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P12820

- ACE_BOVIN

UniProt

P12820 - ACE_BOVIN

Protein

Angiotensin-converting enzyme

Gene

ACE

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II.

    Cofactori

    Binds 2 zinc ions per subunit.By similarity
    Binds 2 chloride ions per subunit.By similarity

    GO - Molecular functioni

    1. carboxypeptidase activity Source: UniProtKB-KW
    2. metallopeptidase activity Source: UniProtKB-KW
    3. peptidyl-dipeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Angiotensin-converting enzyme (EC:3.2.1.-, EC:3.4.15.1)
    Short name:
    ACE
    Alternative name(s):
    Dipeptidyl carboxypeptidase I
    Kininase II
    CD_antigen: CD143
    Gene namesi
    Name:ACE
    Synonyms:DCP1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. membrane Source: InterPro

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 28282 PublicationsAdd
    BLAST
    Chaini29 – ›100›72Angiotensin-converting enzymePRO_0000078151Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiP12820. 1 interaction.
    STRINGi9913.ENSBTAP00000053314.

    Structurei

    3D structure databases

    ProteinModelPortaliP12820.
    SMRiP12820. Positions 30-100.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – ›100›72ExtracellularSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni29 – ›100›72Peptidase M2 1Add
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase M2 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG71044.
    HOGENOMiHOG000007838.
    HOVERGENiHBG103392.

    Family and domain databases

    InterProiIPR001548. Peptidase_M2.
    [Graphical view]
    PANTHERiPTHR10514. PTHR10514. 1 hit.
    PfamiPF01401. Peptidase_M2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12820-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAASGRRSP PLLLPLLLLL LPPPPVILEL DPALQPGNFP ADEAGAQIFA    50
    ASFNSSAEQV LFQSTAASWA HDTNITEENA RLQEEAALLS QEFSEAWGQK 100
    Length:100
    Mass (Da):10,681
    Last modified:September 2, 2008 - v2
    Checksum:iF83F87B94EAFEC59
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei100 – 1001

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ885942 Genomic DNA. Translation: ABI35897.2.
    PIRiA26376.
    UniGeneiBt.62430.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ885942 Genomic DNA. Translation: ABI35897.2 .
    PIRi A26376.
    UniGenei Bt.62430.

    3D structure databases

    ProteinModelPortali P12820.
    SMRi P12820. Positions 30-100.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P12820. 1 interaction.
    STRINGi 9913.ENSBTAP00000053314.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG71044.
    HOGENOMi HOG000007838.
    HOVERGENi HBG103392.

    Family and domain databases

    InterProi IPR001548. Peptidase_M2.
    [Graphical view ]
    PANTHERi PTHR10514. PTHR10514. 1 hit.
    Pfami PF01401. Peptidase_M2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the angiotensin converting enzyme promoter from Bos taurus."
      Mungunsukh O., Day R.M.
      Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Bovine angiotensin-converting enzyme: amino-terminal sequence analysis and preliminary characterization of a hybridization-selected primary translation product."
      St Clair D.K., Presper K.A., Smith P.L., Stump D.C., Heath E.C.
      Biochem. Biophys. Res. Commun. 141:968-972(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 29-50.
      Tissue: Lung.
    3. "Partial protein sequence of mouse and bovine kidney angiotensin converting enzyme."
      Bernstein K.E., Martin B.M., Striker L., Striker G.
      Kidney Int. 33:652-655(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 29-50.

    Entry informationi

    Entry nameiACE_BOVIN
    AccessioniPrimary (citable) accession number: P12820
    Secondary accession number(s): Q0GA41
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3