P12965 (MOS_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase mos
EC=2.7.11.1

Alternative name(s):
pp39-mos

Gene names

Name:

mos

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Disease	Proto-oncogene
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Serine/threonine-protein kinase mos		PRO_0000086358
Regions
	Domain	63 – 336	274	Protein kinase
	Nucleotide binding	69 – 77	9	ATP By similarity
Sites
	Active site	189	1	Proton acceptor By similarity
	Binding site	90	1	ATP By similarity
Experimental info
	Sequence conflict	46	1	P → R in CAA31689. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P12965 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: 6442F2A056738B57	FASTA	359	39,162
	10 20 30 40 50 60 MPSPIPVERF LPRDLSPSID LRPCSSPLEL SHRKLPGGLP ACSGRPRLLP PRLAWCSIDW 70 80 90 100 110 120 EQVLLLEPLG SGGFGSVYRA TYRGETVALK KVKRSTKNSL ASRQSFWAEL NAARLRHPHV 130 140 150 160 170 180 VRVVAASASC PGDPGCPGTI IMEYTGTGTL HQRIYGRSPP LGAEICMRYA RHVADGLRFL 190 200 210 220 230 240 HRDGVVHLDL KPANVLLAPG DLCKIGDFGC SQRLREGDEA AGGEPCCTQL RHVGGTYTHR 250 260 270 280 290 300 APELLKGEPV TAKADIYSFA ITLWQMVSRE LPYTGDRQCV LYAVVAYDLR PEMGPLFSHT 310 320 330 340 350 EEGRAARTIV QSCWAARPQE RPNAEQLLER LEQECAMCTG GPPSCSPESN APPPLGTGL

References

[1]	"Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes." Freeman R.S., Pickham K.M., Kanki J.P., Lee B.A., Pena S.V., Donoghue D.J. Proc. Natl. Acad. Sci. U.S.A. 86:5805-5809(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes." Sagata N., Oskarsson M., Copeland T., Brumbaugh J., Vande Woude G.F. Nature 335:519-525(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M25366 mRNA. Translation: AAA49677.1. X13311 mRNA. Translation: CAA31689.1.
PIR	TVXLMS. S06433.
RefSeq	NP_001081563.1. NM_001088094.1.
UniGene	Xl.599.
3D structure databases
ProteinModelPortal	P12965.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	397924.
KEGG	xla:397924.
Organism-specific databases
CTD	4342.
Xenbase	XB-GENE-1011507. mos.
Phylogenomic databases
HOVERGEN	HBG052499.
KO	K04367.
Enzyme and pathway databases
BRENDA	2.7.10.2. 6726.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MOS_XENLA

Accession

Primary (citable) accession number: P12965

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	April 3, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program