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Protein

Growth-regulated alpha protein

Gene

Cxcl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation (By similarity). Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Keywords - Biological processi

Inflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth-regulated alpha protein
Alternative name(s):
C-X-C motif chemokine 1
Platelet-derived growth factor-inducible protein KC
Secretory protein N51
Cleaved into the following chain:
Alternative name(s):
Hematopoietic synergistic factor
Short name:
HSF
KC-T
Gene namesi
Name:Cxcl1
Synonyms:Gro, Gro1, Mgsa, Scyb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:108068. Cxcl1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424CuratedAdd
BLAST
Chaini25 – 9672Growth-regulated alpha proteinPRO_0000005053Add
BLAST
Chaini29 – 9668KC(5-72)PRO_0000005054Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 59By similarity
Disulfide bondi35 ↔ 75By similarity

Post-translational modificationi

The N-terminal processed form KC(5-72) is produced by proteolytic cleavage after secretion from bone marrow stromal cells.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP12850.
PRIDEiP12850.

Miscellaneous databases

PMAP-CutDBP12850.

Expressioni

Inductioni

By platelet-derived growth factor. In lung, by lipopolysaccharide or inflammation (By similarity).By similarity

Gene expression databases

BgeeiP12850.
CleanExiMM_CXCL1.
ExpressionAtlasiP12850. baseline and differential.
GenevisibleiP12850. MM.

Interactioni

Protein-protein interaction databases

IntActiP12850. 1 interaction.
MINTiMINT-6629043.
STRINGi10090.ENSMUSP00000031327.

Structurei

3D structure databases

ProteinModelPortaliP12850.
SMRiP12850. Positions 30-92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3WE. Eukaryota.
ENOG410ZT1C. LUCA.
GeneTreeiENSGT00530000062901.
HOVERGENiHBG107789.
InParanoidiP12850.
KOiK05505.
OMAiNGREACL.
OrthoDBiEOG7NSB57.
PhylomeDBiP12850.
TreeFamiTF333433.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPATRSLLC AALLLLATSR LATGAPIANE LRCQCLQTMA GIHLKNIQSL
60 70 80 90
KVLPSGPHCT QTEVIATLKN GREACLDPEA PLVQKIVQKM LKGVPK
Length:96
Mass (Da):10,254
Last modified:October 1, 1989 - v1
Checksum:i4A52B5E5C38B45C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04596 mRNA. Translation: AAA40131.1.
U20634, U20527 Genomic DNA. Translation: AAB03376.1.
S79767 Genomic DNA. No translation available.
CCDSiCCDS39143.1.
PIRiA32954.
RefSeqiNP_032202.1. NM_008176.3.
UniGeneiMm.21013.

Genome annotation databases

EnsembliENSMUST00000031327; ENSMUSP00000031327; ENSMUSG00000029380.
GeneIDi14825.
KEGGimmu:14825.
UCSCiuc008ybl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04596 mRNA. Translation: AAA40131.1.
U20634, U20527 Genomic DNA. Translation: AAB03376.1.
S79767 Genomic DNA. No translation available.
CCDSiCCDS39143.1.
PIRiA32954.
RefSeqiNP_032202.1. NM_008176.3.
UniGeneiMm.21013.

3D structure databases

ProteinModelPortaliP12850.
SMRiP12850. Positions 30-92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP12850. 1 interaction.
MINTiMINT-6629043.
STRINGi10090.ENSMUSP00000031327.

Proteomic databases

PaxDbiP12850.
PRIDEiP12850.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031327; ENSMUSP00000031327; ENSMUSG00000029380.
GeneIDi14825.
KEGGimmu:14825.
UCSCiuc008ybl.2. mouse.

Organism-specific databases

CTDi2919.
MGIiMGI:108068. Cxcl1.

Phylogenomic databases

eggNOGiENOG410J3WE. Eukaryota.
ENOG410ZT1C. LUCA.
GeneTreeiENSGT00530000062901.
HOVERGENiHBG107789.
InParanoidiP12850.
KOiK05505.
OMAiNGREACL.
OrthoDBiEOG7NSB57.
PhylomeDBiP12850.
TreeFamiTF333433.

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

NextBioi287031.
PMAP-CutDBP12850.
PROiP12850.
SOURCEiSearch...

Gene expression databases

BgeeiP12850.
CleanExiMM_CXCL1.
ExpressionAtlasiP12850. baseline and differential.
GenevisibleiP12850. MM.

Family and domain databases

InterProiIPR001089. Chemokine_CXC.
IPR018048. Chemokine_CXC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PANTHERiPTHR10179. PTHR10179. 1 hit.
PfamiPF00048. IL8. 1 hit.
[Graphical view]
PRINTSiPR00437. SMALLCYTKCXC.
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00471. SMALL_CYTOKINES_CXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet alpha-granule proteins."
    Oquendo P., Alberta J., Wen D., Graycar J.L., Derynck R., Stiles C.D.
    J. Biol. Chem. 264:4133-4137(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and sequence of a secretory protein induced by growth factors in mouse fibroblasts."
    Ryseck R.P., Macdonald-Bravo H., Mattei M.-G., Bravo R.
    Exp. Cell Res. 180:266-275(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  4. "Two structurally distinct kappa B sequence motifs cooperatively control LPS-induced KC gene transcription in mouse macrophages."
    Ohmori Y., Fukumoto S., Hamilton T.A.
    J. Immunol. 155:3593-3600(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-10.
    Tissue: Liver.
  5. "Identification of unique truncated KC/GRO beta chemokines with potent hematopoietic and anti-infective activities."
    King A.G., Johanson K., Frey C.L., DeMarsh P.L., White J.R., McDevitt P., McNulty D., Balcarek J., Jonak Z.L., Bhatnagar P.K., Pelus L.M.
    J. Immunol. 164:3774-3782(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-46, IDENTIFICATION OF KC(5-72) BY MASS SPECTROMETRY, PROTEOLYTIC PROCESSING OF N-TERMINUS, FUNCTION.

Entry informationi

Entry nameiGROA_MOUSE
AccessioniPrimary (citable) accession number: P12850
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 11, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.