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P12790 (CP2B9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2B9

EC=1.14.14.1
Alternative name(s):
CYPIIB9
Cytochrome P450 clone PF26
Cytochrome P450-16-alpha
Testosterone 16-alpha hydroxylase
Gene names
Name:Cyp2b9
Synonyms:Cyp2b-9, Rip
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Cytochrome P450 2B9
PRO_0000051684

Sites

Metal binding4361Iron (heme axial ligand) By similarity

Amino acid modifications

Modified residue1281Phosphoserine; by PKA By similarity

Experimental info

Sequence conflict2981A → V in AAA40424. Ref.1
Sequence conflict4121H → Q in AAA40424. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P12790 [UniParc].

Last modified September 18, 2013. Version 2.
Checksum: C1E790A7DD1A7298

FASTA49155,741
        10         20         30         40         50         60 
MDPSVLLLLA VLLSLFLLLV RGHAKIHGHL PPGPHPLPLL GNLLQMDRGG LLKCFIQLQE 

        70         80         90        100        110        120 
KHGDVFTVHL GPRPVVVLCG TQTIREALVD HAEAFSGRGT IAAAQLVMQD YGIFFASGQR 

       130        140        150        160        170        180 
WKTLRRFSLA TMKEFGMGKR SVEERIKEEA QCLVEELKKY QGVPLDPTFL FQCITANIIC 

       190        200        210        220        230        240 
SIVFGERFDY TDDQFLHLLN LMYKIFSLLS SFSGQMFELF SGFLKYFPGV HRQIVKKQQE 

       250        260        270        280        290        300 
LLDYIAHSVE KHKATLDPSA PRDYIDTYLL RMEKEKSNHN TEFHHQNLMM SVLSLFFAGT 

       310        320        330        340        350        360 
ETTSATLHYG VLLMLKYPHV TEKVQKEIDQ VIGSHRLPTL DDRTKMPYTD AVIHEIQRFS 

       370        380        390        400        410        420 
DLVPIGLPHK VIKDTLFRGY LLPKNTEVYP VLSSALHDPQ YFEQPDKFNP EHFLDANGAL 

       430        440        450        460        470        480 
KKCEAFLPFS TGKRICLGES IARNELFIFF TTILQNFSVA SPVAPKDIDL TPKESGIGKI 

       490 
PPAHQIYFLA R 

« Hide

References

« Hide 'large scale' references
[1]"Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA."
Noshiro M., Lakso M., Kawajiri K., Negishi M.
Biochemistry 27:6434-6443(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[2]"Structures and characterization of sex-specific mouse cytochrome P-450 genes as members within a large family. Duplication boundary and evolution."
Lakso M., Masaki R., Noshiro M., Negishi M.
Eur. J. Biochem. 195:477-486(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M21855 mRNA. Translation: AAA40424.1.
M60273 expand/collapse EMBL AC list , M60267, M60268, M60269, M60270, M60271, M60272 Genomic DNA. Translation: AAA03648.1.
AC157782 Genomic DNA. No translation available.
BC120525 mRNA. Translation: AAI20526.1.
BC120527 mRNA. Translation: AAI20528.1.
CCDSCCDS21001.1.
PIRA31047.
I84735.
RefSeqNP_034130.1. NM_010000.2.
UniGeneMm.14413.

3D structure databases

ProteinModelPortalP12790.
SMRP12790. Positions 28-491.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP12790. 1 interaction.
STRING10090.ENSMUSP00000080846.

PTM databases

PhosphoSiteP12790.

Proteomic databases

PaxDbP12790.
PRIDEP12790.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000082214; ENSMUSP00000080846; ENSMUSG00000040660.
GeneID13094.
KEGGmmu:13094.
UCSCuc009fuh.1. mouse.

Organism-specific databases

CTD13094.
MGIMGI:88600. Cyp2b9.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00670000097868.
HOGENOMHOG000036992.
HOVERGENHBG015789.
InParanoidP12790.
KOK07412.
OMASCHEWIL.
OrthoDBEOG77M8NM.
TreeFamTF352043.

Gene expression databases

GenevestigatorP12790.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio283070.
PROP12790.
SOURCESearch...

Entry information

Entry nameCP2B9_MOUSE
AccessionPrimary (citable) accession number: P12790
Secondary accession number(s): Q64463
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: September 18, 2013
Last modified: July 9, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot