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Protein

Bowman-Birk type trypsin inhibitor

Gene

BBBI

Organism
Hordeum vulgare (Barley)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This inhibitor interacts with two molecules of trypsin.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei17 – 18Reactive bond2
Sitei75 – 76Reactive bond2

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor
LigandCalcium

Protein family/group databases

MEROPSiI12.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Bowman-Birk type trypsin inhibitor
Gene namesi
Name:BBBI
OrganismiHordeum vulgare (Barley)
Taxonomic identifieri4513 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeHordeinaeHordeum

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001058571 – 124Bowman-Birk type trypsin inhibitorAdd BLAST124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi9 ↔ 622 Publications
Disulfide bondi10 ↔ 252 Publications
Disulfide bondi15 ↔ 232 Publications
Disulfide bondi32 ↔ 392 Publications
Disulfide bondi36 ↔ 502 Publications
Disulfide bondi67 ↔ 1212 Publications
Disulfide bondi68 ↔ 832 Publications
Disulfide bondi73 ↔ 812 Publications
Disulfide bondi90 ↔ 972 Publications
Disulfide bondi94 ↔ 1092 Publications

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP12940.

Expressioni

Gene expression databases

ExpressionAtlasiP12940. differential.

Structurei

Secondary structure

1124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 15Combined sources5
Beta strandi17 – 20Combined sources4
Beta strandi22 – 25Combined sources4
Beta strandi39 – 41Combined sources3
Beta strandi44 – 50Combined sources7
Beta strandi53 – 56Combined sources4
Beta strandi62 – 64Combined sources3
Beta strandi69 – 73Combined sources5
Beta strandi75 – 78Combined sources4
Beta strandi80 – 83Combined sources4
Beta strandi87 – 89Combined sources3
Beta strandi97 – 99Combined sources3
Beta strandi101 – 103Combined sources3
Beta strandi107 – 109Combined sources3
Beta strandi113 – 116Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C2AX-ray1.90A4-122[»]
1TX6X-ray2.20I/J1-124[»]
2FJ8X-ray1.19A1-124[»]
ProteinModelPortaliP12940.
SMRiP12940.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12940.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 62Add BLAST62
Repeati63 – 124Add BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 80Calcium bindingAdd BLAST11

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JW1A. Eukaryota.
ENOG41105CZ. LUCA.

Family and domain databases

CDDicd00023. BBI. 2 hits.
InterProiView protein in InterPro
IPR035995. Bowman-Birk_prot_inh.
IPR000877. Prot_inh_BBI.
PfamiView protein in Pfam
PF00228. Bowman-Birk_leg. 3 hits.
SMARTiView protein in SMART
SM00269. BowB. 2 hits.
SUPFAMiSSF57247. SSF57247. 2 hits.
PROSITEiView protein in PROSITE
PS00281. BOWMAN_BIRK. 2 hits.

Sequencei

Sequence statusi: Complete.

P12940-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AGKKRPWKCC DEAVCTRSIP PICTCMDEVF ECPKTCKSCG PMGDPSRRIC
60 70 80 90 100
QDQYVGDPGP ICRPWECCDK AICTRSNPPT CRCVDEVKKC APTCKTCLPS
110 120
RSRPSRRVCI DSYFGPVPPR CTPR
Length:124
Mass (Da):13,823
Last modified:October 1, 1989 - v1
Checksum:i04CCA1CC80D2FEAD
GO

Sequence databases

PIRiJT0235. TIBHB.

Entry informationi

Entry nameiIBB_HORVU
AccessioniPrimary (citable) accession number: P12940
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: December 20, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families