Nuclear receptor subfamily 4 group A member 1

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P12813 (NR4A1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 130. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Nuclear receptor subfamily 4 group A member 1

Alternative name(s):
Nuclear hormone receptor NUR/77
Nuclear protein N10
Orphan nuclear receptor HMR

Gene names

Name:	Nr4a1
Synonyms:	Gfrp, Hmr, N10, Nur77

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	601 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2 By similarity.
Subunit structure	Interacts with GADD45GIP1. Binds DNA as a monomer By similarity.
Subcellular location	Nucleus.
Tissue specificity	Highest levels occur in the testis followed by brain and muscle tissue.
Developmental stage	Highest levels are found in the adult with barely detectable levels in pre- and early postnatal tissue.
Induction	By serum growth factors and during liver regeneration.
Post-translational modification	Phosphorylated at Ser-354 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli By similarity.
Sequence similarities	Belongs to the nuclear hormone receptor family. NR4 subfamily. Contains 1 nuclear receptor DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Receptor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell migration involved in sprouting angiogenesis Inferred from electronic annotation. Source: Compara cellular response to fibroblast growth factor stimulus Inferred from electronic annotation. Source: Compara cellular response to organic substance Inferred from direct assay PubMed 21357543. Source: MGI cellular response to vascular endothelial growth factor stimulus Inferred from electronic annotation. Source: Compara endothelial cell chemotaxis Inferred from electronic annotation. Source: Compara induction of apoptosis Inferred from direct assay PubMed 14657025. Source: MGI intracellular receptor mediated signaling pathway Inferred from electronic annotation. Source: GOC negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from direct assay PubMed 12815108. Source: MGI positive regulation of endothelial cell proliferation Inferred from electronic annotation. Source: Compara response to inorganic substance Inferred from sequence alignment PubMed 1491694. Source: MGI skeletal muscle cell differentiation Inferred from mutant phenotype PubMed 22147266. Source: MGI
Cellular_component	transcription factor complex Inferred from direct assay PubMed 9155013. Source: MGI
Molecular_function	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Inferred from direct assay PubMed 9155013. Source: MGI ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from electronic annotation. Source: InterPro protein homodimerization activity Inferred from direct assay PubMed 18388149. Source: MGI sequence-specific DNA binding Inferred from direct assay PubMed 18388149 PubMed 8961274. Source: MGI steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 601

601

Nuclear receptor subfamily 4 group A member 1

PRO_0000053716

Regions

DNA binding

267 – 342

Nuclear receptor

Zinc finger

270 – 290

NR C4-type

Zinc finger

306 – 330

NR C4-type

Region

412 – 462

Ligand-binding Potential

Compositional bias

83 – 94

Poly-Ser

Compositional bias

186 – 190

Poly-Pro

Compositional bias

586 – 589

Poly-Pro

Amino acid modifications

Modified residue

344

Phosphoserine; by PKA By similarity

Modified residue

354

Phosphoserine; by PKA, RPS6KA1 and RPS6KA3 By similarity

Experimental info

Sequence conflict

A → T in CAA42718. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P12813 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 8CFF45B58253887B
Show »

FASTA

601

64,738

        10         20         30         40         50         60 
MPCIQAQYGT PATSPGPRDH LTGDPLALEF GKPTMDLASP ETAPAAPATL PSFSTFMDGY 

        70         80         90        100        110        120 
TGEFDTFLYQ LPGTTQPCSS ACSSASSTSS SSSSATSPAS ASFKFEDFQV YGCYPGTLSG 

       130        140        150        160        170        180 
PLDETLSSSG SEYYGSPCSA PSPSTPNFQP SQLSPWDGSF GHFSPSQTYE GLWAWTEQLP 

       190        200        210        220        230        240 
KASSGPPPPP TFFSFSPPTG PSPSLAQSSL KLFPPPATHQ LGEGESYSMP AAFPGLAPTS 

       250        260        270        280        290        300 
PNRDTSGILD APVTSTKSRS GASGGSEGRC AVCGDNASCQ HYGVRTCEGC KGFFKRTVQK 

       310        320        330        340        350        360 
SAKYICLANK DCPVDKRRRN RCQFCRFQKC LAVGMVKEVV RTDSLKGRRG RLPSKPKQPP 

       370        380        390        400        410        420 
DASPTNLLTS LIRAHLDSGP STAKLDYSKF QELVLPRFGK EDAGDVQQFY DLLSGSLDVI 

       430        440        450        460        470        480 
RKWAEKIPGF IELCPGDQDL LLESAFLELF ILRLAYRSKP GEGKLIFCSG LVLHQLQCAR 

       490        500        510        520        530        540 
GFGDWIDNIL AFSRSLHSLG VDVPAFACLS ALVLITDRHG LQDPRRVEEL QNRIASCLKE 

       550        560        570        580        590        600 
HMATVAGDPQ PASCLSRLLG KLPELRTLCT QGLQRIFCLK LEDLVPPPPI VDKIFMDTLS 


F

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily." Hazel T.G., Nathans D., Lau L.F. Proc. Natl. Acad. Sci. U.S.A. 85:8444-8448(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor." Ryseck R.P., Macdonald-Bravo H., Mattei M.-G., Ruppert S., Bravo R. EMBO J. 8:3327-3335(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Kidney and Liver.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J04113 mRNA. Translation: AAA39843.1. X16995 Genomic DNA. Translation: CAA34862.1. X60132 mRNA. Translation: CAA42718.1. BC004770 mRNA. Translation: AAH04770.1.
IPI	IPI00121733.
PIR	QRMSN1. S06953.
RefSeq	NP_034574.1. NM_010444.2.
UniGene	Mm.119.
3D structure databases
ProteinModelPortal	P12813.
SMR	P12813. Positions 268-599.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000023779.
PTM databases
PhosphoSite	P12813.
Proteomic databases
PRIDE	P12813.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000023779; ENSMUSP00000023779; ENSMUSG00000023034.
GeneID	15370.
KEGG	mmu:15370.
Organism-specific databases
CTD	3164.
MGI	MGI:1352454. Nr4a1.
Phylogenomic databases
eggNOG	NOG245120.
HOGENOM	HOG000230925.
HOVERGEN	HBG052663.
InParanoid	P12813.
KO	K04465.
OMA	KWAEKIP.
OrthoDB	EOG4VMFF7.
Gene expression databases
ArrayExpress	P12813.
Bgee	P12813.
CleanEx	MM_NR4A1.
Genevestigator	P12813.
GermOnline	ENSMUSG00000023034. Mus musculus.
Family and domain databases
Gene3D	1.10.565.10. 1 hit. 3.30.50.10. 1 hit.
InterPro	IPR003071. Nuc_orp_HMR_rcpt. IPR003070. Nuc_orph_rcpt. IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR001723. Str_hrmn_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR01285. HMRNUCRECPTR. PR01284. NUCLEARECPTR. PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	288006.
SOURCE	Search...

Entry information

Entry name

NR4A1_MOUSE

Accession

Primary (citable) accession number: P12813

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	May 1, 2013
This is version 130 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents