Reviewed, UniProtKB/Swiss-Prot P12967 (IAPP_FELCA)

Names and origin

Protein names

Recommended name:
    Islet amyloid polypeptide
Alternative name(s):
    Amylin

Gene names

Name:

IAPP

Organism

Felis catus (Cat) (Felis silvestris catus)

Taxonomic identifier

9685 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

Protein attributes

Sequence length	89 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism By similarity.
Subunit structure	Interacts with IDE and INS By similarity.
Subcellular location	Secreted By similarity.
Domain	The mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates By similarity.
Sequence similarities	Belongs to the calcitonin family.

Ontologies

Keywords
Cellular component	Amyloid Secreted
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hormone activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Propeptide	23 – 31	9			PRO_0000004102
	Peptide	34 – 70	37	Islet amyloid polypeptide		PRO_0000004103
	Propeptide	74 – 89	16			PRO_0000004104
Amino acid modifications
	Modified residue	70	1	Tyrosine amide By similarity
	Disulfide bond	35 ↔ 40		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P12967-1 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: 0834D783DEAD72A8	FASTA	89	9,832
	10 20 30 40 50 60 MCLLKLPVVL IVLLVALHHL KATPIESNQV EKRKCNTATC ATQRLANFLI RSSNNLGAIL 70 80 SPTNVGSNTY GKRSTVDILN REPLNYLPF

References

[1]	"Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone." Nishi M., Chan S.J., Nagamatsu S., Bell G.I., Steiner D.F. Proc. Natl. Acad. Sci. U.S.A. 86:5738-5742(1989) [PubMed: 2668946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells." Westermark P., Wernstedt C., Wilander E., Hayden D.W., O'Brien T.D., Johnson K.H. Proc. Natl. Acad. Sci. U.S.A. 84:3881-3885(1987) [PubMed: 3035556] [Abstract] Cited for: PROTEIN SEQUENCE OF 34-60.
[3]	"Structure of cat islet amyloid polypeptide and identification of amino acid residues of potential significance for islet amyloid formation." Betsholtz C., Christmanson L., Engstrom U., Rorsman F., Jordan K., O'Brien T.D., Murtaugh M., Johnson K.H., Westermark P. Diabetes 39:118-122(1990) [PubMed: 2210054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 34-70.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M25388 mRNA. Translation: AAA30813.1.
PIR	A33542.
RefSeq	NP_001036803.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	751513.
Organism-specific databases
CTD	751513.
Phylogenomic databases
HOVERGEN	P12967.
Family and domain databases
InterPro	IPR001693. Calcitonin-like. IPR018360. Calcitonin_CS. IPR000443. Islet_amyloid_polypep. [Graphical view]
PANTHER	PTHR10505. Calcitonin-like. 1 hit.
Pfam	PF00214. Calc_CGRP_IAPP. 1 hit. [Graphical view]
PRINTS	PR00818. ISLETAMYLOID.
SMART	SM00113. CALCITONIN. 1 hit. [Graphical view]
PROSITE	PS00258. CALCITONIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IAPP_FELCA

Accession

Primary (citable) accession number: P12967

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	September 1, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)