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Protein

18 kDa antigen

Gene

hsp18

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Not known. This protein is one of the major immune reactive proteins in mycobacteria.

Enzyme and pathway databases

BioCyciMLEP272631:G1GT5-1969-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
18 kDa antigen
Alternative name(s):
HSP 16.7
Gene namesi
Name:hsp18
Ordered Locus Names:ML1795
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1795

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001260161 – 14818 kDa antigenAdd BLAST148

Interactioni

Protein-protein interaction databases

MINTiP12809
STRINGi272631.ML1795

Structurei

3D structure databases

ProteinModelPortaliP12809
SMRiP12809
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 131sHSPPROSITE-ProRule annotationAdd BLAST111

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG41087EV Bacteria
COG0071 LUCA
HOGENOMiHOG000251751
KOiK13993
OMAiVDPNREM
OrthoDBiPOG091H09C3

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR008978 HSP20-like_chaperone
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequencei

Sequence statusi: Complete.

P12809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMRTDPFRE LDRFAEQVLG TSARPAVMPM DAWREGEEFV VEFDLPGIKA
60 70 80 90 100
DSLDIDIERN VVTVRAERPG VDPDREMLAA ERPRGVFNRQ LVLGENLDTE
110 120 130 140
RILASYQEGV LKLSIPVAER AKPRKISVDR GNNGHQTINK TAHEIIDA
Length:148
Mass (Da):16,707
Last modified:October 1, 1989 - v1
Checksum:i82B11CC40845C391
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13 – 20RFAEQVLG → LRRASVS in AAA25343 (PubMed:3056923).Curated8
Sequence conflicti100E → Q in AAA25343 (PubMed:3056923).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22587 Genomic DNA Translation: AAA25343.1
M19058 Genomic DNA Translation: AAA88229.1
AL583923 Genomic DNA Translation: CAC30748.1
PIRiA27586
RefSeqiNP_302218.1, NC_002677.1
WP_010908539.1, NC_002677.1

Genome annotation databases

EnsemblBacteriaiCAC30748; CAC30748; CAC30748
GeneIDi910696
KEGGimle:ML1795
PATRICifig|272631.5.peg.3418

Similar proteinsi

Entry informationi

Entry namei18KD_MYCLE
AccessioniPrimary (citable) accession number: P12809
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health