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Protein

Islet amyloid polypeptide

Gene

Iapp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

GO - Molecular functioni

GO - Biological processi

  • eating behavior Source: Ensembl
  • endocrine pancreas development Source: Reactome
  • negative regulation of bone resorption Source: MGI
  • negative regulation of cell differentiation Source: MGI
  • sensory perception of pain Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-MMU-210745. Regulation of gene expression in beta cells.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Islet amyloid polypeptide
Alternative name(s):
Amylin
Diabetes-associated peptide
Short name:
DAP
Gene namesi
Name:Iapp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96382. Iapp.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular space Source: MGI
  • neuronal cell body Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Propeptidei24 – 3512PRO_0000004112Add
BLAST
Peptidei38 – 7437Islet amyloid polypeptidePRO_0000004113Add
BLAST
Propeptidei78 – 9316PRO_0000004114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi39 ↔ 44By similarity
Modified residuei74 – 741Tyrosine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP12968.
PRIDEiP12968.

PTM databases

iPTMnetiP12968.
PhosphoSiteiP12968.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041681.
CleanExiMM_IAPP.
GenevisibleiP12968. MM.

Interactioni

Subunit structurei

Interacts with IDE and INS.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043956.

Structurei

3D structure databases

ProteinModelPortaliP12968.
SMRiP12968. Positions 38-74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The mature protein is largely unstructured in the absence of a cognate ligand, but contrary to the human protein, it does not easily form fibrillar aggregates.

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0NB. Eukaryota.
ENOG410Z7V7. LUCA.
GeneTreeiENSGT00510000048671.
HOGENOMiHOG000038203.
HOVERGENiHBG096065.
InParanoidiP12968.
KOiK08039.
OMAiSHQMEKR.
OrthoDBiEOG091G15QG.
PhylomeDBiP12968.
TreeFamiTF330783.

Family and domain databases

InterProiIPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
IPR000443. Pro-islet_amyloid_polypep.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00818. ISLETAMYLOID.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12968-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMCISKLPAV LLILSVALNH LRATPVRSGS NPQMDKRKCN TATCATQRLA
60 70 80 90
NFLVRSSNNL GPVLPPTNVG SNTYGKRNAA GDPNRESLDF LLV
Length:93
Mass (Da):10,022
Last modified:October 1, 1989 - v1
Checksum:iB135DBBC81475B15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25389 mRNA. Translation: AAA37874.1.
D31820 Genomic DNA. Translation: BAA22051.1.
BC027527 mRNA. Translation: AAH27527.1.
CCDSiCCDS39694.1.
PIRiC33542.
RefSeqiNP_034621.1. NM_010491.2.
UniGeneiMm.415.

Genome annotation databases

EnsembliENSMUST00000041993; ENSMUSP00000043956; ENSMUSG00000041681.
GeneIDi15874.
KEGGimmu:15874.
UCSCiuc009epb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25389 mRNA. Translation: AAA37874.1.
D31820 Genomic DNA. Translation: BAA22051.1.
BC027527 mRNA. Translation: AAH27527.1.
CCDSiCCDS39694.1.
PIRiC33542.
RefSeqiNP_034621.1. NM_010491.2.
UniGeneiMm.415.

3D structure databases

ProteinModelPortaliP12968.
SMRiP12968. Positions 38-74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043956.

PTM databases

iPTMnetiP12968.
PhosphoSiteiP12968.

Proteomic databases

PaxDbiP12968.
PRIDEiP12968.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041993; ENSMUSP00000043956; ENSMUSG00000041681.
GeneIDi15874.
KEGGimmu:15874.
UCSCiuc009epb.2. mouse.

Organism-specific databases

CTDi3375.
MGIiMGI:96382. Iapp.

Phylogenomic databases

eggNOGiENOG410J0NB. Eukaryota.
ENOG410Z7V7. LUCA.
GeneTreeiENSGT00510000048671.
HOGENOMiHOG000038203.
HOVERGENiHBG096065.
InParanoidiP12968.
KOiK08039.
OMAiSHQMEKR.
OrthoDBiEOG091G15QG.
PhylomeDBiP12968.
TreeFamiTF330783.

Enzyme and pathway databases

ReactomeiR-MMU-210745. Regulation of gene expression in beta cells.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-419812. Calcitonin-like ligand receptors.

Miscellaneous databases

PROiP12968.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041681.
CleanExiMM_IAPP.
GenevisibleiP12968. MM.

Family and domain databases

InterProiIPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
IPR000443. Pro-islet_amyloid_polypep.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00818. ISLETAMYLOID.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIAPP_MOUSE
AccessioniPrimary (citable) accession number: P12968
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.