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Protein

Fibroleukin

Gene

Fgl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Converts prothrombin to thrombin.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cytolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroleukin
Alternative name(s):
Cytotoxic T-lymphocyte-specific protein
Fibrinogen-like protein 2
Prothrombinase
Gene namesi
Name:Fgl2
Synonyms:Fiblp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:103266. Fgl2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 432413FibroleukinPRO_0000009107Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi206 ↔ 235PROSITE-ProRule annotation
Glycosylationi228 – 2281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi364 ↔ 377PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP12804.
PaxDbiP12804.
PRIDEiP12804.

Expressioni

Tissue specificityi

Constitutively expressed in cytotoxic T-cells.

Inductioni

In macrophages, during infection by mouse hepatitis virus strain 3 (MHV-3).1 Publication

Gene expression databases

BgeeiP12804.
CleanExiMM_FGL2.
ExpressionAtlasiP12804. baseline and differential.
GenevisibleiP12804. MM.

Interactioni

Subunit structurei

Homotetramer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046131.

Structurei

3D structure databases

ProteinModelPortaliP12804.
SMRiP12804. Positions 50-427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini197 – 429233Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili71 – 15787Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG297117.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000252953.
HOVERGENiHBG105002.
InParanoidiP12804.
OMAiFYVANEF.
OrthoDBiEOG7X9G60.
PhylomeDBiP12804.
TreeFamiTF336658.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12804-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLPGWLWLS SAVLAACRAV EEHNLTEGLE DASAQAACPA RLEGSGRCEG
60 70 80 90 100
SQCPFQLTLP TLTIQLPRQL GSMEEVLKEV RTLKEAVDSL KKSCQDCKLQ
110 120 130 140 150
ADDHRDPGGN GGNGAETAED SRVQELESQV NKLSSELKNA KDQIQGLQGR
160 170 180 190 200
LETLHLVNMN NIENYVDNKV ANLTVVVNSL DGKCSKCPSQ EHMQSQPVQH
210 220 230 240 250
LIYKDCSDHY VLGRRSSGAY RVTPDHRNSS FEVYCDMETM GGGWTVLQAR
260 270 280 290 300
LDGSTNFTRE WKDYKAGFGN LEREFWLGND KIHLLTKSKE MILRIDLEDF
310 320 330 340 350
NGLTLYALYD QFYVANEFLK YRLHIGNYNG TAGDALRFSR HYNHDLRFFT
360 370 380 390 400
TPDRDNDRYP SGNCGLYYSS GWWFDSCLSA NLNGKYYHQK YKGVRNGIFW
410 420 430
GTWPGINQAQ PGGYKSSFKQ AKMMIRPKNF KP
Length:432
Mass (Da):48,951
Last modified:October 1, 1989 - v1
Checksum:i2B297F69CCB4A782
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti332 – 3321A → G in AAB34823 (PubMed:7609073).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16238, M15761 Genomic DNA. Translation: AAA37624.1.
S78773 mRNA. Translation: AAB34823.1.
BC028893 mRNA. Translation: AAH28893.1.
CCDSiCCDS19103.1.
PIRiA27447.
I56934.
RefSeqiNP_032039.2. NM_008013.4.
UniGeneiMm.292100.

Genome annotation databases

EnsembliENSMUST00000035799; ENSMUSP00000046131; ENSMUSG00000039899.
GeneIDi14190.
KEGGimmu:14190.
UCSCiuc008wom.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16238, M15761 Genomic DNA. Translation: AAA37624.1.
S78773 mRNA. Translation: AAB34823.1.
BC028893 mRNA. Translation: AAH28893.1.
CCDSiCCDS19103.1.
PIRiA27447.
I56934.
RefSeqiNP_032039.2. NM_008013.4.
UniGeneiMm.292100.

3D structure databases

ProteinModelPortaliP12804.
SMRiP12804. Positions 50-427.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046131.

Proteomic databases

MaxQBiP12804.
PaxDbiP12804.
PRIDEiP12804.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035799; ENSMUSP00000046131; ENSMUSG00000039899.
GeneIDi14190.
KEGGimmu:14190.
UCSCiuc008wom.2. mouse.

Organism-specific databases

CTDi10875.
MGIiMGI:103266. Fgl2.

Phylogenomic databases

eggNOGiNOG297117.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000252953.
HOVERGENiHBG105002.
InParanoidiP12804.
OMAiFYVANEF.
OrthoDBiEOG7X9G60.
PhylomeDBiP12804.
TreeFamiTF336658.

Miscellaneous databases

NextBioi285406.
PROiP12804.
SOURCEiSearch...

Gene expression databases

BgeeiP12804.
CleanExiMM_FGL2.
ExpressionAtlasiP12804. baseline and differential.
GenevisibleiP12804. MM.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure of a cytotoxic T-lymphocyte-specific gene shows a strong homology to fibrinogen beta and gamma chains."
    Koyama T., Hall L.R., Haser W.G., Tonegawa S., Saito H.
    Proc. Natl. Acad. Sci. U.S.A. 84:1609-1613(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Cytotoxic T-cell.
  2. "Association of mouse fibrinogen-like protein with murine hepatitis virus-induced prothrombinase activity."
    Parr R.L., Fung L., Reneker J., Myers-Mason N., Leibowitz J.L., Levy G.
    J. Virol. 69:5033-5038(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Strain: BALB/cJ.
    Tissue: Peritoneal macrophage.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  4. "The nucleocapsid protein of murine hepatitis virus type 3 induces transcription of the novel fgl2 prothrombinase gene."
    Ning Q., Liu M., Kongkham P., Lai M.M.C., Marsden P.A., Tseng J., Pereira B., Belyavskyi M., Leibowitz J., Phillips M.J., Levy G.A.
    J. Biol. Chem. 274:9930-9936(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY MHV-3 NUCLEOCAPSID PROTEIN.

Entry informationi

Entry nameiFGL2_MOUSE
AccessioniPrimary (citable) accession number: P12804
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: July 22, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.