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Protein

Islet amyloid polypeptide

Gene

Iapp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

GO - Molecular functioni

  1. identical protein binding Source: MGI

GO - Biological processi

  1. eating behavior Source: Ensembl
  2. endocrine pancreas development Source: Reactome
  3. negative regulation of bone resorption Source: MGI
  4. negative regulation of cell differentiation Source: MGI
  5. sensory perception of pain Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_198563. Amyloids.
REACT_214529. Regulation of gene expression in beta cells.
REACT_242871. G alpha (s) signalling events.
REACT_255862. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Islet amyloid polypeptide
Alternative name(s):
Amylin
Diabetes-associated peptide
Short name:
DAP
Gene namesi
Name:Iapp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:96382. Iapp.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. extracellular space Source: MGI
  3. neuronal cell body Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 3512PRO_0000004112Add
BLAST
Peptidei38 – 7437Islet amyloid polypeptidePRO_0000004113Add
BLAST
Propeptidei78 – 9316PRO_0000004114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi39 ↔ 44By similarity
Modified residuei74 – 741Tyrosine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiP12968.

PTM databases

PhosphoSiteiP12968.

Expressioni

Gene expression databases

BgeeiP12968.
CleanExiMM_IAPP.
GenevestigatoriP12968.

Interactioni

Subunit structurei

Interacts with IDE and INS.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043956.

Structurei

3D structure databases

ProteinModelPortaliP12968.
SMRiP12968. Positions 38-74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The mature protein is largely unstructured in the absence of a cognate ligand, but contrary to the human protein, it does not easily form fibrillar aggregates.

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG38926.
GeneTreeiENSGT00510000048671.
HOGENOMiHOG000038203.
HOVERGENiHBG096065.
InParanoidiP12968.
KOiK08039.
OMAiSHQMEKR.
OrthoDBiEOG7TMZVK.
PhylomeDBiP12968.
TreeFamiTF330783.

Family and domain databases

InterProiIPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
IPR000443. Pro-islet_amyloid_polypep.
IPR021117. Procalcitonin-like.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00818. ISLETAMYLOID.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12968-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMCISKLPAV LLILSVALNH LRATPVRSGS NPQMDKRKCN TATCATQRLA
60 70 80 90
NFLVRSSNNL GPVLPPTNVG SNTYGKRNAA GDPNRESLDF LLV
Length:93
Mass (Da):10,022
Last modified:October 1, 1989 - v1
Checksum:iB135DBBC81475B15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25389 mRNA. Translation: AAA37874.1.
D31820 Genomic DNA. Translation: BAA22051.1.
BC027527 mRNA. Translation: AAH27527.1.
CCDSiCCDS39694.1.
PIRiC33542.
RefSeqiNP_034621.1. NM_010491.2.
UniGeneiMm.415.

Genome annotation databases

EnsembliENSMUST00000041993; ENSMUSP00000043956; ENSMUSG00000041681.
GeneIDi15874.
KEGGimmu:15874.
UCSCiuc009epb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25389 mRNA. Translation: AAA37874.1.
D31820 Genomic DNA. Translation: BAA22051.1.
BC027527 mRNA. Translation: AAH27527.1.
CCDSiCCDS39694.1.
PIRiC33542.
RefSeqiNP_034621.1. NM_010491.2.
UniGeneiMm.415.

3D structure databases

ProteinModelPortaliP12968.
SMRiP12968. Positions 38-74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043956.

PTM databases

PhosphoSiteiP12968.

Proteomic databases

PRIDEiP12968.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041993; ENSMUSP00000043956; ENSMUSG00000041681.
GeneIDi15874.
KEGGimmu:15874.
UCSCiuc009epb.2. mouse.

Organism-specific databases

CTDi3375.
MGIiMGI:96382. Iapp.

Phylogenomic databases

eggNOGiNOG38926.
GeneTreeiENSGT00510000048671.
HOGENOMiHOG000038203.
HOVERGENiHBG096065.
InParanoidiP12968.
KOiK08039.
OMAiSHQMEKR.
OrthoDBiEOG7TMZVK.
PhylomeDBiP12968.
TreeFamiTF330783.

Enzyme and pathway databases

ReactomeiREACT_198563. Amyloids.
REACT_214529. Regulation of gene expression in beta cells.
REACT_242871. G alpha (s) signalling events.
REACT_255862. Calcitonin-like ligand receptors.

Miscellaneous databases

NextBioi288590.
PROiP12968.
SOURCEiSearch...

Gene expression databases

BgeeiP12968.
CleanExiMM_IAPP.
GenevestigatoriP12968.

Family and domain databases

InterProiIPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
IPR000443. Pro-islet_amyloid_polypep.
IPR021117. Procalcitonin-like.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00818. ISLETAMYLOID.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone."
    Nishi M., Chan S.J., Nagamatsu S., Bell G.I., Steiner D.F.
    Proc. Natl. Acad. Sci. U.S.A. 86:5738-5742(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning of mouse islet amyloid polypeptide gene and characterization of its promoter."
    Ekawa K., Nishi M., Ohagi S., Sanke T., Nanjo K.
    J. Mol. Endocrinol. 19:79-86(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DBA/2J.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  4. "Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species."
    Betsholtz C., Christmansson L., Engstroem U., Rorsman F., Svensson V., Johnson K.H., Westermark P.
    FEBS Lett. 251:261-264(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 38-74.

Entry informationi

Entry nameiIAPP_MOUSE
AccessioniPrimary (citable) accession number: P12968
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: February 4, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.