Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P12872 (MOTI_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Promotilin

Cleaved into the following 2 chains:

  1. Motilin
  2. Motilin-associated peptide
    Short name=MAP
Gene names
Name:MLN
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length115 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.

Subcellular location

Secreted.

Sequence similarities

Belongs to the motilin family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   Molecular functionHormone
   PTMCleavage on pair of basic residues
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement PubMed 10381885. Source: ProtInc

cell-cell signaling

Traceable author statement PubMed 10381885. Source: ProtInc

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

   Molecular_functionreceptor binding

Traceable author statement PubMed 10381885. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P12872-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P12872-2)

The sequence of this isoform differs from the canonical sequence as follows:
     106-113: SEMLPQHA → T
Note: No experimental confirmation available.
Isoform 3 (identifier: P12872-3)

The sequence of this isoform differs from the canonical sequence as follows:
     114-115: AK → K
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Ref.8
Chain26 – 11590Promotilin
PRO_0000342171
Peptide26 – 4722Motilin
PRO_0000019184
Peptide50 – 11566Motilin-associated peptide
PRO_0000019185

Natural variations

Alternative sequence106 – 1138SEMLPQHA → T in isoform 2.
VSP_045484
Alternative sequence114 – 1152AK → K in isoform 3.
VSP_047653
Natural variant151V → A. Ref.7
Corresponds to variant rs2281820 [ dbSNP | Ensembl ].
VAR_020372

Secondary structure

... 115
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 30D4BB59B2F42783

FASTA11512,920
        10         20         30         40         50         60 
MVSRKAVAAL LVVHVAAMLA SQTEAFVPIF TYGELQRMQE KERNKGQKKS LSVWQRSGEE 

        70         80         90        100        110 
GPVDPAEPIR EEENEMIKLT APLEIGMRMN SRQLEKYPAT LEGLLSEMLP QHAAK 

« Hide

Isoform 2 [UniParc].

Checksum: 66C99EF7F1B1E1B6
Show »

FASTA10812,127
Isoform 3 [UniParc].

Checksum: 1A5B59B2F427836F
Show »

FASTA11412,849

References

« Hide 'large scale' references
[1]"Sequence of an intestinal cDNA encoding human motilin precursor."
Seino Y., Tanaka K., Takeda J., Takahashi H., Mitani T., Kurono M., Kayano T., Koh G., Fukumoto H., Yano H., Fujita J., Inagaki N., Yamada Y., Imura H.
FEBS Lett. 223:74-76(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"Exon-intron organization, expression, and chromosomal localization of the human motilin gene."
Yano H., Seino Y., Fujita J., Yamada Y., Inagaki N., Takeda J., Bell G.I., Eddy R.L., Fan Y.-S., Byers M.G., Shows T.B., Imura H.
FEBS Lett. 249:248-252(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Structure and expression of the human motilin gene."
Daikh D.I., Douglass J.O., Adelman J.P.
DNA 8:615-621(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Molecular heterogeneity of human motilin-like immunoreactivity explained by the processing of prepromotilin."
Dea D., Boileau G., Poitras P., Lahaie R.G.
Gastroenterology 96:695-703(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-15.
Tissue: Brain.
[8]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 26-40.
[9]"NMR solution structure and dynamics of motilin in isotropic phospholipid bicellar solution."
Andersson A., Maler L.
J. Biomol. NMR 24:103-112(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 26-47.
+Additional computationally mapped references.

Web resources

Wikipedia

Motilin entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y00695 mRNA. Translation: CAA68690.1.
X15393 expand/collapse EMBL AC list , X15396, X15395, X15394 Genomic DNA. Translation: CAA33448.1.
M30281 expand/collapse EMBL AC list , M30278, M30279, M30280 Genomic DNA. Translation: AAA59860.1.
AL138889, AL158049 Genomic DNA. Translation: CAI21441.2.
AL158049, AL138889 Genomic DNA. Translation: CAI21526.2.
CH471081 Genomic DNA. Translation: EAX03752.1.
CH471081 Genomic DNA. Translation: EAX03753.1.
BC069675 mRNA. Translation: AAH69675.1.
BC112314 mRNA. Translation: AAI12315.1.
BC143981 mRNA. Translation: AAI43982.1.
CCDSCCDS47412.1. [P12872-3]
CCDS4786.1. [P12872-1]
CCDS54993.1. [P12872-2]
PIRA33323.
RefSeqNP_001035198.1. NM_001040109.1. [P12872-3]
NP_001171627.1. NM_001184698.1. [P12872-2]
NP_002409.1. NM_002418.2. [P12872-1]
UniGeneHs.2813.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1LBJNMR-A26-47[»]
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000266003.

Chemistry

BindingDBP12872.

Polymorphism databases

DMDM127253.

Proteomic databases

PaxDbP12872.
PRIDEP12872.

Protocols and materials databases

DNASU4295.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000266003; ENSP00000266003; ENSG00000096395. [P12872-3]
ENST00000430124; ENSP00000388825; ENSG00000096395. [P12872-1]
ENST00000507738; ENSP00000425467; ENSG00000096395. [P12872-2]
GeneID4295.
KEGGhsa:4295.
UCSCuc003off.1. human. [P12872-1]

Organism-specific databases

CTD4295.
GeneCardsGC06M033809.
HGNCHGNC:7141. MLN.
MIM158270. gene.
neXtProtNX_P12872.
PharmGKBPA30856.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG71059.
HOGENOMHOG000108883.
HOVERGENHBG003618.
InParanoidP12872.
KOK05265.
OMAVEIGMRM.
OrthoDBEOG7RRF9Q.
PhylomeDBP12872.
TreeFamTF336217.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP12872.
BgeeP12872.
CleanExHS_MLN.
GenevestigatorP12872.

Family and domain databases

InterProIPR015662. Motilin.
IPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
[Graphical view]
PANTHERPTHR14156. PTHR14156. 1 hit.
PfamPF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP12872.
GenomeRNAi4295.
NextBio16905.
PROP12872.
SOURCESearch...

Entry information

Entry nameMOTI_HUMAN
AccessionPrimary (citable) accession number: P12872
Secondary accession number(s): B7ZLR7 expand/collapse secondary AC list , E9PDN2, J3KN51, Q2M1L2, Q5T975, Q6NSY7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: July 9, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM