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Protein

Islet amyloid polypeptide

Gene

Iapp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.By similarity

GO - Molecular functioni

  • hormone activity Source: RGD

GO - Biological processi

  • eating behavior Source: RGD
  • glucose metabolic process Source: RGD
  • negative regulation of bone resorption Source: Ensembl
  • negative regulation of cell differentiation Source: Ensembl
  • sensory perception of pain Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Islet amyloid polypeptide
Alternative name(s):
Amylin
Diabetes-associated peptide
Short name:
DAP
Gene namesi
Name:Iapp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi2854. Iapp.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: Ensembl
  • neuronal cell body Source: Ensembl
  • secretory granule Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000000412124 – 35Add BLAST12
PeptideiPRO_000000412238 – 74Islet amyloid polypeptideAdd BLAST37
PropeptideiPRO_000000412378 – 93Add BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 441 Publication
Modified residuei74Tyrosine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP12969.
PRIDEiP12969.

Expressioni

Tissue specificityi

Abundant in the islets of Langerhans but is not present in the brain or seven other tissues examined.

Gene expression databases

BgeeiENSRNOG00000012417.
GenevisibleiP12969. RN.

Interactioni

Subunit structurei

Interacts with IDE and INS.By similarity

GO - Molecular functioni

  • hormone activity Source: RGD

Protein-protein interaction databases

BioGridi246637. 1 interactor.
STRINGi10116.ENSRNOP00000016614.

Structurei

Secondary structure

193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi42 – 54Combined sources13
Helixi57 – 60Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KJ7NMR-A38-74[»]
SMRiP12969.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12969.

Family & Domainsi

Domaini

The mature protein is largely unstructured in the absence of a cognate ligand, but contrary to the human protein, it does not easily form fibrillar aggregates.1 Publication

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0NB. Eukaryota.
ENOG410Z7V7. LUCA.
GeneTreeiENSGT00510000048671.
HOGENOMiHOG000038203.
HOVERGENiHBG096065.
InParanoidiP12969.
KOiK08039.
OMAiSHQMEKR.
OrthoDBiEOG091G15QG.
PhylomeDBiP12969.
TreeFamiTF330783.

Family and domain databases

InterProiIPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
IPR000443. Pro-islet_amyloid_polypep.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00818. ISLETAMYLOID.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12969-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCISRLPAV LLILSVALGH LRATPVGSGT NPQVDKRKCN TATCATQRLA
60 70 80 90
NFLVRSSNNL GPVLPPTNVG SNTYGKRNVA EDPNRESLDF LLL
Length:93
Mass (Da):10,015
Last modified:October 1, 1989 - v1
Checksum:i5A76C92E624DA962
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25390 mRNA. Translation: AAA41359.1.
J04544 mRNA. Translation: AAA40730.1.
X52820, X52821 Genomic DNA. Translation: CAA37003.1.
PIRiS13566. TCRTIA.
RefSeqiNP_036718.1. NM_012586.2.
XP_006237676.1. XM_006237614.3.
UniGeneiRn.11394.

Genome annotation databases

EnsembliENSRNOT00000016614; ENSRNOP00000016614; ENSRNOG00000012417.
GeneIDi24476.
KEGGirno:24476.
UCSCiRGD:2854. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25390 mRNA. Translation: AAA41359.1.
J04544 mRNA. Translation: AAA40730.1.
X52820, X52821 Genomic DNA. Translation: CAA37003.1.
PIRiS13566. TCRTIA.
RefSeqiNP_036718.1. NM_012586.2.
XP_006237676.1. XM_006237614.3.
UniGeneiRn.11394.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KJ7NMR-A38-74[»]
SMRiP12969.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246637. 1 interactor.
STRINGi10116.ENSRNOP00000016614.

Proteomic databases

PaxDbiP12969.
PRIDEiP12969.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016614; ENSRNOP00000016614; ENSRNOG00000012417.
GeneIDi24476.
KEGGirno:24476.
UCSCiRGD:2854. rat.

Organism-specific databases

CTDi3375.
RGDi2854. Iapp.

Phylogenomic databases

eggNOGiENOG410J0NB. Eukaryota.
ENOG410Z7V7. LUCA.
GeneTreeiENSGT00510000048671.
HOGENOMiHOG000038203.
HOVERGENiHBG096065.
InParanoidiP12969.
KOiK08039.
OMAiSHQMEKR.
OrthoDBiEOG091G15QG.
PhylomeDBiP12969.
TreeFamiTF330783.

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-419812. Calcitonin-like ligand receptors.

Miscellaneous databases

EvolutionaryTraceiP12969.
PROiP12969.

Gene expression databases

BgeeiENSRNOG00000012417.
GenevisibleiP12969. RN.

Family and domain databases

InterProiIPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
IPR000443. Pro-islet_amyloid_polypep.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00818. ISLETAMYLOID.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIAPP_RAT
AccessioniPrimary (citable) accession number: P12969
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.