SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P12820

- ACE_BOVIN

UniProt

P12820 - ACE_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Angiotensin-converting enzyme

Gene
ACE, DCP1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety By similarity.

Catalytic activityi

Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.

Cofactori

Binds 2 zinc ions per subunit By similarity.
Binds 2 chloride ions per subunit By similarity.

GO - Molecular functioni

  1. carboxypeptidase activity Source: UniProtKB-KW
  2. metallopeptidase activity Source: UniProtKB-KW
  3. peptidyl-dipeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Angiotensin-converting enzyme (EC:3.2.1.-, EC:3.4.15.1)
Short name:
ACE
Alternative name(s):
Dipeptidyl carboxypeptidase I
Kininase II
CD_antigen: CD143
Gene namesi
Name:ACE
Synonyms:DCP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – ›100›72Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28282 PublicationsAdd
BLAST
Chaini29 – ›100›72Angiotensin-converting enzymePRO_0000078151Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiP12820. 1 interaction.
STRINGi9913.ENSBTAP00000053314.

Structurei

3D structure databases

ProteinModelPortaliP12820.
SMRiP12820. Positions 30-100.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni29 – ›100›72Peptidase M2 1Add
BLAST

Sequence similaritiesi

Belongs to the peptidase M2 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG71044.
HOGENOMiHOG000007838.
HOVERGENiHBG103392.

Family and domain databases

InterProiIPR001548. Peptidase_M2.
[Graphical view]
PANTHERiPTHR10514. PTHR10514. 1 hit.
PfamiPF01401. Peptidase_M2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12820-1 [UniParc]FASTAAdd to Basket

« Hide

MGAASGRRSP PLLLPLLLLL LPPPPVILEL DPALQPGNFP ADEAGAQIFA    50
ASFNSSAEQV LFQSTAASWA HDTNITEENA RLQEEAALLS QEFSEAWGQK 100
Length:100
Mass (Da):10,681
Last modified:September 2, 2008 - v2
Checksum:iF83F87B94EAFEC59
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei100 – 1001

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ885942 Genomic DNA. Translation: ABI35897.2.
PIRiA26376.
UniGeneiBt.62430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ885942 Genomic DNA. Translation: ABI35897.2 .
PIRi A26376.
UniGenei Bt.62430.

3D structure databases

ProteinModelPortali P12820.
SMRi P12820. Positions 30-100.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P12820. 1 interaction.
STRINGi 9913.ENSBTAP00000053314.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi NOG71044.
HOGENOMi HOG000007838.
HOVERGENi HBG103392.

Family and domain databases

InterProi IPR001548. Peptidase_M2.
[Graphical view ]
PANTHERi PTHR10514. PTHR10514. 1 hit.
Pfami PF01401. Peptidase_M2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the angiotensin converting enzyme promoter from Bos taurus."
    Mungunsukh O., Day R.M.
    Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Bovine angiotensin-converting enzyme: amino-terminal sequence analysis and preliminary characterization of a hybridization-selected primary translation product."
    St Clair D.K., Presper K.A., Smith P.L., Stump D.C., Heath E.C.
    Biochem. Biophys. Res. Commun. 141:968-972(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-50.
    Tissue: Lung.
  3. "Partial protein sequence of mouse and bovine kidney angiotensin converting enzyme."
    Bernstein K.E., Martin B.M., Striker L., Striker G.
    Kidney Int. 33:652-655(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-50.

Entry informationi

Entry nameiACE_BOVIN
AccessioniPrimary (citable) accession number: P12820
Secondary accession number(s): Q0GA41
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: September 2, 2008
Last modified: June 11, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi