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P12804 (FGL2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroleukin
Alternative name(s):
Cytotoxic T-lymphocyte-specific protein
Fibrinogen-like protein 2
Prothrombinase
Gene names
Name:Fgl2
Synonyms:Fiblp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Converts prothrombin to thrombin.

Subunit structure

Homotetramer; disulfide-linked By similarity.

Subcellular location

Secreted.

Tissue specificity

Constitutively expressed in cytotoxic T-cells.

Induction

In macrophages, during infection by mouse hepatitis virus strain 3 (MHV-3). Ref.4

Sequence similarities

Contains 1 fibrinogen C-terminal domain.

Ontologies

Keywords
   Biological processCytolysis
   Cellular componentSecreted
   DomainCoiled coil
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcytolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 432413Fibroleukin
PRO_0000009107

Regions

Domain197 – 429233Fibrinogen C-terminal
Coiled coil71 – 15787 Potential

Amino acid modifications

Glycosylation241N-linked (GlcNAc...) Potential
Glycosylation1721N-linked (GlcNAc...) Potential
Glycosylation2281N-linked (GlcNAc...) Potential
Glycosylation2561N-linked (GlcNAc...) Potential
Glycosylation3291N-linked (GlcNAc...) Potential
Disulfide bond206 ↔ 235 By similarity
Disulfide bond364 ↔ 377 By similarity

Experimental info

Sequence conflict3321A → G in AAB34823. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P12804 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 2B297F69CCB4A782

FASTA43248,951
        10         20         30         40         50         60 
MRLPGWLWLS SAVLAACRAV EEHNLTEGLE DASAQAACPA RLEGSGRCEG SQCPFQLTLP 

        70         80         90        100        110        120 
TLTIQLPRQL GSMEEVLKEV RTLKEAVDSL KKSCQDCKLQ ADDHRDPGGN GGNGAETAED 

       130        140        150        160        170        180 
SRVQELESQV NKLSSELKNA KDQIQGLQGR LETLHLVNMN NIENYVDNKV ANLTVVVNSL 

       190        200        210        220        230        240 
DGKCSKCPSQ EHMQSQPVQH LIYKDCSDHY VLGRRSSGAY RVTPDHRNSS FEVYCDMETM 

       250        260        270        280        290        300 
GGGWTVLQAR LDGSTNFTRE WKDYKAGFGN LEREFWLGND KIHLLTKSKE MILRIDLEDF 

       310        320        330        340        350        360 
NGLTLYALYD QFYVANEFLK YRLHIGNYNG TAGDALRFSR HYNHDLRFFT TPDRDNDRYP 

       370        380        390        400        410        420 
SGNCGLYYSS GWWFDSCLSA NLNGKYYHQK YKGVRNGIFW GTWPGINQAQ PGGYKSSFKQ 

       430 
AKMMIRPKNF KP 

« Hide

References

« Hide 'large scale' references
[1]"Structure of a cytotoxic T-lymphocyte-specific gene shows a strong homology to fibrinogen beta and gamma chains."
Koyama T., Hall L.R., Haser W.G., Tonegawa S., Saito H.
Proc. Natl. Acad. Sci. U.S.A. 84:1609-1613(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Cytotoxic T-cell.
[2]"Association of mouse fibrinogen-like protein with murine hepatitis virus-induced prothrombinase activity."
Parr R.L., Fung L., Reneker J., Myers-Mason N., Leibowitz J.L., Levy G.
J. Virol. 69:5033-5038(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
Strain: BALB/cJ.
Tissue: Peritoneal macrophage.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
[4]"The nucleocapsid protein of murine hepatitis virus type 3 induces transcription of the novel fgl2 prothrombinase gene."
Ning Q., Liu M., Kongkham P., Lai M.M.C., Marsden P.A., Tseng J., Pereira B., Belyavskyi M., Leibowitz J., Phillips M.J., Levy G.A.
J. Biol. Chem. 274:9930-9936(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY MHV-3 NUCLEOCAPSID PROTEIN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M16238, M15761 Genomic DNA. Translation: AAA37624.1.
S78773 mRNA. Translation: AAB34823.1.
BC028893 mRNA. Translation: AAH28893.1.
CCDSCCDS19103.1.
PIRA27447.
I56934.
RefSeqNP_032039.2. NM_008013.4.
UniGeneMm.292100.

3D structure databases

ProteinModelPortalP12804.
SMRP12804. Positions 50-427.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS67.001.

Proteomic databases

MaxQBP12804.
PaxDbP12804.
PRIDEP12804.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000035799; ENSMUSP00000046131; ENSMUSG00000039899.
GeneID14190.
KEGGmmu:14190.
UCSCuc008wom.2. mouse.

Organism-specific databases

CTD10875.
MGIMGI:103266. Fgl2.

Phylogenomic databases

eggNOGNOG297117.
HOGENOMHOG000252953.
HOVERGENHBG105002.
InParanoidP12804.
OMAYVANEFL.
OrthoDBEOG7X9G60.
PhylomeDBP12804.
TreeFamTF336658.

Gene expression databases

ArrayExpressP12804.
BgeeP12804.
CleanExMM_FGL2.
GenevestigatorP12804.

Family and domain databases

Gene3D3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMSSF56496. SSF56496. 1 hit.
PROSITEPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285406.
PROP12804.
SOURCESearch...

Entry information

Entry nameFGL2_MOUSE
AccessionPrimary (citable) accession number: P12804
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot