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Reviewed, UniProtKB/Swiss-Prot P12931 (SRC_HUMAN)

Last modified November 25, 2008. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (8) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Proto-oncogene tyrosine-protein kinase Src
    EC=2.7.10.2
Alternative name(s):
    pp60c-src
      Short name=p60-Src
      Short name=c-Src
Gene names
Name: SRC
Synonyms: SRC1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length536 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure

Interacts with DDEF1/ASAP1; via the SH3 domain. Interacts with CCPG1 By similarity. Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2. Interacts with the cytoplasmic domain of MUC1, phosphorylates it and increases binding of MUC1 with beta-catenin. Interacts with RALGPS1; via the SH3 domain. Interacts with HEV ORF3 protein; via the SH3 domain.

Post-translational modification

Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ABL1P005191EBI-621482,EBI-375543
ABL2P426841EBI-621482,EBI-1102694
ACTN1P128142EBI-621482,EBI-351710
AIREO439181EBI-621482,EBI-1753081
AKAP2Q9Y2D51EBI-621482,EBI-1754555
AKAP6Q130231EBI-621482,EBI-1056102
ALS2CR12Q96Q351EBI-621482,EBI-1755548
APOL5Q9BWW91EBI-621482,EBI-1753592
ASB16Q96NS51EBI-621482,EBI-1751918
Bcar1Q637671EBI-621482,EBI-1176801From a different organism.
CASTP208101EBI-621482,EBI-1268770
CD97P489601EBI-621482,EBI-1756009
CDKN1BP465271EBI-621482,EBI-519280
CELSR2Q9HCU41EBI-621482,EBI-724117
CENTB1Q150271EBI-621482,EBI-751746
Centd3Q8R5G73EBI-621482,EBI-621463From a different organism.
CKAP5Q140081EBI-621482,EBI-310585
CYP4F2P783291EBI-621482,EBI-1752413
DAG1Q141181EBI-621482,EBI-1755945
DDEF1Q9ULH11EBI-621482,EBI-346622
DDEF2O431501EBI-621482,EBI-310968
DLGAP1O144901EBI-621482,EBI-1753207
DLGAP2Q9P1A61EBI-621482,EBI-1753397
DLGAP3O958861EBI-621482,EBI-1752541
DLGAP4Q9Y2H01EBI-621482,EBI-722139
DLX4Q929881EBI-621482,EBI-1752755
DOCK1Q141851EBI-621482,EBI-446740
DOCK3Q8IZD91EBI-621482,EBI-1752361
DUSP15Q9H1R21EBI-621482,EBI-1752795
EFSO432811EBI-621482,EBI-718488
EIF3DO153711EBI-621482,EBI-353818
EPB41L3Q9Y2J21EBI-621482,EBI-310986
EXTL3O439091EBI-621482,EBI-1754679
F2RL2O002541EBI-621482,EBI-1751853
FANCAO153601EBI-621482,EBI-81570
FASP254452EBI-621482,EBI-494743
FCGR2BP319941EBI-621482,EBI-724784
FCGR2CP319951EBI-621482,EBI-1396036
GLTSCR1Q9NZM41EBI-621482,EBI-1754943
GNSP155861EBI-621482,EBI-1752200
HCN2Q9UL511EBI-621482,EBI-1751885
HOXC8P312731EBI-621482,EBI-1752118
ID4P479281EBI-621482,EBI-1754719
IKBKGQ9Y6K91EBI-621482,EBI-81279
ISG20L2Q9H9L31EBI-621482,EBI-751335
Khdrbs1Q607491EBI-621482,EBI-519077From a different organism.
KIAA1219Q86X101EBI-621482,EBI-1755842
LIG3P499161EBI-621482,EBI-1753381
MAP4K1Q929181EBI-621482,EBI-881
MED28Q9H2041EBI-621482,EBI-514199
MEPEQ9NQ761EBI-621482,EBI-1753293
MKI67P460131EBI-621482,EBI-876367
NKX2-1P436991EBI-621482,EBI-1391923
NXPH3O951571EBI-621482,EBI-1752913
OGNP207741EBI-621482,EBI-1753690
PARCQ8IWT31EBI-621482,EBI-311123
PAX3P237601EBI-621482,EBI-1167564
PAX7P237591EBI-621482,EBI-1042757
PDIA2Q130871EBI-621482,EBI-1752525
PECAM1P162841EBI-621482,EBI-716404
PHACTR2O751671EBI-621482,EBI-1754409
POLD1P283401EBI-621482,EBI-716569
PRICKLE3O439001EBI-621482,EBI-1751761
PTK2Q053971EBI-621482,EBI-702142
RAPGEF1Q139051EBI-621482,EBI-976876
RIN3Q8TB241EBI-621482,EBI-1570523
RPL13P263731EBI-621482,EBI-356849
RPP38P783451EBI-621482,EBI-366493
RRASP103011EBI-621482,EBI-968703
RTN4Q9NQC31EBI-621482,EBI-715945
SEPN1Q9NZV51EBI-621482,EBI-1751965
SHANK2Q9UPX81EBI-621482,EBI-1570571
SHANK3Q9BYB01EBI-621482,EBI-1752330
SHROOM2Q137961EBI-621482,EBI-1644065
SNX17Q150361EBI-621482,EBI-1752620
SNX3O604931EBI-621482,EBI-727209
SOS1Q078891EBI-621482,EBI-297487
SOS2Q078901EBI-621482,EBI-298181
SP1P080471EBI-621482,EBI-298336
Stat3P422271EBI-621482,EBI-602878From a different organism.
TULP4Q9NRJ41EBI-621482,EBI-1753487
ZP2Q059961EBI-621482,EBI-1755919

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P12931-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P12931-2)

The sequence of this isoform differs from the canonical sequence as follows:
     117-117: T → TRKVDVR

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 536535Proto-oncogene tyrosine-protein kinase Src
PRO_0000088141

Regions

Domain84 – 14562SH3
Domain151 – 24898SH2
Domain270 – 523254Protein kinase
Nucleotide binding276 – 2849ATP

Sites

Active site3891Proton acceptor
Binding site2981ATP

Amino acid modifications

Modified residue171Phosphoserine
Modified residue691Phosphoserine
Modified residue741Phosphothreonine
Modified residue751Phosphoserine
Modified residue1871Phosphotyrosine By similarity
Modified residue4191Phosphotyrosine; by autocatalysis
Modified residue4391Phosphotyrosine
Modified residue5301Phosphotyrosine; by CSK
Lipidation21N-myristoyl glycine By similarity

Natural variations

Alternative sequence1171T → TRKVDVR in isoform 2.
VSP_012134
Natural variant2371A → T
VAR_041830

Secondary structure

............................................................................... 536
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: C1908084683E5DE8

FASTA53659,835
        10         20         30         40         50         60 
MGSNKSKPKD ASQRRRSLEP AENVHGAGGG AFPASQTPSK PASADGHRGP