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P12872

- MOTI_HUMAN

UniProt

P12872 - MOTI_HUMAN

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Protein

Promotilin

Gene

MLN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.

GO - Molecular functioni

  1. receptor binding Source: ProtInc

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. G-protein coupled receptor signaling pathway Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiREACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Promotilin
Cleaved into the following 2 chains:
Gene namesi
Name:MLN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:7141. MLN.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30856.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 11590PromotilinPRO_0000342171Add
BLAST
Peptidei26 – 4722MotilinPRO_0000019184Add
BLAST
Peptidei50 – 11566Motilin-associated peptidePRO_0000019185Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP12872.
PRIDEiP12872.

Expressioni

Gene expression databases

BgeeiP12872.
CleanExiHS_MLN.
GenevestigatoriP12872.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000266003.

Structurei

Secondary structure

1
115
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi32 – 4615

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LBJNMR-A26-47[»]
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12872.

Family & Domainsi

Sequence similaritiesi

Belongs to the motilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG71059.
GeneTreeiENSGT00390000000489.
HOGENOMiHOG000108883.
HOVERGENiHBG003618.
InParanoidiP12872.
KOiK05265.
OMAiVEIGMRM.
OrthoDBiEOG7RRF9Q.
PhylomeDBiP12872.
TreeFamiTF336217.

Family and domain databases

InterProiIPR015662. Motilin.
IPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
[Graphical view]
PANTHERiPTHR14156. PTHR14156. 1 hit.
PfamiPF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P12872-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSRKAVAAL LVVHVAAMLA SQTEAFVPIF TYGELQRMQE KERNKGQKKS
60 70 80 90 100
LSVWQRSGEE GPVDPAEPIR EEENEMIKLT APLEIGMRMN SRQLEKYPAT
110
LEGLLSEMLP QHAAK
Length:115
Mass (Da):12,920
Last modified:October 1, 1989 - v1
Checksum:i30D4BB59B2F42783
GO
Isoform 2 (identifier: P12872-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-113: SEMLPQHA → T

Note: No experimental confirmation available.

Show »
Length:108
Mass (Da):12,127
Checksum:i66C99EF7F1B1E1B6
GO
Isoform 3 (identifier: P12872-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-115: AK → K

Note: No experimental confirmation available.

Show »
Length:114
Mass (Da):12,849
Checksum:i1A5B59B2F427836F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151V → A.1 Publication
Corresponds to variant rs2281820 [ dbSNP | Ensembl ].
VAR_020372

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei106 – 1138SEMLPQHA → T in isoform 2. 1 PublicationVSP_045484
Alternative sequencei114 – 1152AK → K in isoform 3. CuratedVSP_047653

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00695 mRNA. Translation: CAA68690.1.
X15393
, X15396, X15395, X15394 Genomic DNA. Translation: CAA33448.1.
M30281
, M30278, M30279, M30280 Genomic DNA. Translation: AAA59860.1.
AL138889, AL158049 Genomic DNA. Translation: CAI21441.2.
AL158049, AL138889 Genomic DNA. Translation: CAI21526.2.
CH471081 Genomic DNA. Translation: EAX03752.1.
CH471081 Genomic DNA. Translation: EAX03753.1.
BC069675 mRNA. Translation: AAH69675.1.
BC112314 mRNA. Translation: AAI12315.1.
BC143981 mRNA. Translation: AAI43982.1.
CCDSiCCDS47412.1. [P12872-3]
CCDS4786.1. [P12872-1]
CCDS54993.1. [P12872-2]
PIRiA33323.
RefSeqiNP_001035198.1. NM_001040109.1. [P12872-3]
NP_001171627.1. NM_001184698.1. [P12872-2]
NP_002409.1. NM_002418.2. [P12872-1]
UniGeneiHs.2813.

Genome annotation databases

EnsembliENST00000266003; ENSP00000266003; ENSG00000096395. [P12872-3]
ENST00000430124; ENSP00000388825; ENSG00000096395. [P12872-1]
ENST00000507738; ENSP00000425467; ENSG00000096395. [P12872-2]
GeneIDi4295.
KEGGihsa:4295.
UCSCiuc003off.1. human. [P12872-1]
uc003ofg.1. human.

Polymorphism databases

DMDMi127253.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Motilin entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00695 mRNA. Translation: CAA68690.1 .
X15393
, X15396 , X15395 , X15394 Genomic DNA. Translation: CAA33448.1 .
M30281
, M30278 , M30279 , M30280 Genomic DNA. Translation: AAA59860.1 .
AL138889 , AL158049 Genomic DNA. Translation: CAI21441.2 .
AL158049 , AL138889 Genomic DNA. Translation: CAI21526.2 .
CH471081 Genomic DNA. Translation: EAX03752.1 .
CH471081 Genomic DNA. Translation: EAX03753.1 .
BC069675 mRNA. Translation: AAH69675.1 .
BC112314 mRNA. Translation: AAI12315.1 .
BC143981 mRNA. Translation: AAI43982.1 .
CCDSi CCDS47412.1. [P12872-3 ]
CCDS4786.1. [P12872-1 ]
CCDS54993.1. [P12872-2 ]
PIRi A33323.
RefSeqi NP_001035198.1. NM_001040109.1. [P12872-3 ]
NP_001171627.1. NM_001184698.1. [P12872-2 ]
NP_002409.1. NM_002418.2. [P12872-1 ]
UniGenei Hs.2813.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1LBJ NMR - A 26-47 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000266003.

Chemistry

BindingDBi P12872.

Polymorphism databases

DMDMi 127253.

Proteomic databases

PaxDbi P12872.
PRIDEi P12872.

Protocols and materials databases

DNASUi 4295.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000266003 ; ENSP00000266003 ; ENSG00000096395 . [P12872-3 ]
ENST00000430124 ; ENSP00000388825 ; ENSG00000096395 . [P12872-1 ]
ENST00000507738 ; ENSP00000425467 ; ENSG00000096395 . [P12872-2 ]
GeneIDi 4295.
KEGGi hsa:4295.
UCSCi uc003off.1. human. [P12872-1 ]
uc003ofg.1. human.

Organism-specific databases

CTDi 4295.
GeneCardsi GC06M033762.
HGNCi HGNC:7141. MLN.
MIMi 158270. gene.
neXtProti NX_P12872.
PharmGKBi PA30856.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG71059.
GeneTreei ENSGT00390000000489.
HOGENOMi HOG000108883.
HOVERGENi HBG003618.
InParanoidi P12872.
KOi K05265.
OMAi VEIGMRM.
OrthoDBi EOG7RRF9Q.
PhylomeDBi P12872.
TreeFami TF336217.

Enzyme and pathway databases

Reactomei REACT_14819. Peptide ligand-binding receptors.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

EvolutionaryTracei P12872.
GenomeRNAii 4295.
NextBioi 16905.
PROi P12872.
SOURCEi Search...

Gene expression databases

Bgeei P12872.
CleanExi HS_MLN.
Genevestigatori P12872.

Family and domain databases

InterProi IPR015662. Motilin.
IPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
[Graphical view ]
PANTHERi PTHR14156. PTHR14156. 1 hit.
Pfami PF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Exon-intron organization, expression, and chromosomal localization of the human motilin gene."
    Yano H., Seino Y., Fujita J., Yamada Y., Inagaki N., Takeda J., Bell G.I., Eddy R.L., Fan Y.-S., Byers M.G., Shows T.B., Imura H.
    FEBS Lett. 249:248-252(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Structure and expression of the human motilin gene."
    Daikh D.I., Douglass J.O., Adelman J.P.
    DNA 8:615-621(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Molecular heterogeneity of human motilin-like immunoreactivity explained by the processing of prepromotilin."
    Dea D., Boileau G., Poitras P., Lahaie R.G.
    Gastroenterology 96:695-703(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-15.
    Tissue: Brain.
  8. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-40.
  9. "NMR solution structure and dynamics of motilin in isotropic phospholipid bicellar solution."
    Andersson A., Maler L.
    J. Biomol. NMR 24:103-112(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 26-47.

Entry informationi

Entry nameiMOTI_HUMAN
AccessioniPrimary (citable) accession number: P12872
Secondary accession number(s): B7ZLR7
, E9PDN2, J3KN51, Q2M1L2, Q5T975, Q6NSY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: October 29, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3