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Protein

Fibroleukin

Gene

Fgl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Converts prothrombin to thrombin.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cytolysis

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroleukin
Alternative name(s):
Cytotoxic T-lymphocyte-specific protein
Fibrinogen-like protein 2
Prothrombinase
Gene namesi
Name:Fgl2
Synonyms:Fiblp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:103266. Fgl2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000000910720 – 432FibroleukinAdd BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Glycosylationi172N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi206 ↔ 235PROSITE-ProRule annotation
Glycosylationi228N-linked (GlcNAc...)Sequence analysis1
Glycosylationi256N-linked (GlcNAc...)Sequence analysis1
Glycosylationi329N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi364 ↔ 377PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP12804.
PaxDbiP12804.
PeptideAtlasiP12804.
PRIDEiP12804.

PTM databases

PhosphoSitePlusiP12804.

Expressioni

Tissue specificityi

Constitutively expressed in cytotoxic T-cells.

Inductioni

In macrophages, during infection by mouse hepatitis virus strain 3 (MHV-3).1 Publication

Gene expression databases

BgeeiENSMUSG00000039899.
CleanExiMM_FGL2.
ExpressionAtlasiP12804. baseline and differential.
GenevisibleiP12804. MM.

Interactioni

Subunit structurei

Homotetramer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046131.

Structurei

3D structure databases

ProteinModelPortaliP12804.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini197 – 429Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST233

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili71 – 157Sequence analysisAdd BLAST87

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000252953.
HOVERGENiHBG105002.
InParanoidiP12804.
OMAiFYVANEF.
OrthoDBiEOG091G03M1.
PhylomeDBiP12804.
TreeFamiTF336658.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR033083. Fgl2.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PANTHERiPTHR19143:SF189. PTHR19143:SF189. 1 hit.
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12804-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLPGWLWLS SAVLAACRAV EEHNLTEGLE DASAQAACPA RLEGSGRCEG
60 70 80 90 100
SQCPFQLTLP TLTIQLPRQL GSMEEVLKEV RTLKEAVDSL KKSCQDCKLQ
110 120 130 140 150
ADDHRDPGGN GGNGAETAED SRVQELESQV NKLSSELKNA KDQIQGLQGR
160 170 180 190 200
LETLHLVNMN NIENYVDNKV ANLTVVVNSL DGKCSKCPSQ EHMQSQPVQH
210 220 230 240 250
LIYKDCSDHY VLGRRSSGAY RVTPDHRNSS FEVYCDMETM GGGWTVLQAR
260 270 280 290 300
LDGSTNFTRE WKDYKAGFGN LEREFWLGND KIHLLTKSKE MILRIDLEDF
310 320 330 340 350
NGLTLYALYD QFYVANEFLK YRLHIGNYNG TAGDALRFSR HYNHDLRFFT
360 370 380 390 400
TPDRDNDRYP SGNCGLYYSS GWWFDSCLSA NLNGKYYHQK YKGVRNGIFW
410 420 430
GTWPGINQAQ PGGYKSSFKQ AKMMIRPKNF KP
Length:432
Mass (Da):48,951
Last modified:October 1, 1989 - v1
Checksum:i2B297F69CCB4A782
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti332A → G in AAB34823 (PubMed:7609073).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16238, M15761 Genomic DNA. Translation: AAA37624.1.
S78773 mRNA. Translation: AAB34823.1.
BC028893 mRNA. Translation: AAH28893.1.
CCDSiCCDS19103.1.
PIRiA27447.
I56934.
RefSeqiNP_032039.2. NM_008013.4.
UniGeneiMm.292100.

Genome annotation databases

EnsembliENSMUST00000035799; ENSMUSP00000046131; ENSMUSG00000039899.
GeneIDi14190.
KEGGimmu:14190.
UCSCiuc008wom.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16238, M15761 Genomic DNA. Translation: AAA37624.1.
S78773 mRNA. Translation: AAB34823.1.
BC028893 mRNA. Translation: AAH28893.1.
CCDSiCCDS19103.1.
PIRiA27447.
I56934.
RefSeqiNP_032039.2. NM_008013.4.
UniGeneiMm.292100.

3D structure databases

ProteinModelPortaliP12804.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046131.

PTM databases

PhosphoSitePlusiP12804.

Proteomic databases

EPDiP12804.
PaxDbiP12804.
PeptideAtlasiP12804.
PRIDEiP12804.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035799; ENSMUSP00000046131; ENSMUSG00000039899.
GeneIDi14190.
KEGGimmu:14190.
UCSCiuc008wom.2. mouse.

Organism-specific databases

CTDi10875.
MGIiMGI:103266. Fgl2.

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000252953.
HOVERGENiHBG105002.
InParanoidiP12804.
OMAiFYVANEF.
OrthoDBiEOG091G03M1.
PhylomeDBiP12804.
TreeFamiTF336658.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiP12804.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039899.
CleanExiMM_FGL2.
ExpressionAtlasiP12804. baseline and differential.
GenevisibleiP12804. MM.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR033083. Fgl2.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PANTHERiPTHR19143:SF189. PTHR19143:SF189. 1 hit.
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGL2_MOUSE
AccessioniPrimary (citable) accession number: P12804
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.