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Reviewed, UniProtKB/Swiss-Prot P12872 (MOTI_HUMAN)

Last modified February 9, 2010. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Promotilin
Cleaved into the following 2 chains:
    1- Recommended name:
            Motilin
    2- Recommended name:
            Motilin-associated peptide
                Short name=MAP
Gene names
Name: MLN
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length115 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.

Subcellular location

Secreted.

Sequence similarities

Belongs to the motilin family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionHormone
   PTMCleavage on pair of basic residues
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological processG-protein coupled receptor protein signaling pathway

Traceable author statement. Source: ProtInc

cell-cell signaling

Traceable author statement. Source: ProtInc

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

soluble fraction

Traceable author statement. Source: ProtInc

   Molecular functionhormone activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Ref.8
Chain26 – 11590Promotilin
PRO_0000342171
Peptide26 – 4722Motilin
PRO_0000019184
Peptide50 – 11566Motilin-associated peptide
PRO_0000019185

Natural variations

Natural variant151V → A: dbSNP rs2281820. Ref.7
VAR_020372

Secondary structure

... 115
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P12872-1 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 30D4BB59B2F42783

FASTA11512,920
        10         20         30         40         50         60 
MVSRKAVAAL LVVHVAAMLA SQTEAFVPIF TYGELQRMQE KERNKGQKKS LSVWQRSGEE 

        70         80         90        100        110 
GPVDPAEPIR EEENEMIKLT APLEIGMRMN SRQLEKYPAT LEGLLSEMLP QHAAK 

« Hide

References

« Hide 'large scale' references
[1]"Sequence of an intestinal cDNA encoding human motilin precursor."
Seino Y., Tanaka K., Takeda J., Takahashi H., Mitani T., Kurono M., Kayano T., Koh G., Fukumoto H., Yano H., Fujita J., Inagaki N., Yamada Y., Imura H.
FEBS Lett. 223:74-76(1987) [PubMed: 3666144] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Exon-intron organization, expression, and chromosomal localization of the human motilin gene."
Yano H., Seino Y., Fujita J., Yamada Y., Inagaki N., Takeda J., Bell G.I., Eddy R.L., Fan Y.-S., Byers M.G., Shows T.B., Imura H.
FEBS Lett. 249:248-252(1989) [PubMed: 2737284] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Structure and expression of the human motilin gene."
Daikh D.I., Douglass J.O., Adelman J.P.
DNA 8:615-621(1989) [PubMed: 2574660] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Molecular heterogeneity of human motilin-like immunoreactivity explained by the processing of prepromotilin."
Dea D., Boileau G., Poitras P., Lahaie R.G.
Gastroenterology 96:695-703(1989) [PubMed: 2914635] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed: 14574404] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-15.
Tissue: Brain.
[8]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]
Cited for: PROTEIN SEQUENCE OF 26-40.
[9]"NMR solution structure and dynamics of motilin in isotropic phospholipid bicellar solution."
Andersson A., Maler L.
J. Biomol. NMR 24:103-112(2002) [PubMed: 12495026] [Abstract]
Cited for: STRUCTURE BY NMR OF 26-47.
+Additional computationally mapped references.

Web resources

Wikipedia

Motilin entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y00695 mRNA. Translation: CAA68690.1.
X15393 expand/collapse EMBL AC list , X15396, X15395, X15394 Genomic DNA. Translation: CAA33448.1.
M30281 expand/collapse EMBL AC list , M30278, M30279, M30280 Genomic DNA. Translation: AAA59860.1.
AL138889, AL158049 Genomic DNA. Translation: CAI21441.2.
AL158049, AL138889 Genomic DNA. Translation: CAI21526.2.
CH471081 Genomic DNA. Translation: EAX03753.1.
BC069675 mRNA. Translation: AAH69675.1.
BC112314 mRNA. Translation: AAI12315.1.
IPIIPI00025878.
PIRA33323.
RefSeqNP_001035198.1.
NP_002409.1.
UniGeneHs.2813

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1LBJNMR-A26-47[»]
ModBaseSearch...

Protein-protein interaction databases

STRINGP12872.

Proteomic databases

PRIDEP12872.

Genome annotation databases

EnsemblENST00000266003; ENSP00000266003; ENSG00000096395; Homo sapiens. [Genome view]
GeneID4295.
KEGGhsa:4295.
UCSCuc003off.1. human.

Organism-specific databases

CTD4295.
GeneCardsGC06M033870.
H-InvDBHIX0032938.
HGNCHGNC:7141. MLN.
MIM158270. gene.
PharmGKBPA30402.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG20517.
HOGENOMHBG100930.
HOVERGENP12872.
InParanoidP12872.
OMAERNKGQK.
OrthoDBEOG9D299F.
PhylomeDBP12872.

Gene expression databases

ArrayExpressP12872.
BgeeP12872.
CleanExHS_MLN.
GenevestigatorP12872.
GermOnlineENSG00000096395. Homo sapiens.

Family and domain databases

InterProIPR015662. Motilin.
IPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
[Graphical view]
PANTHERPTHR14156. Motilin. 1 hit.
PfamPF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio16905.
SOURCESearch...

Entry information

Entry nameMOTI_HUMAN
AccessionPrimary (citable) accession number: P12872
Secondary accession number(s): Q2M1L2, Q5T975, Q6NSY7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: February 9, 2010
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Recent format changes

Overview of recent format changes

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents