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P12804

- FGL2_MOUSE

UniProt

P12804 - FGL2_MOUSE

Protein

Fibroleukin

Gene

Fgl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
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    Functioni

    Converts prothrombin to thrombin.

    GO - Biological processi

    1. cytolysis Source: UniProtKB-KW

    Keywords - Biological processi

    Cytolysis

    Protein family/group databases

    MEROPSiS67.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroleukin
    Alternative name(s):
    Cytotoxic T-lymphocyte-specific protein
    Fibrinogen-like protein 2
    Prothrombinase
    Gene namesi
    Name:Fgl2
    Synonyms:Fiblp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:103266. Fgl2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 432413FibroleukinPRO_0000009107Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi206 ↔ 235PROSITE-ProRule annotation
    Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi364 ↔ 377PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP12804.
    PaxDbiP12804.
    PRIDEiP12804.

    Expressioni

    Tissue specificityi

    Constitutively expressed in cytotoxic T-cells.

    Inductioni

    In macrophages, during infection by mouse hepatitis virus strain 3 (MHV-3).1 Publication

    Gene expression databases

    ArrayExpressiP12804.
    BgeeiP12804.
    CleanExiMM_FGL2.
    GenevestigatoriP12804.

    Interactioni

    Subunit structurei

    Homotetramer; disulfide-linked.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP12804.
    SMRiP12804. Positions 50-427.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini197 – 429233Fibrinogen C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili71 – 15787Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Signal

    Phylogenomic databases

    eggNOGiNOG297117.
    HOGENOMiHOG000252953.
    HOVERGENiHBG105002.
    InParanoidiP12804.
    OMAiYVANEFL.
    OrthoDBiEOG7X9G60.
    PhylomeDBiP12804.
    TreeFamiTF336658.

    Family and domain databases

    Gene3Di3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProiIPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR020837. Fibrinogen_CS.
    [Graphical view]
    PfamiPF00147. Fibrinogen_C. 1 hit.
    [Graphical view]
    SMARTiSM00186. FBG. 1 hit.
    [Graphical view]
    SUPFAMiSSF56496. SSF56496. 1 hit.
    PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12804-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLPGWLWLS SAVLAACRAV EEHNLTEGLE DASAQAACPA RLEGSGRCEG    50
    SQCPFQLTLP TLTIQLPRQL GSMEEVLKEV RTLKEAVDSL KKSCQDCKLQ 100
    ADDHRDPGGN GGNGAETAED SRVQELESQV NKLSSELKNA KDQIQGLQGR 150
    LETLHLVNMN NIENYVDNKV ANLTVVVNSL DGKCSKCPSQ EHMQSQPVQH 200
    LIYKDCSDHY VLGRRSSGAY RVTPDHRNSS FEVYCDMETM GGGWTVLQAR 250
    LDGSTNFTRE WKDYKAGFGN LEREFWLGND KIHLLTKSKE MILRIDLEDF 300
    NGLTLYALYD QFYVANEFLK YRLHIGNYNG TAGDALRFSR HYNHDLRFFT 350
    TPDRDNDRYP SGNCGLYYSS GWWFDSCLSA NLNGKYYHQK YKGVRNGIFW 400
    GTWPGINQAQ PGGYKSSFKQ AKMMIRPKNF KP 432
    Length:432
    Mass (Da):48,951
    Last modified:October 1, 1989 - v1
    Checksum:i2B297F69CCB4A782
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti332 – 3321A → G in AAB34823. (PubMed:7609073)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16238, M15761 Genomic DNA. Translation: AAA37624.1.
    S78773 mRNA. Translation: AAB34823.1.
    BC028893 mRNA. Translation: AAH28893.1.
    CCDSiCCDS19103.1.
    PIRiA27447.
    I56934.
    RefSeqiNP_032039.2. NM_008013.4.
    UniGeneiMm.292100.

    Genome annotation databases

    EnsembliENSMUST00000035799; ENSMUSP00000046131; ENSMUSG00000039899.
    GeneIDi14190.
    KEGGimmu:14190.
    UCSCiuc008wom.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16238 , M15761 Genomic DNA. Translation: AAA37624.1 .
    S78773 mRNA. Translation: AAB34823.1 .
    BC028893 mRNA. Translation: AAH28893.1 .
    CCDSi CCDS19103.1.
    PIRi A27447.
    I56934.
    RefSeqi NP_032039.2. NM_008013.4.
    UniGenei Mm.292100.

    3D structure databases

    ProteinModelPortali P12804.
    SMRi P12804. Positions 50-427.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S67.001.

    Proteomic databases

    MaxQBi P12804.
    PaxDbi P12804.
    PRIDEi P12804.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000035799 ; ENSMUSP00000046131 ; ENSMUSG00000039899 .
    GeneIDi 14190.
    KEGGi mmu:14190.
    UCSCi uc008wom.2. mouse.

    Organism-specific databases

    CTDi 10875.
    MGIi MGI:103266. Fgl2.

    Phylogenomic databases

    eggNOGi NOG297117.
    HOGENOMi HOG000252953.
    HOVERGENi HBG105002.
    InParanoidi P12804.
    OMAi YVANEFL.
    OrthoDBi EOG7X9G60.
    PhylomeDBi P12804.
    TreeFami TF336658.

    Miscellaneous databases

    NextBioi 285406.
    PROi P12804.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P12804.
    Bgeei P12804.
    CleanExi MM_FGL2.
    Genevestigatori P12804.

    Family and domain databases

    Gene3Di 3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProi IPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR020837. Fibrinogen_CS.
    [Graphical view ]
    Pfami PF00147. Fibrinogen_C. 1 hit.
    [Graphical view ]
    SMARTi SM00186. FBG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56496. SSF56496. 1 hit.
    PROSITEi PS00514. FIBRINOGEN_C_1. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of a cytotoxic T-lymphocyte-specific gene shows a strong homology to fibrinogen beta and gamma chains."
      Koyama T., Hall L.R., Haser W.G., Tonegawa S., Saito H.
      Proc. Natl. Acad. Sci. U.S.A. 84:1609-1613(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Cytotoxic T-cell.
    2. "Association of mouse fibrinogen-like protein with murine hepatitis virus-induced prothrombinase activity."
      Parr R.L., Fung L., Reneker J., Myers-Mason N., Leibowitz J.L., Levy G.
      J. Virol. 69:5033-5038(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
      Strain: BALB/cJ.
      Tissue: Peritoneal macrophage.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.
    4. "The nucleocapsid protein of murine hepatitis virus type 3 induces transcription of the novel fgl2 prothrombinase gene."
      Ning Q., Liu M., Kongkham P., Lai M.M.C., Marsden P.A., Tseng J., Pereira B., Belyavskyi M., Leibowitz J., Phillips M.J., Levy G.A.
      J. Biol. Chem. 274:9930-9936(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY MHV-3 NUCLEOCAPSID PROTEIN.

    Entry informationi

    Entry nameiFGL2_MOUSE
    AccessioniPrimary (citable) accession number: P12804
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3