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Protein

ADP,ATP carrier protein 2, mitochondrial

Gene

ANT2

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei160ADPBy similarity1
Binding sitei172ADPBy similarity1
Binding sitei317ADPBy similarity1

GO - Molecular functioni

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein 2, mitochondrial
Alternative name(s):
ADP/ATP translocase 2
Adenine nucleotide translocator 2
Short name:
ANT 2
Gene namesi
Name:ANT2
Synonyms:ANT-G2
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Chromosome 4

Organism-specific databases

MaizeGDBi17145

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei87 – 114Helical; Name=1By similarityAdd BLAST28
Transmembranei155 – 179Helical; Name=2By similarityAdd BLAST25
Transmembranei188 – 208Helical; Name=3By similarityAdd BLAST21
Transmembranei258 – 279Helical; Name=4By similarityAdd BLAST22
Transmembranei293 – 313Helical; Name=5By similarityAdd BLAST21
Transmembranei353 – 373Helical; Name=6By similarityAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 77MitochondrionSequence analysisAdd BLAST77
ChainiPRO_000001924978 – 387ADP,ATP carrier protein 2, mitochondrialAdd BLAST310

Proteomic databases

PaxDbiP12857
PRIDEiP12857

Expressioni

Gene expression databases

ExpressionAtlasiP12857 differential
GenevisibleiP12857 ZM

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi4577.GRMZM2G135186_P03

Structurei

3D structure databases

ProteinModelPortaliP12857
SMRiP12857
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati85 – 178Solcar 1Add BLAST94
Repeati190 – 282Solcar 2Add BLAST93
Repeati290 – 376Solcar 3Add BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni317 – 322Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi317 – 322Nucleotide carrier signature motifBy similarity6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
KOiK05863

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12857-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQANQPTV LHKLGGQFHL SSSFSEGVRA RNICPSFSPY ERRFATRNYM
60 70 80 90 100
TQSLWGPSMS VSGGINVPVM PTPLFANAPA EKGGKNFMID FMMGGVSAAV
110 120 130 140 150
SKTAAAPIER VKLLIQNQDE MIKSGRLSEP YKGIADCFKR TIKDEGFSSL
160 170 180 190 200
WRGNTANVIR YFPTQALNFA FKDYFKRLFN FKKDRDGYWK WFAGNLASGG
210 220 230 240 250
AAGASSLFFV YSLDYARTRL ANDAKAAKGG GDRQFNGLVD VYRKTLKSDG
260 270 280 290 300
IAGLYRGFNI SCVGIIVYRG LYFGLYDSIK PVVLTGSLQD NFFASFALGW
310 320 330 340 350
LITNGAGLAS YPIDTVRRRM MMTSGEAVKY KSSLDAFQQI LKKEGPKSLF
360 370 380
KGAGANILRA IAGAGVLSGY DQLQILFFGK KYGSGGA
Length:387
Mass (Da):42,333
Last modified:August 1, 1992 - v2
Checksum:i020E616DC5EC2664
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242Y → I in CAA33743 (PubMed:2547608).Curated1
Sequence conflicti327A → G in CAA33743 (PubMed:2547608).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59086 mRNA Translation: CAA41812.1
X15712 Genomic DNA Translation: CAA33743.1
PIRiS16568
RefSeqiNP_001105434.1, NM_001111964.1
XP_008677791.1, XM_008679569.1
UniGeneiZm.75

Genome annotation databases

EnsemblPlantsiZm00001d051685_T001; Zm00001d051685_P001; Zm00001d051685
Zm00001d051685_T002; Zm00001d051685_P002; Zm00001d051685
GeneIDi542389
GrameneiZm00001d051685_T001; Zm00001d051685_P001; Zm00001d051685
Zm00001d051685_T002; Zm00001d051685_P002; Zm00001d051685
KEGGizma:542389

Similar proteinsi

Entry informationi

Entry nameiADT2_MAIZE
AccessioniPrimary (citable) accession number: P12857
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: August 1, 1992
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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