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Protein

Cytochrome P450 2B10

Gene

Cyp2b10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi445Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2B10 (EC:1.14.14.1)
Alternative name(s):
CYPIIB10
CYPIIB20
Cytochrome P450 2B20
Cytochrome P450 clone PF3/46
Cytochrome P450-16-alpha
P24
Testosterone 16-alpha hydroxylase
Gene namesi
Name:Cyp2b10
Synonyms:Cyp2b-10, Cyp2b20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:88598. Cyp2b10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1907983.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516851 – 500Cytochrome P450 2B10Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei128Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP12791.
PaxDbiP12791.
PeptideAtlasiP12791.
PRIDEiP12791.

PTM databases

iPTMnetiP12791.
PhosphoSitePlusiP12791.

Expressioni

Inductioni

Up-regulated by cannabidiol.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072264.

Structurei

3D structure databases

ProteinModelPortaliP12791.
SMRiP12791.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP12791.
PhylomeDBiP12791.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P12791-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPSVLLLLA LLVGFLLLLA RGHPKSRGNF PPGPRPLPLL GNLLQMDRGG
60 70 80 90 100
LLKSLIQLRE KYGDVFTVHL GPRPVVMLCG TDTIREALVG QAEAFSGRGT
110 120 130 140 150
VAVVEPTFKE YGVIFANGER WKTLRRFSLA TMRDFGMGKR SVEERIQEEA
160 170 180 190 200
QCLVEELRKS QGAPLDPTFL FQCITANVIC SIVFGERFEY TDRQFLRLLE
210 220 230 240 250
LFYQTFSLIS SFSSQMFELF SGFLKYFPGA HRQISKNLQE LLDYIGHSVE
260 270 280 290 300
RHKATLDPSV PRDFIDIYLL RMEKEKSNQN AEFHHQNLMM SVLSLFFVGT
310 320 330 340 350
ETSSTTLHYG FLLMLKYPHV TEKVQKEIDQ VIGSHRLPTL DDRTKMPYSD
360 370 380 390 400
AVIHEIQRFS DLIPIGVPHR VTKDTLFRGY LLPKNTEVYP ILSSALHDPQ
410 420 430 440 450
YFEQPDSFNP DQFLDANGAL KKSEAFLPFS TGQIFDQKSV GKRICLGESI
460 470 480 490 500
ARSELFLFFT SILQNFSVAS HVAPKDIDLT PKESGIGKIP PTYQICFLAR
Length:500
Mass (Da):56,744
Last modified:October 1, 1989 - v1
Checksum:iF660A00D8D0FBA94
GO
Isoform 2 (identifier: P12791-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     433-441: Missing.

Show »
Length:491
Mass (Da):55,740
Checksum:iB4C7AAE1435FC7C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55L → F in CAA68051 (PubMed:8831708).Curated1
Sequence conflicti178V → I in CAA68051 (PubMed:8831708).Curated1
Sequence conflicti251 – 253RHK → KHR in CAA68051 (PubMed:8831708).Curated3
Sequence conflicti280 – 281NA → HT in CAA68051 (PubMed:8831708).Curated2
Sequence conflicti298V → A in CAA68051 (PubMed:8831708).Curated1
Sequence conflicti308H → R in CAA68051 (PubMed:8831708).Curated1
Sequence conflicti321T → A in CAA68051 (PubMed:8831708).Curated1
Sequence conflicti349S → T in CAA68051 (PubMed:8831708).Curated1
Sequence conflicti376L → M in CAA68051 (PubMed:8831708).Curated1
Sequence conflicti412Q → H in CAA68051 (PubMed:8831708).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022500433 – 441Missing in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21856 mRNA. Translation: AAA40425.1.
X99715 mRNA. Translation: CAA68051.1. Sequence problems.
CCDSiCCDS20999.1. [P12791-2]
PIRiB31047.
UniGeneiMm.218749.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21856 mRNA. Translation: AAA40425.1.
X99715 mRNA. Translation: CAA68051.1. Sequence problems.
CCDSiCCDS20999.1. [P12791-2]
PIRiB31047.
UniGeneiMm.218749.

3D structure databases

ProteinModelPortaliP12791.
SMRiP12791.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072264.

Chemistry databases

ChEMBLiCHEMBL1907983.

PTM databases

iPTMnetiP12791.
PhosphoSitePlusiP12791.

Proteomic databases

MaxQBiP12791.
PaxDbiP12791.
PeptideAtlasiP12791.
PRIDEiP12791.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:88598. Cyp2b10.

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP12791.
PhylomeDBiP12791.

Miscellaneous databases

ChiTaRSiCyp2b10. mouse.
PROiP12791.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCP2BA_MOUSE
AccessioniPrimary (citable) accession number: P12791
Secondary accession number(s): Q62397
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.