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P12794

- GRP78_PLAFA

UniProt

P12794 - GRP78_PLAFA

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Protein

78 kDa glucose-regulated protein homolog

Gene
N/A
Organism
Plasmodium falciparum
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_192758. ATF6-alpha activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein homolog
Short name:
GRP-78
Alternative name(s):
Antigenic heat shock protein 70
HSP70-2
OrganismiPlasmodium falciparum
Taxonomic identifieri5833 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 279›27978 kDa glucose-regulated protein homologPRO_0000078664Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP12794.
SMRiP12794. Positions 1-200.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi276 – 2794Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiCOG0443.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P12794-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
EFFNGKEPNR GINPDEAVAY GAAIQAGIIL GEELQDVVLL DVTPLTLGIE
60 70 80 90 100
TVGGIMTQLI KRNTVIPTKK SQTFSTYQDN QPAVLIQVFE GERALTKDNH
110 120 130 140 150
LLGKFELSGI PPAQRGVPKI EVTFTVDKNG ILHVEAEDKG TGKSRGITIT
160 170 180 190 200
NDKGRLSKEQ IEKMINDAEK FADEDKNLRE KVEAKNNLDN YIQSMKATVE
210 220 230 240 250
DKDKLADKIE KEDKNTILSA VKDAEDWLNN NSNADSEALK QKLKDLEAVC
260 270
QPIIVKLYGQ PGGPSPQPSG DEDVDSDEL
Length:279
Mass (Da):30,657
Last modified:October 1, 1989 - v1
Checksum:iE0F8A52FECB6544F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18836 mRNA. Translation: AAA29502.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18836 mRNA. Translation: AAA29502.1 .

3D structure databases

ProteinModelPortali P12794.
SMRi P12794. Positions 1-200.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0443.

Enzyme and pathway databases

Reactomei REACT_192758. ATF6-alpha activates chaperone genes.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGRP78_PLAFA
AccessioniPrimary (citable) accession number: P12794
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3