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P12804

- FGL2_MOUSE

UniProt

P12804 - FGL2_MOUSE

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Protein

Fibroleukin

Gene
Fgl2, Fiblp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Converts prothrombin to thrombin.

GO - Biological processi

  1. cytolysis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cytolysis

Protein family/group databases

MEROPSiS67.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroleukin
Alternative name(s):
Cytotoxic T-lymphocyte-specific protein
Fibrinogen-like protein 2
Prothrombinase
Gene namesi
Name:Fgl2
Synonyms:Fiblp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:103266. Fgl2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 432413FibroleukinPRO_0000009107Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi24 – 241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi172 – 1721N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi206 ↔ 235 By similarity
Glycosylationi228 – 2281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi256 – 2561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi329 – 3291N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi364 ↔ 377 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP12804.
PaxDbiP12804.
PRIDEiP12804.

Expressioni

Tissue specificityi

Constitutively expressed in cytotoxic T-cells.

Inductioni

In macrophages, during infection by mouse hepatitis virus strain 3 (MHV-3).1 Publication

Gene expression databases

ArrayExpressiP12804.
BgeeiP12804.
CleanExiMM_FGL2.
GenevestigatoriP12804.

Interactioni

Subunit structurei

Homotetramer; disulfide-linked By similarity.

Structurei

3D structure databases

ProteinModelPortaliP12804.
SMRiP12804. Positions 50-427.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini197 – 429233Fibrinogen C-terminalAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili71 – 15787 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG297117.
HOGENOMiHOG000252953.
HOVERGENiHBG105002.
InParanoidiP12804.
OMAiYVANEFL.
OrthoDBiEOG7X9G60.
PhylomeDBiP12804.
TreeFamiTF336658.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12804-1 [UniParc]FASTAAdd to Basket

« Hide

MRLPGWLWLS SAVLAACRAV EEHNLTEGLE DASAQAACPA RLEGSGRCEG    50
SQCPFQLTLP TLTIQLPRQL GSMEEVLKEV RTLKEAVDSL KKSCQDCKLQ 100
ADDHRDPGGN GGNGAETAED SRVQELESQV NKLSSELKNA KDQIQGLQGR 150
LETLHLVNMN NIENYVDNKV ANLTVVVNSL DGKCSKCPSQ EHMQSQPVQH 200
LIYKDCSDHY VLGRRSSGAY RVTPDHRNSS FEVYCDMETM GGGWTVLQAR 250
LDGSTNFTRE WKDYKAGFGN LEREFWLGND KIHLLTKSKE MILRIDLEDF 300
NGLTLYALYD QFYVANEFLK YRLHIGNYNG TAGDALRFSR HYNHDLRFFT 350
TPDRDNDRYP SGNCGLYYSS GWWFDSCLSA NLNGKYYHQK YKGVRNGIFW 400
GTWPGINQAQ PGGYKSSFKQ AKMMIRPKNF KP 432
Length:432
Mass (Da):48,951
Last modified:October 1, 1989 - v1
Checksum:i2B297F69CCB4A782
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti332 – 3321A → G in AAB34823. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16238, M15761 Genomic DNA. Translation: AAA37624.1.
S78773 mRNA. Translation: AAB34823.1.
BC028893 mRNA. Translation: AAH28893.1.
CCDSiCCDS19103.1.
PIRiA27447.
I56934.
RefSeqiNP_032039.2. NM_008013.4.
UniGeneiMm.292100.

Genome annotation databases

EnsembliENSMUST00000035799; ENSMUSP00000046131; ENSMUSG00000039899.
GeneIDi14190.
KEGGimmu:14190.
UCSCiuc008wom.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16238 , M15761 Genomic DNA. Translation: AAA37624.1 .
S78773 mRNA. Translation: AAB34823.1 .
BC028893 mRNA. Translation: AAH28893.1 .
CCDSi CCDS19103.1.
PIRi A27447.
I56934.
RefSeqi NP_032039.2. NM_008013.4.
UniGenei Mm.292100.

3D structure databases

ProteinModelPortali P12804.
SMRi P12804. Positions 50-427.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S67.001.

Proteomic databases

MaxQBi P12804.
PaxDbi P12804.
PRIDEi P12804.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000035799 ; ENSMUSP00000046131 ; ENSMUSG00000039899 .
GeneIDi 14190.
KEGGi mmu:14190.
UCSCi uc008wom.2. mouse.

Organism-specific databases

CTDi 10875.
MGIi MGI:103266. Fgl2.

Phylogenomic databases

eggNOGi NOG297117.
HOGENOMi HOG000252953.
HOVERGENi HBG105002.
InParanoidi P12804.
OMAi YVANEFL.
OrthoDBi EOG7X9G60.
PhylomeDBi P12804.
TreeFami TF336658.

Miscellaneous databases

NextBioi 285406.
PROi P12804.
SOURCEi Search...

Gene expression databases

ArrayExpressi P12804.
Bgeei P12804.
CleanExi MM_FGL2.
Genevestigatori P12804.

Family and domain databases

Gene3Di 3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProi IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view ]
Pfami PF00147. Fibrinogen_C. 1 hit.
[Graphical view ]
SMARTi SM00186. FBG. 1 hit.
[Graphical view ]
SUPFAMi SSF56496. SSF56496. 1 hit.
PROSITEi PS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of a cytotoxic T-lymphocyte-specific gene shows a strong homology to fibrinogen beta and gamma chains."
    Koyama T., Hall L.R., Haser W.G., Tonegawa S., Saito H.
    Proc. Natl. Acad. Sci. U.S.A. 84:1609-1613(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Cytotoxic T-cell.
  2. "Association of mouse fibrinogen-like protein with murine hepatitis virus-induced prothrombinase activity."
    Parr R.L., Fung L., Reneker J., Myers-Mason N., Leibowitz J.L., Levy G.
    J. Virol. 69:5033-5038(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Strain: BALB/cJ.
    Tissue: Peritoneal macrophage.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  4. "The nucleocapsid protein of murine hepatitis virus type 3 induces transcription of the novel fgl2 prothrombinase gene."
    Ning Q., Liu M., Kongkham P., Lai M.M.C., Marsden P.A., Tseng J., Pereira B., Belyavskyi M., Leibowitz J., Phillips M.J., Levy G.A.
    J. Biol. Chem. 274:9930-9936(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY MHV-3 NUCLEOCAPSID PROTEIN.

Entry informationi

Entry nameiFGL2_MOUSE
AccessioniPrimary (citable) accession number: P12804
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: July 9, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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