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P12882 (MYH1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 140. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myosin-1
Alternative name(s):
Myosin heavy chain 1
Myosin heavy chain 2x
Short name=MyHC-2x
Myosin heavy chain IIx/d
Short name=MyHC-IIx/d
Myosin heavy chain, skeletal muscle, adult 1
Gene names
Name:MYH1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1939 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Muscle contraction.

Subunit structure

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

Subcellular location

Cytoplasmmyofibril. Note: Thick filaments of the myofibrils.

Domain

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.

Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

Sequence similarities

Contains 1 IQ domain.

Contains 1 myosin head-like domain.

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1).

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 19391939Myosin-1
PRO_0000123391

Regions

Domain1 – 784784Myosin head-like
Domain785 – 81430IQ
Nucleotide binding179 – 1868ATP Potential
Region659 – 68123Actin-binding By similarity
Region761 – 77515Actin-binding By similarity
Coiled coil843 – 19391097 Potential

Amino acid modifications

Modified residue1301N6,N6,N6-trimethyllysine Potential

Natural variations

Natural variant6401G → S. Ref.6
Corresponds to variant rs150346984 [ dbSNP | Ensembl ].
VAR_054159
Natural variant13061S → L in a breast cancer sample; somatic mutation. Ref.5
VAR_036003
Natural variant13411R → C.
Corresponds to variant rs3744564 [ dbSNP | Ensembl ].
VAR_030193
Natural variant14451A → T in a breast cancer sample; somatic mutation. Ref.5
VAR_036004
Natural variant15391Q → H.
Corresponds to variant rs3764850 [ dbSNP | Ensembl ].
VAR_030194
Natural variant15661Q → K Found in a renal cell carcinoma sample; somatic mutation. Ref.7
VAR_064735
Natural variant15981V → M in a breast cancer sample; somatic mutation. Ref.5
VAR_036005
Natural variant17161R → C.
Corresponds to variant rs1077841 [ dbSNP | Ensembl ].
VAR_030195

Experimental info

Sequence conflict10701T → A in AAD29951. Ref.1
Sequence conflict10701T → A in CAA27380. Ref.4
Sequence conflict11311A → T in CAA27380. Ref.4
Sequence conflict11391Q → L in CAA27380. Ref.4
Sequence conflict11581G → V in CAA27380. Ref.4
Sequence conflict11631A → T in CAA27380. Ref.4
Sequence conflict1286 – 12894TESG → QNQV in CAA27380. Ref.4
Sequence conflict1302 – 13032VS → ET in CAA27380. Ref.4
Sequence conflict14511R → T in CAA27380. Ref.4
Sequence conflict14701E → V in CAA27380. Ref.4
Sequence conflict1473 – 14742AS → SF in CAA27380. Ref.4
Sequence conflict15311E → K in AAI14546. Ref.3
Sequence conflict15691L → V in CAA27380. Ref.4
Sequence conflict15981V → E in CAA27380. Ref.4
Sequence conflict16061D → N in CAA27380. Ref.4
Sequence conflict16431A → D in CAA27380. Ref.4
Sequence conflict16481R → Q in CAA27380. Ref.4
Sequence conflict17501Q → K in CAA27380. Ref.4
Sequence conflict18221R → K in CAA27380. Ref.4
Sequence conflict18451R → H in CAA27380. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P12882 [UniParc].

Last modified April 14, 2009. Version 3.
Checksum: D2B6F28C2C63CBDF

FASTA1,939223,145
        10         20         30         40         50         60 
MSSDSEMAIF GEAAPFLRKS ERERIEAQNK PFDAKTSVFV VDPKESFVKA TVQSREGGKV 

        70         80         90        100        110        120 
TAKTEAGATV TVKDDQVFPM NPPKYDKIED MAMMTHLHEP AVLYNLKERY AAWMIYTYSG 

       130        140        150        160        170        180 
LFCVTVNPYK WLPVYNAEVV TAYRGKKRQE APPHIFSISD NAYQFMLTDR ENQSILITGE 

       190        200        210        220        230        240 
SGAGKTVNTK RVIQYFATIA VTGEKKKEEV TSGKMQGTLE DQIISANPLL EAFGNAKTVR 

       250        260        270        280        290        300 
NDNSSRFGKF IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QIMSNKKPDL 

       310        320        330        340        350        360 
IEMLLITTNP YDYAFVSQGE ITVPSIDDQE ELMATDSAIE ILGFTSDERV SIYKLTGAVM 

       370        380        390        400        410        420 
HYGNMKFKQK QREEQAEPDG TEVADKAAYL QNLNSADLLK ALCYPRVKVG NEYVTKGQTV 

       430        440        450        460        470        480 
QQVYNAVGAL AKAVYDKMFL WMVTRINQQL DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC 

       490        500        510        520        530        540 
INFTNEKLQQ FFNHHMFVLE QEEYKKEGIE WTFIDFGMDL AACIELIEKP MGIFSILEEE 

       550        560        570        580        590        600 
CMFPKATDTS FKNKLYEQHL GKSNNFQKPK PAKGKPEAHF SLIHYAGTVD YNIAGWLDKN 

       610        620        630        640        650        660 
KDPLNETVVG LYQKSAMKTL ALLFVGATGA EAEAGGGKKG GKKKGSSFQT VSALFRENLN 

       670        680        690        700        710        720 
KLMTNLRSTH PHFVRCIIPN ETKTPGAMEH ELVLHQLRCN GVLEGIRICR KGFPSRILYA 

       730        740        750        760        770        780 
DFKQRYKVLN ASAIPEGQFI DSKKASEKLL GSIDIDHTQY KFGHTKVFFK AGLLGLLEEM 

       790        800        810        820        830        840 
RDEKLAQLIT RTQAMCRGFL ARVEYQKMVE RRESIFCIQY NVRAFMNVKH WPWMKLYFKI 

       850        860        870        880        890        900 
KPLLKSAETE KEMANMKEEF EKTKEELAKT EAKRKELEEK MVTLMQEKND LQLQVQAEAD 

       910        920        930        940        950        960 
SLADAEERCD QLIKTKIQLE AKIKEVTERA EDEEEINAEL TAKKRKLEDE CSELKKDIDD 

       970        980        990       1000       1010       1020 
LELTLAKVEK EKHATENKVK NLTEEMAGLD ETIAKLTKEK KALQEAHQQT LDDLQAEEDK 

      1030       1040       1050       1060       1070       1080 
VNTLTKAKIK LEQQVDDLEG SLEQEKKIRM DLERAKRKLE GDLKLAQEST MDIENDKQQL 

      1090       1100       1110       1120       1130       1140 
DEKLKKKEFE MSGLQSKIED EQALGMQLQK KIKELQARIE ELEEEIEAER ASRAKAEKQR 

      1150       1160       1170       1180       1190       1200 
SDLSRELEEI SERLEEAGGA TSAQIEMNKK REAEFQKMRR DLEEATLQHE ATAATLRKKH 

      1210       1220       1230       1240       1250       1260 
ADSVAELGEQ IDNLQRVKQK LEKEKSEMKM EIDDLASNME TVSKAKGNLE KMCRALEDQL 

      1270       1280       1290       1300       1310       1320 
SEIKTKEEEQ QRLINDLTAQ RARLQTESGE YSRQLDEKDT LVSQLSRGKQ AFTQQIEELK 

      1330       1340       1350       1360       1370       1380 
RQLEEEIKAK SALAHALQSS RHDCDLLREQ YEEEQEAKAE LQRAMSKANS EVAQWRTKYE 

      1390       1400       1410       1420       1430       1440 
TDAIQRTEEL EEAKKKLAQR LQDAEEHVEA VNAKCASLEK TKQRLQNEVE DLMIDVERTN 

      1450       1460       1470       1480       1490       1500 
AACAALDKKQ RNFDKILAEW KQKCEETHAE LEASQKESRS LSTELFKIKN AYEESLDQLE 

      1510       1520       1530       1540       1550       1560 
TLKRENKNLQ QEISDLTEQI AEGGKRIHEL EKIKKQVEQE KSELQAALEE AEASLEHEEG 

      1570       1580       1590       1600       1610       1620 
KILRIQLELN QVKSEVDRKI AEKDEEIDQM KRNHIRIVES MQSTLDAEIR SRNDAIRLKK 

      1630       1640       1650       1660       1670       1680 
KMEGDLNEME IQLNHANRMA AEALRNYRNT QAILKDTQLH LDDALRSQED LKEQLAMVER 

      1690       1700       1710       1720       1730       1740 
RANLLQAEIE ELRATLEQTE RSRKIAEQEL LDASERVQLL HTQNTSLINT KKKLETDISQ 

      1750       1760       1770       1780       1790       1800 
IQGEMEDIIQ EARNAEEKAK KAITDAAMMA EELKKEQDTS AHLERMKKNL EQTVKDLQHR 

      1810       1820       1830       1840       1850       1860 
LDEAEQLALK GGKKQIQKLE ARVRELEGEV ESEQKRNVEA VKGLRKHERK VKELTYQTEE 

      1870       1880       1890       1900       1910       1920 
DRKNILRLQD LVDKLQAKVK SYKRQAEEAE EQSNVNLSKF RRIQHELEEA EERADIAESQ 

      1930 
VNKLRVKSRE VHTKIISEE 

« Hide

References

« Hide 'large scale' references
[1]"Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity."
Weiss A., Schiaffino S., Leinwand L.A.
J. Mol. Biol. 290:61-75(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.
[2]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle."
Saez L., Leinwand L.A.
Nucleic Acids Res. 14:2951-2969(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1064-1939.
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-1306; THR-1445 AND MET-1598.
[6]"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome."
Ley T.J., Mardis E.R., Ding L., Fulton B., McLellan M.D., Chen K., Dooling D., Dunford-Shore B.H., McGrath S., Hickenbotham M., Cook L., Abbott R., Larson D.E., Koboldt D.C., Pohl C., Smith S., Hawkins A., Abbott S. expand/collapse author list , Locke D., Hillier L.W., Miner T., Fulton L., Magrini V., Wylie T., Glasscock J., Conyers J., Sander N., Shi X., Osborne J.R., Minx P., Gordon D., Chinwalla A., Zhao Y., Ries R.E., Payton J.E., Westervelt P., Tomasson M.H., Watson M., Baty J., Ivanovich J., Heath S., Shannon W.D., Nagarajan R., Walter M.J., Link D.C., Graubert T.A., DiPersio J.F., Wilson R.K.
Nature 456:66-72(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-640.
[7]"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma."
Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H., Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J., Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M. expand/collapse author list , Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L., Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J., Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A., Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K., Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A.
Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT LYS-1566.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF111785 mRNA. Translation: AAD29951.1.
AC005323 Genomic DNA. No translation available.
BC114545 mRNA. Translation: AAI14546.1.
X03740 mRNA. Translation: CAA27380.1.
PIRA23767.
RefSeqNP_005954.3. NM_005963.3.
UniGeneHs.689619.

3D structure databases

ProteinModelPortalP12882.
SMRP12882. Positions 4-967.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110704. 3 interactions.
IntActP12882. 3 interactions.
STRING9606.ENSP00000226207.

PTM databases

PhosphoSiteP12882.

Polymorphism databases

DMDM226694176.

2D gel databases

UCD-2DPAGEP12882.

Proteomic databases

PaxDbP12882.
PRIDEP12882.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000226207; ENSP00000226207; ENSG00000109061.
GeneID4619.
KEGGhsa:4619.
UCSCuc002gmo.3. human.

Organism-specific databases

CTD4619.
GeneCardsGC17M010395.
H-InvDBHIX0027129.
HGNCHGNC:7567. MYH1.
HPACAB010759.
HPA001349.
MIM160730. gene.
neXtProtNX_P12882.
PharmGKBPA31365.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5022.
HOGENOMHOG000173959.
HOVERGENHBG004704.
InParanoidP12882.
KOK10352.
OMAQPTEEIS.
OrthoDBEOG7RBZ7G.
PhylomeDBP12882.
TreeFamTF314375.

Enzyme and pathway databases

ReactomeREACT_11123. Membrane Trafficking.

Gene expression databases

BgeeP12882.
CleanExHS_MYH1.
GenevestigatorP12882.

Family and domain databases

Gene3D4.10.270.10. 1 hit.
InterProIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR015650. Myosin_1/23/4/6/7/8/13/15.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR13140:SF22. PTHR13140:SF22. 1 hit.
PfamPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSPR00193. MYOSINHEAVY.
SMARTSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS50096. IQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMYH1.
GenomeRNAi4619.
NextBio17780.
PROP12882.
SOURCESearch...

Entry information

Entry nameMYH1_HUMAN
AccessionPrimary (citable) accession number: P12882
Secondary accession number(s): Q14CA4, Q9Y622
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: April 14, 2009
Last modified: April 16, 2014
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM