P12794 (GRP78_PLAFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: 78 kDa glucose-regulated protein homolog Short name=GRP-78 Alternative name(s): Antigenic heat shock protein 70 HSP70-2
Organism	Plasmodium falciparum
Taxonomic identifier	5833 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania)

Protein attributes

Sequence length	279 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.
Subcellular location	Endoplasmic reticulum lumen By similarity.
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Endoplasmic reticulum
Ligand	ATP-binding Nucleotide-binding
Gene Ontology (GO)
Biological_process	response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 279	›279	78 kDa glucose-regulated protein homolog		PRO_0000078664
Regions
	Motif	276 – 279	4	Prevents secretion from ER Potential
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P12794 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: E0F8A52FECB6544F	FASTA	279	30,657
	10 20 30 40 50 60 EFFNGKEPNR GINPDEAVAY GAAIQAGIIL GEELQDVVLL DVTPLTLGIE TVGGIMTQLI 70 80 90 100 110 120 KRNTVIPTKK SQTFSTYQDN QPAVLIQVFE GERALTKDNH LLGKFELSGI PPAQRGVPKI 130 140 150 160 170 180 EVTFTVDKNG ILHVEAEDKG TGKSRGITIT NDKGRLSKEQ IEKMINDAEK FADEDKNLRE 190 200 210 220 230 240 KVEAKNNLDN YIQSMKATVE DKDKLADKIE KEDKNTILSA VKDAEDWLNN NSNADSEALK 250 260 270 QKLKDLEAVC QPIIVKLYGQ PGGPSPQPSG DEDVDSDEL

References

[1]	"A second antigenic heat shock protein of Plasmodium falciparum." Peterson M.G., Crewther P.E., Thompson J.K., Corcoran L.M., Coppel R.L., Brown G.V., Anders R.F., Kemp D.J. DNA 7:71-78(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M18836 mRNA. Translation: AAA29502.1.
3D structure databases
ProteinModelPortal	P12794.
SMR	P12794. Positions 1-200.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	COG0443.
Family and domain databases
InterPro	IPR013126. Hsp_70_fam. [Graphical view]
Pfam	PF00012. HSP70. 1 hit. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
PROSITE	PS00014. ER_TARGET. 1 hit. PS00297. HSP70_1. Partial match. PS00329. HSP70_2. Partial match. PS01036. HSP70_3. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GRP78_PLAFA

Accession

Primary (citable) accession number: P12794

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)