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Protein

60S ribosomal protein L7a

Gene

Rpl7a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-6791226. Major pathway of rRNA processing in the nucleolus.
R-MMU-72689. Formation of a pool of free 40S subunits.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L7a
Alternative name(s):
Surfeit locus protein 3
Gene namesi
Name:Rpl7a
Synonyms:Surf-3, Surf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1353472. Rpl7a.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosolic large ribosomal subunit Source: MGI
  • extracellular exosome Source: MGI
  • focal adhesion Source: MGI
  • membrane Source: BHF-UCL
  • nucleolus Source: MGI
  • nucleus Source: MGI
  • polysomal ribosome Source: HGNC
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 26626560S ribosomal protein L7aPRO_0000136748Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341N6-acetyllysineBy similarity
Modified residuei97 – 971N6-acetyllysineBy similarity
Modified residuei217 – 2171N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP12970.
PaxDbiP12970.
PeptideAtlasiP12970.
PRIDEiP12970.

PTM databases

iPTMnetiP12970.
PhosphoSiteiP12970.
SwissPalmiP12970.

Expressioni

Gene expression databases

BgeeiP12970.
CleanExiMM_RPL7A.
ExpressionAtlasiP12970. baseline and differential.
GenevisibleiP12970. MM.

Interactioni

Subunit structurei

Interacts with CRY1 (By similarity). Interacts with DICER1, AGO2, TARBP2, MOV10 and EIF6; they form a large RNA-induced silencing complex (RISC) (By similarity).By similarity

Protein-protein interaction databases

BioGridi205125. 4 interactions.
IntActiP12970. 8 interactions.
MINTiMINT-4132646.
STRINGi10090.ENSMUSP00000135914.

Structurei

3D structure databases

ProteinModelPortaliP12970.
SMRiP12970. Positions 136-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L7Ae family.Curated

Phylogenomic databases

eggNOGiKOG3166. Eukaryota.
COG1358. LUCA.
HOVERGENiHBG002936.
InParanoidiP12970.
KOiK02936.
OMAiTCTCVAF.
OrthoDBiEOG712TXC.
PhylomeDBiP12970.
TreeFamiTF300788.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR029064. L30e-like.
IPR001921. Ribosomal_L7A/L8.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR018492. Ribosomal_L7Ae/L8/Nhp2.
IPR004037. Ribosomal_L7Ae_CS.
[Graphical view]
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
PRINTSiPR00881. L7ARS6FAMILY.
PR00882. RIBOSOMALL7A.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiPS01082. RIBOSOMAL_L7AE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKGKKAKGK KVAPAPAVVK KQEAKKVVNP LFEKRPKNFG IGQDIQPKRD
60 70 80 90 100
LTRFVKWPRY IRLQRQRAIL YKRLKVPPAI NQFTQALDRQ TATQLLKLAH
110 120 130 140 150
KYRPETKQEK KQRLLARAEK KAAGKGDVPT KRPPVLRAGV NTVTTLVENK
160 170 180 190 200
KAQLVVIAHD VDPIELVVFL PALCRKMGVP YCIIKGKARL GHLVHRKTCT
210 220 230 240 250
TVAFTQVNSE DKGALAKLVE AIRTNYNDRY DEIRRHWGGN VLGPKSVARI
260
AKLEKAKAKE LATKLG
Length:266
Mass (Da):29,977
Last modified:January 23, 2007 - v2
Checksum:i54EF5F1CD3C519F6
GO

Sequence cautioni

The sequence AAH16489.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14689
, M21455, M21456, M21457, M21458, M21459, M21460, M14692 Genomic DNA. Translation: AAA40152.1.
AK019449 mRNA. Translation: BAB31725.1.
BC016489 mRNA. Translation: AAH16489.1. Different initiation.
BC080663 mRNA. Translation: AAH80663.1.
BC080669 mRNA. Translation: AAH80669.1.
BC080712 mRNA. Translation: AAH80712.1.
BC084678 mRNA. Translation: AAH84678.1.
CCDSiCCDS15815.1.
PIRiA30241.
RefSeqiNP_038749.1. NM_013721.3.
UniGeneiMm.328601.
Mm.398371.

Genome annotation databases

EnsembliENSMUST00000102898; ENSMUSP00000099962; ENSMUSG00000062647.
GeneIDi27176.
KEGGimmu:27176.
UCSCiuc008iwf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14689
, M21455, M21456, M21457, M21458, M21459, M21460, M14692 Genomic DNA. Translation: AAA40152.1.
AK019449 mRNA. Translation: BAB31725.1.
BC016489 mRNA. Translation: AAH16489.1. Different initiation.
BC080663 mRNA. Translation: AAH80663.1.
BC080669 mRNA. Translation: AAH80669.1.
BC080712 mRNA. Translation: AAH80712.1.
BC084678 mRNA. Translation: AAH84678.1.
CCDSiCCDS15815.1.
PIRiA30241.
RefSeqiNP_038749.1. NM_013721.3.
UniGeneiMm.328601.
Mm.398371.

3D structure databases

ProteinModelPortaliP12970.
SMRiP12970. Positions 136-223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205125. 4 interactions.
IntActiP12970. 8 interactions.
MINTiMINT-4132646.
STRINGi10090.ENSMUSP00000135914.

PTM databases

iPTMnetiP12970.
PhosphoSiteiP12970.
SwissPalmiP12970.

Proteomic databases

EPDiP12970.
PaxDbiP12970.
PeptideAtlasiP12970.
PRIDEiP12970.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102898; ENSMUSP00000099962; ENSMUSG00000062647.
GeneIDi27176.
KEGGimmu:27176.
UCSCiuc008iwf.1. mouse.

Organism-specific databases

CTDi6130.
MGIiMGI:1353472. Rpl7a.

Phylogenomic databases

eggNOGiKOG3166. Eukaryota.
COG1358. LUCA.
HOVERGENiHBG002936.
InParanoidiP12970.
KOiK02936.
OMAiTCTCVAF.
OrthoDBiEOG712TXC.
PhylomeDBiP12970.
TreeFamiTF300788.

Enzyme and pathway databases

ReactomeiR-MMU-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-6791226. Major pathway of rRNA processing in the nucleolus.
R-MMU-72689. Formation of a pool of free 40S subunits.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP12970.
SOURCEiSearch...

Gene expression databases

BgeeiP12970.
CleanExiMM_RPL7A.
ExpressionAtlasiP12970. baseline and differential.
GenevisibleiP12970. MM.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR029064. L30e-like.
IPR001921. Ribosomal_L7A/L8.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR018492. Ribosomal_L7Ae/L8/Nhp2.
IPR004037. Ribosomal_L7Ae_CS.
[Graphical view]
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
PRINTSiPR00881. L7ARS6FAMILY.
PR00882. RIBOSOMALL7A.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiPS01082. RIBOSOMAL_L7AE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "One of the tightly clustered genes of the mouse surfeit locus is a highly expressed member of a multigene family whose other members are predominantly processed pseudogenes."
    Huxley C., Williams T., Fried M.
    Mol. Cell. Biol. 8:3898-3905(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: 129 and C57BL/6J.
    Tissue: Embryo and Mammary gland.
  4. "Molecular characterization of Mybbp1a as a co-repressor on the Period2 promoter."
    Hara Y., Onishi Y., Oishi K., Miyazaki K., Fukamizu A., Ishida N.
    Nucleic Acids Res. 37:1115-1126(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CRY1.

Entry informationi

Entry nameiRL7A_MOUSE
AccessioniPrimary (citable) accession number: P12970
Secondary accession number(s): Q91YM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.