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Protein

Serine/threonine-protein kinase mos

Gene

mos

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei90ATPPROSITE-ProRule annotation1
Active sitei189Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi69 – 77ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase kinase kinase activity Source: UniProtKB

GO - Biological processi

  • activation of MAPKK activity Source: UniProtKB
  • protein autophosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 6725.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase mos (EC:2.7.11.1)
Alternative name(s):
pp39-mos
Gene namesi
Name:mos
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1011507. mos.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000863581 – 359Serine/threonine-protein kinase mosAdd BLAST359

PTM databases

iPTMnetiP12965.

Interactioni

Protein-protein interaction databases

BioGridi99260. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliP12965.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 336Protein kinasePROSITE-ProRule annotationAdd BLAST274

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG052499.
KOiK04367.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12965-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSPIPVERF LPRDLSPSID LRPCSSPLEL SHRKLPGGLP ACSGRPRLLP
60 70 80 90 100
PRLAWCSIDW EQVLLLEPLG SGGFGSVYRA TYRGETVALK KVKRSTKNSL
110 120 130 140 150
ASRQSFWAEL NAARLRHPHV VRVVAASASC PGDPGCPGTI IMEYTGTGTL
160 170 180 190 200
HQRIYGRSPP LGAEICMRYA RHVADGLRFL HRDGVVHLDL KPANVLLAPG
210 220 230 240 250
DLCKIGDFGC SQRLREGDEA AGGEPCCTQL RHVGGTYTHR APELLKGEPV
260 270 280 290 300
TAKADIYSFA ITLWQMVSRE LPYTGDRQCV LYAVVAYDLR PEMGPLFSHT
310 320 330 340 350
EEGRAARTIV QSCWAARPQE RPNAEQLLER LEQECAMCTG GPPSCSPESN

APPPLGTGL
Length:359
Mass (Da):39,162
Last modified:October 1, 1989 - v1
Checksum:i6442F2A056738B57
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46P → R in CAA31689 (PubMed:2971141).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25366 mRNA. Translation: AAA49677.1.
X13311 mRNA. Translation: CAA31689.1.
PIRiS06433. TVXLMS.
RefSeqiNP_001081563.1. NM_001088094.1.
UniGeneiXl.599.

Genome annotation databases

GeneIDi397924.
KEGGixla:397924.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25366 mRNA. Translation: AAA49677.1.
X13311 mRNA. Translation: CAA31689.1.
PIRiS06433. TVXLMS.
RefSeqiNP_001081563.1. NM_001088094.1.
UniGeneiXl.599.

3D structure databases

ProteinModelPortaliP12965.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi99260. 2 interactors.

PTM databases

iPTMnetiP12965.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397924.
KEGGixla:397924.

Organism-specific databases

CTDi4342.
XenbaseiXB-GENE-1011507. mos.

Phylogenomic databases

HOVERGENiHBG052499.
KOiK04367.

Enzyme and pathway databases

BRENDAi2.7.10.2. 6725.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOS_XENLA
AccessioniPrimary (citable) accession number: P12965
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: July 6, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.