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P12843

- IBP2_RAT

UniProt

P12843 - IBP2_RAT

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Protein

Insulin-like growth factor-binding protein 2

Gene
Igfbp2, Igfbp-2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibits IGF-mediated growth and developmental rates By similarity. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

  1. insulin-like growth factor I binding Source: UniProtKB
  2. insulin-like growth factor II binding Source: UniProtKB

GO - Biological processi

  1. aging Source: RGD
  2. cellular response to hormone stimulus Source: RGD
  3. female pregnancy Source: RGD
  4. multicellular organismal development Source: UniProtKB-KW
  5. positive regulation of activated T cell proliferation Source: UniProtKB
  6. regulation of cell growth Source: InterPro
  7. regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
  8. response to drug Source: RGD
  9. response to estradiol Source: RGD
  10. response to estrogen Source: RGD
  11. response to glucocorticoid Source: RGD
  12. response to lithium ion Source: RGD
  13. response to mechanical stimulus Source: RGD
  14. response to nutrient Source: RGD
  15. response to retinoic acid Source: RGD
  16. response to steroid hormone Source: RGD
  17. signal transduction Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Growth regulation

Keywords - Ligandi

Growth factor binding

Protein family/group databases

MEROPSiI31.953.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 2
Short name:
IBP-2
Short name:
IGF-binding protein 2
Short name:
IGFBP-2
Alternative name(s):
BRL-BP
Gene namesi
Name:Igfbp2
Synonyms:Igfbp-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 9

Organism-specific databases

RGDi2873. Igfbp2.

Subcellular locationi

Secreted 3 Publications

GO - Cellular componenti

  1. apical plasma membrane Source: RGD
  2. cytoplasmic vesicle Source: RGD
  3. extracellular region Source: UniProtKB
  4. extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 34341 PublicationAdd
BLAST
Chaini35 – 304270Insulin-like growth factor-binding protein 2PRO_0000014373Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi206 ↔ 240 By similarity
Disulfide bondi251 ↔ 262 By similarity
Disulfide bondi264 ↔ 285 By similarity

Post-translational modificationi

O-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP12843.

PTM databases

PhosphoSiteiP12843.

Expressioni

Tissue specificityi

In adults, expressed in brain, testes, ovaries, and kidney. Expression in the adult liver is barely detectable.1 Publication

Developmental stagei

Predominantly expressed at fetal stages with highest expression in fetal liver. Also expressed in fetal kidney, intestine and lung, as well as muscle, heart and stomach.2 Publications

Gene expression databases

ArrayExpressiP12843.
GenevestigatoriP12843.

Interactioni

Subunit structurei

Binds IGF2 more than IGF1.

Structurei

3D structure databases

ProteinModelPortaliP12843.
SMRiP12843. Positions 199-304.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 11883IGFBP N-terminalAdd
BLAST
Domaini203 – 28583Thyroglobulin type-1Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi280 – 2823Cell attachment site

Domaini

The C-terminus is required for IGF-binding and growth inhibition.1 Publication

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47500.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP12843.
OMAiGAGTCEK.
OrthoDBiEOG74N5HG.
PhylomeDBiP12843.
TreeFamiTF331211.

Family and domain databases

Gene3Di4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_N_dom.
IPR012210. IGFBP-2.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PTHR11551:SF5. PTHR11551:SF5. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01978. IGFBPFAMILY2.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12843-1 [UniParc]FASTAAdd to Basket

« Hide

MLPRLGGPAL PLLLPSLLLL LLLGAGGCGP GVRAEVLFRC PPCTPERLAA    50
CGPPPDAPCA ELVREPGCGC CSVCARQEGE ACGVYIPRCA QTLRCYPNPG 100
SELPLKALVT GAGTCEKRRV GATPQQVADS EDDHSEGGLV ENHVDGTMNM 150
LGGSSAGRKP PKSGMKELAV FREKVNEQHR QMGKGAKHLS LEEPKKLRPP 200
PARTPCQQEL DQVLERISTM RLPDDRGPLE HLYSLHIPNC DKHGLYNLKQ 250
CKMSLNGQRG ECWCVNPNTG KPIQGAPTIR GDPECHLFYN EQQENDGAHA 300
QRVQ 304
Length:304
Mass (Da):32,855
Last modified:May 1, 2007 - v3
Checksum:i8558B7E2C9152B9F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti298 – 2981A → V in AAA40829. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04486 mRNA. Translation: AAA40829.1.
M31672 mRNA. Translation: AAA41381.1.
BC092570 mRNA. Translation: AAH92570.1.
PIRiA33274.
RefSeqiNP_037254.2. NM_013122.2.
UniGeneiRn.6813.

Genome annotation databases

EnsembliENSRNOT00000023068; ENSRNOP00000023068; ENSRNOG00000016957.
GeneIDi25662.
KEGGirno:25662.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J04486 mRNA. Translation: AAA40829.1 .
M31672 mRNA. Translation: AAA41381.1 .
BC092570 mRNA. Translation: AAH92570.1 .
PIRi A33274.
RefSeqi NP_037254.2. NM_013122.2.
UniGenei Rn.6813.

3D structure databases

ProteinModelPortali P12843.
SMRi P12843. Positions 199-304.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I31.953.

PTM databases

PhosphoSitei P12843.

Proteomic databases

PRIDEi P12843.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000023068 ; ENSRNOP00000023068 ; ENSRNOG00000016957 .
GeneIDi 25662.
KEGGi rno:25662.

Organism-specific databases

CTDi 3485.
RGDi 2873. Igfbp2.

Phylogenomic databases

eggNOGi NOG47500.
GeneTreei ENSGT00550000074457.
HOGENOMi HOG000253012.
HOVERGENi HBG002631.
InParanoidi P12843.
OMAi GAGTCEK.
OrthoDBi EOG74N5HG.
PhylomeDBi P12843.
TreeFami TF331211.

Miscellaneous databases

NextBioi 607569.
PROi P12843.

Gene expression databases

ArrayExpressi P12843.
Genevestigatori P12843.

Family and domain databases

Gene3Di 4.10.40.20. 1 hit.
4.10.800.10. 1 hit.
InterProi IPR009030. Growth_fac_rcpt_N_dom.
IPR012210. IGFBP-2.
IPR000867. IGFBP-like.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view ]
PANTHERi PTHR11551. PTHR11551. 1 hit.
PTHR11551:SF5. PTHR11551:SF5. 1 hit.
Pfami PF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view ]
PRINTSi PR01976. IGFBPFAMILY.
PR01978. IGFBPFAMILY2.
SMARTi SM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEi PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence and expression of a cDNA clone encoding a fetal rat binding protein for insulin-like growth factors."
    Brown A.L., Chiariotti L., Orlowski C.C., Mehlman T., Burgers W.H., Ackerman E.J., Bruni C.B., Rechler M.M.
    J. Biol. Chem. 264:5148-5154(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, INTERACTION WITH IGF1 AND IGF2, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  2. "A low molecular weight insulin-like growth factor binding protein from rat: cDNA cloning and tissue distribution of its messenger RNA."
    Margot J.B., Binkert C., Mary J.-L., Landwehr J., Heinrich G., Schwander J.
    Mol. Endocrinol. 3:1053-1060(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  4. "Identification of a novel binding protein for insulin-like growth factors in adult rat serum."
    Shimonaka M., Schroeder R., Shimasaki S., Ling N.
    Biochem. Biophys. Res. Commun. 165:189-195(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 35-64, SUBCELLULAR LOCATION.
    Tissue: Serum.
  5. "Purification and amino-terminal sequence of an insulin-like growth factor-binding protein secreted by rat liver BRL-3A cells."
    Mottola C., Macdonald R.G., Brackett J.L., Mole J.E., Anderson J.K., Czech M.P.
    J. Biol. Chem. 261:11180-11188(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 38-68, SUBCELLULAR LOCATION.
  6. "Isolation of a biologically active fragment from the carboxy terminus of the fetal rat binding protein for insulin-like growth factors."
    Wang J.F., Hampton B., Mehlman T., Burgess W.H., Rechler M.M.
    Biochem. Biophys. Res. Commun. 157:718-726(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 178-204, INTERACTION WITH IGF2, DOMAIN.

Entry informationi

Entry nameiIBP2_RAT
AccessioniPrimary (citable) accession number: P12843
Secondary accession number(s): Q569C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: May 1, 2007
Last modified: July 9, 2014
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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