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P12872

- MOTI_HUMAN

UniProt

P12872 - MOTI_HUMAN

Protein

Promotilin

Gene

MLN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.

    GO - Molecular functioni

    1. receptor binding Source: ProtInc

    GO - Biological processi

    1. cell-cell signaling Source: ProtInc
    2. G-protein coupled receptor signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Promotilin
    Cleaved into the following 2 chains:
    Gene namesi
    Name:MLN
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:7141. MLN.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30856.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 25251 PublicationAdd
    BLAST
    Chaini26 – 11590PromotilinPRO_0000342171Add
    BLAST
    Peptidei26 – 4722MotilinPRO_0000019184Add
    BLAST
    Peptidei50 – 11566Motilin-associated peptidePRO_0000019185Add
    BLAST

    Keywords - PTMi

    Cleavage on pair of basic residues

    Proteomic databases

    PaxDbiP12872.
    PRIDEiP12872.

    Expressioni

    Gene expression databases

    ArrayExpressiP12872.
    BgeeiP12872.
    CleanExiHS_MLN.
    GenevestigatoriP12872.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000266003.

    Structurei

    Secondary structure

    1
    115
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi32 – 4615

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1LBJNMR-A26-47[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP12872.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the motilin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG71059.
    HOGENOMiHOG000108883.
    HOVERGENiHBG003618.
    InParanoidiP12872.
    KOiK05265.
    OMAiVEIGMRM.
    OrthoDBiEOG7RRF9Q.
    PhylomeDBiP12872.
    TreeFamiTF336217.

    Family and domain databases

    InterProiIPR015662. Motilin.
    IPR006737. Motilin_assoc.
    IPR006738. Motilin_ghrelin.
    [Graphical view]
    PANTHERiPTHR14156. PTHR14156. 1 hit.
    PfamiPF04643. Motilin_assoc. 1 hit.
    PF04644. Motilin_ghrelin. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P12872-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVSRKAVAAL LVVHVAAMLA SQTEAFVPIF TYGELQRMQE KERNKGQKKS    50
    LSVWQRSGEE GPVDPAEPIR EEENEMIKLT APLEIGMRMN SRQLEKYPAT 100
    LEGLLSEMLP QHAAK 115
    Length:115
    Mass (Da):12,920
    Last modified:October 1, 1989 - v1
    Checksum:i30D4BB59B2F42783
    GO
    Isoform 2 (identifier: P12872-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         106-113: SEMLPQHA → T

    Note: No experimental confirmation available.

    Show »
    Length:108
    Mass (Da):12,127
    Checksum:i66C99EF7F1B1E1B6
    GO
    Isoform 3 (identifier: P12872-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         114-115: AK → K

    Note: No experimental confirmation available.

    Show »
    Length:114
    Mass (Da):12,849
    Checksum:i1A5B59B2F427836F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151V → A.1 Publication
    Corresponds to variant rs2281820 [ dbSNP | Ensembl ].
    VAR_020372

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei106 – 1138SEMLPQHA → T in isoform 2. 1 PublicationVSP_045484
    Alternative sequencei114 – 1152AK → K in isoform 3. CuratedVSP_047653

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00695 mRNA. Translation: CAA68690.1.
    X15393
    , X15396, X15395, X15394 Genomic DNA. Translation: CAA33448.1.
    M30281
    , M30278, M30279, M30280 Genomic DNA. Translation: AAA59860.1.
    AL138889, AL158049 Genomic DNA. Translation: CAI21441.2.
    AL158049, AL138889 Genomic DNA. Translation: CAI21526.2.
    CH471081 Genomic DNA. Translation: EAX03752.1.
    CH471081 Genomic DNA. Translation: EAX03753.1.
    BC069675 mRNA. Translation: AAH69675.1.
    BC112314 mRNA. Translation: AAI12315.1.
    BC143981 mRNA. Translation: AAI43982.1.
    CCDSiCCDS47412.1. [P12872-3]
    CCDS4786.1. [P12872-1]
    CCDS54993.1. [P12872-2]
    PIRiA33323.
    RefSeqiNP_001035198.1. NM_001040109.1. [P12872-3]
    NP_001171627.1. NM_001184698.1. [P12872-2]
    NP_002409.1. NM_002418.2. [P12872-1]
    UniGeneiHs.2813.

    Genome annotation databases

    EnsembliENST00000266003; ENSP00000266003; ENSG00000096395. [P12872-3]
    ENST00000430124; ENSP00000388825; ENSG00000096395. [P12872-1]
    ENST00000507738; ENSP00000425467; ENSG00000096395. [P12872-2]
    GeneIDi4295.
    KEGGihsa:4295.
    UCSCiuc003off.1. human. [P12872-1]
    uc003ofg.1. human.

    Polymorphism databases

    DMDMi127253.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Motilin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y00695 mRNA. Translation: CAA68690.1 .
    X15393
    , X15396 , X15395 , X15394 Genomic DNA. Translation: CAA33448.1 .
    M30281
    , M30278 , M30279 , M30280 Genomic DNA. Translation: AAA59860.1 .
    AL138889 , AL158049 Genomic DNA. Translation: CAI21441.2 .
    AL158049 , AL138889 Genomic DNA. Translation: CAI21526.2 .
    CH471081 Genomic DNA. Translation: EAX03752.1 .
    CH471081 Genomic DNA. Translation: EAX03753.1 .
    BC069675 mRNA. Translation: AAH69675.1 .
    BC112314 mRNA. Translation: AAI12315.1 .
    BC143981 mRNA. Translation: AAI43982.1 .
    CCDSi CCDS47412.1. [P12872-3 ]
    CCDS4786.1. [P12872-1 ]
    CCDS54993.1. [P12872-2 ]
    PIRi A33323.
    RefSeqi NP_001035198.1. NM_001040109.1. [P12872-3 ]
    NP_001171627.1. NM_001184698.1. [P12872-2 ]
    NP_002409.1. NM_002418.2. [P12872-1 ]
    UniGenei Hs.2813.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1LBJ NMR - A 26-47 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000266003.

    Chemistry

    BindingDBi P12872.

    Polymorphism databases

    DMDMi 127253.

    Proteomic databases

    PaxDbi P12872.
    PRIDEi P12872.

    Protocols and materials databases

    DNASUi 4295.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000266003 ; ENSP00000266003 ; ENSG00000096395 . [P12872-3 ]
    ENST00000430124 ; ENSP00000388825 ; ENSG00000096395 . [P12872-1 ]
    ENST00000507738 ; ENSP00000425467 ; ENSG00000096395 . [P12872-2 ]
    GeneIDi 4295.
    KEGGi hsa:4295.
    UCSCi uc003off.1. human. [P12872-1 ]
    uc003ofg.1. human.

    Organism-specific databases

    CTDi 4295.
    GeneCardsi GC06M033809.
    HGNCi HGNC:7141. MLN.
    MIMi 158270. gene.
    neXtProti NX_P12872.
    PharmGKBi PA30856.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG71059.
    HOGENOMi HOG000108883.
    HOVERGENi HBG003618.
    InParanoidi P12872.
    KOi K05265.
    OMAi VEIGMRM.
    OrthoDBi EOG7RRF9Q.
    PhylomeDBi P12872.
    TreeFami TF336217.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_18283. G alpha (q) signalling events.

    Miscellaneous databases

    EvolutionaryTracei P12872.
    GenomeRNAii 4295.
    NextBioi 16905.
    PROi P12872.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P12872.
    Bgeei P12872.
    CleanExi HS_MLN.
    Genevestigatori P12872.

    Family and domain databases

    InterProi IPR015662. Motilin.
    IPR006737. Motilin_assoc.
    IPR006738. Motilin_ghrelin.
    [Graphical view ]
    PANTHERi PTHR14156. PTHR14156. 1 hit.
    Pfami PF04643. Motilin_assoc. 1 hit.
    PF04644. Motilin_ghrelin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Exon-intron organization, expression, and chromosomal localization of the human motilin gene."
      Yano H., Seino Y., Fujita J., Yamada Y., Inagaki N., Takeda J., Bell G.I., Eddy R.L., Fan Y.-S., Byers M.G., Shows T.B., Imura H.
      FEBS Lett. 249:248-252(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Structure and expression of the human motilin gene."
      Daikh D.I., Douglass J.O., Adelman J.P.
      DNA 8:615-621(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Molecular heterogeneity of human motilin-like immunoreactivity explained by the processing of prepromotilin."
      Dea D., Boileau G., Poitras P., Lahaie R.G.
      Gastroenterology 96:695-703(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-15.
      Tissue: Brain.
    8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 26-40.
    9. "NMR solution structure and dynamics of motilin in isotropic phospholipid bicellar solution."
      Andersson A., Maler L.
      J. Biomol. NMR 24:103-112(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 26-47.

    Entry informationi

    Entry nameiMOTI_HUMAN
    AccessioniPrimary (citable) accession number: P12872
    Secondary accession number(s): B7ZLR7
    , E9PDN2, J3KN51, Q2M1L2, Q5T975, Q6NSY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3