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P12968 (IAPP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Islet amyloid polypeptide
Alternative name(s):
Amylin
Diabetes-associated peptide
Short name=DAP
Gene names
Name:Iapp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length93 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

Subunit structure

Interacts with IDE and INS By similarity.

Subcellular location

Secreted.

Domain

The mature protein is largely unstructured in the absence of a cognate ligand, but contrary to the human protein, it does not easily form fibrillar aggregates.

Sequence similarities

Belongs to the calcitonin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Propeptide24 – 3512
PRO_0000004112
Peptide38 – 7437Islet amyloid polypeptide
PRO_0000004113
Propeptide78 – 9316
PRO_0000004114

Amino acid modifications

Modified residue741Tyrosine amide By similarity
Disulfide bond39 ↔ 44 By similarity

Sequences

Sequence LengthMass (Da)Tools
P12968 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: B135DBBC81475B15

FASTA9310,022
        10         20         30         40         50         60 
MMCISKLPAV LLILSVALNH LRATPVRSGS NPQMDKRKCN TATCATQRLA NFLVRSSNNL 

        70         80         90 
GPVLPPTNVG SNTYGKRNAA GDPNRESLDF LLV 

« Hide

References

« Hide 'large scale' references
[1]"Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone."
Nishi M., Chan S.J., Nagamatsu S., Bell G.I., Steiner D.F.
Proc. Natl. Acad. Sci. U.S.A. 86:5738-5742(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of mouse islet amyloid polypeptide gene and characterization of its promoter."
Ekawa K., Nishi M., Ohagi S., Sanke T., Nanjo K.
J. Mol. Endocrinol. 19:79-86(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DBA/2J.
Tissue: Liver.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Thymus.
[4]"Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species."
Betsholtz C., Christmansson L., Engstroem U., Rorsman F., Svensson V., Johnson K.H., Westermark P.
FEBS Lett. 251:261-264(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 38-74.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M25389 mRNA. Translation: AAA37874.1.
D31820 Genomic DNA. Translation: BAA22051.1.
BC027527 mRNA. Translation: AAH27527.1.
CCDSCCDS39694.1.
PIRC33542.
RefSeqNP_034621.1. NM_010491.2.
UniGeneMm.415.

3D structure databases

ProteinModelPortalP12968.
SMRP12968. Positions 38-74.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000043956.

PTM databases

PhosphoSiteP12968.

Proteomic databases

PRIDEP12968.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000041993; ENSMUSP00000043956; ENSMUSG00000041681.
GeneID15874.
KEGGmmu:15874.
UCSCuc009epb.2. mouse.

Organism-specific databases

CTD3375.
MGIMGI:96382. Iapp.

Phylogenomic databases

eggNOGNOG38926.
GeneTreeENSGT00510000048671.
HOGENOMHOG000038203.
HOVERGENHBG096065.
InParanoidP12968.
KOK08039.
OMASHQMEKR.
OrthoDBEOG7TMZVK.
PhylomeDBP12968.
TreeFamTF330783.

Enzyme and pathway databases

ReactomeREACT_13641. Regulation of Beta-Cell Development.
REACT_188576. Developmental Biology.

Gene expression databases

BgeeP12968.
CleanExMM_IAPP.
GenevestigatorP12968.

Family and domain databases

InterProIPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
IPR000443. Pro-islet_amyloid_polypep.
IPR021117. Procalcitonin-like.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view]
PANTHERPTHR10505. PTHR10505. 1 hit.
PfamPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSPR00818. ISLETAMYLOID.
SMARTSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288590.
PROP12968.
SOURCESearch...

Entry information

Entry nameIAPP_MOUSE
AccessionPrimary (citable) accession number: P12968
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot