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P12965 (MOS_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase mos

EC=2.7.11.1
Alternative name(s):
pp39-mos
Gene names
Name:mos
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Serine/threonine-protein kinase mos
PRO_0000086358

Regions

Domain63 – 336274Protein kinase
Nucleotide binding69 – 779ATP By similarity

Sites

Active site1891Proton acceptor By similarity
Binding site901ATP By similarity

Experimental info

Sequence conflict461P → R in CAA31689. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P12965 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 6442F2A056738B57

FASTA35939,162
        10         20         30         40         50         60 
MPSPIPVERF LPRDLSPSID LRPCSSPLEL SHRKLPGGLP ACSGRPRLLP PRLAWCSIDW 

        70         80         90        100        110        120 
EQVLLLEPLG SGGFGSVYRA TYRGETVALK KVKRSTKNSL ASRQSFWAEL NAARLRHPHV 

       130        140        150        160        170        180 
VRVVAASASC PGDPGCPGTI IMEYTGTGTL HQRIYGRSPP LGAEICMRYA RHVADGLRFL 

       190        200        210        220        230        240 
HRDGVVHLDL KPANVLLAPG DLCKIGDFGC SQRLREGDEA AGGEPCCTQL RHVGGTYTHR 

       250        260        270        280        290        300 
APELLKGEPV TAKADIYSFA ITLWQMVSRE LPYTGDRQCV LYAVVAYDLR PEMGPLFSHT 

       310        320        330        340        350 
EEGRAARTIV QSCWAARPQE RPNAEQLLER LEQECAMCTG GPPSCSPESN APPPLGTGL 

« Hide

References

[1]"Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes."
Freeman R.S., Pickham K.M., Kanki J.P., Lee B.A., Pena S.V., Donoghue D.J.
Proc. Natl. Acad. Sci. U.S.A. 86:5805-5809(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes."
Sagata N., Oskarsson M., Copeland T., Brumbaugh J., Vande Woude G.F.
Nature 335:519-525(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M25366 mRNA. Translation: AAA49677.1.
X13311 mRNA. Translation: CAA31689.1.
PIRTVXLMS. S06433.
RefSeqNP_001081563.1. NM_001088094.1.
UniGeneXl.599.

3D structure databases

ProteinModelPortalP12965.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid99260. 2 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397924.
KEGGxla:397924.

Organism-specific databases

CTD4342.
XenbaseXB-GENE-1011507. mos.

Phylogenomic databases

HOVERGENHBG052499.
KOK04367.

Enzyme and pathway databases

BRENDA2.7.10.2. 6726.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMOS_XENLA
AccessionPrimary (citable) accession number: P12965
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 14, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families