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P12794 (GRP78_PLAFA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
78 kDa glucose-regulated protein homolog

Short name=GRP-78
Alternative name(s):
Antigenic heat shock protein 70
HSP70-2
OrganismPlasmodium falciparum
Taxonomic identifier5833 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

Protein attributes

Sequence length279 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
   Biological processStress response
   Cellular componentEndoplasmic reticulum
   LigandATP-binding
Nucleotide-binding
Gene Ontology (GO)
   Biological_processresponse to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 279›27978 kDa glucose-regulated protein homolog
PRO_0000078664

Regions

Motif276 – 2794Prevents secretion from ER Potential

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P12794 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: E0F8A52FECB6544F

FASTA27930,657
        10         20         30         40         50         60 
EFFNGKEPNR GINPDEAVAY GAAIQAGIIL GEELQDVVLL DVTPLTLGIE TVGGIMTQLI 

        70         80         90        100        110        120 
KRNTVIPTKK SQTFSTYQDN QPAVLIQVFE GERALTKDNH LLGKFELSGI PPAQRGVPKI 

       130        140        150        160        170        180 
EVTFTVDKNG ILHVEAEDKG TGKSRGITIT NDKGRLSKEQ IEKMINDAEK FADEDKNLRE 

       190        200        210        220        230        240 
KVEAKNNLDN YIQSMKATVE DKDKLADKIE KEDKNTILSA VKDAEDWLNN NSNADSEALK 

       250        260        270 
QKLKDLEAVC QPIIVKLYGQ PGGPSPQPSG DEDVDSDEL 

« Hide

References

[1]"A second antigenic heat shock protein of Plasmodium falciparum."
Peterson M.G., Crewther P.E., Thompson J.K., Corcoran L.M., Coppel R.L., Brown G.V., Anders R.F., Kemp D.J.
DNA 7:71-78(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M18836 mRNA. Translation: AAA29502.1.

3D structure databases

ProteinModelPortalP12794.
SMRP12794. Positions 1-200.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0443.

Family and domain databases

InterProIPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGRP78_PLAFA
AccessionPrimary (citable) accession number: P12794
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families