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Protein

Alcohol dehydrogenase 1

Gene
N/A
Organism
Pisum sativum (Garden pea)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.1 Publication

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48Zinc 1; catalyticBy similarity1
Metal bindingi50Zinc 1By similarity1
Binding sitei50NADBy similarity1
Binding sitei50SubstrateBy similarity1
Metal bindingi70Zinc 1; catalyticBy similarity1
Binding sitei70SubstrateBy similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi114Zinc 2By similarity1
Metal bindingi178Zinc 1; catalyticBy similarity1
Binding sitei227NADBy similarity1
Binding sitei232NADBy similarity1
Binding sitei273NAD; via carbonyl oxygenBy similarity1
Binding sitei296NAD; via carbonyl oxygenBy similarity1
Binding sitei373NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi203 – 208NADBy similarity6
Nucleotide bindingi296 – 298NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15105.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 11 Publication (EC:1.1.1.11 Publication)
OrganismiPisum sativum (Garden pea)
Taxonomic identifieri3888 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeFabeaePisum

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607091 – 380Alcohol dehydrogenase 1Add BLAST380

Proteomic databases

PRIDEiP12886.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP12886.
SMRiP12886.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P12886-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTVGQIIK CRAAVAWEAG KPLVIEEVEV APPQAGEVRL KILFTSLCHT
60 70 80 90 100
DVYFWEAKGQ TPLFPRIFGH EAGGIVESVG EGVTHLKPGD HALPVFTGEC
110 120 130 140 150
GECPHCKSEE SNMCDLLRIN TDRGVMLNDN KSRFSIKGQP VHHFVGTSTF
160 170 180 190 200
SEYTVVHAGC VAKINPDAPL DKVCILSCGI CTGLGATINV AKPKPGSSVA
210 220 230 240 250
IFGLGAVGLA AAEGARISGA SRIIGVDLVS SRFELAKKFG VNEFVNPKEH
260 270 280 290 300
DKPVQQVIAE MTNGGVDRAV ECTGSIQAMI SAFECVHDGW GVAVLVGVPS
310 320 330 340 350
KDDAFKTHPM NFLNERTLKG TFYGNYKPRT DLPNVVEKYM KGELELEKFI
360 370 380
THTVPFSEIN KAFDYMLKGE SIRCIIKMEE
Length:380
Mass (Da):41,155
Last modified:October 1, 1989 - v1
Checksum:i09CECCBB889BF475
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06281 Genomic DNA. Translation: CAA29609.1.
PIRiS00912.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06281 Genomic DNA. Translation: CAA29609.1.
PIRiS00912.

3D structure databases

ProteinModelPortaliP12886.
SMRiP12886.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP12886.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15105.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_PEA
AccessioniPrimary (citable) accession number: P12886
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 10, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.