P12929 (VNCS_PAVCN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Non-capsid protein NS-1

Alternative name(s):
Non-structural protein NS1

Gene names

Name:

NS1

Organism

Canine parvovirus type 2 (isolate Dog/United States/CPV-N/1978) (CPV-2) [Complete proteome]

Taxonomic identifier

10791 [NCBI]

Taxonomic lineage

Viruses › ssDNA viruses › Parvoviridae › Parvovirinae › Parvovirus

Virus host

Canis familiaris (Dog) (Canis lupus familiaris) [TaxID: 9615]
Felis catus (Cat) (Felis silvestris catus) [TaxID: 9685]

Protein attributes

Sequence length	668 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Seems necessary for viral DNA replication.
Sequence similarities	Belongs to the parvoviruses non-capsid protein family. Contains 1 SF3 helicase domain.

Ontologies

Keywords
Biological process	DNA replication Initiation of viral infection Viral penetration into host cytoplasm Viral penetration via permeabilization of host organellar membrane
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW viral genome replication Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 668	668	Non-capsid protein NS-1		PRO_0000222470
Regions
	Domain	367 – 529	163	SF3 helicase
	Nucleotide binding	400 – 407	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	P12929 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: DE2CCEA69D2A63A6	FASTA	668	76,764
	10 20 30 40 50 60 MSGNQYTEEV MEGVNWLKKH AENEAFSFVF KCDNVQLNGK DVRWNNYTKP IQNEELTSLI 70 80 90 100 110 120 RGAQTAMDQT EEEEMDWESE VDSLAKKQVQ TFDALIKKCL FEVFVSKNIE PNECVWFIQH 130 140 150 160 170 180 EWGKDQGWHC HVLLHSKNLQ QATGKWLRRQ MNMYWSRWLV TLCSVNLTPT EKIKLREIAE 190 200 210 220 230 240 DSEWVTILTY RHKQTKKDYV KMVHFGNMIA YYFLTKKKIV HMTKESGYFL STDSGWKFNF 250 260 270 280 290 300 MKYQDRQIVS TLYTEQMKPE TVETTVTTAQ ETKRGRIQTK KEVSIKCTLR DLVSKRVTSP 310 320 330 340 350 360 EDWMMLQPDS YIEMMAQPGG ENLLKNTLEI CTLTLARTKT AFELILEKAD NTKLTNFDLA 370 380 390 400 410 420 NSRTCQIFRM HGWNWIKVCH AIACVLNRQG GKRNTVLFHG PASTGKSIIA QAIAQAVGNV 430 440 450 460 470 480 GCYNAANVNF PFNDCTNKNL IWIEEAGNFG QQVNQFKAIC SGQTIRIDQK GKGSKQIEPT 490 500 510 520 530 540 PVIMTTNENI TIVRIGCEER PEHTQPIRDR MLNIKLVCKL PGDFGLVDKE EWPLICAWLV 550 560 570 580 590 600 KHGYESTMAN YTHHWGKVPE WDENWAEPKI QEGINSPGCK DLETQAASNP QSQDQVLTPL 610 620 630 640 650 660 TPDVVDLALE PWSTPDTPIA ETANQQSNQL GVTHKDVQAS PTWSEIEADL RAIFTSEQLE EDFRDDLD

References

[1]	"Nucleotide sequence and genome organization of canine parvovirus." Reed A.P., Jones E.V., Miller T.J. J. Virol. 62:266-276(1988) [PubMed: 2824850] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Parrish C.R. Submitted (AUG-1990) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M19296 Genomic DNA. Translation: AAA67459.1. M38245 Genomic DNA. Translation: AAB02798.1.
PIR	UYPVCP. A29962.
RefSeq	NP_041399.1. NC_001539.1.
3D structure databases
ProteinModelPortal	P12929.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1724588.
Family and domain databases
InterPro	IPR003593. ATPase_AAA+_core. IPR014015. Helicase_SF3_DNA-vir. IPR021972. Parvovirus_NS1_C. IPR001257. Parvovirus_NS1_helicase. IPR021076. Parvovirus_NS1_N. [Graphical view]
Pfam	PF12117. DUF3580. 1 hit. PF01057. Parvo_NS1. 1 hit. PF12433. PV_NSP1. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS51206. SF3_HELICASE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VNCS_PAVCN

Accession

Primary (citable) accession number: P12929

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	September 21, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program