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P12880

- CAPP_CORGL

UniProt

P12880 - CAPP_CORGL

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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activity not stimulated by acetyl-CoA in the absence of any allosteric inhibitor, while the corresponding protein from E.coli is strongly stimulated.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381By similarity
Active sitei579 – 5791By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylase (EC:4.1.1.31)
Short name:
PEPC
Short name:
PEPCase
Gene namesi
Name:ppc
Ordered Locus Names:Cgl1585, cg1787
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 919918Phosphoenolpyruvate carboxylasePRO_0000166591Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi196627.cg1787.

Structurei

3D structure databases

ProteinModelPortaliP12880.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.Curated

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiWYGAGSA.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12880-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDFLRDDIR FLGQILGEVI AEQEGQEVYE LVEQARLTSF DIAKGNAEMD
60 70 80 90 100
SLVQVFDGIT PAKATPIARA FSHFALLANL AEDLYDEELR EQALDAGDTP
110 120 130 140 150
PDSTLDATWL KLNEGNVGAE AVADVLRNAE VAPVLTAHPT ETRRRTVFDA
160 170 180 190 200
QKWITTHMRE RHALQSAEPT ARTQSKLDEI EKNIRRRITI LWQTALIRVA
210 220 230 240 250
RPRIEDEIEV GLRYYKLSLL EEIPRINRDV AVELRERFGE GVPLKPVVKP
260 270 280 290 300
GSWIGGDHDG NPYVTAETVE YSTHRAAETV LKYYARQLHS LEHELSLSDR
310 320 330 340 350
MNKVTPQLLA LADAGHNDVP SRVDEPYRRA VHGVRGRILA TTAELIGEDA
360 370 380 390 400
VEGVWFKVFT PYASPEEFLN DALTIDHSLR ESKDVLIADD RLSVLISAIE
410 420 430 440 450
SFGFNLYALD LRQNSESYED VLTELFERAQ VTANYRELSE AEKLEVLLKE
460 470 480 490 500
LRSPRPLIPH GSDEYSEVTD RELGIFRTAS EAVKKFGPRM VPHCIISMAS
510 520 530 540 550
SVTDVLEPMV LLKEFGLIAA NGDNPRGTVD VIPLFETIED LQAGAGILDE
560 570 580 590 600
LWKIDLYRNY LLQRDNVQEV MLGYSDSNKD GGYFSANWAL YDAELQLVEL
610 620 630 640 650
CRSAGVKLRL FHGRGGTVGR GGGPSYDAIL AQPRGAVQGS VRITEQGEII
660 670 680 690 700
SAKYGNPETA RRNLEALVSA TLEASLLDVS ELTDHQRAYD IMSEISELSL
710 720 730 740 750
KKYASLVHED QGFIDYFTQS TPLQEIGSLN IGSRPSSRKQ TSSVEDLRAI
760 770 780 790 800
PWVLSWSQSR VMLPGWFGVG TALEQWIGEG EQATQRIAEL QTLNESWPFF
810 820 830 840 850
TSVLDNMAQV MSKAELRLAK LYADLIPDTE VAERVYSVIR EEYFLTKKMF
860 870 880 890 900
CVITGSDDLL DDNPLLARSV QRRYPYLLPL NVIQVEMMRR YRKGDQSEQV
910
SRNIQLTMNG LSTALRNSG
Length:919
Mass (Da):103,198
Last modified:January 23, 2007 - v4
Checksum:i676C45D0EAAF3F54
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti607 – 6082KL → NV in CAA32450. (PubMed:2779518)Curated
Sequence conflicti800 – 8012FT → LP in CAA32450. (PubMed:2779518)Curated
Sequence conflicti915 – 9151L → V in CAA32450. (PubMed:2779518)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14234 Genomic DNA. Translation: CAA32450.1.
M25819 Genomic DNA. Translation: AAA83537.1.
BA000036 Genomic DNA. Translation: BAB98978.1.
BX927152 Genomic DNA. Translation: CAF21593.1.
PIRiS05512. QYFKG.
RefSeqiNP_600799.1. NC_003450.3.
WP_011014465.1. NC_006958.1.
YP_225869.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB98978; BAB98978; BAB98978.
CAF21593; CAF21593; cg1787.
GeneIDi1019553.
3343481.
KEGGicgl:NCgl1523.
PATRICi21495205. VBICorGlu203724_1546.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14234 Genomic DNA. Translation: CAA32450.1 .
M25819 Genomic DNA. Translation: AAA83537.1 .
BA000036 Genomic DNA. Translation: BAB98978.1 .
BX927152 Genomic DNA. Translation: CAF21593.1 .
PIRi S05512. QYFKG.
RefSeqi NP_600799.1. NC_003450.3.
WP_011014465.1. NC_006958.1.
YP_225869.1. NC_006958.1.

3D structure databases

ProteinModelPortali P12880.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg1787.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB98978 ; BAB98978 ; BAB98978 .
CAF21593 ; CAF21593 ; cg1787 .
GeneIDi 1019553.
3343481.
KEGGi cgl:NCgl1523.
PATRICi 21495205. VBICorGlu203724_1546.

Phylogenomic databases

eggNOGi COG2352.
HOGENOMi HOG000238647.
KOi K01595.
OMAi WYGAGSA.
OrthoDBi EOG6TJ7T8.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The phosphoenolpyruvate carboxylase gene of Corynebacterium glutamicum: molecular cloning, nucleotide sequence, and expression."
    Eikmanns B.J., Follettie M.T., Griot M.U., Sinskey A.J.
    Mol. Gen. Genet. 218:330-339(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 13059 / LMG 3658 / NCIB 10332 / AS019 / 613.
  2. "Cloning and nucleotide sequence of the phosphoenolpyruvate carboxylase-coding gene of Corynebacterium glutamicum ATCC13032."
    O'Regan M., Thierbach G., Bachmann B., Villeval D., Lepage P., Viret J.F., Lemoine Y.
    Gene 77:237-251(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-16.
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiCAPP_CORGL
AccessioniPrimary (citable) accession number: P12880
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 111 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3