ID   NCAP_SFSV               Reviewed;         246 AA.
AC   P12793;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   08-NOV-2023, entry version 74.
DE   RecName: Full=Nucleoprotein;
DE   AltName: Full=Nucleocapsid protein;
DE            Short=Protein N;
GN   Name=N;
OS   Sandfly fever sicilian virus (SFS).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Ellioviricetes; Bunyavirales; Phenuiviridae; Phlebovirus;
OC   Phlebovirus siciliaense.
OX   NCBI_TaxID=28292;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=29031; Phlebotomus papatasi (Sandfly).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2705301; DOI=10.1016/0042-6822(89)90159-1;
RA   Marriott A.C., Ward V.K., Nuttall P.A.;
RT   "The S RNA segment of Sandfly Fever Sicilian virus: evidence for an
RT   ambisense genome.";
RL   Virology 169:341-345(1989).
RN   [2]
RP   SEQUENCE REVISION.
RA   Marriott A.C., Ward V.K., Nuttall P.A.;
RL   Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Encapsidates the genomic RNA, protecting it from nucleases.
CC       Displays high affinity for single-stranded nucleic acid. The
CC       encapsidated genomic RNA is termed the nucleocapsid (NC) or
CC       ribonucleoprotein. The ribonucleoprotein has a non-helical structure
CC       (By similarity). Serves as template for viral transcription and
CC       replication. After replication, the nucleocapsid is recruited to the
CC       host Golgi apparatus by glycoprotein Gn for packaging into virus
CC       particles (By similarity). {ECO:0000250|UniProtKB:D3K5I7,
CC       ECO:0000250|UniProtKB:P21700}.
CC   -!- SUBUNIT: Homodimer. Homohexamer; ring-shaped, necessary to form the
CC       nucleocapsid (By similarity). Homopentamers; opened pentamers in
CC       solution (By similarity). Binds to viral genomic RNA (By similarity).
CC       Interacts with glycoprotein Gn; this interaction allows packaging of
CC       nucleocapsids into virions (By similarity).
CC       {ECO:0000250|UniProtKB:D3K5I7, ECO:0000250|UniProtKB:P21700,
CC       ECO:0000250|UniProtKB:P21701}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:D3K5I7}. Host
CC       cytoplasm {ECO:0000250|UniProtKB:D3K5I7}. Host nucleus
CC       {ECO:0000250|UniProtKB:D3K5I7}. Host endoplasmic reticulum-Golgi
CC       intermediate compartment {ECO:0000250|UniProtKB:I6WJ72}. Host Golgi
CC       apparatus {ECO:0000250|UniProtKB:I6WJ72}.
CC   -!- SIMILARITY: Belongs to the phlebovirus nucleocapsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; J04418; AAA47458.1; -; Genomic_RNA.
DR   PIR; A30180; VHVUSS.
DR   SMR; P12793; -.
DR   GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0044172; C:host cell endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR   GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR   GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR009522; Capsid_Phlebovir/Tenuivir.
DR   InterPro; IPR015971; Nucleocapsid_Phlebovirus.
DR   Pfam; PF05733; Tenui_N; 1.
DR   PIRSF; PIRSF003953; N_PhelboV; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Helical capsid protein; Host cytoplasm;
KW   Host Golgi apparatus; Host nucleus; Ribonucleoprotein; RNA-binding;
KW   Viral nucleoprotein; Virion.
FT   CHAIN           1..246
FT                   /note="Nucleoprotein"
FT                   /id="PRO_0000221996"
FT   SITE            30
FT                   /note="RNA-binding"
FT                   /evidence="ECO:0000250|UniProtKB:D3K5I7"
FT   SITE            33
FT                   /note="RNA-binding"
FT                   /evidence="ECO:0000250|UniProtKB:D3K5I7"
FT   SITE            66
FT                   /note="RNA-binding"
FT                   /evidence="ECO:0000250|UniProtKB:D3K5I7"
FT   SITE            67
FT                   /note="RNA-binding"
FT                   /evidence="ECO:0000250|UniProtKB:D3K5I7"
FT   SITE            99
FT                   /note="RNA-binding"
FT                   /evidence="ECO:0000250|UniProtKB:D3K5I7"
FT   SITE            106
FT                   /note="RNA-binding"
FT                   /evidence="ECO:0000250|UniProtKB:D3K5I7"
SQ   SEQUENCE   246 AA;  27896 MW;  7ED416E06F3449F1 CRC64;
     MDEYQKIAVE FGEQAIDETV IQDWLQAFAY QGFDARTIIH NLVQLGGKSW EEDAKKMIIL
     SLTRGNKPKK MVERMSPEGA REVKSLVAKY KIVEGRPGRN GITLSRVLQP WLGGQSKLWK
     WLKTSYQSQG AQWTALCGQT YPRQMMHPSF AGLIDPSLDQ EDFNAVLDAH KLFLFMFSKT
     INVSLRGAQK RDIEESFSQP MLAAINSSFI DNTQRRAFLT KFGILTSGAR ATAVVKKIAE
     VYRKLE
//