Reviewed, UniProtKB/Swiss-Prot P12864 (GLRX1_RABIT)

Names and origin

Protein names

Recommended name:
    Glutaredoxin-1
Alternative name(s):
    Thioltransferase-1
      Short name=TTase-1

Gene names

Name:	GLRX
Synonyms:	GRX

Organism

Oryctolagus cuniculus (Rabbit)

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	106 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the glutaredoxin family. Contains 1 glutaredoxin domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Cytoplasm
Domain	Redox-active center
PTM	Acetylation Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 106	106	Glutaredoxin-1		PRO_0000141603
Regions
	Domain	2 – 105	104	Glutaredoxin
Amino acid modifications
	Modified residue	1	1	N-acetylalanine
	Disulfide bond	22 ↔ 25		Redox-active
	Disulfide bond	78 ↔ 82

Sequences

	Sequence		Length	Mass (Da)
	P12864-1 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: F6A1D7CC096A2105	FASTA	106	11,822
	10 20 30 40 50 60 AQEFVNSKIQ PGKVVVFIKP TCPYCRKTQE ILSQLPFKQG LLEFVDITAT SDMSEIQDYL 70 80 90 100 QQLTGARTVP RVFLGKDCIG GCSDLIAMQE KGELLARLKE MGALRQ

References

[1]	"Glutaredoxin from rabbit bone marrow. Purification, characterization, and amino acid sequence determined by tandem mass spectrometry." Hopper S., Johnson R.S., Vath J.E., Biemann K. J. Biol. Chem. 264:20438-20447(1989) [PubMed: 2684977] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Bone marrow.

Cross-references

Sequence databases
PIR	GDRB. A32682.
3D structure databases
HSSP	HSSP built from PDB template 1JHB based on UniProtKB P35754.
SMR	P12864. Positions 1-105.
ModBase	Search...
Genome annotation databases
Ensembl	ENSOCUG00000015853. Oryctolagus cuniculus. [Contig view]
Phylogenomic databases
HOVERGEN	P12864.
Family and domain databases
InterPro	IPR011767. GLR_AS. IPR002109. Glutaredoxin. IPR014025. Glutaredoxin_sub. IPR011899. GRX_euk. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00462. Glutaredoxin. 1 hit. [Graphical view]
PRINTS	PR00160. GLUTAREDOXIN.
TIGRFAMs	TIGR02180. GRX_euk. 1 hit.
PROSITE	PS00195. GLUTAREDOXIN_1. 1 hit. PS51354. GLUTAREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLRX1_RABIT

Accession

Primary (citable) accession number: P12864

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	June 16, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)