Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P12820 (ACE_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Angiotensin-converting enzyme

Short name=ACE
EC=3.2.1.-
EC=3.4.15.1
Alternative name(s):
Dipeptidyl carboxypeptidase I
Kininase II
CD_antigen=CD143
Gene names
Name:ACE
Synonyms:DCP1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length100 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety By similarity.

Catalytic activity

Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Binds 2 chloride ions per subunit By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the peptidase M2 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Ref.2 Ref.3
Chain29 – ›100›72Angiotensin-converting enzyme
PRO_0000078151

Regions

Topological domain29 – ›100›72Extracellular Potential
Region29 – ›100›72Peptidase M2 1

Experimental info

Non-terminal residue1001

Sequences

Sequence LengthMass (Da)Tools
P12820 [UniParc].

Last modified September 2, 2008. Version 2.
Checksum: F83F87B94EAFEC59

FASTA10010,681
        10         20         30         40         50         60 
MGAASGRRSP PLLLPLLLLL LPPPPVILEL DPALQPGNFP ADEAGAQIFA ASFNSSAEQV 

        70         80         90        100 
LFQSTAASWA HDTNITEENA RLQEEAALLS QEFSEAWGQK 

« Hide

References

[1]"Analysis of the angiotensin converting enzyme promoter from Bos taurus."
Mungunsukh O., Day R.M.
Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Bovine angiotensin-converting enzyme: amino-terminal sequence analysis and preliminary characterization of a hybridization-selected primary translation product."
St Clair D.K., Presper K.A., Smith P.L., Stump D.C., Heath E.C.
Biochem. Biophys. Res. Commun. 141:968-972(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 29-50.
Tissue: Lung.
[3]"Partial protein sequence of mouse and bovine kidney angiotensin converting enzyme."
Bernstein K.E., Martin B.M., Striker L., Striker G.
Kidney Int. 33:652-655(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 29-50.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ885942 Genomic DNA. Translation: ABI35897.2.
PIRA26376.
UniGeneBt.62430.

3D structure databases

ProteinModelPortalP12820.
SMRP12820. Positions 30-100.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP12820. 1 interaction.
STRING9913.ENSBTAP00000053314.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG71044.
HOGENOMHOG000007838.
HOVERGENHBG103392.

Family and domain databases

InterProIPR001548. Peptidase_M2.
[Graphical view]
PfamPF01401. Peptidase_M2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACE_BOVIN
AccessionPrimary (citable) accession number: P12820
Secondary accession number(s): Q0GA41
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: September 2, 2008
Last modified: February 19, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries