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Protein

18 kDa antigen

Gene

hsp18

Organism
Mycobacterium leprae (strain TN)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Not known. This protein is one of the major immune reactive proteins in mycobacteria.

Names & Taxonomyi

Protein namesi
Recommended name:
18 kDa antigen
Alternative name(s):
HSP 16.7
Gene namesi
Name:hsp18
Ordered Locus Names:ML1795
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000000806 Componenti: Chromosome

Organism-specific databases

LepromaiML1795.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14814818 kDa antigenPRO_0000126016Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272631.ML1795.

Structurei

3D structure databases

ProteinModelPortaliP12809.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG41087EV. Bacteria.
COG0071. LUCA.
HOGENOMiHOG000251751.
KOiK13993.
OMAiAWRDGDQ.
OrthoDBiEOG6PZXGF.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLMRTDPFRE LDRFAEQVLG TSARPAVMPM DAWREGEEFV VEFDLPGIKA
60 70 80 90 100
DSLDIDIERN VVTVRAERPG VDPDREMLAA ERPRGVFNRQ LVLGENLDTE
110 120 130 140
RILASYQEGV LKLSIPVAER AKPRKISVDR GNNGHQTINK TAHEIIDA
Length:148
Mass (Da):16,707
Last modified:October 1, 1989 - v1
Checksum:i82B11CC40845C391
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 208RFAEQVLG → LRRASVS in AAA25343 (PubMed:3056923).Curated
Sequence conflicti100 – 1001E → Q in AAA25343 (PubMed:3056923).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22587 Genomic DNA. Translation: AAA25343.1.
M19058 Genomic DNA. Translation: AAA88229.1.
AL583923 Genomic DNA. Translation: CAC30748.1.
PIRiA27586.
RefSeqiNP_302218.1. NC_002677.1.
WP_010908539.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC30748; CAC30748; CAC30748.
GeneIDi910696.
KEGGimle:ML1795.
PATRICi18056982. VBIMycLep78757_3418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22587 Genomic DNA. Translation: AAA25343.1.
M19058 Genomic DNA. Translation: AAA88229.1.
AL583923 Genomic DNA. Translation: CAC30748.1.
PIRiA27586.
RefSeqiNP_302218.1. NC_002677.1.
WP_010908539.1. NC_002677.1.

3D structure databases

ProteinModelPortaliP12809.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272631.ML1795.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC30748; CAC30748; CAC30748.
GeneIDi910696.
KEGGimle:ML1795.
PATRICi18056982. VBIMycLep78757_3418.

Organism-specific databases

LepromaiML1795.

Phylogenomic databases

eggNOGiENOG41087EV. Bacteria.
COG0071. LUCA.
HOGENOMiHOG000251751.
KOiK13993.
OMAiAWRDGDQ.
OrthoDBiEOG6PZXGF.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A protein antigen of Mycobacterium leprae is related to a family of small heat shock proteins."
    Nerland A.H., Mustafa A.S., Sweetser D., Godal T., Young R.A.
    J. Bacteriol. 170:5919-5921(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Antigenic proteins of Mycobacterium leprae. Complete sequence of the gene for the 18-kDa protein."
    Booth R.J., Harris D.P., Love J.M., Watson J.D.
    J. Immunol. 140:597-601(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry namei18KD_MYCLE
AccessioniPrimary (citable) accession number: P12809
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 11, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.