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Protein

Uracil-DNA glycosylase

Gene

UNG

Organism
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.By similarity

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylase (EC:3.2.2.27)
Short name:
UDG
Gene namesi
Name:UNG
ORF Names:BKRF3
OrganismiEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10377 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000007640 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001761831 – 255Uracil-DNA glycosylaseAdd BLAST255

Interactioni

Protein-protein interaction databases

IntActiP12888. 2 interactors.

Structurei

Secondary structure

1255
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi32 – 38Combined sources7
Helixi42 – 59Combined sources18
Beta strandi64 – 66Combined sources3
Turni68 – 72Combined sources5
Helixi73 – 75Combined sources3
Beta strandi76 – 78Combined sources3
Helixi80 – 82Combined sources3
Beta strandi85 – 89Combined sources5
Beta strandi94 – 96Combined sources3
Beta strandi100 – 103Combined sources4
Helixi113 – 125Combined sources13
Helixi138 – 141Combined sources4
Turni142 – 144Combined sources3
Beta strandi145 – 151Combined sources7
Turni159 – 164Combined sources6
Helixi167 – 181Combined sources15
Beta strandi186 – 191Combined sources6
Helixi192 – 195Combined sources4
Helixi196 – 200Combined sources5
Turni203 – 205Combined sources3
Beta strandi206 – 211Combined sources6
Helixi216 – 220Combined sources5
Helixi235 – 245Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J8XX-ray2.30A/C25-255[»]
ProteinModelPortaliP12888.
SMRiP12888.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12888.
Q777D9.

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase family.Curated

Phylogenomic databases

KOiK03648.

Family and domain databases

CDDicd10027. UDG_F1. 1 hit.
Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG. 1 hit.
InterProiIPR002043. UDG_fam1.
IPR018085. Ura-DNA_Glyclase_AS.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SMARTiSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.
TIGRFAMsiTIGR00628. ung. 1 hit.
PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRGLDLWL DEHVWKRKQE IGVKGENLLL PDLWLDFLQL SPIFQRKLAA
60 70 80 90 100
VIACVRRLRT QATVYPEEDM CMAWARFCDP SDIKVVILGQ DPYHGGQANG
110 120 130 140 150
LAFSVAYGFP VPPSLRNIYA ELHRSLPEFS PPDHGCLDAW ASQGVLLLNT
160 170 180 190 200
ILTVQKGKPG SHADIGWAWF TDHVISLLSE RLKACVFMLW GAKAGDKASL
210 220 230 240 250
INSKKHLVLT SQHPSPLAQN STRKSAQQKF LGNNHFVLAN NFLREKGLGE

IDWRL
Length:255
Mass (Da):28,605
Last modified:October 1, 1989 - v1
Checksum:iF7A26FB6F674E689
GO

Sequence cautioni

The sequence CAA24818 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA. Translation: CAA24818.1. Different initiation.
AJ507799 Genomic DNA. Translation: CAD53429.1.
RefSeqiYP_401679.1. NC_007605.1.

Genome annotation databases

GeneIDi3783711.
KEGGivg:3783711.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA. Translation: CAA24818.1. Different initiation.
AJ507799 Genomic DNA. Translation: CAD53429.1.
RefSeqiYP_401679.1. NC_007605.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J8XX-ray2.30A/C25-255[»]
ProteinModelPortaliP12888.
SMRiP12888.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP12888. 2 interactors.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3783711.
KEGGivg:3783711.

Phylogenomic databases

KOiK03648.

Miscellaneous databases

EvolutionaryTraceiP12888.
Q777D9.

Family and domain databases

CDDicd10027. UDG_F1. 1 hit.
Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG. 1 hit.
InterProiIPR002043. UDG_fam1.
IPR018085. Ura-DNA_Glyclase_AS.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SMARTiSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.
TIGRFAMsiTIGR00628. ung. 1 hit.
PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUNG_EBVB9
AccessioniPrimary (citable) accession number: P12888
Secondary accession number(s): Q777D9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.