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Protein

Myosin-1

Gene

MYH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Muscle contraction.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi179 – 186ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109061-MONOMER.
ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
SIGNORiP12882.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-1
Alternative name(s):
Myosin heavy chain 1
Myosin heavy chain 2x
Short name:
MyHC-2x
Myosin heavy chain IIx/d
Short name:
MyHC-IIx/d
Myosin heavy chain, skeletal muscle, adult 1
Gene namesi
Name:MYH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:7567. MYH1.

Subcellular locationi

GO - Cellular componenti

  • A band Source: Ensembl
  • cytoplasmic ribonucleoprotein granule Source: ParkinsonsUK-UCL
  • intercalated disc Source: Ensembl
  • muscle myosin complex Source: MGI
  • myosin filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Thick filament

Pathology & Biotechi

Organism-specific databases

DisGeNETi4619.
OpenTargetsiENSG00000109061.
PharmGKBiPA31365.

Polymorphism and mutation databases

BioMutaiMYH1.
DMDMi226694176.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001233911 – 1939Myosin-1Add BLAST1939

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64PhosphothreonineBy similarity1
Modified residuei69PhosphothreonineBy similarity1
Modified residuei130N6,N6,N6-trimethyllysineSequence analysis1
Modified residuei389PhosphotyrosineBy similarity1
Modified residuei419PhosphothreonineBy similarity1
Modified residuei424PhosphotyrosineBy similarity1
Modified residuei757Pros-methylhistidineBy similarity1
Modified residuei1092PhosphoserineBy similarity1
Modified residuei1096PhosphoserineBy similarity1
Modified residuei1162PhosphoserineBy similarity1
Modified residuei1237PhosphoserineBy similarity1
Modified residuei1241PhosphothreonineBy similarity1
Modified residuei1243PhosphoserineBy similarity1
Modified residuei1261PhosphoserineBy similarity1
Modified residuei1265PhosphothreonineBy similarity1
Modified residuei1286PhosphothreonineBy similarity1
Modified residuei1288PhosphoserineBy similarity1
Modified residuei1292PhosphoserineBy similarity1
Modified residuei1303PhosphoserineBy similarity1
Modified residuei1306PhosphoserineBy similarity1
Modified residuei1467PhosphothreonineBy similarity1
Modified residuei1474PhosphoserineBy similarity1
Modified residuei1492PhosphotyrosineBy similarity1
Modified residuei1495PhosphoserineBy similarity1
Modified residuei1501PhosphothreonineBy similarity1
Modified residuei1514PhosphoserineBy similarity1
Modified residuei1517PhosphothreonineBy similarity1
Modified residuei1542PhosphoserineBy similarity1
Modified residuei1554PhosphoserineBy similarity1
Modified residuei1574PhosphoserineBy similarity1
Modified residuei1600PhosphoserineBy similarity1
Modified residuei1603PhosphoserineBy similarity1
Modified residuei1714PhosphoserineBy similarity1
Modified residuei1726PhosphoserineBy similarity1
Modified residuei1730PhosphothreonineBy similarity1
Modified residuei1736PhosphothreonineBy similarity1
Modified residuei1739PhosphoserineBy similarity1
Cross-linki1813Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP12882.
MaxQBiP12882.
PaxDbiP12882.
PeptideAtlasiP12882.
PRIDEiP12882.

2D gel databases

UCD-2DPAGEP12882.

PTM databases

iPTMnetiP12882.
PhosphoSitePlusiP12882.

Expressioni

Gene expression databases

BgeeiENSG00000109061.
CleanExiHS_MYH1.
GenevisibleiP12882. HS.

Organism-specific databases

HPAiCAB010759.
HPA001349.

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT13A1A4E93EBI-366238,EBI-10171552

Protein-protein interaction databases

BioGridi110704. 22 interactors.
IntActiP12882. 13 interactors.
STRINGi9606.ENSP00000226207.

Structurei

3D structure databases

ProteinModelPortaliP12882.
SMRiP12882.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 782Myosin motorAdd BLAST697
Domaini785 – 814IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni659 – 681Actin-bindingBy similarityAdd BLAST23
Regioni761 – 775Actin-bindingBy similarityAdd BLAST15

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili843 – 1939Sequence analysisAdd BLAST1097

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00760000118919.
HOGENOMiHOG000173959.
HOVERGENiHBG004704.
InParanoidiP12882.
KOiK10352.
OMAiIMDVEND.
OrthoDBiEOG091G07UM.
PhylomeDBiP12882.
TreeFamiTF314375.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12882-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDSEMAIF GEAAPFLRKS ERERIEAQNK PFDAKTSVFV VDPKESFVKA
60 70 80 90 100
TVQSREGGKV TAKTEAGATV TVKDDQVFPM NPPKYDKIED MAMMTHLHEP
110 120 130 140 150
AVLYNLKERY AAWMIYTYSG LFCVTVNPYK WLPVYNAEVV TAYRGKKRQE
160 170 180 190 200
APPHIFSISD NAYQFMLTDR ENQSILITGE SGAGKTVNTK RVIQYFATIA
210 220 230 240 250
VTGEKKKEEV TSGKMQGTLE DQIISANPLL EAFGNAKTVR NDNSSRFGKF
260 270 280 290 300
IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QIMSNKKPDL
310 320 330 340 350
IEMLLITTNP YDYAFVSQGE ITVPSIDDQE ELMATDSAIE ILGFTSDERV
360 370 380 390 400
SIYKLTGAVM HYGNMKFKQK QREEQAEPDG TEVADKAAYL QNLNSADLLK
410 420 430 440 450
ALCYPRVKVG NEYVTKGQTV QQVYNAVGAL AKAVYDKMFL WMVTRINQQL
460 470 480 490 500
DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC INFTNEKLQQ FFNHHMFVLE
510 520 530 540 550
QEEYKKEGIE WTFIDFGMDL AACIELIEKP MGIFSILEEE CMFPKATDTS
560 570 580 590 600
FKNKLYEQHL GKSNNFQKPK PAKGKPEAHF SLIHYAGTVD YNIAGWLDKN
610 620 630 640 650
KDPLNETVVG LYQKSAMKTL ALLFVGATGA EAEAGGGKKG GKKKGSSFQT
660 670 680 690 700
VSALFRENLN KLMTNLRSTH PHFVRCIIPN ETKTPGAMEH ELVLHQLRCN
710 720 730 740 750
GVLEGIRICR KGFPSRILYA DFKQRYKVLN ASAIPEGQFI DSKKASEKLL
760 770 780 790 800
GSIDIDHTQY KFGHTKVFFK AGLLGLLEEM RDEKLAQLIT RTQAMCRGFL
810 820 830 840 850
ARVEYQKMVE RRESIFCIQY NVRAFMNVKH WPWMKLYFKI KPLLKSAETE
860 870 880 890 900
KEMANMKEEF EKTKEELAKT EAKRKELEEK MVTLMQEKND LQLQVQAEAD
910 920 930 940 950
SLADAEERCD QLIKTKIQLE AKIKEVTERA EDEEEINAEL TAKKRKLEDE
960 970 980 990 1000
CSELKKDIDD LELTLAKVEK EKHATENKVK NLTEEMAGLD ETIAKLTKEK
1010 1020 1030 1040 1050
KALQEAHQQT LDDLQAEEDK VNTLTKAKIK LEQQVDDLEG SLEQEKKIRM
1060 1070 1080 1090 1100
DLERAKRKLE GDLKLAQEST MDIENDKQQL DEKLKKKEFE MSGLQSKIED
1110 1120 1130 1140 1150
EQALGMQLQK KIKELQARIE ELEEEIEAER ASRAKAEKQR SDLSRELEEI
1160 1170 1180 1190 1200
SERLEEAGGA TSAQIEMNKK REAEFQKMRR DLEEATLQHE ATAATLRKKH
1210 1220 1230 1240 1250
ADSVAELGEQ IDNLQRVKQK LEKEKSEMKM EIDDLASNME TVSKAKGNLE
1260 1270 1280 1290 1300
KMCRALEDQL SEIKTKEEEQ QRLINDLTAQ RARLQTESGE YSRQLDEKDT
1310 1320 1330 1340 1350
LVSQLSRGKQ AFTQQIEELK RQLEEEIKAK SALAHALQSS RHDCDLLREQ
1360 1370 1380 1390 1400
YEEEQEAKAE LQRAMSKANS EVAQWRTKYE TDAIQRTEEL EEAKKKLAQR
1410 1420 1430 1440 1450
LQDAEEHVEA VNAKCASLEK TKQRLQNEVE DLMIDVERTN AACAALDKKQ
1460 1470 1480 1490 1500
RNFDKILAEW KQKCEETHAE LEASQKESRS LSTELFKIKN AYEESLDQLE
1510 1520 1530 1540 1550
TLKRENKNLQ QEISDLTEQI AEGGKRIHEL EKIKKQVEQE KSELQAALEE
1560 1570 1580 1590 1600
AEASLEHEEG KILRIQLELN QVKSEVDRKI AEKDEEIDQM KRNHIRIVES
1610 1620 1630 1640 1650
MQSTLDAEIR SRNDAIRLKK KMEGDLNEME IQLNHANRMA AEALRNYRNT
1660 1670 1680 1690 1700
QAILKDTQLH LDDALRSQED LKEQLAMVER RANLLQAEIE ELRATLEQTE
1710 1720 1730 1740 1750
RSRKIAEQEL LDASERVQLL HTQNTSLINT KKKLETDISQ IQGEMEDIIQ
1760 1770 1780 1790 1800
EARNAEEKAK KAITDAAMMA EELKKEQDTS AHLERMKKNL EQTVKDLQHR
1810 1820 1830 1840 1850
LDEAEQLALK GGKKQIQKLE ARVRELEGEV ESEQKRNVEA VKGLRKHERK
1860 1870 1880 1890 1900
VKELTYQTEE DRKNILRLQD LVDKLQAKVK SYKRQAEEAE EQSNVNLSKF
1910 1920 1930
RRIQHELEEA EERADIAESQ VNKLRVKSRE VHTKIISEE
Length:1,939
Mass (Da):223,145
Last modified:April 14, 2009 - v3
Checksum:iD2B6F28C2C63CBDF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1070T → A in AAD29951 (PubMed:10388558).Curated1
Sequence conflicti1070T → A in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1131A → T in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1139Q → L in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1158G → V in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1163A → T in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1286 – 1289TESG → QNQV in CAA27380 (PubMed:2421254).Curated4
Sequence conflicti1302 – 1303VS → ET in CAA27380 (PubMed:2421254).Curated2
Sequence conflicti1451R → T in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1470E → V in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1473 – 1474AS → SF in CAA27380 (PubMed:2421254).Curated2
Sequence conflicti1531E → K in AAI14546 (PubMed:15489334).Curated1
Sequence conflicti1569L → V in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1598V → E in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1606D → N in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1643A → D in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1648R → Q in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1750Q → K in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1822R → K in CAA27380 (PubMed:2421254).Curated1
Sequence conflicti1845R → H in CAA27380 (PubMed:2421254).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054159640G → S.1 PublicationCorresponds to variant rs150346984dbSNPEnsembl.1
Natural variantiVAR_0360031306S → L in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs752643679dbSNPEnsembl.1
Natural variantiVAR_0301931341R → C.Corresponds to variant rs3744564dbSNPEnsembl.1
Natural variantiVAR_0360041445A → T in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs139860229dbSNPEnsembl.1
Natural variantiVAR_0301941539Q → H.Corresponds to variant rs3764850dbSNPEnsembl.1
Natural variantiVAR_0647351566Q → K Found in a renal cell carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0360051598V → M in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant rs150456818dbSNPEnsembl.1
Natural variantiVAR_0301951716R → C.Corresponds to variant rs1077841dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111785 mRNA. Translation: AAD29951.1.
AC005323 Genomic DNA. No translation available.
BC114545 mRNA. Translation: AAI14546.1.
X03740 mRNA. Translation: CAA27380.1.
CCDSiCCDS11155.1.
PIRiA23767.
RefSeqiNP_005954.3. NM_005963.3.
XP_016880164.1. XM_017024675.1.
UniGeneiHs.689619.

Genome annotation databases

EnsembliENST00000226207; ENSP00000226207; ENSG00000109061.
GeneIDi4619.
KEGGihsa:4619.
UCSCiuc002gmo.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF111785 mRNA. Translation: AAD29951.1.
AC005323 Genomic DNA. No translation available.
BC114545 mRNA. Translation: AAI14546.1.
X03740 mRNA. Translation: CAA27380.1.
CCDSiCCDS11155.1.
PIRiA23767.
RefSeqiNP_005954.3. NM_005963.3.
XP_016880164.1. XM_017024675.1.
UniGeneiHs.689619.

3D structure databases

ProteinModelPortaliP12882.
SMRiP12882.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110704. 22 interactors.
IntActiP12882. 13 interactors.
STRINGi9606.ENSP00000226207.

PTM databases

iPTMnetiP12882.
PhosphoSitePlusiP12882.

Polymorphism and mutation databases

BioMutaiMYH1.
DMDMi226694176.

2D gel databases

UCD-2DPAGEP12882.

Proteomic databases

EPDiP12882.
MaxQBiP12882.
PaxDbiP12882.
PeptideAtlasiP12882.
PRIDEiP12882.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000226207; ENSP00000226207; ENSG00000109061.
GeneIDi4619.
KEGGihsa:4619.
UCSCiuc002gmo.4. human.

Organism-specific databases

CTDi4619.
DisGeNETi4619.
GeneCardsiMYH1.
H-InvDBHIX0027129.
HGNCiHGNC:7567. MYH1.
HPAiCAB010759.
HPA001349.
MIMi160730. gene.
neXtProtiNX_P12882.
OpenTargetsiENSG00000109061.
PharmGKBiPA31365.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00760000118919.
HOGENOMiHOG000173959.
HOVERGENiHBG004704.
InParanoidiP12882.
KOiK10352.
OMAiIMDVEND.
OrthoDBiEOG091G07UM.
PhylomeDBiP12882.
TreeFamiTF314375.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109061-MONOMER.
ReactomeiR-HSA-1445148. Translocation of GLUT4 to the plasma membrane.
SIGNORiP12882.

Miscellaneous databases

GeneWikiiMYH1.
GenomeRNAii4619.
PROiP12882.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109061.
CleanExiHS_MYH1.
GenevisibleiP12882. HS.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYH1_HUMAN
AccessioniPrimary (citable) accession number: P12882
Secondary accession number(s): Q14CA4, Q9Y622
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: April 14, 2009
Last modified: November 30, 2016
This is version 167 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.