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P12965

- MOS_XENLA

UniProt

P12965 - MOS_XENLA

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Protein
Serine/threonine-protein kinase mos
Gene
mos
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei90 – 901ATP By similarity
Active sitei189 – 1891Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 779ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase kinase kinase activity Source: UniProt
Complete GO annotation...

GO - Biological processi

  1. MAPK cascade Source: GOC
  2. activation of MAPKK activity Source: UniProt
  3. protein autophosphorylation Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 6726.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase mos (EC:2.7.11.1)
Alternative name(s):
pp39-mos
Gene namesi
Name:mos
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1011507. mos.

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Serine/threonine-protein kinase mos
PRO_0000086358Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi99260. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP12965.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 336274Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG052499.
KOiK04367.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12965-1 [UniParc]FASTAAdd to Basket

« Hide

MPSPIPVERF LPRDLSPSID LRPCSSPLEL SHRKLPGGLP ACSGRPRLLP    50
PRLAWCSIDW EQVLLLEPLG SGGFGSVYRA TYRGETVALK KVKRSTKNSL 100
ASRQSFWAEL NAARLRHPHV VRVVAASASC PGDPGCPGTI IMEYTGTGTL 150
HQRIYGRSPP LGAEICMRYA RHVADGLRFL HRDGVVHLDL KPANVLLAPG 200
DLCKIGDFGC SQRLREGDEA AGGEPCCTQL RHVGGTYTHR APELLKGEPV 250
TAKADIYSFA ITLWQMVSRE LPYTGDRQCV LYAVVAYDLR PEMGPLFSHT 300
EEGRAARTIV QSCWAARPQE RPNAEQLLER LEQECAMCTG GPPSCSPESN 350
APPPLGTGL 359
Length:359
Mass (Da):39,162
Last modified:October 1, 1989 - v1
Checksum:i6442F2A056738B57
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461P → R in CAA31689. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25366 mRNA. Translation: AAA49677.1.
X13311 mRNA. Translation: CAA31689.1.
PIRiS06433. TVXLMS.
RefSeqiNP_001081563.1. NM_001088094.1.
UniGeneiXl.599.

Genome annotation databases

GeneIDi397924.
KEGGixla:397924.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M25366 mRNA. Translation: AAA49677.1 .
X13311 mRNA. Translation: CAA31689.1 .
PIRi S06433. TVXLMS.
RefSeqi NP_001081563.1. NM_001088094.1.
UniGenei Xl.599.

3D structure databases

ProteinModelPortali P12965.
ModBasei Search...

Protein-protein interaction databases

BioGridi 99260. 2 interactions.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397924.
KEGGi xla:397924.

Organism-specific databases

CTDi 4342.
Xenbasei XB-GENE-1011507. mos.

Phylogenomic databases

HOVERGENi HBG052499.
KOi K04367.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 6726.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes."
    Freeman R.S., Pickham K.M., Kanki J.P., Lee B.A., Pena S.V., Donoghue D.J.
    Proc. Natl. Acad. Sci. U.S.A. 86:5805-5809(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes."
    Sagata N., Oskarsson M., Copeland T., Brumbaugh J., Vande Woude G.F.
    Nature 335:519-525(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiMOS_XENLA
AccessioniPrimary (citable) accession number: P12965
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 14, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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