Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P12829 (MYL4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myosin light chain 4
Alternative name(s):
Myosin light chain 1, embryonic muscle/atrial isoform
Myosin light chain alkali GT-1 isoform
Gene names
Name:MYL4
Synonyms:MLC1
ORF Names:PRO1957
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length197 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulatory light chain of myosin. Does not bind calcium.

Subunit structure

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Sequence similarities

Contains 3 EF-hand domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 197197Myosin light chain 4
PRO_0000198699

Regions

Domain51 – 8838EF-hand 1
Domain130 – 16536EF-hand 2
Domain165 – 19733EF-hand 3

Natural variations

Natural variant1861N → Y.
Corresponds to variant rs16941677 [ dbSNP | Ensembl ].
VAR_050458

Experimental info

Sequence conflict511D → E in AAA59891. Ref.2
Sequence conflict561F → L in AAA59891. Ref.2
Sequence conflict1191I → V in AAA59856. Ref.9
Sequence conflict1431D → E in AAA59891. Ref.2
Sequence conflict1501V → D in AAA59891. Ref.2
Sequence conflict1811A → V in AAA59856. Ref.9
Sequence conflict1851I → V in AAA59856. Ref.9

Sequences

Sequence LengthMass (Da)Tools
P12829 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: FB147B49E8506E6C

FASTA19721,565
        10         20         30         40         50         60 
MAPKKPEPKK EAAKPAPAPA PAPAPAPAPA PEAPKEPAFD PKSVKIDFTA DQIEEFKEAF 

        70         80         90        100        110        120 
SLFDRTPTGE MKITYGQCGD VLRALGQNPT NAEVLRVLGK PKPEEMNVKM LDFETFLPIL 

       130        140        150        160        170        180 
QHISRNKEQG TYEDFVEGLR VFDKESNGTV MGAELRHVLA TLGEKMTEAE VEQLLAGQED 

       190 
ANGCINYEAF VKHIMSG 

« Hide

References

« Hide 'large scale' references
[1]"A novel human myosin alkali light chain is developmentally regulated. Expression in fetal cardiac and skeletal muscle and in adult atria."
Arnold H.H., Lohse P., Seidel U., Bober E.
Eur. J. Biochem. 178:53-60(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.
[2]"Molecular cloning and characterization of human atrial and ventricular myosin alkali light chain cDNA clones."
Kurabayashi M., Komuro I., Tsuchimochi H., Takaku F., Yazaki Y.
J. Biol. Chem. 263:13930-13936(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Human embryonic/atrial myosin alkali light chain gene: characterization, sequence, and chromosomal location."
Seharaseyon J., Bober E., Hsieh C.L., Fodor W.L., Francke U., Arnold H.H., Vanin E.F.
Genomics 7:289-293(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Heterogenic mRNAs with an identical protein-coding region of the human embryonic myosin alkali light chain in skeletal muscle cells."
Zimmermann K., Kautz S., Hajdu G., Winter C., Whalen R.G., Starzinski-Powitz A.
J. Mol. Biol. 211:505-513(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"The human embryonic myosin alkali light chain gene: use of alternative promoters and 3' non-coding regions."
Rotter M., Zimmerman K., Poustka A., Starzinski-Powitz A.
Nucleic Acids Res. 19:1497-1504(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Blood.
[6]"Functional prediction of the coding sequences of 121 new genes deduced by analysis of cDNA clones from human fetal liver."
Zhang C., Yu Y., Zhang S., Wei H., Zhou G., Ouyang S., Luo L., Bi J., Liu M., He F.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Fetal liver.
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas and Spleen.
[9]"Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms."
Seidel U., Bober E., Winter B., Lenz S., Lohse P., Goedde H., Grzeschik K., Arnold H.H.
Gene 66:135-146(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 104-197.
[10]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M36172 mRNA. Translation: AAA36319.1.
X13955 mRNA. Translation: CAA32137.1.
M24121 mRNA. Translation: AAA59891.1.
M37074 expand/collapse EMBL AC list , M37069, M37070, M37071, M37072, M37073 Genomic DNA. Translation: AAA59858.1.
X58851 expand/collapse EMBL AC list , X58852, X58853, X58854 Genomic DNA. Translation: CAA41655.1.
AF116676 mRNA. Translation: AAF71096.1.
CH471231 Genomic DNA. Translation: EAW57684.1.
CH471231 Genomic DNA. Translation: EAW57685.1.
BC030228 mRNA. Translation: AAH30228.1.
M20641 mRNA. Translation: AAA59856.1.
CCDSCCDS11510.1.
PIRMOHU4E. A32730.
RefSeqNP_001002841.1. NM_001002841.1.
NP_002467.1. NM_002476.2.
XP_005257448.1. XM_005257391.2.
XP_005257449.1. XM_005257392.1.
UniGeneHs.463300.

3D structure databases

ProteinModelPortalP12829.
SMRP12829. Positions 51-196.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110719. 6 interactions.
IntActP12829. 4 interactions.
STRING9606.ENSP00000347055.

PTM databases

PhosphoSiteP12829.

Polymorphism databases

DMDM127138.

2D gel databases

UCD-2DPAGEP12829.

Proteomic databases

MaxQBP12829.
PaxDbP12829.
PeptideAtlasP12829.
PRIDEP12829.

Protocols and materials databases

DNASU4635.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000354968; ENSP00000347055; ENSG00000198336.
ENST00000393450; ENSP00000377096; ENSG00000198336.
ENST00000536623; ENSP00000442375; ENSG00000198336.
ENST00000572316; ENSP00000461570; ENSG00000198336.
GeneID4635.
KEGGhsa:4635.
UCSCuc002ilg.3. human.

Organism-specific databases

CTD4635.
GeneCardsGC17P045286.
HGNCHGNC:7585. MYL4.
HPAHPA051884.
MIM160770. gene.
neXtProtNX_P12829.
PharmGKBPA31382.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5126.
HOGENOMHOG000233018.
HOVERGENHBG012180.
InParanoidP12829.
KOK12750.
OMARNKDQGT.
PhylomeDBP12829.
TreeFamTF351553.

Enzyme and pathway databases

ReactomeREACT_17044. Muscle contraction.

Gene expression databases

ArrayExpressP12829.
BgeeP12829.
CleanExHS_MLC1.
HS_MYL4.
GenevestigatorP12829.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamPF13405. EF-hand_6. 1 hit.
[Graphical view]
PROSITEPS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMYL4.
GenomeRNAi4635.
NextBio17844.
PROP12829.
SOURCESearch...

Entry information

Entry nameMYL4_HUMAN
AccessionPrimary (citable) accession number: P12829
Secondary accession number(s): D3DXJ7, P11783
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM