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Protein

Uracil-DNA glycosylase

Gene

UNG

Organism
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Alternative name(s):
UNGUniRule annotation
Gene namesi
Name:UNG
ORF Names:BKRF3
OrganismiEpstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10377 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000153037 Componenti: Genome

Subcellular locationi

  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001761831 – 255Uracil-DNA glycosylaseAdd BLAST255

Proteomic databases

PRIDEiP12888

Interactioni

Protein-protein interaction databases

IntActiP12888, 2 interactors
MINTiP12888

Structurei

Secondary structure

1255
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi32 – 38Combined sources7
Helixi42 – 59Combined sources18
Beta strandi64 – 66Combined sources3
Turni68 – 72Combined sources5
Helixi73 – 75Combined sources3
Beta strandi76 – 78Combined sources3
Helixi80 – 82Combined sources3
Beta strandi85 – 89Combined sources5
Beta strandi94 – 96Combined sources3
Beta strandi100 – 103Combined sources4
Helixi113 – 125Combined sources13
Helixi138 – 141Combined sources4
Turni142 – 144Combined sources3
Beta strandi145 – 151Combined sources7
Turni159 – 164Combined sources6
Helixi167 – 181Combined sources15
Beta strandi186 – 191Combined sources6
Helixi192 – 195Combined sources4
Helixi196 – 200Combined sources5
Turni203 – 205Combined sources3
Beta strandi206 – 211Combined sources6
Helixi216 – 220Combined sources5
Helixi235 – 245Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J8XX-ray2.30A/C25-255[»]
ProteinModelPortaliP12888
SMRiP12888
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12888

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000E7

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

P12888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRGLDLWL DEHVWKRKQE IGVKGENLLL PDLWLDFLQL SPIFQRKLAA
60 70 80 90 100
VIACVRRLRT QATVYPEEDM CMAWARFCDP SDIKVVILGQ DPYHGGQANG
110 120 130 140 150
LAFSVAYGFP VPPSLRNIYA ELHRSLPEFS PPDHGCLDAW ASQGVLLLNT
160 170 180 190 200
ILTVQKGKPG SHADIGWAWF TDHVISLLSE RLKACVFMLW GAKAGDKASL
210 220 230 240 250
INSKKHLVLT SQHPSPLAQN STRKSAQQKF LGNNHFVLAN NFLREKGLGE

IDWRL
Length:255
Mass (Da):28,605
Last modified:October 1, 1989 - v1
Checksum:iF7A26FB6F674E689
GO

Sequence cautioni

The sequence CAA24818 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01555 Genomic DNA Translation: CAA24818.1 Different initiation.
AJ507799 Genomic DNA Translation: CAD53429.1
RefSeqiYP_401679.1, NC_007605.1

Genome annotation databases

GeneIDi3783711
KEGGivg:3783711

Similar proteinsi

Entry informationi

Entry nameiUNG_EBVB9
AccessioniPrimary (citable) accession number: P12888
Secondary accession number(s): Q777D9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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