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Protein

Islet amyloid polypeptide

Gene

IAPP

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Islet amyloid polypeptide
Alternative name(s):
Amylin
Gene namesi
Name:IAPP
OrganismiFelis catus (Cat) (Felis silvestris catus)
Taxonomic identifieri9685 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
Proteomesi
  • UP000011712 Componenti: Chromosome B4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 319PRO_0000004102
Peptidei34 – 7037Islet amyloid polypeptidePRO_0000004103Add
BLAST
Propeptidei74 – 8916PRO_0000004104Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 40By similarity
Modified residuei70 – 701Tyrosine amideBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Interactioni

Subunit structurei

Interacts with IDE and INS.By similarity

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000020627.

Structurei

3D structure databases

ProteinModelPortaliP12967.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The mature protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates.By similarity

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0NB. Eukaryota.
ENOG410Z7V7. LUCA.
GeneTreeiENSGT00510000048671.
HOVERGENiHBG096065.
InParanoidiP12967.
KOiK08039.
OMAiSHQMEKR.

Family and domain databases

InterProiIPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
IPR000443. Pro-islet_amyloid_polypep.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00818. ISLETAMYLOID.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCLLKLPVVL IVLLVALHHL KATPIESNQV EKRKCNTATC ATQRLANFLI
60 70 80
RSSNNLGAIL SPTNVGSNTY GKRSTVDILN REPLNYLPF
Length:89
Mass (Da):9,832
Last modified:October 1, 1989 - v1
Checksum:i0834D783DEAD72A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25388 mRNA. Translation: AAA30813.1.
PIRiA33542.
RefSeqiNP_001036803.1. NM_001043338.1.

Genome annotation databases

EnsembliENSFCAT00000024980; ENSFCAP00000020627; ENSFCAG00000029193.
GeneIDi751513.
KEGGifca:751513.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25388 mRNA. Translation: AAA30813.1.
PIRiA33542.
RefSeqiNP_001036803.1. NM_001043338.1.

3D structure databases

ProteinModelPortaliP12967.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9685.ENSFCAP00000020627.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSFCAT00000024980; ENSFCAP00000020627; ENSFCAG00000029193.
GeneIDi751513.
KEGGifca:751513.

Organism-specific databases

CTDi3375.

Phylogenomic databases

eggNOGiENOG410J0NB. Eukaryota.
ENOG410Z7V7. LUCA.
GeneTreeiENSGT00510000048671.
HOVERGENiHBG096065.
InParanoidiP12967.
KOiK08039.
OMAiSHQMEKR.

Family and domain databases

InterProiIPR021117. Calcitonin-like.
IPR021116. Calcitonin/adrenomedullin.
IPR018360. Calcitonin_CS.
IPR001693. Calcitonin_peptide-like.
IPR000443. Pro-islet_amyloid_polypep.
[Graphical view]
PANTHERiPTHR10505. PTHR10505. 1 hit.
PfamiPF00214. Calc_CGRP_IAPP. 1 hit.
[Graphical view]
PRINTSiPR00818. ISLETAMYLOID.
SMARTiSM00113. CALCITONIN. 1 hit.
[Graphical view]
PROSITEiPS00258. CALCITONIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone."
    Nishi M., Chan S.J., Nagamatsu S., Bell G.I., Steiner D.F.
    Proc. Natl. Acad. Sci. U.S.A. 86:5738-5742(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells."
    Westermark P., Wernstedt C., Wilander E., Hayden D.W., O'Brien T.D., Johnson K.H.
    Proc. Natl. Acad. Sci. U.S.A. 84:3881-3885(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 34-60.
  3. "Structure of cat islet amyloid polypeptide and identification of amino acid residues of potential significance for islet amyloid formation."
    Betsholtz C., Christmanson L., Engstrom U., Rorsman F., Jordan K., O'Brien T.D., Murtaugh M., Johnson K.H., Westermark P.
    Diabetes 39:118-122(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 34-70.

Entry informationi

Entry nameiIAPP_FELCA
AccessioniPrimary (citable) accession number: P12967
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: March 16, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.