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P12882

- MYH1_HUMAN

UniProt

P12882 - MYH1_HUMAN

Protein

Myosin-1

Gene

MYH1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 3 (14 Apr 2009)
      Previous versions | rss
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    Functioni

    Muscle contraction.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi179 – 1868ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. motor activity Source: InterPro

    GO - Biological processi

    1. muscle contraction Source: Ensembl

    Keywords - Molecular functioni

    Motor protein, Muscle protein, Myosin

    Keywords - Ligandi

    Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myosin-1
    Alternative name(s):
    Myosin heavy chain 1
    Myosin heavy chain 2x
    Short name:
    MyHC-2x
    Myosin heavy chain IIx/d
    Short name:
    MyHC-IIx/d
    Myosin heavy chain, skeletal muscle, adult 1
    Gene namesi
    Name:MYH1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:7567. MYH1.

    Subcellular locationi

    Cytoplasmmyofibril
    Note: Thick filaments of the myofibrils.

    GO - Cellular componenti

    1. A band Source: Ensembl
    2. cytoplasmic ribonucleoprotein granule Source: ParkinsonsUK-UCL
    3. intercalated disc Source: Ensembl
    4. muscle myosin complex Source: MGI
    5. myosin filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm, Thick filament

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31365.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19391939Myosin-1PRO_0000123391Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei130 – 1301N6,N6,N6-trimethyllysineSequence Analysis

    Keywords - PTMi

    Methylation

    Proteomic databases

    MaxQBiP12882.
    PaxDbiP12882.
    PRIDEiP12882.

    2D gel databases

    UCD-2DPAGEP12882.

    PTM databases

    PhosphoSiteiP12882.

    Expressioni

    Gene expression databases

    BgeeiP12882.
    CleanExiHS_MYH1.
    GenevestigatoriP12882.

    Organism-specific databases

    HPAiCAB010759.
    HPA001349.

    Interactioni

    Subunit structurei

    Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

    Protein-protein interaction databases

    BioGridi110704. 4 interactions.
    IntActiP12882. 3 interactions.
    STRINGi9606.ENSP00000226207.

    Structurei

    3D structure databases

    ProteinModelPortaliP12882.
    SMRiP12882. Positions 4-967.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini86 – 782697Myosin motorAdd
    BLAST
    Domaini785 – 81430IQPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni659 – 68123Actin-bindingBy similarityAdd
    BLAST
    Regioni761 – 77515Actin-bindingBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili843 – 19391097Sequence AnalysisAdd
    BLAST

    Domaini

    The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
    Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

    Sequence similaritiesi

    Contains 1 IQ domain.PROSITE-ProRule annotation
    Contains 1 myosin motor domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5022.
    HOGENOMiHOG000173959.
    HOVERGENiHBG004704.
    InParanoidiP12882.
    KOiK10352.
    OMAiIMDVEND.
    OrthoDBiEOG7RBZ7G.
    PhylomeDBiP12882.
    TreeFamiTF314375.

