SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P12829

- MYL4_HUMAN

UniProt

P12829 - MYL4_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Myosin light chain 4
Gene
MYL4, MLC1, PRO1957
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regulatory light chain of myosin. Does not bind calcium.

GO - Molecular functioni

  1. actin filament binding Source: BHF-UCL
  2. actin monomer binding Source: BHF-UCL
  3. calcium ion binding Source: InterPro
  4. myosin II heavy chain binding Source: BHF-UCL

GO - Biological processi

  1. cardiac muscle contraction Source: BHF-UCL
  2. muscle filament sliding Source: Reactome
  3. positive regulation of ATPase activity Source: BHF-UCL
  4. regulation of the force of heart contraction Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Enzyme and pathway databases

ReactomeiREACT_16969. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain 4
Alternative name(s):
Myosin light chain 1, embryonic muscle/atrial isoform
Myosin light chain alkali GT-1 isoform
Gene namesi
Name:MYL4
Synonyms:MLC1
ORF Names:PRO1957
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:7585. MYL4.

Subcellular locationi

GO - Cellular componenti

  1. A band Source: BHF-UCL
  2. cytosol Source: Reactome
  3. myosin complex Source: UniProtKB-KW
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31382.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197Myosin light chain 4
PRO_0000198699Add
BLAST

Proteomic databases

MaxQBiP12829.
PaxDbiP12829.
PeptideAtlasiP12829.
PRIDEiP12829.

2D gel databases

UCD-2DPAGEP12829.

PTM databases

PhosphoSiteiP12829.

Expressioni

Gene expression databases

ArrayExpressiP12829.
BgeeiP12829.
CleanExiHS_MLC1.
HS_MYL4.
GenevestigatoriP12829.

Organism-specific databases

HPAiHPA051884.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Protein-protein interaction databases

BioGridi110719. 6 interactions.
IntActiP12829. 4 interactions.
STRINGi9606.ENSP00000347055.

Structurei

3D structure databases

ProteinModelPortaliP12829.
SMRiP12829. Positions 51-196.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 8838EF-hand 1
Add
BLAST
Domaini130 – 16536EF-hand 2
Add
BLAST
Domaini165 – 19733EF-hand 3
Add
BLAST

Sequence similaritiesi

Contains 3 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP12829.
KOiK12750.
OMAiRNKDQGT.
PhylomeDBiP12829.
TreeFamiTF351553.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12829-1 [UniParc]FASTAAdd to Basket

« Hide

MAPKKPEPKK EAAKPAPAPA PAPAPAPAPA PEAPKEPAFD PKSVKIDFTA    50
DQIEEFKEAF SLFDRTPTGE MKITYGQCGD VLRALGQNPT NAEVLRVLGK 100
PKPEEMNVKM LDFETFLPIL QHISRNKEQG TYEDFVEGLR VFDKESNGTV 150
MGAELRHVLA TLGEKMTEAE VEQLLAGQED ANGCINYEAF VKHIMSG 197
Length:197
Mass (Da):21,565
Last modified:January 23, 2007 - v3
Checksum:iFB147B49E8506E6C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti186 – 1861N → Y.
Corresponds to variant rs16941677 [ dbSNP | Ensembl ].
VAR_050458

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511D → E in AAA59891. 1 Publication
Sequence conflicti56 – 561F → L in AAA59891. 1 Publication
Sequence conflicti119 – 1191I → V in AAA59856. 1 Publication
Sequence conflicti143 – 1431D → E in AAA59891. 1 Publication
Sequence conflicti150 – 1501V → D in AAA59891. 1 Publication
Sequence conflicti181 – 1811A → V in AAA59856. 1 Publication
Sequence conflicti185 – 1851I → V in AAA59856. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M36172 mRNA. Translation: AAA36319.1.
X13955 mRNA. Translation: CAA32137.1.
M24121 mRNA. Translation: AAA59891.1.
M37074
, M37069, M37070, M37071, M37072, M37073 Genomic DNA. Translation: AAA59858.1.
X58851
, X58852, X58853, X58854 Genomic DNA. Translation: CAA41655.1.
AF116676 mRNA. Translation: AAF71096.1.
CH471231 Genomic DNA. Translation: EAW57684.1.
CH471231 Genomic DNA. Translation: EAW57685.1.
BC030228 mRNA. Translation: AAH30228.1.
M20641 mRNA. Translation: AAA59856.1.
CCDSiCCDS11510.1.
PIRiA32730. MOHU4E.
RefSeqiNP_001002841.1. NM_001002841.1.
NP_002467.1. NM_002476.2.
XP_005257448.1. XM_005257391.2.
XP_005257449.1. XM_005257392.1.
UniGeneiHs.463300.

Genome annotation databases

EnsembliENST00000354968; ENSP00000347055; ENSG00000198336.
ENST00000393450; ENSP00000377096; ENSG00000198336.
ENST00000536623; ENSP00000442375; ENSG00000198336.
ENST00000572316; ENSP00000461570; ENSG00000198336.
GeneIDi4635.
KEGGihsa:4635.
UCSCiuc002ilg.3. human.

