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Protein

Promotilin

Gene

MLN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.

GO - Molecular functioni

  • receptor binding Source: ProtInc

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

BioCyciZFISH:ENSG00000096395-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiP12872.

Names & Taxonomyi

Protein namesi
Recommended name:
Promotilin
Cleaved into the following 2 chains:
Gene namesi
Name:MLN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:7141. MLN.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4295.
OpenTargetsiENSG00000096395.
PharmGKBiPA30856.

Polymorphism and mutation databases

BioMutaiMLN.
DMDMi127253.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000034217126 – 115PromotilinAdd BLAST90
PeptideiPRO_000001918426 – 47MotilinAdd BLAST22
PeptideiPRO_000001918550 – 115Motilin-associated peptideAdd BLAST66

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP12872.
PeptideAtlasiP12872.
PRIDEiP12872.

PTM databases

PhosphoSitePlusiP12872.

Expressioni

Gene expression databases

BgeeiENSG00000096395.
CleanExiHS_MLN.
GenevisibleiP12872. HS.

Organism-specific databases

HPAiHPA069392.

Interactioni

GO - Molecular functioni

  • receptor binding Source: ProtInc

Protein-protein interaction databases

STRINGi9606.ENSP00000388825.

Chemistry databases

BindingDBiP12872.

Structurei

Secondary structure

1115
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi32 – 46Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LBJNMR-A26-47[»]
ProteinModelPortaliP12872.
SMRiP12872.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12872.

Family & Domainsi

Sequence similaritiesi

Belongs to the motilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J17F. Eukaryota.
ENOG411197B. LUCA.
GeneTreeiENSGT00390000000489.
HOGENOMiHOG000108883.
HOVERGENiHBG003618.
InParanoidiP12872.
KOiK05265.
OMAiIFTYGEL.
OrthoDBiEOG091G0X9Z.
PhylomeDBiP12872.
TreeFamiTF336217.

Family and domain databases

InterProiIPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
IPR015662. Promotilin.
[Graphical view]
PANTHERiPTHR14156. PTHR14156. 1 hit.
PfamiPF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P12872-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSRKAVAAL LVVHVAAMLA SQTEAFVPIF TYGELQRMQE KERNKGQKKS
60 70 80 90 100
LSVWQRSGEE GPVDPAEPIR EEENEMIKLT APLEIGMRMN SRQLEKYPAT
110
LEGLLSEMLP QHAAK
Length:115
Mass (Da):12,920
Last modified:October 1, 1989 - v1
Checksum:i30D4BB59B2F42783
GO
Isoform 2 (identifier: P12872-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-113: SEMLPQHA → T

Note: No experimental confirmation available.
Show »
Length:108
Mass (Da):12,127
Checksum:i66C99EF7F1B1E1B6
GO
Isoform 3 (identifier: P12872-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-115: AK → K

Note: No experimental confirmation available.
Show »
Length:114
Mass (Da):12,849
Checksum:i1A5B59B2F427836F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02037215V → A.1 PublicationCorresponds to variant rs2281820dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_045484106 – 113SEMLPQHA → T in isoform 2. 1 Publication8
Alternative sequenceiVSP_047653114 – 115AK → K in isoform 3. Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00695 mRNA. Translation: CAA68690.1.
X15393
, X15396, X15395, X15394 Genomic DNA. Translation: CAA33448.1.
M30281
, M30278, M30279, M30280 Genomic DNA. Translation: AAA59860.1.
AL138889, AL158049 Genomic DNA. Translation: CAI21441.2.
AL158049, AL138889 Genomic DNA. Translation: CAI21526.2.
CH471081 Genomic DNA. Translation: EAX03752.1.
CH471081 Genomic DNA. Translation: EAX03753.1.
BC069675 mRNA. Translation: AAH69675.1.
BC112314 mRNA. Translation: AAI12315.1.
BC143981 mRNA. Translation: AAI43982.1.
CCDSiCCDS47412.1. [P12872-3]
CCDS4786.1. [P12872-1]
CCDS54993.1. [P12872-2]
PIRiA33323.
RefSeqiNP_001035198.1. NM_001040109.1. [P12872-3]
NP_001171627.1. NM_001184698.1. [P12872-2]
NP_002409.1. NM_002418.2. [P12872-1]
UniGeneiHs.2813.

Genome annotation databases

EnsembliENST00000266003; ENSP00000266003; ENSG00000096395. [P12872-3]
ENST00000430124; ENSP00000388825; ENSG00000096395. [P12872-1]
ENST00000507738; ENSP00000425467; ENSG00000096395. [P12872-2]
GeneIDi4295.
KEGGihsa:4295.
UCSCiuc003off.2. human. [P12872-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Motilin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00695 mRNA. Translation: CAA68690.1.
X15393
, X15396, X15395, X15394 Genomic DNA. Translation: CAA33448.1.
M30281
, M30278, M30279, M30280 Genomic DNA. Translation: AAA59860.1.
AL138889, AL158049 Genomic DNA. Translation: CAI21441.2.
AL158049, AL138889 Genomic DNA. Translation: CAI21526.2.
CH471081 Genomic DNA. Translation: EAX03752.1.
CH471081 Genomic DNA. Translation: EAX03753.1.
BC069675 mRNA. Translation: AAH69675.1.
BC112314 mRNA. Translation: AAI12315.1.
BC143981 mRNA. Translation: AAI43982.1.
CCDSiCCDS47412.1. [P12872-3]
CCDS4786.1. [P12872-1]
CCDS54993.1. [P12872-2]
PIRiA33323.
RefSeqiNP_001035198.1. NM_001040109.1. [P12872-3]
NP_001171627.1. NM_001184698.1. [P12872-2]
NP_002409.1. NM_002418.2. [P12872-1]
UniGeneiHs.2813.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LBJNMR-A26-47[»]
ProteinModelPortaliP12872.
SMRiP12872.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000388825.

Chemistry databases

BindingDBiP12872.

PTM databases

PhosphoSitePlusiP12872.

Polymorphism and mutation databases

BioMutaiMLN.
DMDMi127253.

Proteomic databases

PaxDbiP12872.
PeptideAtlasiP12872.
PRIDEiP12872.

Protocols and materials databases

DNASUi4295.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266003; ENSP00000266003; ENSG00000096395. [P12872-3]
ENST00000430124; ENSP00000388825; ENSG00000096395. [P12872-1]
ENST00000507738; ENSP00000425467; ENSG00000096395. [P12872-2]
GeneIDi4295.
KEGGihsa:4295.
UCSCiuc003off.2. human. [P12872-1]

Organism-specific databases

CTDi4295.
DisGeNETi4295.
GeneCardsiMLN.
HGNCiHGNC:7141. MLN.
HPAiHPA069392.
MIMi158270. gene.
neXtProtiNX_P12872.
OpenTargetsiENSG00000096395.
PharmGKBiPA30856.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J17F. Eukaryota.
ENOG411197B. LUCA.
GeneTreeiENSGT00390000000489.
HOGENOMiHOG000108883.
HOVERGENiHBG003618.
InParanoidiP12872.
KOiK05265.
OMAiIFTYGEL.
OrthoDBiEOG091G0X9Z.
PhylomeDBiP12872.
TreeFamiTF336217.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000096395-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-416476. G alpha (q) signalling events.
SIGNORiP12872.

Miscellaneous databases

EvolutionaryTraceiP12872.
GenomeRNAii4295.
PROiP12872.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000096395.
CleanExiHS_MLN.
GenevisibleiP12872. HS.

Family and domain databases

InterProiIPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
IPR015662. Promotilin.
[Graphical view]
PANTHERiPTHR14156. PTHR14156. 1 hit.
PfamiPF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOTI_HUMAN
AccessioniPrimary (citable) accession number: P12872
Secondary accession number(s): B7ZLR7
, E9PDN2, J3KN51, Q2M1L2, Q5T975, Q6NSY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 2, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.