    Family and domain databases

    Gene3Di4.10.270.10. 1 hit.
    InterProiIPR000048. IQ_motif_EF-hand-BS.
    IPR027401. Myosin-like_IQ_dom.
    IPR001609. Myosin_head_motor_dom.
    IPR004009. Myosin_N.
    IPR002928. Myosin_tail.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00063. Myosin_head. 1 hit.
    PF02736. Myosin_N. 1 hit.
    PF01576. Myosin_tail_1. 1 hit.
    [Graphical view]
    PRINTSiPR00193. MYOSINHEAVY.
    SMARTiSM00015. IQ. 1 hit.
    SM00242. MYSc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS50096. IQ. 1 hit.
    PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P12882-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSDSEMAIF GEAAPFLRKS ERERIEAQNK PFDAKTSVFV VDPKESFVKA     50
    TVQSREGGKV TAKTEAGATV TVKDDQVFPM NPPKYDKIED MAMMTHLHEP 100
    AVLYNLKERY AAWMIYTYSG LFCVTVNPYK WLPVYNAEVV TAYRGKKRQE 150
    APPHIFSISD NAYQFMLTDR ENQSILITGE SGAGKTVNTK RVIQYFATIA 200
    VTGEKKKEEV TSGKMQGTLE DQIISANPLL EAFGNAKTVR NDNSSRFGKF 250
    IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QIMSNKKPDL 300
    IEMLLITTNP YDYAFVSQGE ITVPSIDDQE ELMATDSAIE ILGFTSDERV 350
    SIYKLTGAVM HYGNMKFKQK QREEQAEPDG TEVADKAAYL QNLNSADLLK 400
    ALCYPRVKVG NEYVTKGQTV QQVYNAVGAL AKAVYDKMFL WMVTRINQQL 450
    DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC INFTNEKLQQ FFNHHMFVLE 500
    QEEYKKEGIE WTFIDFGMDL AACIELIEKP MGIFSILEEE CMFPKATDTS 550
    FKNKLYEQHL GKSNNFQKPK PAKGKPEAHF SLIHYAGTVD YNIAGWLDKN 600
    KDPLNETVVG LYQKSAMKTL ALLFVGATGA EAEAGGGKKG GKKKGSSFQT 650
    VSALFRENLN KLMTNLRSTH PHFVRCIIPN ETKTPGAMEH ELVLHQLRCN 700
    GVLEGIRICR KGFPSRILYA DFKQRYKVLN ASAIPEGQFI DSKKASEKLL 750
    GSIDIDHTQY KFGHTKVFFK AGLLGLLEEM RDEKLAQLIT RTQAMCRGFL 800
    ARVEYQKMVE RRESIFCIQY NVRAFMNVKH WPWMKLYFKI KPLLKSAETE 850
    KEMANMKEEF EKTKEELAKT EAKRKELEEK MVTLMQEKND LQLQVQAEAD 900
    SLADAEERCD QLIKTKIQLE AKIKEVTERA EDEEEINAEL TAKKRKLEDE 950
    CSELKKDIDD LELTLAKVEK EKHATENKVK NLTEEMAGLD ETIAKLTKEK 1000
    KALQEAHQQT LDDLQAEEDK VNTLTKAKIK LEQQVDDLEG SLEQEKKIRM 1050
    DLERAKRKLE GDLKLAQEST MDIENDKQQL DEKLKKKEFE MSGLQSKIED 1100
    EQALGMQLQK KIKELQARIE ELEEEIEAER ASRAKAEKQR SDLSRELEEI 1150
    SERLEEAGGA TSAQIEMNKK REAEFQKMRR DLEEATLQHE ATAATLRKKH 1200
    ADSVAELGEQ IDNLQRVKQK LEKEKSEMKM EIDDLASNME TVSKAKGNLE 1250
    KMCRALEDQL SEIKTKEEEQ QRLINDLTAQ RARLQTESGE YSRQLDEKDT 1300
    LVSQLSRGKQ AFTQQIEELK RQLEEEIKAK SALAHALQSS RHDCDLLREQ 1350
    YEEEQEAKAE LQRAMSKANS EVAQWRTKYE TDAIQRTEEL EEAKKKLAQR 1400
    LQDAEEHVEA VNAKCASLEK TKQRLQNEVE DLMIDVERTN AACAALDKKQ 1450
    RNFDKILAEW KQKCEETHAE LEASQKESRS LSTELFKIKN AYEESLDQLE 1500
    TLKRENKNLQ QEISDLTEQI AEGGKRIHEL EKIKKQVEQE KSELQAALEE 1550
    AEASLEHEEG KILRIQLELN QVKSEVDRKI AEKDEEIDQM KRNHIRIVES 1600
    MQSTLDAEIR SRNDAIRLKK KMEGDLNEME IQLNHANRMA AEALRNYRNT 1650
    QAILKDTQLH LDDALRSQED LKEQLAMVER RANLLQAEIE ELRATLEQTE 1700
    RSRKIAEQEL LDASERVQLL HTQNTSLINT KKKLETDISQ IQGEMEDIIQ 1750
    EARNAEEKAK KAITDAAMMA EELKKEQDTS AHLERMKKNL EQTVKDLQHR 1800
    LDEAEQLALK GGKKQIQKLE ARVRELEGEV ESEQKRNVEA VKGLRKHERK 1850
    VKELTYQTEE DRKNILRLQD LVDKLQAKVK SYKRQAEEAE EQSNVNLSKF 1900
    RRIQHELEEA EERADIAESQ VNKLRVKSRE VHTKIISEE 1939
    Length:1,939
    Mass (Da):223,145
    Last modified:April 14, 2009 - v3
    Checksum:iD2B6F28C2C63CBDF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1070 – 10701T → A in AAD29951. (PubMed:10388558)Curated
    Sequence conflicti1070 – 10701T → A in CAA27380. (PubMed:2421254)Curated
    Sequence conflicti1131 – 11311A → T in CAA27380. (PubMed:2421254)Curated
    Sequence conflicti1139 – 11391Q → L in CAA27380. (PubMed:2421254)Curated
    Sequence conflicti1158 – 11581G → V in CAA27380. (PubMed:2421254)Curated
    Sequence conflicti1163 – 11631A → T in CAA27380. (PubMed:2421254)Curated
    Sequence conflicti1286 – 12894TESG → QNQV in CAA27380. (PubMed:2421254)Curated
    Sequence conflicti1302 – 13032VS → ET in CAA27380. (PubMed:2421254)Curated
    Sequence conflicti1451 – 14511R → T in CAA27380. (PubMed:2421254)Curated
    Sequence conflicti1470 – 14701E → V in CAA27380. (PubMed:2421254)Curated
    Sequence conflicti1473 – 14742AS → SF in CAA27380. (PubMed:2421254)Curated
    Sequence conflicti1531 – 15311E → K in AAI14546. (PubMed:15489334)Curated
    Sequence conflicti1569 – 15691L → V in CAA27380. (PubMed:2421254)Curated
    Sequence conflicti1598 – 15981V → E in CAA27380. (PubMed:2421254)Curated
    Sequence conflicti1606 – 16061D → N in CAA27380. (PubMed:2421254)Curated
    Sequence conflicti1643 – 16431A → D in CAA27380. (PubMed:2421254)Curated
    Sequence conflicti1648 – 16481R → Q in CAA27380. (PubMed:2421254)Curated
    Sequence conflicti1750 – 17501Q → K in CAA27380. (PubMed:2421254)Curated
    Sequence conflicti1822 – 18221R → K in CAA27380. (PubMed:2421254)Curated
    Sequence conflicti1845 – 18451R → H in CAA27380. (PubMed:2421254)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti640 – 6401G → S.1 Publication
    Corresponds to variant rs150346984 [ dbSNP | Ensembl ].
    VAR_054159
    Natural varianti1306 – 13061S → L in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036003
    Natural varianti1341 – 13411R → C.
    Corresponds to variant rs3744564 [ dbSNP | Ensembl ].
    VAR_030193
    Natural varianti1445 – 14451A → T in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036004
    Natural varianti1539 – 15391Q → H.
    Corresponds to variant rs3764850 [ dbSNP | Ensembl ].
    VAR_030194
    Natural varianti1566 – 15661Q → K Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
    VAR_064735
    Natural varianti1598 – 15981V → M in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036005
    Natural varianti1716 – 17161R → C.
    Corresponds to variant rs1077841 [ dbSNP | Ensembl ].
    VAR_030195

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF111785 mRNA. Translation: AAD29951.1.
    AC005323 Genomic DNA. No translation available.
    BC114545 mRNA. Translation: AAI14546.1.
    X03740 mRNA. Translation: CAA27380.1.
    CCDSiCCDS11155.1.
    PIRiA23767.
    RefSeqiNP_005954.3. NM_005963.3.
    UniGeneiHs.689619.

    Genome annotation databases

    EnsembliENST00000226207; ENSP00000226207; ENSG00000109061.
    GeneIDi4619.
    KEGGihsa:4619.
    UCSCiuc002gmo.3. human.

    Polymorphism databases

    DMDMi226694176.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF111785 mRNA. Translation: AAD29951.1 .
    AC005323 Genomic DNA. No translation available.
    BC114545 mRNA. Translation: AAI14546.1 .
    X03740 mRNA. Translation: CAA27380.1 .
    CCDSi CCDS11155.1.
    PIRi A23767.
    RefSeqi NP_005954.3. NM_005963.3.
    UniGenei Hs.689619.

    3D structure databases

    ProteinModelPortali P12882.
    SMRi P12882. Positions 4-967.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110704. 4 interactions.
    IntActi P12882. 3 interactions.
    STRINGi 9606.ENSP00000226207.

    PTM databases

    PhosphoSitei P12882.

    Polymorphism databases

    DMDMi 226694176.

    2D gel databases

    UCD-2DPAGE P12882.

    Proteomic databases

    MaxQBi P12882.
    PaxDbi P12882.
    PRIDEi P12882.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000226207 ; ENSP00000226207 ; ENSG00000109061 .
    GeneIDi 4619.
    KEGGi hsa:4619.
    UCSCi uc002gmo.3. human.

    Organism-specific databases

    CTDi 4619.
    GeneCardsi GC17M010395.
    H-InvDB HIX0027129.
    HGNCi HGNC:7567. MYH1.
    HPAi CAB010759.
    HPA001349.
    MIMi 160730. gene.
    neXtProti NX_P12882.
    PharmGKBi PA31365.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5022.
    HOGENOMi HOG000173959.
    HOVERGENi HBG004704.
    InParanoidi P12882.
    KOi K10352.
    OMAi IMDVEND.
    OrthoDBi EOG7RBZ7G.
    PhylomeDBi P12882.
    TreeFami TF314375.

    Enzyme and pathway databases

    Reactomei REACT_147867. Translocation of GLUT4 to the plasma membrane.

    Miscellaneous databases

    GeneWikii MYH1.
    GenomeRNAii 4619.
    NextBioi 17780.
    PROi P12882.
    SOURCEi Search...

    Gene expression databases

    Bgeei P12882.
    CleanExi HS_MYH1.
    Genevestigatori P12882.

    Family and domain databases

    Gene3Di 4.10.270.10. 1 hit.
    InterProi IPR000048. IQ_motif_EF-hand-BS.
    IPR027401. Myosin-like_IQ_dom.
    IPR001609. Myosin_head_motor_dom.
    IPR004009. Myosin_N.
    IPR002928. Myosin_tail.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00063. Myosin_head. 1 hit.
    PF02736. Myosin_N. 1 hit.
    PF01576. Myosin_tail_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00193. MYOSINHEAVY.
    SMARTi SM00015. IQ. 1 hit.
    SM00242. MYSc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS50096. IQ. 1 hit.
    PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity."
      Weiss A., Schiaffino S., Leinwand L.A.
      J. Mol. Biol. 290:61-75(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.
    2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle."
      Saez L., Leinwand L.A.
      Nucleic Acids Res. 14:2951-2969(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1064-1939.
    5. Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-1306; THR-1445 AND MET-1598.
    6. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-640.
    7. Cited for: VARIANT LYS-1566.

    Entry informationi

    Entry nameiMYH1_HUMAN
    AccessioniPrimary (citable) accession number: P12882
    Secondary accession number(s): Q14CA4, Q9Y622
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: April 14, 2009
    Last modified: October 1, 2014
    This is version 145 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1).Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3