Reviewed, UniProtKB/Swiss-Prot P12886 (ADH1_PEA)

Names and origin

Protein names	Recommended name:     Alcohol dehydrogenase 1     EC=1.1.1.1
Organism	Pisum sativum (Garden pea)
Taxonomic identifier	3888 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids I › Fabales › Fabaceae › Papilionoideae › Fabeae › Pisum

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An alcohol + NAD(+) = an aldehyde or ketone + NADH.
Cofactor	Binds 2 zinc ions per subunit.
Subunit structure	Homodimer.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alcohol dehydrogenase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 380	380	Alcohol dehydrogenase 1		PRO_0000160709
Sites
	Metal binding	48	1	Zinc 1; catalytic By similarity
	Metal binding	70	1	Zinc 1; catalytic By similarity
	Metal binding	100	1	Zinc 2 By similarity
	Metal binding	103	1	Zinc 2 By similarity
	Metal binding	106	1	Zinc 2 By similarity
	Metal binding	114	1	Zinc 2 By similarity
	Metal binding	178	1	Zinc 1; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	P12886-1 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: 09CECCBB889BF475	FASTA	380	41,155
	10 20 30 40 50 60 MSNTVGQIIK CRAAVAWEAG KPLVIEEVEV APPQAGEVRL KILFTSLCHT DVYFWEAKGQ 70 80 90 100 110 120 TPLFPRIFGH EAGGIVESVG EGVTHLKPGD HALPVFTGEC GECPHCKSEE SNMCDLLRIN 130 140 150 160 170 180 TDRGVMLNDN KSRFSIKGQP VHHFVGTSTF SEYTVVHAGC VAKINPDAPL DKVCILSCGI 190 200 210 220 230 240 CTGLGATINV AKPKPGSSVA IFGLGAVGLA AAEGARISGA SRIIGVDLVS SRFELAKKFG 250 260 270 280 290 300 VNEFVNPKEH DKPVQQVIAE MTNGGVDRAV ECTGSIQAMI SAFECVHDGW GVAVLVGVPS 310 320 330 340 350 360 KDDAFKTHPM NFLNERTLKG TFYGNYKPRT DLPNVVEKYM KGELELEKFI THTVPFSEIN 370 380 KAFDYMLKGE SIRCIIKMEE

References

[1]

"Structure and expression of an alcohol dehydrogenase 1 gene from Pisum sativum (cv. 'Greenfeast')." Llewellyn D.J., Finnegan E.J., Ellis J.G., Dennis E.S., Peacock W.J. J. Mol. Biol. 195:115-123(1987) [PubMed: 3309331] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: cv. Greenfeast.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X06281 Genomic DNA. Translation: CAA29609.1.
PIR	S00912.
3D structure databases
HSSP	HSSP built from PDB template 1M6H based on UniProtKB P11766.
ModBase	Search...
Family and domain databases
InterPro	IPR013154. AlcDHase_GroES-like. IPR002085. AlcDHase_SF_Zn. IPR013149. AlcDHase_Zn-bd. IPR002328. AlcDHase_Zn_CS. [Graphical view]
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADH1_PEA

Accession

Primary (citable) accession number: P12886

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	November 25, 2008
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)