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Protein

Bowman-Birk type trypsin inhibitor

Gene

BBBI

Organism
Hordeum vulgare (Barley)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This inhibitor interacts with two molecules of trypsin.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei17 – 18Reactive bond2
Sitei75 – 76Reactive bond2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Ligandi

Calcium

Protein family/group databases

MEROPSiI12.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Bowman-Birk type trypsin inhibitor
Gene namesi
Name:BBBI
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeHordeinaeHordeum

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001058571 – 124Bowman-Birk type trypsin inhibitorAdd BLAST124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi9 ↔ 622 Publications
Disulfide bondi10 ↔ 252 Publications
Disulfide bondi15 ↔ 232 Publications
Disulfide bondi32 ↔ 392 Publications
Disulfide bondi36 ↔ 502 Publications
Disulfide bondi67 ↔ 1212 Publications
Disulfide bondi68 ↔ 832 Publications
Disulfide bondi73 ↔ 812 Publications
Disulfide bondi90 ↔ 972 Publications
Disulfide bondi94 ↔ 1092 Publications

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP12940.

Structurei

Secondary structure

1124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 15Combined sources5
Beta strandi17 – 20Combined sources4
Beta strandi22 – 25Combined sources4
Beta strandi39 – 41Combined sources3
Beta strandi44 – 50Combined sources7
Beta strandi53 – 56Combined sources4
Beta strandi62 – 64Combined sources3
Beta strandi69 – 73Combined sources5
Beta strandi75 – 78Combined sources4
Beta strandi80 – 83Combined sources4
Beta strandi87 – 89Combined sources3
Beta strandi97 – 99Combined sources3
Beta strandi101 – 103Combined sources3
Beta strandi107 – 109Combined sources3
Beta strandi113 – 116Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C2AX-ray1.90A4-122[»]
1TX6X-ray2.20I/J1-124[»]
2FJ8X-ray1.19A1-124[»]
ProteinModelPortaliP12940.
SMRiP12940.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12940.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 62Add BLAST62
Repeati63 – 124Add BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 80Calcium bindingAdd BLAST11

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JW1A. Eukaryota.
ENOG41105CZ. LUCA.

Family and domain databases

CDDicd00023. BBI. 2 hits.
Gene3Di2.10.69.10. 2 hits.
InterProiIPR000877. Prot_inh_BBI.
[Graphical view]
PfamiPF00228. Bowman-Birk_leg. 3 hits.
[Graphical view]
SMARTiSM00269. BowB. 2 hits.
[Graphical view]
SUPFAMiSSF57247. SSF57247. 2 hits.
PROSITEiPS00281. BOWMAN_BIRK. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AGKKRPWKCC DEAVCTRSIP PICTCMDEVF ECPKTCKSCG PMGDPSRRIC
60 70 80 90 100
QDQYVGDPGP ICRPWECCDK AICTRSNPPT CRCVDEVKKC APTCKTCLPS
110 120
RSRPSRRVCI DSYFGPVPPR CTPR
Length:124
Mass (Da):13,823
Last modified:October 1, 1989 - v1
Checksum:i04CCA1CC80D2FEAD
GO

Sequence databases

PIRiJT0235. TIBHB.

Cross-referencesi

Sequence databases

PIRiJT0235. TIBHB.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C2AX-ray1.90A4-122[»]
1TX6X-ray2.20I/J1-124[»]
2FJ8X-ray1.19A1-124[»]
ProteinModelPortaliP12940.
SMRiP12940.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI12.009.

Proteomic databases

PRIDEiP12940.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410JW1A. Eukaryota.
ENOG41105CZ. LUCA.

Miscellaneous databases

EvolutionaryTraceiP12940.

Family and domain databases

CDDicd00023. BBI. 2 hits.
Gene3Di2.10.69.10. 2 hits.
InterProiIPR000877. Prot_inh_BBI.
[Graphical view]
PfamiPF00228. Bowman-Birk_leg. 3 hits.
[Graphical view]
SMARTiSM00269. BowB. 2 hits.
[Graphical view]
SUPFAMiSSF57247. SSF57247. 2 hits.
PROSITEiPS00281. BOWMAN_BIRK. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIBB_HORVU
AccessioniPrimary (citable) accession number: P12940
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.