Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P12829

- MYL4_HUMAN

UniProt

P12829 - MYL4_HUMAN

Protein

Myosin light chain 4

Gene

MYL4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Regulatory light chain of myosin. Does not bind calcium.

    GO - Molecular functioni

    1. actin filament binding Source: BHF-UCL
    2. actin monomer binding Source: BHF-UCL
    3. calcium ion binding Source: InterPro
    4. myosin II heavy chain binding Source: BHF-UCL

    GO - Biological processi

    1. cardiac muscle contraction Source: BHF-UCL
    2. muscle filament sliding Source: Reactome
    3. positive regulation of ATPase activity Source: BHF-UCL
    4. regulation of the force of heart contraction Source: BHF-UCL

    Keywords - Molecular functioni

    Motor protein, Muscle protein, Myosin

    Enzyme and pathway databases

    ReactomeiREACT_16969. Striated Muscle Contraction.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myosin light chain 4
    Alternative name(s):
    Myosin light chain 1, embryonic muscle/atrial isoform
    Myosin light chain alkali GT-1 isoform
    Gene namesi
    Name:MYL4
    Synonyms:MLC1
    ORF Names:PRO1957
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:7585. MYL4.

    Subcellular locationi

    GO - Cellular componenti

    1. A band Source: BHF-UCL
    2. cytosol Source: Reactome
    3. myosin complex Source: UniProtKB-KW

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31382.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 197197Myosin light chain 4PRO_0000198699Add
    BLAST

    Proteomic databases

    MaxQBiP12829.
    PaxDbiP12829.
    PeptideAtlasiP12829.
    PRIDEiP12829.

    2D gel databases

    UCD-2DPAGEP12829.

    PTM databases

    PhosphoSiteiP12829.

    Expressioni

    Gene expression databases

    ArrayExpressiP12829.
    BgeeiP12829.
    CleanExiHS_MLC1.
    HS_MYL4.
    GenevestigatoriP12829.

    Organism-specific databases

    HPAiHPA051884.

    Interactioni

    Subunit structurei

    Myosin is a hexamer of 2 heavy chains and 4 light chains.

    Protein-protein interaction databases

    BioGridi110719. 6 interactions.
    IntActiP12829. 4 interactions.
    STRINGi9606.ENSP00000347055.

    Structurei

    3D structure databases

    ProteinModelPortaliP12829.
    SMRiP12829. Positions 51-196.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini51 – 8838EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini130 – 16536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini165 – 19733EF-hand 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    HOGENOMiHOG000233018.
    HOVERGENiHBG012180.
    InParanoidiP12829.
    KOiK12750.
    OMAiRNKDQGT.
    PhylomeDBiP12829.
    TreeFamiTF351553.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13405. EF-hand_6. 1 hit.
    [Graphical view]
    PROSITEiPS50222. EF_HAND_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P12829-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPKKPEPKK EAAKPAPAPA PAPAPAPAPA PEAPKEPAFD PKSVKIDFTA    50
    DQIEEFKEAF SLFDRTPTGE MKITYGQCGD VLRALGQNPT NAEVLRVLGK 100
    PKPEEMNVKM LDFETFLPIL QHISRNKEQG TYEDFVEGLR VFDKESNGTV 150
    MGAELRHVLA TLGEKMTEAE VEQLLAGQED ANGCINYEAF VKHIMSG 197
    Length:197
    Mass (Da):21,565
    Last modified:January 23, 2007 - v3
    Checksum:iFB147B49E8506E6C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti51 – 511D → E in AAA59891. (PubMed:3417683)Curated
    Sequence conflicti56 – 561F → L in AAA59891. (PubMed:3417683)Curated
    Sequence conflicti119 – 1191I → V in AAA59856. (PubMed:2458299)Curated
    Sequence conflicti143 – 1431D → E in AAA59891. (PubMed:3417683)Curated
    Sequence conflicti150 – 1501V → D in AAA59891. (PubMed:3417683)Curated
    Sequence conflicti181 – 1811A → V in AAA59856. (PubMed:2458299)Curated
    Sequence conflicti185 – 1851I → V in AAA59856. (PubMed:2458299)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti186 – 1861N → Y.
    Corresponds to variant rs16941677 [ dbSNP | Ensembl ].
    VAR_050458

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M36172 mRNA. Translation: AAA36319.1.
    X13955 mRNA. Translation: CAA32137.1.
    M24121 mRNA. Translation: AAA59891.1.
    M37074
    , M37069, M37070, M37071, M37072, M37073 Genomic DNA. Translation: AAA59858.1.
    X58851
    , X58852, X58853, X58854 Genomic DNA. Translation: CAA41655.1.
    AF116676 mRNA. Translation: AAF71096.1.
    CH471231 Genomic DNA. Translation: EAW57684.1.
    CH471231 Genomic DNA. Translation: EAW57685.1.
    BC030228 mRNA. Translation: AAH30228.1.
    M20641 mRNA. Translation: AAA59856.1.
    CCDSiCCDS11510.1.
    PIRiA32730. MOHU4E.
    RefSeqiNP_001002841.1. NM_001002841.1.
    NP_002467.1. NM_002476.2.
    XP_005257448.1. XM_005257391.2.
    XP_005257449.1. XM_005257392.1.
    UniGeneiHs.463300.

    Genome annotation databases

    EnsembliENST00000354968; ENSP00000347055; ENSG00000198336.
    ENST00000393450; ENSP00000377096; ENSG00000198336.
    ENST00000572316; ENSP00000461570; ENSG00000198336.
    GeneIDi4635.
    KEGGihsa:4635.
    UCSCiuc002ilg.3. human.

    Polymorphism databases

    DMDMi127138.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M36172 mRNA. Translation: AAA36319.1 .
    X13955 mRNA. Translation: CAA32137.1 .
    M24121 mRNA. Translation: AAA59891.1 .
    M37074
    , M37069 , M37070 , M37071 , M37072 , M37073 Genomic DNA. Translation: AAA59858.1 .
    X58851
    , X58852 , X58853 , X58854 Genomic DNA. Translation: CAA41655.1 .
    AF116676 mRNA. Translation: AAF71096.1 .
    CH471231 Genomic DNA. Translation: EAW57684.1 .
    CH471231 Genomic DNA. Translation: EAW57685.1 .
    BC030228 mRNA. Translation: AAH30228.1 .
    M20641 mRNA. Translation: AAA59856.1 .
    CCDSi CCDS11510.1.
    PIRi A32730. MOHU4E.
    RefSeqi NP_001002841.1. NM_001002841.1.
    NP_002467.1. NM_002476.2.
    XP_005257448.1. XM_005257391.2.
    XP_005257449.1. XM_005257392.1.
    UniGenei Hs.463300.

    3D structure databases

    ProteinModelPortali P12829.
    SMRi P12829. Positions 51-196.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110719. 6 interactions.
    IntActi P12829. 4 interactions.
    STRINGi 9606.ENSP00000347055.

    PTM databases

    PhosphoSitei P12829.

    Polymorphism databases

    DMDMi 127138.

    2D gel databases

    UCD-2DPAGE P12829.

    Proteomic databases

    MaxQBi P12829.
    PaxDbi P12829.
    PeptideAtlasi P12829.
    PRIDEi P12829.

    Protocols and materials databases

    DNASUi 4635.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354968 ; ENSP00000347055 ; ENSG00000198336 .
    ENST00000393450 ; ENSP00000377096 ; ENSG00000198336 .
    ENST00000572316 ; ENSP00000461570 ; ENSG00000198336 .
    GeneIDi 4635.
    KEGGi hsa:4635.
    UCSCi uc002ilg.3. human.

    Organism-specific databases

    CTDi 4635.
    GeneCardsi GC17P045286.
    HGNCi HGNC:7585. MYL4.
    HPAi HPA051884.
    MIMi 160770. gene.
    neXtProti NX_P12829.
    PharmGKBi PA31382.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5126.
    HOGENOMi HOG000233018.
    HOVERGENi HBG012180.
    InParanoidi P12829.
    KOi K12750.
    OMAi RNKDQGT.
    PhylomeDBi P12829.
    TreeFami TF351553.

    Enzyme and pathway databases

    Reactomei REACT_16969. Striated Muscle Contraction.

    Miscellaneous databases

    GeneWikii MYL4.
    GenomeRNAii 4635.
    NextBioi 17844.
    PROi P12829.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P12829.
    Bgeei P12829.
    CleanExi HS_MLC1.
    HS_MYL4.
    Genevestigatori P12829.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13405. EF-hand_6. 1 hit.
    [Graphical view ]
    PROSITEi PS50222. EF_HAND_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel human myosin alkali light chain is developmentally regulated. Expression in fetal cardiac and skeletal muscle and in adult atria."
      Arnold H.H., Lohse P., Seidel U., Bober E.
      Eur. J. Biochem. 178:53-60(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.
    2. "Molecular cloning and characterization of human atrial and ventricular myosin alkali light chain cDNA clones."
      Kurabayashi M., Komuro I., Tsuchimochi H., Takaku F., Yazaki Y.
      J. Biol. Chem. 263:13930-13936(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Human embryonic/atrial myosin alkali light chain gene: characterization, sequence, and chromosomal location."
      Seharaseyon J., Bober E., Hsieh C.L., Fodor W.L., Francke U., Arnold H.H., Vanin E.F.
      Genomics 7:289-293(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Heterogenic mRNAs with an identical protein-coding region of the human embryonic myosin alkali light chain in skeletal muscle cells."
      Zimmermann K., Kautz S., Hajdu G., Winter C., Whalen R.G., Starzinski-Powitz A.
      J. Mol. Biol. 211:505-513(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "The human embryonic myosin alkali light chain gene: use of alternative promoters and 3' non-coding regions."
      Rotter M., Zimmerman K., Poustka A., Starzinski-Powitz A.
      Nucleic Acids Res. 19:1497-1504(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Blood.
    6. "Functional prediction of the coding sequences of 121 new genes deduced by analysis of cDNA clones from human fetal liver."
      Zhang C., Yu Y., Zhang S., Wei H., Zhou G., Ouyang S., Luo L., Bi J., Liu M., He F.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal liver.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas and Spleen.
    9. "Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms."
      Seidel U., Bober E., Winter B., Lenz S., Lohse P., Goedde H., Grzeschik K., Arnold H.H.
      Gene 66:135-146(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 104-197.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMYL4_HUMAN
    AccessioniPrimary (citable) accession number: P12829
    Secondary accession number(s): D3DXJ7, P11783
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 138 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3