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P12965

- MOS_XENLA

UniProt

P12965 - MOS_XENLA

Protein

Serine/threonine-protein kinase mos

Gene

mos

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei90 – 901ATPPROSITE-ProRule annotation
    Active sitei189 – 1891Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi69 – 779ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase kinase kinase activity Source: UniProt

    GO - Biological processi

    1. activation of MAPKK activity Source: UniProt
    2. MAPK cascade Source: GOC
    3. protein autophosphorylation Source: UniProt

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 6726.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase mos (EC:2.7.11.1)
    Alternative name(s):
    pp39-mos
    Gene namesi
    Name:mos
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-1011507. mos.

    Pathology & Biotechi

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Serine/threonine-protein kinase mosPRO_0000086358Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    BioGridi99260. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP12965.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini63 – 336274Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG052499.
    KOiK04367.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P12965-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSPIPVERF LPRDLSPSID LRPCSSPLEL SHRKLPGGLP ACSGRPRLLP    50
    PRLAWCSIDW EQVLLLEPLG SGGFGSVYRA TYRGETVALK KVKRSTKNSL 100
    ASRQSFWAEL NAARLRHPHV VRVVAASASC PGDPGCPGTI IMEYTGTGTL 150
    HQRIYGRSPP LGAEICMRYA RHVADGLRFL HRDGVVHLDL KPANVLLAPG 200
    DLCKIGDFGC SQRLREGDEA AGGEPCCTQL RHVGGTYTHR APELLKGEPV 250
    TAKADIYSFA ITLWQMVSRE LPYTGDRQCV LYAVVAYDLR PEMGPLFSHT 300
    EEGRAARTIV QSCWAARPQE RPNAEQLLER LEQECAMCTG GPPSCSPESN 350
    APPPLGTGL 359
    Length:359
    Mass (Da):39,162
    Last modified:October 1, 1989 - v1
    Checksum:i6442F2A056738B57
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti46 – 461P → R in CAA31689. (PubMed:2971141)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25366 mRNA. Translation: AAA49677.1.
    X13311 mRNA. Translation: CAA31689.1.
    PIRiS06433. TVXLMS.
    RefSeqiNP_001081563.1. NM_001088094.1.
    UniGeneiXl.599.

    Genome annotation databases

    GeneIDi397924.
    KEGGixla:397924.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25366 mRNA. Translation: AAA49677.1 .
    X13311 mRNA. Translation: CAA31689.1 .
    PIRi S06433. TVXLMS.
    RefSeqi NP_001081563.1. NM_001088094.1.
    UniGenei Xl.599.

    3D structure databases

    ProteinModelPortali P12965.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 99260. 2 interactions.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397924.
    KEGGi xla:397924.

    Organism-specific databases

    CTDi 4342.
    Xenbasei XB-GENE-1011507. mos.

    Phylogenomic databases

    HOVERGENi HBG052499.
    KOi K04367.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 6726.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes."
      Freeman R.S., Pickham K.M., Kanki J.P., Lee B.A., Pena S.V., Donoghue D.J.
      Proc. Natl. Acad. Sci. U.S.A. 86:5805-5809(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes."
      Sagata N., Oskarsson M., Copeland T., Brumbaugh J., Vande Woude G.F.
      Nature 335:519-525(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiMOS_XENLA
    AccessioniPrimary (citable) accession number: P12965
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3