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Protein

Cytochrome P450 2B10

Gene

Cyp2b10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi445Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2B10 (EC:1.14.14.1)
Alternative name(s):
CYPIIB10
CYPIIB20
Cytochrome P450 2B20
Cytochrome P450 clone PF3/46
Cytochrome P450-16-alpha
P24
Testosterone 16-alpha hydroxylase
Gene namesi
Name:Cyp2b10
Synonyms:Cyp2b-10, Cyp2b20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:88598 Cyp2b10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1907983

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516851 – 500Cytochrome P450 2B10Add BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei128Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP12791
PaxDbiP12791
PeptideAtlasiP12791
PRIDEiP12791

PTM databases

iPTMnetiP12791
PhosphoSitePlusiP12791
SwissPalmiP12791

Expressioni

Inductioni

Up-regulated by cannabidiol.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072264

Structurei

3D structure databases

ProteinModelPortaliP12791
SMRiP12791
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156 Eukaryota
COG2124 LUCA
HOGENOMiHOG000036992
HOVERGENiHBG015789
InParanoidiP12791
PhylomeDBiP12791

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR002401 Cyt_P450_E_grp-I
IPR008068 Cyt_P450_E_grp-I_CYP2B-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01685 EP450ICYP2B
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P12791-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPSVLLLLA LLVGFLLLLA RGHPKSRGNF PPGPRPLPLL GNLLQMDRGG
60 70 80 90 100
LLKSLIQLRE KYGDVFTVHL GPRPVVMLCG TDTIREALVG QAEAFSGRGT
110 120 130 140 150
VAVVEPTFKE YGVIFANGER WKTLRRFSLA TMRDFGMGKR SVEERIQEEA
160 170 180 190 200
QCLVEELRKS QGAPLDPTFL FQCITANVIC SIVFGERFEY TDRQFLRLLE
210 220 230 240 250
LFYQTFSLIS SFSSQMFELF SGFLKYFPGA HRQISKNLQE LLDYIGHSVE
260 270 280 290 300
RHKATLDPSV PRDFIDIYLL RMEKEKSNQN AEFHHQNLMM SVLSLFFVGT
310 320 330 340 350
ETSSTTLHYG FLLMLKYPHV TEKVQKEIDQ VIGSHRLPTL DDRTKMPYSD
360 370 380 390 400
AVIHEIQRFS DLIPIGVPHR VTKDTLFRGY LLPKNTEVYP ILSSALHDPQ
410 420 430 440 450
YFEQPDSFNP DQFLDANGAL KKSEAFLPFS TGQIFDQKSV GKRICLGESI
460 470 480 490 500
ARSELFLFFT SILQNFSVAS HVAPKDIDLT PKESGIGKIP PTYQICFLAR
Length:500
Mass (Da):56,744
Last modified:October 1, 1989 - v1
Checksum:iF660A00D8D0FBA94
GO
Isoform 2 (identifier: P12791-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     433-441: Missing.

Show »
Length:491
Mass (Da):55,740
Checksum:iB4C7AAE1435FC7C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55L → F in CAA68051 (PubMed:8831708).Curated1
Sequence conflicti178V → I in CAA68051 (PubMed:8831708).Curated1
Sequence conflicti251 – 253RHK → KHR in CAA68051 (PubMed:8831708).Curated3
Sequence conflicti280 – 281NA → HT in CAA68051 (PubMed:8831708).Curated2
Sequence conflicti298V → A in CAA68051 (PubMed:8831708).Curated1
Sequence conflicti308H → R in CAA68051 (PubMed:8831708).Curated1
Sequence conflicti321T → A in CAA68051 (PubMed:8831708).Curated1
Sequence conflicti349S → T in CAA68051 (PubMed:8831708).Curated1
Sequence conflicti376L → M in CAA68051 (PubMed:8831708).Curated1
Sequence conflicti412Q → H in CAA68051 (PubMed:8831708).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022500433 – 441Missing in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21856 mRNA Translation: AAA40425.1
X99715 mRNA Translation: CAA68051.1 Sequence problems.
CCDSiCCDS20999.1 [P12791-2]
PIRiB31047
UniGeneiMm.218749

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCP2BA_MOUSE
AccessioniPrimary (citable) accession number: P12791
Secondary accession number(s): Q62397
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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