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P12813

- NR4A1_MOUSE

UniProt

P12813 - NR4A1_MOUSE

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Protein

Nuclear receptor subfamily 4 group A member 1

Gene

Nr4a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi267 – 34276Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 29021NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri306 – 33025NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: BHF-UCL
  2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  3. protein heterodimerization activity Source: MGI
  4. protein homodimerization activity Source: MGI
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  6. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  7. sequence-specific DNA binding Source: MGI
  8. steroid hormone receptor activity Source: InterPro
  9. zinc ion binding Source: InterPro

GO - Biological processi

  1. apoptotic process Source: MGI
  2. cell migration involved in sprouting angiogenesis Source: Ensembl
  3. cellular response to fibroblast growth factor stimulus Source: Ensembl
  4. cellular response to organic substance Source: MGI
  5. cellular response to vascular endothelial growth factor stimulus Source: Ensembl
  6. endothelial cell chemotaxis Source: Ensembl
  7. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  8. positive regulation of apoptotic process Source: MGI
  9. positive regulation of endothelial cell proliferation Source: Ensembl
  10. positive regulation of transcription, DNA-templated Source: MGI
  11. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  12. response to inorganic substance Source: MGI
  13. skeletal muscle cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_218211. AKT phosphorylates targets in the nucleus.
REACT_234105. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 4 group A member 1
Alternative name(s):
Nuclear hormone receptor NUR/77
Nuclear protein N10
Orphan nuclear receptor HMR
Gene namesi
Name:Nr4a1
Synonyms:Gfrp, Hmr, N10, Nur77
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1352454. Nr4a1.

Subcellular locationi

Cytoplasm By similarity. Nucleus

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: BHF-UCL
  3. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 601601Nuclear receptor subfamily 4 group A member 1PRO_0000053716Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei344 – 3441Phosphoserine; by PKABy similarity
Modified residuei354 – 3541Phosphoserine; by PKA, RPS6KA1 and RPS6KA3By similarity

Post-translational modificationi

Phosphorylated at Ser-354 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli.By similarity
Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1 (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiP12813.

PTM databases

PhosphoSiteiP12813.

Expressioni

Tissue specificityi

Highest levels occur in the testis followed by brain and muscle tissue.

Developmental stagei

Highest levels are found in the adult with barely detectable levels in pre- and early postnatal tissue.

Inductioni

By serum growth factors and during liver regeneration.

Gene expression databases

BgeeiP12813.
CleanExiMM_NR4A1.
ExpressionAtlasiP12813. baseline and differential.
GenevestigatoriP12813.

Interactioni

Subunit structurei

Interacts with GADD45GIP1. Interacts with STK11. Binds DNA as a monomer (By similarity).By similarity

Protein-protein interaction databases

BioGridi200346. 4 interactions.
STRINGi10090.ENSMUSP00000023779.

Structurei

3D structure databases

ProteinModelPortaliP12813.
SMRiP12813. Positions 268-599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni412 – 46251Ligand-bindingSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi83 – 9412Poly-SerAdd
BLAST
Compositional biasi186 – 1905Poly-Pro
Compositional biasi586 – 5894Poly-Pro

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri270 – 29021NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri306 – 33025NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG245120.
HOGENOMiHOG000230925.
HOVERGENiHBG052663.
InParanoidiP12813.
KOiK04465.
OMAiYSKFQEL.
OrthoDBiEOG75XGKJ.
PhylomeDBiP12813.
TreeFamiTF315430.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003071. Nuc_orp_HMR_rcpt.
IPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01285. HMRNUCRECPTR.
PR01284. NUCLEARECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12813-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPCIQAQYGT PATSPGPRDH LTGDPLALEF GKPTMDLASP ETAPAAPATL
60 70 80 90 100
PSFSTFMDGY TGEFDTFLYQ LPGTTQPCSS ACSSASSTSS SSSSATSPAS
110 120 130 140 150
ASFKFEDFQV YGCYPGTLSG PLDETLSSSG SEYYGSPCSA PSPSTPNFQP
160 170 180 190 200
SQLSPWDGSF GHFSPSQTYE GLWAWTEQLP KASSGPPPPP TFFSFSPPTG
210 220 230 240 250
PSPSLAQSSL KLFPPPATHQ LGEGESYSMP AAFPGLAPTS PNRDTSGILD
260 270 280 290 300
APVTSTKSRS GASGGSEGRC AVCGDNASCQ HYGVRTCEGC KGFFKRTVQK
310 320 330 340 350
SAKYICLANK DCPVDKRRRN RCQFCRFQKC LAVGMVKEVV RTDSLKGRRG
360 370 380 390 400
RLPSKPKQPP DASPTNLLTS LIRAHLDSGP STAKLDYSKF QELVLPRFGK
410 420 430 440 450
EDAGDVQQFY DLLSGSLDVI RKWAEKIPGF IELCPGDQDL LLESAFLELF
460 470 480 490 500
ILRLAYRSKP GEGKLIFCSG LVLHQLQCAR GFGDWIDNIL AFSRSLHSLG
510 520 530 540 550
VDVPAFACLS ALVLITDRHG LQDPRRVEEL QNRIASCLKE HMATVAGDPQ
560 570 580 590 600
PASCLSRLLG KLPELRTLCT QGLQRIFCLK LEDLVPPPPI VDKIFMDTLS

F
Length:601
Mass (Da):64,738
Last modified:October 1, 1989 - v1
Checksum:i8CFF45B58253887B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451A → T in CAA42718. (PubMed:2555161)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04113 mRNA. Translation: AAA39843.1.
X16995 Genomic DNA. Translation: CAA34862.1.
X60132 mRNA. Translation: CAA42718.1.
BC004770 mRNA. Translation: AAH04770.1.
CCDSiCCDS27848.1.
PIRiS06953. QRMSN1.
RefSeqiNP_034574.1. NM_010444.2.
XP_006520519.1. XM_006520456.1.
XP_006520520.1. XM_006520457.1.
XP_006520521.1. XM_006520458.1.
XP_006520522.1. XM_006520459.1.
UniGeneiMm.119.

Genome annotation databases

EnsembliENSMUST00000023779; ENSMUSP00000023779; ENSMUSG00000023034.
GeneIDi15370.
KEGGimmu:15370.
UCSCiuc007xsv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04113 mRNA. Translation: AAA39843.1 .
X16995 Genomic DNA. Translation: CAA34862.1 .
X60132 mRNA. Translation: CAA42718.1 .
BC004770 mRNA. Translation: AAH04770.1 .
CCDSi CCDS27848.1.
PIRi S06953. QRMSN1.
RefSeqi NP_034574.1. NM_010444.2.
XP_006520519.1. XM_006520456.1.
XP_006520520.1. XM_006520457.1.
XP_006520521.1. XM_006520458.1.
XP_006520522.1. XM_006520459.1.
UniGenei Mm.119.

3D structure databases

ProteinModelPortali P12813.
SMRi P12813. Positions 268-599.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200346. 4 interactions.
STRINGi 10090.ENSMUSP00000023779.

PTM databases

PhosphoSitei P12813.

Proteomic databases

PRIDEi P12813.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023779 ; ENSMUSP00000023779 ; ENSMUSG00000023034 .
GeneIDi 15370.
KEGGi mmu:15370.
UCSCi uc007xsv.2. mouse.

Organism-specific databases

CTDi 3164.
MGIi MGI:1352454. Nr4a1.

Phylogenomic databases

eggNOGi NOG245120.
HOGENOMi HOG000230925.
HOVERGENi HBG052663.
InParanoidi P12813.
KOi K04465.
OMAi YSKFQEL.
OrthoDBi EOG75XGKJ.
PhylomeDBi P12813.
TreeFami TF315430.

Enzyme and pathway databases

Reactomei REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_218211. AKT phosphorylates targets in the nucleus.
REACT_234105. Nuclear Receptor transcription pathway.

Miscellaneous databases

NextBioi 288006.
PROi P12813.
SOURCEi Search...

Gene expression databases

Bgeei P12813.
CleanExi MM_NR4A1.
ExpressionAtlasi P12813. baseline and differential.
Genevestigatori P12813.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR003071. Nuc_orp_HMR_rcpt.
IPR003070. Nuc_orph_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR01285. HMRNUCRECPTR.
PR01284. NUCLEARECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily."
    Hazel T.G., Nathans D., Lau L.F.
    Proc. Natl. Acad. Sci. U.S.A. 85:8444-8448(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor."
    Ryseck R.P., Macdonald-Bravo H., Mattei M.-G., Ruppert S., Bravo R.
    EMBO J. 8:3327-3335(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Kidney and Liver.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiNR4A1_MOUSE
AccessioniPrimary (citable) accession number: P12813
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 26, 2014
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3