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P12880

- CAPP_CORGL

UniProt

P12880 - CAPP_CORGL

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Protein
Phosphoenolpyruvate carboxylase
Gene
ppc, Cgl1585, cg1787
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Enzyme regulationi

Activity not stimulated by acetyl-CoA in the absence of any allosteric inhibitor, while the corresponding protein from E.coli is strongly stimulated.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381 By similarity
Active sitei579 – 5791 By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylase (EC:4.1.1.31)
Short name:
PEPC
Short name:
PEPCase
Gene namesi
Name:ppc
Ordered Locus Names:Cgl1585, cg1787
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 919918Phosphoenolpyruvate carboxylaseUniRule annotation
PRO_0000166591Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196627.cg1787.

Structurei

3D structure databases

ProteinModelPortaliP12880.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiWYGAGSA.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12880-1 [UniParc]FASTAAdd to Basket

« Hide

MTDFLRDDIR FLGQILGEVI AEQEGQEVYE LVEQARLTSF DIAKGNAEMD    50
SLVQVFDGIT PAKATPIARA FSHFALLANL AEDLYDEELR EQALDAGDTP 100
PDSTLDATWL KLNEGNVGAE AVADVLRNAE VAPVLTAHPT ETRRRTVFDA 150
QKWITTHMRE RHALQSAEPT ARTQSKLDEI EKNIRRRITI LWQTALIRVA 200
RPRIEDEIEV GLRYYKLSLL EEIPRINRDV AVELRERFGE GVPLKPVVKP 250
GSWIGGDHDG NPYVTAETVE YSTHRAAETV LKYYARQLHS LEHELSLSDR 300
MNKVTPQLLA LADAGHNDVP SRVDEPYRRA VHGVRGRILA TTAELIGEDA 350
VEGVWFKVFT PYASPEEFLN DALTIDHSLR ESKDVLIADD RLSVLISAIE 400
SFGFNLYALD LRQNSESYED VLTELFERAQ VTANYRELSE AEKLEVLLKE 450
LRSPRPLIPH GSDEYSEVTD RELGIFRTAS EAVKKFGPRM VPHCIISMAS 500
SVTDVLEPMV LLKEFGLIAA NGDNPRGTVD VIPLFETIED LQAGAGILDE 550
LWKIDLYRNY LLQRDNVQEV MLGYSDSNKD GGYFSANWAL YDAELQLVEL 600
CRSAGVKLRL FHGRGGTVGR GGGPSYDAIL AQPRGAVQGS VRITEQGEII 650
SAKYGNPETA RRNLEALVSA TLEASLLDVS ELTDHQRAYD IMSEISELSL 700
KKYASLVHED QGFIDYFTQS TPLQEIGSLN IGSRPSSRKQ TSSVEDLRAI 750
PWVLSWSQSR VMLPGWFGVG TALEQWIGEG EQATQRIAEL QTLNESWPFF 800
TSVLDNMAQV MSKAELRLAK LYADLIPDTE VAERVYSVIR EEYFLTKKMF 850
CVITGSDDLL DDNPLLARSV QRRYPYLLPL NVIQVEMMRR YRKGDQSEQV 900
SRNIQLTMNG LSTALRNSG 919
Length:919
Mass (Da):103,198
Last modified:January 23, 2007 - v4
Checksum:i676C45D0EAAF3F54
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti607 – 6082KL → NV in CAA32450. 1 Publication
Sequence conflicti800 – 8012FT → LP in CAA32450. 1 Publication
Sequence conflicti915 – 9151L → V in CAA32450. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14234 Genomic DNA. Translation: CAA32450.1.
M25819 Genomic DNA. Translation: AAA83537.1.
BA000036 Genomic DNA. Translation: BAB98978.1.
BX927152 Genomic DNA. Translation: CAF21593.1.
PIRiS05512. QYFKG.
RefSeqiNP_600799.1. NC_003450.3.
WP_011014465.1. NC_006958.1.
YP_225869.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB98978; BAB98978; BAB98978.
CAF21593; CAF21593; cg1787.
GeneIDi1019553.
KEGGicgb:cg1787.
cgl:NCgl1523.
PATRICi21495205. VBICorGlu203724_1546.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14234 Genomic DNA. Translation: CAA32450.1 .
M25819 Genomic DNA. Translation: AAA83537.1 .
BA000036 Genomic DNA. Translation: BAB98978.1 .
BX927152 Genomic DNA. Translation: CAF21593.1 .
PIRi S05512. QYFKG.
RefSeqi NP_600799.1. NC_003450.3.
WP_011014465.1. NC_006958.1.
YP_225869.1. NC_006958.1.

3D structure databases

ProteinModelPortali P12880.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg1787.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB98978 ; BAB98978 ; BAB98978 .
CAF21593 ; CAF21593 ; cg1787 .
GeneIDi 1019553.
KEGGi cgb:cg1787.
cgl:NCgl1523.
PATRICi 21495205. VBICorGlu203724_1546.

Phylogenomic databases

eggNOGi COG2352.
HOGENOMi HOG000238647.
KOi K01595.
OMAi WYGAGSA.
OrthoDBi EOG6TJ7T8.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The phosphoenolpyruvate carboxylase gene of Corynebacterium glutamicum: molecular cloning, nucleotide sequence, and expression."
    Eikmanns B.J., Follettie M.T., Griot M.U., Sinskey A.J.
    Mol. Gen. Genet. 218:330-339(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 13059 / LMG 3658 / NCIB 10332 / AS019 / 613.
  2. "Cloning and nucleotide sequence of the phosphoenolpyruvate carboxylase-coding gene of Corynebacterium glutamicum ATCC13032."
    O'Regan M., Thierbach G., Bachmann B., Villeval D., Lepage P., Viret J.F., Lemoine Y.
    Gene 77:237-251(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-16.
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiCAPP_CORGL
AccessioniPrimary (citable) accession number: P12880
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 108 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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