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P12882

- MYH1_HUMAN

UniProt

P12882 - MYH1_HUMAN

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Protein

Myosin-1

Gene

MYH1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Muscle contraction.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi179 – 1868ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. motor activity Source: InterPro

GO - Biological processi

  1. muscle contraction Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-1
Alternative name(s):
Myosin heavy chain 1
Myosin heavy chain 2x
Short name:
MyHC-2x
Myosin heavy chain IIx/d
Short name:
MyHC-IIx/d
Myosin heavy chain, skeletal muscle, adult 1
Gene namesi
Name:MYH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:7567. MYH1.

Subcellular locationi

Cytoplasmmyofibril
Note: Thick filaments of the myofibrils.

GO - Cellular componenti

  1. A band Source: Ensembl
  2. cytoplasmic ribonucleoprotein granule Source: ParkinsonsUK-UCL
  3. intercalated disc Source: Ensembl
  4. muscle myosin complex Source: MGI
  5. myosin filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Thick filament

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31365.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19391939Myosin-1PRO_0000123391Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei130 – 1301N6,N6,N6-trimethyllysineSequence Analysis

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiP12882.
PaxDbiP12882.
PRIDEiP12882.

2D gel databases

UCD-2DPAGEP12882.

PTM databases

PhosphoSiteiP12882.

Expressioni

Gene expression databases

BgeeiP12882.
CleanExiHS_MYH1.
GenevestigatoriP12882.

Organism-specific databases

HPAiCAB010759.
HPA001349.

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

Protein-protein interaction databases

BioGridi110704. 6 interactions.
IntActiP12882. 3 interactions.
STRINGi9606.ENSP00000226207.

Structurei

3D structure databases

ProteinModelPortaliP12882.
SMRiP12882. Positions 4-967.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 782697Myosin motorAdd
BLAST
Domaini785 – 81430IQPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni659 – 68123Actin-bindingBy similarityAdd
BLAST
Regioni761 – 77515Actin-bindingBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili843 – 19391097Sequence AnalysisAdd
BLAST

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00760000118919.
HOGENOMiHOG000173959.
HOVERGENiHBG004704.
InParanoidiP12882.
KOiK10352.
OMAiIMDVEND.
OrthoDBiEOG7RBZ7G.
PhylomeDBiP12882.
TreeFamiTF314375.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12882-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSDSEMAIF GEAAPFLRKS ERERIEAQNK PFDAKTSVFV VDPKESFVKA
60 70 80 90 100
TVQSREGGKV TAKTEAGATV TVKDDQVFPM NPPKYDKIED MAMMTHLHEP
110 120 130 140 150
AVLYNLKERY AAWMIYTYSG LFCVTVNPYK WLPVYNAEVV TAYRGKKRQE
160 170 180 190 200
APPHIFSISD NAYQFMLTDR ENQSILITGE SGAGKTVNTK RVIQYFATIA
210 220 230 240 250
VTGEKKKEEV TSGKMQGTLE DQIISANPLL EAFGNAKTVR NDNSSRFGKF
260 270 280 290 300
IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QIMSNKKPDL
310 320 330 340 350
IEMLLITTNP YDYAFVSQGE ITVPSIDDQE ELMATDSAIE ILGFTSDERV
360 370 380 390 400
SIYKLTGAVM HYGNMKFKQK QREEQAEPDG TEVADKAAYL QNLNSADLLK
410 420 430 440 450
ALCYPRVKVG NEYVTKGQTV QQVYNAVGAL AKAVYDKMFL WMVTRINQQL
460 470 480 490 500
DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC INFTNEKLQQ FFNHHMFVLE
510 520 530 540 550
QEEYKKEGIE WTFIDFGMDL AACIELIEKP MGIFSILEEE CMFPKATDTS
560 570 580 590 600
FKNKLYEQHL GKSNNFQKPK PAKGKPEAHF SLIHYAGTVD YNIAGWLDKN
610 620 630 640 650
KDPLNETVVG LYQKSAMKTL ALLFVGATGA EAEAGGGKKG GKKKGSSFQT
660 670 680 690 700
VSALFRENLN KLMTNLRSTH PHFVRCIIPN ETKTPGAMEH ELVLHQLRCN
710 720 730 740 750
GVLEGIRICR KGFPSRILYA DFKQRYKVLN ASAIPEGQFI DSKKASEKLL
760 770 780 790 800
GSIDIDHTQY KFGHTKVFFK AGLLGLLEEM RDEKLAQLIT RTQAMCRGFL
810 820 830 840 850
ARVEYQKMVE RRESIFCIQY NVRAFMNVKH WPWMKLYFKI KPLLKSAETE
860 870 880 890 900
KEMANMKEEF EKTKEELAKT EAKRKELEEK MVTLMQEKND LQLQVQAEAD
910 920 930 940 950
SLADAEERCD QLIKTKIQLE AKIKEVTERA EDEEEINAEL TAKKRKLEDE
960 970 980 990 1000
CSELKKDIDD LELTLAKVEK EKHATENKVK NLTEEMAGLD ETIAKLTKEK
1010 1020 1030 1040 1050
KALQEAHQQT LDDLQAEEDK VNTLTKAKIK LEQQVDDLEG SLEQEKKIRM
1060 1070 1080 1090 1100
DLERAKRKLE GDLKLAQEST MDIENDKQQL DEKLKKKEFE MSGLQSKIED
1110 1120 1130 1140 1150
EQALGMQLQK KIKELQARIE ELEEEIEAER ASRAKAEKQR SDLSRELEEI
1160 1170 1180 1190 1200
SERLEEAGGA TSAQIEMNKK REAEFQKMRR DLEEATLQHE ATAATLRKKH
1210 1220 1230 1240 1250
ADSVAELGEQ IDNLQRVKQK LEKEKSEMKM EIDDLASNME TVSKAKGNLE
1260 1270 1280 1290 1300
KMCRALEDQL SEIKTKEEEQ QRLINDLTAQ RARLQTESGE YSRQLDEKDT
1310 1320 1330 1340 1350
LVSQLSRGKQ AFTQQIEELK RQLEEEIKAK SALAHALQSS RHDCDLLREQ
1360 1370 1380 1390 1400
YEEEQEAKAE LQRAMSKANS EVAQWRTKYE TDAIQRTEEL EEAKKKLAQR
1410 1420 1430 1440 1450
LQDAEEHVEA VNAKCASLEK TKQRLQNEVE DLMIDVERTN AACAALDKKQ
1460 1470 1480 1490 1500
RNFDKILAEW KQKCEETHAE LEASQKESRS LSTELFKIKN AYEESLDQLE
1510 1520 1530 1540 1550
TLKRENKNLQ QEISDLTEQI AEGGKRIHEL EKIKKQVEQE KSELQAALEE
1560 1570 1580 1590 1600
AEASLEHEEG KILRIQLELN QVKSEVDRKI AEKDEEIDQM KRNHIRIVES
1610 1620 1630 1640 1650
MQSTLDAEIR SRNDAIRLKK KMEGDLNEME IQLNHANRMA AEALRNYRNT
1660 1670 1680 1690 1700
QAILKDTQLH LDDALRSQED LKEQLAMVER RANLLQAEIE ELRATLEQTE
1710 1720 1730 1740 1750
RSRKIAEQEL LDASERVQLL HTQNTSLINT KKKLETDISQ IQGEMEDIIQ
1760 1770 1780 1790 1800
EARNAEEKAK KAITDAAMMA EELKKEQDTS AHLERMKKNL EQTVKDLQHR
1810 1820 1830 1840 1850
LDEAEQLALK GGKKQIQKLE ARVRELEGEV ESEQKRNVEA VKGLRKHERK
1860 1870 1880 1890 1900
VKELTYQTEE DRKNILRLQD LVDKLQAKVK SYKRQAEEAE EQSNVNLSKF
1910 1920 1930
RRIQHELEEA EERADIAESQ VNKLRVKSRE VHTKIISEE
Length:1,939
Mass (Da):223,145
Last modified:April 14, 2009 - v3
Checksum:iD2B6F28C2C63CBDF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1070 – 10701T → A in AAD29951. (PubMed:10388558)Curated
Sequence conflicti1070 – 10701T → A in CAA27380. (PubMed:2421254)Curated
Sequence conflicti1131 – 11311A → T in CAA27380. (PubMed:2421254)Curated
Sequence conflicti1139 – 11391Q → L in CAA27380. (PubMed:2421254)Curated
Sequence conflicti1158 – 11581G → V in CAA27380. (PubMed:2421254)Curated
Sequence conflicti1163 – 11631A → T in CAA27380. (PubMed:2421254)Curated
Sequence conflicti1286 – 12894TESG → QNQV in CAA27380. (PubMed:2421254)Curated
Sequence conflicti1302 – 13032VS → ET in CAA27380. (PubMed:2421254)Curated
Sequence conflicti1451 – 14511R → T in CAA27380. (PubMed:2421254)Curated
Sequence conflicti1470 – 14701E → V in CAA27380. (PubMed:2421254)Curated
Sequence conflicti1473 – 14742AS → SF in CAA27380. (PubMed:2421254)Curated
Sequence conflicti1531 – 15311E → K in AAI14546. (PubMed:15489334)Curated
Sequence conflicti1569 – 15691L → V in CAA27380. (PubMed:2421254)Curated
Sequence conflicti1598 – 15981V → E in CAA27380. (PubMed:2421254)Curated
Sequence conflicti1606 – 16061D → N in CAA27380. (PubMed:2421254)Curated
Sequence conflicti1643 – 16431A → D in CAA27380. (PubMed:2421254)Curated
Sequence conflicti1648 – 16481R → Q in CAA27380. (PubMed:2421254)Curated
Sequence conflicti1750 – 17501Q → K in CAA27380. (PubMed:2421254)Curated
Sequence conflicti1822 – 18221R → K in CAA27380. (PubMed:2421254)Curated
Sequence conflicti1845 – 18451R → H in CAA27380. (PubMed:2421254)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti640 – 6401G → S.1 Publication
Corresponds to variant rs150346984 [ dbSNP | Ensembl ].
VAR_054159
Natural varianti1306 – 13061S → L in a breast cancer sample; somatic mutation. 1 Publication
VAR_036003
Natural varianti1341 – 13411R → C.
Corresponds to variant rs3744564 [ dbSNP | Ensembl ].
VAR_030193
Natural varianti1445 – 14451A → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_036004
Natural varianti1539 – 15391Q → H.
Corresponds to variant rs3764850 [ dbSNP | Ensembl ].
VAR_030194
Natural varianti1566 – 15661Q → K Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064735
Natural varianti1598 – 15981V → M in a breast cancer sample; somatic mutation. 1 Publication
VAR_036005
Natural varianti1716 – 17161R → C.
Corresponds to variant rs1077841 [ dbSNP | Ensembl ].
VAR_030195

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF111785 mRNA. Translation: AAD29951.1.
AC005323 Genomic DNA. No translation available.
BC114545 mRNA. Translation: AAI14546.1.
X03740 mRNA. Translation: CAA27380.1.
CCDSiCCDS11155.1.
PIRiA23767.
RefSeqiNP_005954.3. NM_005963.3.
UniGeneiHs.689619.

Genome annotation databases

EnsembliENST00000226207; ENSP00000226207; ENSG00000109061.
GeneIDi4619.
KEGGihsa:4619.
UCSCiuc002gmo.3. human.

Polymorphism databases

DMDMi226694176.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF111785 mRNA. Translation: AAD29951.1 .
AC005323 Genomic DNA. No translation available.
BC114545 mRNA. Translation: AAI14546.1 .
X03740 mRNA. Translation: CAA27380.1 .
CCDSi CCDS11155.1.
PIRi A23767.
RefSeqi NP_005954.3. NM_005963.3.
UniGenei Hs.689619.

3D structure databases

ProteinModelPortali P12882.
SMRi P12882. Positions 4-967.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110704. 6 interactions.
IntActi P12882. 3 interactions.
STRINGi 9606.ENSP00000226207.

PTM databases

PhosphoSitei P12882.

Polymorphism databases

DMDMi 226694176.

2D gel databases

UCD-2DPAGE P12882.

Proteomic databases

MaxQBi P12882.
PaxDbi P12882.
PRIDEi P12882.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000226207 ; ENSP00000226207 ; ENSG00000109061 .
GeneIDi 4619.
KEGGi hsa:4619.
UCSCi uc002gmo.3. human.

Organism-specific databases

CTDi 4619.
GeneCardsi GC17M010395.
H-InvDB HIX0027129.
HGNCi HGNC:7567. MYH1.
HPAi CAB010759.
HPA001349.
MIMi 160730. gene.
neXtProti NX_P12882.
PharmGKBi PA31365.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5022.
GeneTreei ENSGT00760000118919.
HOGENOMi HOG000173959.
HOVERGENi HBG004704.
InParanoidi P12882.
KOi K10352.
OMAi IMDVEND.
OrthoDBi EOG7RBZ7G.
PhylomeDBi P12882.
TreeFami TF314375.

Enzyme and pathway databases

Reactomei REACT_147867. Translocation of GLUT4 to the plasma membrane.

Miscellaneous databases

GeneWikii MYH1.
GenomeRNAii 4619.
NextBioi 17780.
PROi P12882.
SOURCEi Search...

Gene expression databases

Bgeei P12882.
CleanExi HS_MYH1.
Genevestigatori P12882.

Family and domain databases

Gene3Di 4.10.270.10. 1 hit.
InterProi IPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity."
    Weiss A., Schiaffino S., Leinwand L.A.
    J. Mol. Biol. 290:61-75(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle."
    Saez L., Leinwand L.A.
    Nucleic Acids Res. 14:2951-2969(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1064-1939.
  5. Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-1306; THR-1445 AND MET-1598.
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-640.
  7. Cited for: VARIANT LYS-1566.

Entry informationi

Entry nameiMYH1_HUMAN
AccessioniPrimary (citable) accession number: P12882
Secondary accession number(s): Q14CA4, Q9Y622
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: April 14, 2009
Last modified: October 29, 2014
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3