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Protein

Xylose isomerase

Gene

xylA

Organism
Actinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NCIMB 12654 / NBRC 102363 / 431)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Mg2+Note: Binds 2 magnesium ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei541
Active sitei57By similarity1
Metal bindingi181Magnesium 11
Metal bindingi217Magnesium 11
Metal bindingi217Magnesium 21
Metal bindingi220Magnesium 21
Metal bindingi245Magnesium 11
Metal bindingi255Magnesium 21
Metal bindingi257Magnesium 21
Metal bindingi292Magnesium 11

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BRENDAi5.3.1.5. 141.
SABIO-RKP12851.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
Synonyms:XI
Ordered Locus Names:AMIS_10350
OrganismiActinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NCIMB 12654 / NBRC 102363 / 431)
Taxonomic identifieri512565 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeActinoplanes
Proteomesi
  • UP000007882 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

DrugBankiDB01638. D-Sorbitol.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001957572 – 394Xylose isomeraseAdd BLAST393

Proteomic databases

PRIDEiP12851.

Interactioni

Subunit structurei

Homotetramer.

Structurei

Secondary structure

1394
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 9Combined sources3
Beta strandi11 – 14Combined sources4
Helixi15 – 18Combined sources4
Helixi36 – 46Combined sources11
Beta strandi49 – 52Combined sources4
Helixi55 – 58Combined sources4
Helixi65 – 82Combined sources18
Beta strandi88 – 90Combined sources3
Beta strandi94 – 96Combined sources3
Helixi97 – 99Combined sources3
Helixi109 – 129Combined sources21
Beta strandi133 – 137Combined sources5
Beta strandi141 – 145Combined sources5
Helixi146 – 148Combined sources3
Helixi151 – 172Combined sources22
Beta strandi177 – 181Combined sources5
Beta strandi184 – 193Combined sources10
Helixi196 – 203Combined sources8
Beta strandi206 – 208Combined sources3
Helixi209 – 211Combined sources3
Beta strandi212 – 214Combined sources3
Helixi218 – 222Combined sources5
Turni223 – 225Combined sources3
Helixi228 – 238Combined sources11
Beta strandi244 – 246Combined sources3
Beta strandi251 – 254Combined sources4
Beta strandi262 – 264Combined sources3
Helixi265 – 276Combined sources12
Helixi279 – 281Combined sources3
Beta strandi289 – 291Combined sources3
Helixi301 – 327Combined sources27
Helixi329 – 337Combined sources9
Helixi341 – 344Combined sources4
Helixi354 – 359Combined sources6
Helixi361 – 363Combined sources3
Turni364 – 366Combined sources3
Helixi369 – 373Combined sources5
Helixi379 – 390Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BHWX-ray4.10A/B/C/D2-394[»]
1XIMX-ray2.20A/B/C/D2-394[»]
1XINX-ray2.40A/B/C/D2-394[»]
2XIMX-ray2.30A/B/C/D2-394[»]
2XINX-ray2.30A/B/C/D2-394[»]
3XIMX-ray2.30A/B/C/D2-394[»]
3XINX-ray2.30A/B/C/D2-394[»]
4XIMX-ray2.30A/B/C/D2-394[»]
5XIMX-ray2.60A/B/C/D2-394[»]
5XINX-ray2.30A/B/C/D2-394[»]
6XIMX-ray2.50A/B/C/D2-394[»]
7XIMX-ray2.40A/B/C/D2-394[»]
8XIMX-ray2.40A/B/C/D2-394[»]
9XIMX-ray2.40A/B/C/D2-394[»]
ProteinModelPortaliP12851.
SMRiP12851.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12851.

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Phylogenomic databases

KOiK01805.
OMAiWSGKLFH.
OrthoDBiPOG091H07LC.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12851-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVQATREDK FSFGLWTVGW QARDAFGDAT RTALDPVEAV HKLAEIGAYG
60 70 80 90 100
ITFHDDDLVP FGSDAQTRDG IIAGFKKALD ETGLIVPMVT TNLFTHPVFK
110 120 130 140 150
DGGFTSNDRS VRRYAIRKVL RQMDLGAELG AKTLVLWGGR EGAEYDSAKD
160 170 180 190 200
VSAALDRYRE ALNLLAQYSE DRGYGLRFAI EPKPNEPRGD ILLPTAGHAI
210 220 230 240 250
AFVQELERPE LFGINPETGH EQMSNLNFTQ GIAQALWHKK LFHIDLNGQH
260 270 280 290 300
GPKFDQDLVF GHGDLLNAFS LVDLLENGPD GAPAYDGPRH FDYKPSRTED
310 320 330 340 350
YDGVWESAKA NIRMYLLLKE RAKAFRADPE VQEALAASKV AELKTPTLNP
360 370 380 390
GEGYAELLAD RSAFEDYDAD AVGAKGFGFV KLNQLAIEHL LGAR
Length:394
Mass (Da):43,499
Last modified:January 23, 2007 - v3
Checksum:i764B1FC35AE7A780
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16042 Genomic DNA. Translation: CAA34164.1.
AP012319 Genomic DNA. Translation: BAL86255.1.
PIRiS05998. ISMAXM.
RefSeqiWP_014441152.1. NC_017093.1.

Genome annotation databases

EnsemblBacteriaiBAL86255; BAL86255; AMIS_10350.
KEGGiams:AMIS_10350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16042 Genomic DNA. Translation: CAA34164.1.
AP012319 Genomic DNA. Translation: BAL86255.1.
PIRiS05998. ISMAXM.
RefSeqiWP_014441152.1. NC_017093.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BHWX-ray4.10A/B/C/D2-394[»]
1XIMX-ray2.20A/B/C/D2-394[»]
1XINX-ray2.40A/B/C/D2-394[»]
2XIMX-ray2.30A/B/C/D2-394[»]
2XINX-ray2.30A/B/C/D2-394[»]
3XIMX-ray2.30A/B/C/D2-394[»]
3XINX-ray2.30A/B/C/D2-394[»]
4XIMX-ray2.30A/B/C/D2-394[»]
5XIMX-ray2.60A/B/C/D2-394[»]
5XINX-ray2.30A/B/C/D2-394[»]
6XIMX-ray2.50A/B/C/D2-394[»]
7XIMX-ray2.40A/B/C/D2-394[»]
8XIMX-ray2.40A/B/C/D2-394[»]
9XIMX-ray2.40A/B/C/D2-394[»]
ProteinModelPortaliP12851.
SMRiP12851.
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

DrugBankiDB01638. D-Sorbitol.

Proteomic databases

PRIDEiP12851.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAL86255; BAL86255; AMIS_10350.
KEGGiams:AMIS_10350.

Phylogenomic databases

KOiK01805.
OMAiWSGKLFH.
OrthoDBiPOG091H07LC.

Enzyme and pathway databases

BRENDAi5.3.1.5. 141.
SABIO-RKP12851.

Miscellaneous databases

EvolutionaryTraceiP12851.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXYLA_ACTM4
AccessioniPrimary (citable) accession number: P12851
Secondary accession number(s): I0GZR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.