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P12790

- CP2B9_MOUSE

UniProt

P12790 - CP2B9_MOUSE

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Protein

Cytochrome P450 2B9

Gene

Cyp2b9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi436 – 4361Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. response to stilbenoid Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2B9 (EC:1.14.14.1)
Alternative name(s):
CYPIIB9
Cytochrome P450 clone PF26
Cytochrome P450-16-alpha
Testosterone 16-alpha hydroxylase
Gene namesi
Name:Cyp2b9
Synonyms:Cyp2b-9, Rip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:88600. Cyp2b9.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Cytochrome P450 2B9PRO_0000051684Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei128 – 1281Phosphoserine; by PKABy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP12790.
PRIDEiP12790.

PTM databases

PhosphoSiteiP12790.

Expressioni

Gene expression databases

ExpressionAtlasiP12790. baseline and differential.
GenevestigatoriP12790.

Interactioni

Protein-protein interaction databases

IntActiP12790. 1 interaction.
STRINGi10090.ENSMUSP00000080846.

Structurei

3D structure databases

ProteinModelPortaliP12790.
SMRiP12790. Positions 28-491.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP12790.
KOiK07412.
OMAiSCHEWIL.
OrthoDBiEOG77M8NM.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12790-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPSVLLLLA VLLSLFLLLV RGHAKIHGHL PPGPHPLPLL GNLLQMDRGG
60 70 80 90 100
LLKCFIQLQE KHGDVFTVHL GPRPVVVLCG TQTIREALVD HAEAFSGRGT
110 120 130 140 150
IAAAQLVMQD YGIFFASGQR WKTLRRFSLA TMKEFGMGKR SVEERIKEEA
160 170 180 190 200
QCLVEELKKY QGVPLDPTFL FQCITANIIC SIVFGERFDY TDDQFLHLLN
210 220 230 240 250
LMYKIFSLLS SFSGQMFELF SGFLKYFPGV HRQIVKKQQE LLDYIAHSVE
260 270 280 290 300
KHKATLDPSA PRDYIDTYLL RMEKEKSNHN TEFHHQNLMM SVLSLFFAGT
310 320 330 340 350
ETTSATLHYG VLLMLKYPHV TEKVQKEIDQ VIGSHRLPTL DDRTKMPYTD
360 370 380 390 400
AVIHEIQRFS DLVPIGLPHK VIKDTLFRGY LLPKNTEVYP VLSSALHDPQ
410 420 430 440 450
YFEQPDKFNP EHFLDANGAL KKCEAFLPFS TGKRICLGES IARNELFIFF
460 470 480 490
TTILQNFSVA SPVAPKDIDL TPKESGIGKI PPAHQIYFLA R
Length:491
Mass (Da):55,741
Last modified:September 18, 2013 - v2
Checksum:iC1E790A7DD1A7298
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti298 – 2981A → V in AAA40424. (PubMed:3219345)Curated
Sequence conflicti412 – 4121H → Q in AAA40424. (PubMed:3219345)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21855 mRNA. Translation: AAA40424.1.
M60273
, M60267, M60268, M60269, M60270, M60271, M60272 Genomic DNA. Translation: AAA03648.1.
AC157782 Genomic DNA. No translation available.
BC120525 mRNA. Translation: AAI20526.1.
BC120527 mRNA. Translation: AAI20528.1.
CCDSiCCDS21001.1.
PIRiA31047.
I84735.
RefSeqiNP_034130.1. NM_010000.2.
UniGeneiMm.14413.

Genome annotation databases

EnsembliENSMUST00000082214; ENSMUSP00000080846; ENSMUSG00000040660.
GeneIDi13094.
KEGGimmu:13094.
UCSCiuc009fuh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M21855 mRNA. Translation: AAA40424.1 .
M60273
, M60267 , M60268 , M60269 , M60270 , M60271 , M60272 Genomic DNA. Translation: AAA03648.1 .
AC157782 Genomic DNA. No translation available.
BC120525 mRNA. Translation: AAI20526.1 .
BC120527 mRNA. Translation: AAI20528.1 .
CCDSi CCDS21001.1.
PIRi A31047.
I84735.
RefSeqi NP_034130.1. NM_010000.2.
UniGenei Mm.14413.

3D structure databases

ProteinModelPortali P12790.
SMRi P12790. Positions 28-491.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P12790. 1 interaction.
STRINGi 10090.ENSMUSP00000080846.

Chemistry

DrugBanki DB08834. Tauroursodeoxycholic acid.

PTM databases

PhosphoSitei P12790.

Proteomic databases

PaxDbi P12790.
PRIDEi P12790.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000082214 ; ENSMUSP00000080846 ; ENSMUSG00000040660 .
GeneIDi 13094.
KEGGi mmu:13094.
UCSCi uc009fuh.1. mouse.

Organism-specific databases

CTDi 13094.
MGIi MGI:88600. Cyp2b9.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118775.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi P12790.
KOi K07412.
OMAi SCHEWIL.
OrthoDBi EOG77M8NM.
TreeFami TF352043.

Miscellaneous databases

NextBioi 283070.
PROi P12790.
SOURCEi Search...

Gene expression databases

ExpressionAtlasi P12790. baseline and differential.
Genevestigatori P12790.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA."
    Noshiro M., Lakso M., Kawajiri K., Negishi M.
    Biochemistry 27:6434-6443(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Structures and characterization of sex-specific mouse cytochrome P-450 genes as members within a large family. Duplication boundary and evolution."
    Lakso M., Masaki R., Noshiro M., Negishi M.
    Eur. J. Biochem. 195:477-486(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCP2B9_MOUSE
AccessioniPrimary (citable) accession number: P12790
Secondary accession number(s): Q64463
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: September 18, 2013
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3