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P12939

- CP2DA_RAT

UniProt

P12939 - CP2DA_RAT

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Protein

Cytochrome P450 2D10

Gene

Cyp2d10

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi446 – 4461Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. monooxygenase activity Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2D10 (EC:1.14.14.1)
Alternative name(s):
CYPIID10
Cytochrome P450-CMF1B
Cytochrome P450-DB5
Debrisoquine 4-hydroxylase
Gene namesi
Name:Cyp2d10
Synonyms:Cyp2d-10, Cyp2d5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi628630. Cyp2d5.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Cytochrome P450 2D10PRO_0000051736Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi382 – 3821O-linked (GlcNAc)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP12939.
PRIDEiP12939.

PTM databases

PhosphoSiteiP12939.

Expressioni

Inductioni

P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

GenevestigatoriP12939.

Interactioni

Protein-protein interaction databases

IntActiP12939. 1 interaction.
MINTiMINT-4564031.
STRINGi10116.ENSRNOP00000040266.

Structurei

3D structure databases

ProteinModelPortaliP12939.
SMRiP12939. Positions 37-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036991.
HOVERGENiHBG015789.
InParanoidiP12939.
KOiK07414.
PhylomeDBiP12939.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12939-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELLNGTGLW PMAIFTVIFI LLVDLMHRHQ RWTSRYPPGP VPWPVLGNLL
60 70 80 90 100
QVDPSNMPYS MYKLQHRYGD VFSLQMGWKP MVIVNRLKAV QEVLVTHGED
110 120 130 140 150
TADRPPVPIF KCLGVKPRSQ GVVFASYGPE WREQRRFSVS TLRTFGMGKK
160 170 180 190 200
SLEEWVTKEA GHLCDAFTAQ NGRSINPKAM LNKALCNVIA SLIFARRFEY
210 220 230 240 250
EDPYLIRMLT LVEESLIEVS GFIPEVLNTF PALLRIPGLA DKVFQGQKTF
260 270 280 290 300
MAFLDNLLAE NRTTWDPAQP PRNLTDAFLA EVEKAKGNPE SSFNDENLRM
310 320 330 340 350
VVVDLFTAGM VTTATTLTWA LLLMILYPDV QRRVQQEIDE VIGQVRCPEM
360 370 380 390 400
TDQAHMPYTN AVIHEVQRFG DIAPLNLPRI TSCDIEVQDF VIPKGTTLII
410 420 430 440 450
NLSSVLKDET VWEKPLRFHP EHFLDAQGNF VKHEAFMPFS AGRRACLGEP
460 470 480 490 500
LARMELFLFF TCLLQHFSFS VPAGQPRPST LGNFAISVAP LPYQLCAAVR

EQGH
Length:504
Mass (Da):57,076
Last modified:October 1, 1989 - v1
Checksum:iF308EE06F2605DFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02869 mRNA. Translation: AAA41003.1.
M25143 mRNA. Translation: AAA41034.1.
X52030 Genomic DNA. Translation: CAA36272.1.
M22329 mRNA. Translation: AAA41045.1.
PIRiS09611. O4RTD5.
RefSeqiNP_775426.1. NM_173304.2.
UniGeneiRn.10842.

Genome annotation databases

GeneIDi286963.
KEGGirno:286963.
UCSCiRGD:628630. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02869 mRNA. Translation: AAA41003.1 .
M25143 mRNA. Translation: AAA41034.1 .
X52030 Genomic DNA. Translation: CAA36272.1 .
M22329 mRNA. Translation: AAA41045.1 .
PIRi S09611. O4RTD5.
RefSeqi NP_775426.1. NM_173304.2.
UniGenei Rn.10842.

3D structure databases

ProteinModelPortali P12939.
SMRi P12939. Positions 37-500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P12939. 1 interaction.
MINTi MINT-4564031.
STRINGi 10116.ENSRNOP00000040266.

PTM databases

PhosphoSitei P12939.

Proteomic databases

PaxDbi P12939.
PRIDEi P12939.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 286963.
KEGGi rno:286963.
UCSCi RGD:628630. rat.

Organism-specific databases

CTDi 286963.
RGDi 628630. Cyp2d5.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000036991.
HOVERGENi HBG015789.
InParanoidi P12939.
KOi K07414.
PhylomeDBi P12939.

Miscellaneous databases

NextBioi 625171.

Gene expression databases

Genevestigatori P12939.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008069. Cyt_P450_E_grp-I_CYP2D-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01686. EP450ICYP2D.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats."
    Matsunaga E., Zanger U.M., Hardwick J.P., Gelboin H.V., Meyer U.A., Gonzalez F.J.
    Biochemistry 28:7349-7355(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The rat P450 IID subfamily: complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450 active site."
    Matsunaga E., Umeno M., Gonzalez F.J.
    J. Mol. Evol. 30:155-169(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  4. "Four species of cDNAs for cytochrome P450 isozymes immunorelated to P450C-M/F encode for members of P450IID subfamily, increasing the number of members within the subfamily."
    Ishida N., Tawaragi Y., Inuzuka C., Sugita O., Kubota I., Nakazato H., Noguchi T., Sassa S.
    Biochem. Biophys. Res. Commun. 156:681-688(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-504.
  5. "Discovery and confirmation of O-GlcNAcylated proteins in rat liver mitochondria by combination of mass spectrometry and immunological methods."
    Cao W., Cao J., Huang J., Yao J., Yan G., Xu H., Yang P.
    PLoS ONE 8:E76399-E76399(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT SER-382.

Entry informationi

Entry nameiCP2DA_RAT
AccessioniPrimary (citable) accession number: P12939
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 26, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3