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P12968

- IAPP_MOUSE

UniProt

P12968 - IAPP_MOUSE

Protein

Islet amyloid polypeptide

Gene

Iapp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

    GO - Biological processi

    1. eating behavior Source: Ensembl
    2. endocrine pancreas development Source: Reactome
    3. negative regulation of bone resorption Source: MGI
    4. negative regulation of cell differentiation Source: MGI
    5. sensory perception of pain Source: MGI

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_198563. Amyloids.
    REACT_214529. Regulation of gene expression in beta cells.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Islet amyloid polypeptide
    Alternative name(s):
    Amylin
    Diabetes-associated peptide
    Short name:
    DAP
    Gene namesi
    Name:Iapp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:96382. Iapp.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. extracellular space Source: MGI
    3. neuronal cell body Source: MGI

    Keywords - Cellular componenti

    Amyloid, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Propeptidei24 – 3512PRO_0000004112Add
    BLAST
    Peptidei38 – 7437Islet amyloid polypeptidePRO_0000004113Add
    BLAST
    Propeptidei78 – 9316PRO_0000004114Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi39 ↔ 44By similarity
    Modified residuei74 – 741Tyrosine amideBy similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Disulfide bond

    Proteomic databases

    PRIDEiP12968.

    PTM databases

    PhosphoSiteiP12968.

    Expressioni

    Gene expression databases

    BgeeiP12968.
    CleanExiMM_IAPP.
    GenevestigatoriP12968.

    Interactioni

    Subunit structurei

    Interacts with IDE and INS.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000043956.

    Structurei

    3D structure databases

    ProteinModelPortaliP12968.
    SMRiP12968. Positions 38-74.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The mature protein is largely unstructured in the absence of a cognate ligand, but contrary to the human protein, it does not easily form fibrillar aggregates.

    Sequence similaritiesi

    Belongs to the calcitonin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG38926.
    GeneTreeiENSGT00510000048671.
    HOGENOMiHOG000038203.
    HOVERGENiHBG096065.
    InParanoidiP12968.
    KOiK08039.
    OMAiSHQMEKR.
    OrthoDBiEOG7TMZVK.
    PhylomeDBiP12968.
    TreeFamiTF330783.

    Family and domain databases

    InterProiIPR018360. Calcitonin_CS.
    IPR001693. Calcitonin_peptide-like.
    IPR000443. Pro-islet_amyloid_polypep.
    IPR021117. Procalcitonin-like.
    IPR021116. Procalcitonin/adrenomedullin.
    [Graphical view]
    PANTHERiPTHR10505. PTHR10505. 1 hit.
    PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
    [Graphical view]
    PRINTSiPR00818. ISLETAMYLOID.
    SMARTiSM00113. CALCITONIN. 1 hit.
    [Graphical view]
    PROSITEiPS00258. CALCITONIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12968-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMCISKLPAV LLILSVALNH LRATPVRSGS NPQMDKRKCN TATCATQRLA   50
    NFLVRSSNNL GPVLPPTNVG SNTYGKRNAA GDPNRESLDF LLV 93
    Length:93
    Mass (Da):10,022
    Last modified:October 1, 1989 - v1
    Checksum:iB135DBBC81475B15
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25389 mRNA. Translation: AAA37874.1.
    D31820 Genomic DNA. Translation: BAA22051.1.
    BC027527 mRNA. Translation: AAH27527.1.
    CCDSiCCDS39694.1.
    PIRiC33542.
    RefSeqiNP_034621.1. NM_010491.2.
    UniGeneiMm.415.

    Genome annotation databases

    EnsembliENSMUST00000041993; ENSMUSP00000043956; ENSMUSG00000041681.
    GeneIDi15874.
    KEGGimmu:15874.
    UCSCiuc009epb.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25389 mRNA. Translation: AAA37874.1 .
    D31820 Genomic DNA. Translation: BAA22051.1 .
    BC027527 mRNA. Translation: AAH27527.1 .
    CCDSi CCDS39694.1.
    PIRi C33542.
    RefSeqi NP_034621.1. NM_010491.2.
    UniGenei Mm.415.

    3D structure databases

    ProteinModelPortali P12968.
    SMRi P12968. Positions 38-74.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000043956.

    PTM databases

    PhosphoSitei P12968.

    Proteomic databases

    PRIDEi P12968.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000041993 ; ENSMUSP00000043956 ; ENSMUSG00000041681 .
    GeneIDi 15874.
    KEGGi mmu:15874.
    UCSCi uc009epb.2. mouse.

    Organism-specific databases

    CTDi 3375.
    MGIi MGI:96382. Iapp.

    Phylogenomic databases

    eggNOGi NOG38926.
    GeneTreei ENSGT00510000048671.
    HOGENOMi HOG000038203.
    HOVERGENi HBG096065.
    InParanoidi P12968.
    KOi K08039.
    OMAi SHQMEKR.
    OrthoDBi EOG7TMZVK.
    PhylomeDBi P12968.
    TreeFami TF330783.

    Enzyme and pathway databases

    Reactomei REACT_198563. Amyloids.
    REACT_214529. Regulation of gene expression in beta cells.

    Miscellaneous databases

    NextBioi 288590.
    PROi P12968.
    SOURCEi Search...

    Gene expression databases

    Bgeei P12968.
    CleanExi MM_IAPP.
    Genevestigatori P12968.

    Family and domain databases

    InterProi IPR018360. Calcitonin_CS.
    IPR001693. Calcitonin_peptide-like.
    IPR000443. Pro-islet_amyloid_polypep.
    IPR021117. Procalcitonin-like.
    IPR021116. Procalcitonin/adrenomedullin.
    [Graphical view ]
    PANTHERi PTHR10505. PTHR10505. 1 hit.
    Pfami PF00214. Calc_CGRP_IAPP. 1 hit.
    [Graphical view ]
    PRINTSi PR00818. ISLETAMYLOID.
    SMARTi SM00113. CALCITONIN. 1 hit.
    [Graphical view ]
    PROSITEi PS00258. CALCITONIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone."
      Nishi M., Chan S.J., Nagamatsu S., Bell G.I., Steiner D.F.
      Proc. Natl. Acad. Sci. U.S.A. 86:5738-5742(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of mouse islet amyloid polypeptide gene and characterization of its promoter."
      Ekawa K., Nishi M., Ohagi S., Sanke T., Nanjo K.
      J. Mol. Endocrinol. 19:79-86(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DBA/2J.
      Tissue: Liver.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Thymus.
    4. "Sequence divergence in a specific region of islet amyloid polypeptide (IAPP) explains differences in islet amyloid formation between species."
      Betsholtz C., Christmansson L., Engstroem U., Rorsman F., Svensson V., Johnson K.H., Westermark P.
      FEBS Lett. 251:261-264(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 38-74.

    Entry informationi

    Entry nameiIAPP_MOUSE
    AccessioniPrimary (citable) accession number: P12968
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3