##gff-version 3 P12931 UniProtKB Initiator methionine 1 1 . . . Note=Removed P12931 UniProtKB Chain 2 536 . . . ID=PRO_0000088141;Note=Proto-oncogene tyrosine-protein kinase Src P12931 UniProtKB Domain 84 145 . . . Note=SH3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00192 P12931 UniProtKB Domain 151 248 . . . Note=SH2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00191 P12931 UniProtKB Domain 270 523 . . . Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P12931 UniProtKB Region 1 53 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P12931 UniProtKB Active site 389 389 . . . Note=Proton acceptor P12931 UniProtKB Binding site 276 284 . . . . P12931 UniProtKB Binding site 298 298 . . . . P12931 UniProtKB Modified residue 17 17 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18088087,ECO:0007744|PubMed:19369195,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18088087,PMID:19369195,PMID:23186163,PMID:24275569 P12931 UniProtKB Modified residue 75 75 . . . Note=Phosphoserine%3B by CDK5;Ontology_term=ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:21442427,ECO:0007744|PubMed:23186163;Dbxref=PMID:21442427,PMID:23186163 P12931 UniProtKB Modified residue 187 187 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P05480 P12931 UniProtKB Modified residue 419 419 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14661060,ECO:0000269|PubMed:18936167,ECO:0000269|PubMed:19307596,ECO:0000269|PubMed:25731159,ECO:0000269|PubMed:26936507,ECO:0000269|PubMed:6273838;Dbxref=PMID:14661060,PMID:18936167,PMID:19307596,PMID:25731159,PMID:26936507,PMID:6273838 P12931 UniProtKB Modified residue 419 419 . . . Note=Phosphotyrosine%3B by FAK2;Ontology_term=ECO:0000250;evidence=ECO:0000250 P12931 UniProtKB Modified residue 530 530 . . . Note=Phosphotyrosine%3B by CSK;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0007744;evidence=ECO:0000269|PubMed:19307596,ECO:0000269|PubMed:26936507,ECO:0000269|PubMed:7525268,ECO:0000269|PubMed:7929427,ECO:0007744|PubMed:19369195;Dbxref=PMID:19307596,PMID:19369195,PMID:26936507,PMID:7525268,PMID:7929427 P12931 UniProtKB Lipidation 2 2 . . . Note=N-myristoyl glycine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7525268;Dbxref=PMID:7525268 P12931 UniProtKB Alternative sequence 117 117 . . . ID=VSP_012134;Note=In isoform 2. T->TRKVDVR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:2681803;Dbxref=PMID:2681803 P12931 UniProtKB Alternative sequence 117 117 . . . ID=VSP_061494;Note=In isoform 3. T->TRKVDVSQTWFTFRWLQR P12931 UniProtKB Natural variant 176 176 . . . ID=VAR_051699;Note=L->F;Dbxref=dbSNP:rs6018260 P12931 UniProtKB Natural variant 237 237 . . . ID=VAR_041830;Note=A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs34881773,PMID:17344846 P12931 UniProtKB Natural variant 527 527 . . . ID=VAR_076919;Note=In THC6%3B increased protein tyrosine kinase activity%3B increased autophosphorylation at Y-419%3B causes defective megakaryopoiesis associated with increased overall tyrosine phosphorylation in megakaryocytes. E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:26936507;Dbxref=dbSNP:rs879255268,PMID:26936507 P12931 UniProtKB Mutagenesis 298 298 . . . Note=Kinase inactive. Abolishes ubiquitination promoted by CBLC. K->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14661060;Dbxref=PMID:14661060 P12931 UniProtKB Mutagenesis 302 302 . . . Note=Kinase active. Interacts with PDLIM4%3B when associated with E-307 and F-419. P->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19307596;Dbxref=PMID:19307596 P12931 UniProtKB Mutagenesis 307 307 . . . Note=Kinase active. Interacts with PDLIM4%3B when associated with E-302 and F-419. P->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19307596;Dbxref=PMID:19307596 P12931 UniProtKB Mutagenesis 419 419 . . . Note=Loss of kinase activity. Loss of interaction with PDLIM4. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19307596;Dbxref=PMID:19307596 P12931 UniProtKB Beta strand 87 93 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 99 102 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 110 114 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 118 126 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Turn 127 129 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 132 136 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Helix 137 139 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 140 142 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Helix 146 148 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 152 154 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Helix 158 165 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 167 170 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1SHD P12931 UniProtKB Beta strand 174 179 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 181 183 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 187 195 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Turn 196 198 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 199 209 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 211 213 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2SRC P12931 UniProtKB Beta strand 215 218 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 221 225 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Helix 226 233 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 240 242 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 256 259 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Helix 267 269 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 270 278 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 280 282 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ATE P12931 UniProtKB Beta strand 283 289 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Turn 290 292 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 293 299 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Turn 302 304 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2BDF P12931 UniProtKB Helix 307 319 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 328 332 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 334 336 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 338 341 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 345 348 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6ATE P12931 UniProtKB Helix 349 353 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Helix 355 358 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Helix 363 382 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Helix 392 394 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 395 397 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Helix 399 401 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Beta strand 403 405 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Helix 410 413 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2SRC P12931 UniProtKB Helix 417 420 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2SRC P12931 UniProtKB Turn 423 426 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1Y57 P12931 UniProtKB Helix 429 431 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Helix 434 439 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Helix 444 459 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Turn 460 462 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Helix 471 479 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Helix 492 501 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Helix 506 508 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Helix 512 520 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK P12931 UniProtKB Turn 521 523 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:1FMK