, M21460, M14692 Genomic DNA. Translation: AAA40152.1.
AK019449 mRNA. Translation: BAB31725.1.
BC016489 mRNA. Translation: AAH16489.1. Different initiation.
BC080663 mRNA. Translation: AAH80663.1.
BC080669 mRNA. Translation: AAH80669.1.
BC080712 mRNA. Translation: AAH80712.1.
BC084678 mRNA. Translation: AAH84678.1.
CCDSiCCDS15815.1.
PIRiA30241.
RefSeqiNP_038749.1. NM_013721.3.
UniGeneiMm.328601.
Mm.398371.

Genome annotation databases

EnsembliENSMUST00000102898; ENSMUSP00000099962; ENSMUSG00000062647.
GeneIDi27176.
KEGGimmu:27176.
UCSCiuc008iwf.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiRL7A_MOUSE
AccessioniPrimary (citable) accession number: P12970
Secondary accession number(s): Q91YM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families