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P12790

- CP2B9_MOUSE

UniProt

P12790 - CP2B9_MOUSE

Protein

Cytochrome P450 2B9

Gene

Cyp2b9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (18 Sep 2013)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi436 – 4361Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. response to stilbenoid Source: UniProtKB

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2B9 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIB9
    Cytochrome P450 clone PF26
    Cytochrome P450-16-alpha
    Testosterone 16-alpha hydroxylase
    Gene namesi
    Name:Cyp2b9
    Synonyms:Cyp2b-9, Rip
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:88600. Cyp2b9.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Cytochrome P450 2B9PRO_0000051684Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei128 – 1281Phosphoserine; by PKABy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP12790.
    PRIDEiP12790.

    PTM databases

    PhosphoSiteiP12790.

    Expressioni

    Gene expression databases

    GenevestigatoriP12790.

    Interactioni

    Protein-protein interaction databases

    IntActiP12790. 1 interaction.
    STRINGi10090.ENSMUSP00000080846.

    Structurei

    3D structure databases

    ProteinModelPortaliP12790.
    SMRiP12790. Positions 28-491.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00670000097868.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    InParanoidiP12790.
    KOiK07412.
    OMAiSCHEWIL.
    OrthoDBiEOG77M8NM.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01685. EP450ICYP2B.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P12790-1 [UniParc]FASTAAdd to Basket

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    MDPSVLLLLA VLLSLFLLLV RGHAKIHGHL PPGPHPLPLL GNLLQMDRGG    50
    LLKCFIQLQE KHGDVFTVHL GPRPVVVLCG TQTIREALVD HAEAFSGRGT 100
    IAAAQLVMQD YGIFFASGQR WKTLRRFSLA TMKEFGMGKR SVEERIKEEA 150
    QCLVEELKKY QGVPLDPTFL FQCITANIIC SIVFGERFDY TDDQFLHLLN 200
    LMYKIFSLLS SFSGQMFELF SGFLKYFPGV HRQIVKKQQE LLDYIAHSVE 250
    KHKATLDPSA PRDYIDTYLL RMEKEKSNHN TEFHHQNLMM SVLSLFFAGT 300
    ETTSATLHYG VLLMLKYPHV TEKVQKEIDQ VIGSHRLPTL DDRTKMPYTD 350
    AVIHEIQRFS DLVPIGLPHK VIKDTLFRGY LLPKNTEVYP VLSSALHDPQ 400
    YFEQPDKFNP EHFLDANGAL KKCEAFLPFS TGKRICLGES IARNELFIFF 450
    TTILQNFSVA SPVAPKDIDL TPKESGIGKI PPAHQIYFLA R 491
    Length:491
    Mass (Da):55,741
    Last modified:September 18, 2013 - v2
    Checksum:iC1E790A7DD1A7298
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti298 – 2981A → V in AAA40424. (PubMed:3219345)Curated
    Sequence conflicti412 – 4121H → Q in AAA40424. (PubMed:3219345)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21855 mRNA. Translation: AAA40424.1.
    M60273
    , M60267, M60268, M60269, M60270, M60271, M60272 Genomic DNA. Translation: AAA03648.1.
    AC157782 Genomic DNA. No translation available.
    BC120525 mRNA. Translation: AAI20526.1.
    BC120527 mRNA. Translation: AAI20528.1.
    CCDSiCCDS21001.1.
    PIRiA31047.
    I84735.
    RefSeqiNP_034130.1. NM_010000.2.
    UniGeneiMm.14413.

    Genome annotation databases

    EnsembliENSMUST00000082214; ENSMUSP00000080846; ENSMUSG00000040660.
    GeneIDi13094.
    KEGGimmu:13094.
    UCSCiuc009fuh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M21855 mRNA. Translation: AAA40424.1 .
    M60273
    , M60267 , M60268 , M60269 , M60270 , M60271 , M60272 Genomic DNA. Translation: AAA03648.1 .
    AC157782 Genomic DNA. No translation available.
    BC120525 mRNA. Translation: AAI20526.1 .
    BC120527 mRNA. Translation: AAI20528.1 .
    CCDSi CCDS21001.1.
    PIRi A31047.
    I84735.
    RefSeqi NP_034130.1. NM_010000.2.
    UniGenei Mm.14413.

    3D structure databases

    ProteinModelPortali P12790.
    SMRi P12790. Positions 28-491.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P12790. 1 interaction.
    STRINGi 10090.ENSMUSP00000080846.

    PTM databases

    PhosphoSitei P12790.

    Proteomic databases

    PaxDbi P12790.
    PRIDEi P12790.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000082214 ; ENSMUSP00000080846 ; ENSMUSG00000040660 .
    GeneIDi 13094.
    KEGGi mmu:13094.
    UCSCi uc009fuh.1. mouse.

    Organism-specific databases

    CTDi 13094.
    MGIi MGI:88600. Cyp2b9.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00670000097868.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    InParanoidi P12790.
    KOi K07412.
    OMAi SCHEWIL.
    OrthoDBi EOG77M8NM.
    TreeFami TF352043.

    Miscellaneous databases

    NextBioi 283070.
    PROi P12790.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P12790.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01685. EP450ICYP2B.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA."
      Noshiro M., Lakso M., Kawajiri K., Negishi M.
      Biochemistry 27:6434-6443(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Structures and characterization of sex-specific mouse cytochrome P-450 genes as members within a large family. Duplication boundary and evolution."
      Lakso M., Masaki R., Noshiro M., Negishi M.
      Eur. J. Biochem. 195:477-486(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCP2B9_MOUSE
    AccessioniPrimary (citable) accession number: P12790
    Secondary accession number(s): Q64463
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: September 18, 2013
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3