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P12939

- CP2DA_RAT

UniProt

P12939 - CP2DA_RAT

Protein

Cytochrome P450 2D10

Gene

Cyp2d10

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi446 – 4461Iron (heme axial ligand)

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. monooxygenase activity Source: RGD

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2D10 (EC:1.14.14.1)
    Alternative name(s):
    CYPIID10
    Cytochrome P450-CMF1B
    Cytochrome P450-DB5
    Debrisoquine 4-hydroxylase
    Gene namesi
    Name:Cyp2d10
    Synonyms:Cyp2d-10, Cyp2d5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi628630. Cyp2d5.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Cytochrome P450 2D10PRO_0000051736Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi382 – 3821O-linked (GlcNAc)1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP12939.
    PRIDEiP12939.

    PTM databases

    PhosphoSiteiP12939.

    Expressioni

    Inductioni

    P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

    Gene expression databases

    GenevestigatoriP12939.

    Interactioni

    Protein-protein interaction databases

    IntActiP12939. 1 interaction.
    MINTiMINT-4564031.
    STRINGi10116.ENSRNOP00000040266.

    Structurei

    3D structure databases

    ProteinModelPortaliP12939.
    SMRiP12939. Positions 37-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036991.
    HOVERGENiHBG015789.
    InParanoidiP12939.
    KOiK07414.
    PhylomeDBiP12939.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P12939-1 [UniParc]FASTAAdd to Basket

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    MELLNGTGLW PMAIFTVIFI LLVDLMHRHQ RWTSRYPPGP VPWPVLGNLL    50
    QVDPSNMPYS MYKLQHRYGD VFSLQMGWKP MVIVNRLKAV QEVLVTHGED 100
    TADRPPVPIF KCLGVKPRSQ GVVFASYGPE WREQRRFSVS TLRTFGMGKK 150
    SLEEWVTKEA GHLCDAFTAQ NGRSINPKAM LNKALCNVIA SLIFARRFEY 200
    EDPYLIRMLT LVEESLIEVS GFIPEVLNTF PALLRIPGLA DKVFQGQKTF 250
    MAFLDNLLAE NRTTWDPAQP PRNLTDAFLA EVEKAKGNPE SSFNDENLRM 300
    VVVDLFTAGM VTTATTLTWA LLLMILYPDV QRRVQQEIDE VIGQVRCPEM 350
    TDQAHMPYTN AVIHEVQRFG DIAPLNLPRI TSCDIEVQDF VIPKGTTLII 400
    NLSSVLKDET VWEKPLRFHP EHFLDAQGNF VKHEAFMPFS AGRRACLGEP 450
    LARMELFLFF TCLLQHFSFS VPAGQPRPST LGNFAISVAP LPYQLCAAVR 500
    EQGH 504
    Length:504
    Mass (Da):57,076
    Last modified:October 1, 1989 - v1
    Checksum:iF308EE06F2605DFE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02869 mRNA. Translation: AAA41003.1.
    M25143 mRNA. Translation: AAA41034.1.
    X52030 Genomic DNA. Translation: CAA36272.1.
    M22329 mRNA. Translation: AAA41045.1.
    PIRiS09611. O4RTD5.
    RefSeqiNP_775426.1. NM_173304.2.
    UniGeneiRn.10842.

    Genome annotation databases

    GeneIDi286963.
    KEGGirno:286963.
    UCSCiRGD:628630. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02869 mRNA. Translation: AAA41003.1 .
    M25143 mRNA. Translation: AAA41034.1 .
    X52030 Genomic DNA. Translation: CAA36272.1 .
    M22329 mRNA. Translation: AAA41045.1 .
    PIRi S09611. O4RTD5.
    RefSeqi NP_775426.1. NM_173304.2.
    UniGenei Rn.10842.

    3D structure databases

    ProteinModelPortali P12939.
    SMRi P12939. Positions 37-500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P12939. 1 interaction.
    MINTi MINT-4564031.
    STRINGi 10116.ENSRNOP00000040266.

    PTM databases

    PhosphoSitei P12939.

    Proteomic databases

    PaxDbi P12939.
    PRIDEi P12939.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 286963.
    KEGGi rno:286963.
    UCSCi RGD:628630. rat.

    Organism-specific databases

    CTDi 286963.
    RGDi 628630. Cyp2d5.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036991.
    HOVERGENi HBG015789.
    InParanoidi P12939.
    KOi K07414.
    PhylomeDBi P12939.

    Miscellaneous databases

    NextBioi 625171.

    Gene expression databases

    Genevestigatori P12939.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01686. EP450ICYP2D.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats."
      Matsunaga E., Zanger U.M., Hardwick J.P., Gelboin H.V., Meyer U.A., Gonzalez F.J.
      Biochemistry 28:7349-7355(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The rat P450 IID subfamily: complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450 active site."
      Matsunaga E., Umeno M., Gonzalez F.J.
      J. Mol. Evol. 30:155-169(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.
    4. "Four species of cDNAs for cytochrome P450 isozymes immunorelated to P450C-M/F encode for members of P450IID subfamily, increasing the number of members within the subfamily."
      Ishida N., Tawaragi Y., Inuzuka C., Sugita O., Kubota I., Nakazato H., Noguchi T., Sassa S.
      Biochem. Biophys. Res. Commun. 156:681-688(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-504.
    5. "Discovery and confirmation of O-GlcNAcylated proteins in rat liver mitochondria by combination of mass spectrometry and immunological methods."
      Cao W., Cao J., Huang J., Yao J., Yan G., Xu H., Yang P.
      PLoS ONE 8:E76399-E76399(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT SER-382.

    Entry informationi

    Entry nameiCP2DA_RAT
    AccessioniPrimary (citable) accession number: P12939
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3