Polymorphism databases

DMDMi127138.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M36172 mRNA. Translation: AAA36319.1 .
X13955 mRNA. Translation: CAA32137.1 .
M24121 mRNA. Translation: AAA59891.1 .
M37074
, M37069 , M37070 , M37071 , M37072 , M37073 Genomic DNA. Translation: AAA59858.1 .
X58851
, X58852 , X58853 , X58854 Genomic DNA. Translation: CAA41655.1 .
AF116676 mRNA. Translation: AAF71096.1 .
CH471231 Genomic DNA. Translation: EAW57684.1 .
CH471231 Genomic DNA. Translation: EAW57685.1 .
BC030228 mRNA. Translation: AAH30228.1 .
M20641 mRNA. Translation: AAA59856.1 .
CCDSi CCDS11510.1.
PIRi A32730. MOHU4E.
RefSeqi NP_001002841.1. NM_001002841.1.
NP_002467.1. NM_002476.2.
XP_005257448.1. XM_005257391.2.
XP_005257449.1. XM_005257392.1.
UniGenei Hs.463300.

3D structure databases

ProteinModelPortali P12829.
SMRi P12829. Positions 51-196.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110719. 6 interactions.
IntActi P12829. 4 interactions.
STRINGi 9606.ENSP00000347055.

PTM databases

PhosphoSitei P12829.

Polymorphism databases

DMDMi 127138.

2D gel databases

UCD-2DPAGE P12829.

Proteomic databases

MaxQBi P12829.
PaxDbi P12829.
PeptideAtlasi P12829.
PRIDEi P12829.

Protocols and materials databases

DNASUi 4635.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354968 ; ENSP00000347055 ; ENSG00000198336 .
ENST00000393450 ; ENSP00000377096 ; ENSG00000198336 .
ENST00000536623 ; ENSP00000442375 ; ENSG00000198336 .
ENST00000572316 ; ENSP00000461570 ; ENSG00000198336 .
GeneIDi 4635.
KEGGi hsa:4635.
UCSCi uc002ilg.3. human.

Organism-specific databases

CTDi 4635.
GeneCardsi GC17P045286.
HGNCi HGNC:7585. MYL4.
HPAi HPA051884.
MIMi 160770. gene.
neXtProti NX_P12829.
PharmGKBi PA31382.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5126.
HOGENOMi HOG000233018.
HOVERGENi HBG012180.
InParanoidi P12829.
KOi K12750.
OMAi RNKDQGT.
PhylomeDBi P12829.
TreeFami TF351553.

Enzyme and pathway databases

Reactomei REACT_16969. Striated Muscle Contraction.

Miscellaneous databases

GeneWikii MYL4.
GenomeRNAii 4635.
NextBioi 17844.
PROi P12829.
SOURCEi Search...

Gene expression databases

ArrayExpressi P12829.
Bgeei P12829.
CleanExi HS_MLC1.
HS_MYL4.
Genevestigatori P12829.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF13405. EF-hand_6. 1 hit.
[Graphical view ]
PROSITEi PS50222. EF_HAND_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel human myosin alkali light chain is developmentally regulated. Expression in fetal cardiac and skeletal muscle and in adult atria."
    Arnold H.H., Lohse P., Seidel U., Bober E.
    Eur. J. Biochem. 178:53-60(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "Molecular cloning and characterization of human atrial and ventricular myosin alkali light chain cDNA clones."
    Kurabayashi M., Komuro I., Tsuchimochi H., Takaku F., Yazaki Y.
    J. Biol. Chem. 263:13930-13936(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Human embryonic/atrial myosin alkali light chain gene: characterization, sequence, and chromosomal location."
    Seharaseyon J., Bober E., Hsieh C.L., Fodor W.L., Francke U., Arnold H.H., Vanin E.F.
    Genomics 7:289-293(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Heterogenic mRNAs with an identical protein-coding region of the human embryonic myosin alkali light chain in skeletal muscle cells."
    Zimmermann K., Kautz S., Hajdu G., Winter C., Whalen R.G., Starzinski-Powitz A.
    J. Mol. Biol. 211:505-513(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "The human embryonic myosin alkali light chain gene: use of alternative promoters and 3' non-coding regions."
    Rotter M., Zimmerman K., Poustka A., Starzinski-Powitz A.
    Nucleic Acids Res. 19:1497-1504(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.
  6. "Functional prediction of the coding sequences of 121 new genes deduced by analysis of cDNA clones from human fetal liver."
    Zhang C., Yu Y., Zhang S., Wei H., Zhou G., Ouyang S., Luo L., Bi J., Liu M., He F.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal liver.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas and Spleen.
  9. "Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms."
    Seidel U., Bober E., Winter B., Lenz S., Lohse P., Goedde H., Grzeschik K., Arnold H.H.
    Gene 66:135-146(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 104-197.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMYL4_HUMAN
AccessioniPrimary (citable) accession number: P12829
Secondary accession number(s): D3DXJ7, P11783
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi