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P12967 (IAPP_FELCA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 28, 2011. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Islet amyloid polypeptide
Alternative name(s):
Amylin
Gene names
Name:IAPP
OrganismFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Protein attributes

Sequence length89 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism By similarity.

Subunit structure

Interacts with IDE and INS By similarity.

Subcellular location

Secreted By similarity.

Domain

The mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates By similarity.

Sequence similarities

Belongs to the calcitonin family.

Ontologies

Keywords
   Cellular componentAmyloid
Secreted
   DomainSignal
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
Disulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionhormone activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Propeptide23 – 319
PRO_0000004102
Peptide34 – 7037Islet amyloid polypeptide
PRO_0000004103
Propeptide74 – 8916
PRO_0000004104

Amino acid modifications

Modified residue701Tyrosine amide By similarity
Disulfide bond35 ↔ 40 By similarity

Sequences

Sequence LengthMass (Da)Tools
P12967 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 0834D783DEAD72A8

FASTA899,832
        10         20         30         40         50         60 
MCLLKLPVVL IVLLVALHHL KATPIESNQV EKRKCNTATC ATQRLANFLI RSSNNLGAIL 

        70         80 
SPTNVGSNTY GKRSTVDILN REPLNYLPF 

« Hide

References

[1]"Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone."
Nishi M., Chan S.J., Nagamatsu S., Bell G.I., Steiner D.F.
Proc. Natl. Acad. Sci. U.S.A. 86:5738-5742(1989) [PubMed: 2668946] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells."
Westermark P., Wernstedt C., Wilander E., Hayden D.W., O'Brien T.D., Johnson K.H.
Proc. Natl. Acad. Sci. U.S.A. 84:3881-3885(1987) [PubMed: 3035556] [Abstract]
Cited for: PROTEIN SEQUENCE OF 34-60.
[3]"Structure of cat islet amyloid polypeptide and identification of amino acid residues of potential significance for islet amyloid formation."
Betsholtz C., Christmanson L., Engstrom U., Rorsman F., Jordan K., O'Brien T.D., Murtaugh M., Johnson K.H., Westermark P.
Diabetes 39:118-122(1990) [PubMed: 2210054] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 34-70.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M25388 mRNA. Translation: AAA30813.1.
PIRA33542.
RefSeqNP_001036803.1. NM_001043338.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID751513.

Organism-specific databases

CTD3375.

Phylogenomic databases

eggNOGmaNOG20772.
HOVERGENHBG096065.

Family and domain databases

InterProIPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
IPR000443. Pro-islet_amyloid_polypep.
IPR021117. Procalcitonin-like.
IPR021116. Procalcitonin/adrenomedullin.
[Graphical view]
PANTHERPTHR10505. Calcitonin-like. 1 hit.
PfamPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSPR00818. ISLETAMYLOID.
SMARTSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIAPP_FELCA
AccessionPrimary (citable) accession number: P12967
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: June 28, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families