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Protein

Insulin-like growth factor-binding protein 2

Gene

Igfbp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.By similarity

GO - Molecular functioni

  • insulin-like growth factor I binding Source: UniProtKB
  • insulin-like growth factor II binding Source: RGD

GO - Biological processi

  • aging Source: RGD
  • cellular response to hormone stimulus Source: RGD
  • female pregnancy Source: RGD
  • multicellular organism development Source: UniProtKB-KW
  • positive regulation of activated T cell proliferation Source: UniProtKB
  • regulation of cell growth Source: InterPro
  • regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
  • response to drug Source: RGD
  • response to estradiol Source: RGD
  • response to estrogen Source: RGD
  • response to glucocorticoid Source: RGD
  • response to lithium ion Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to nutrient Source: RGD
  • response to retinoic acid Source: RGD
  • response to steroid hormone Source: RGD
  • signal transduction Source: RGD

Keywordsi

Molecular functionDevelopmental protein, Growth factor binding
Biological processGrowth regulation

Enzyme and pathway databases

ReactomeiR-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Protein family/group databases

MEROPSiI31.953

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 2
Short name:
IBP-2
Short name:
IGF-binding protein 2
Short name:
IGFBP-2
Alternative name(s):
BRL-BP
Gene namesi
Name:Igfbp2
Synonyms:Igfbp-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi2873 Igfbp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 341 PublicationAdd BLAST34
ChainiPRO_000001437335 – 304Insulin-like growth factor-binding protein 2Add BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi206 ↔ 240PROSITE-ProRule annotation
Disulfide bondi251 ↔ 262PROSITE-ProRule annotation
Disulfide bondi264 ↔ 285PROSITE-ProRule annotation

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP12843
PRIDEiP12843

PTM databases

iPTMnetiP12843
PhosphoSitePlusiP12843

Expressioni

Tissue specificityi

In adults, expressed in brain, testes, ovaries, and kidney. Expression in the adult liver is barely detectable.1 Publication

Developmental stagei

Predominantly expressed at fetal stages with highest expression in fetal liver. Also expressed in fetal kidney, intestine and lung, as well as muscle, heart and stomach.2 Publications

Gene expression databases

BgeeiENSRNOG00000016957
GenevisibleiP12843 RN

Interactioni

Subunit structurei

Binds IGF2 more than IGF1.

GO - Molecular functioni

  • insulin-like growth factor I binding Source: UniProtKB
  • insulin-like growth factor II binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023068

Structurei

3D structure databases

ProteinModelPortaliP12843
SMRiP12843
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 118IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST83
Domaini203 – 285Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi280 – 282Cell attachment site3

Domaini

The C-terminus is required for IGF-binding and growth inhibition.1 Publication

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHUR Eukaryota
ENOG4111GWQ LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP12843
OMAiDGTMNML
OrthoDBiEOG091G0EIN
PhylomeDBiP12843
TreeFamiTF331211

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR012210 IGFBP-2
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01978 IGFBPFAMILY2
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPRLGGPAL PLLLPSLLLL LLLGAGGCGP GVRAEVLFRC PPCTPERLAA
60 70 80 90 100
CGPPPDAPCA ELVREPGCGC CSVCARQEGE ACGVYIPRCA QTLRCYPNPG
110 120 130 140 150
SELPLKALVT GAGTCEKRRV GATPQQVADS EDDHSEGGLV ENHVDGTMNM
160 170 180 190 200
LGGSSAGRKP PKSGMKELAV FREKVNEQHR QMGKGAKHLS LEEPKKLRPP
210 220 230 240 250
PARTPCQQEL DQVLERISTM RLPDDRGPLE HLYSLHIPNC DKHGLYNLKQ
260 270 280 290 300
CKMSLNGQRG ECWCVNPNTG KPIQGAPTIR GDPECHLFYN EQQENDGAHA

QRVQ
Length:304
Mass (Da):32,855
Last modified:May 1, 2007 - v3
Checksum:i8558B7E2C9152B9F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti298A → V in AAA40829 (PubMed:2538475).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04486 mRNA Translation: AAA40829.1
M31672 mRNA Translation: AAA41381.1
BC092570 mRNA Translation: AAH92570.1
PIRiA33274
RefSeqiNP_037254.2, NM_013122.2
UniGeneiRn.6813

Genome annotation databases

EnsembliENSRNOT00000023068; ENSRNOP00000023068; ENSRNOG00000016957
GeneIDi25662
KEGGirno:25662

Similar proteinsi

Entry informationi

Entry nameiIBP2_RAT
AccessioniPrimary (citable) accession number: P12843
Secondary accession number(s): Q569C7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: May 1, 2007
Last modified: May 23, 2018
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health