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P12789

- CP2B5_RABIT

UniProt

P12789 - CP2B5_RABIT

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Protein
Cytochrome P450 2B5
Gene
CYP2B5
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi436 – 4361Iron (heme axial ligand)

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2B5 (EC:1.14.14.1)
Alternative name(s):
CYPIIB5
Cytochrome P450 form HP1
Cytochrome P450 type B2
Gene namesi
Name:CYP2B5
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Cytochrome P450 2B5
PRO_0000051682Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei128 – 1281Phosphoserine; by PKA By similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

By phenobarbital.

Structurei

3D structure databases

ProteinModelPortaliP12789.
SMRiP12789. Positions 28-491.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

eggNOGiCOG2124.
HOVERGENiHBG015789.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12789-1 [UniParc]FASTAAdd to Basket

« Hide

MEFSLLLLLA FLAGLLLLLF RGHPKAHGRL PPGPPPLPVL GNLLQMDRKG    50
LLRSFLRLRE KYGDVFTVYL GSRPVVVLCG TDAIREALVD QAEAFSGRGK 100
IAVVDPIFQG YGVFFANGEH WRALRRFSLA TMRDFGMGKR SVEERIQEEA 150
RCLVEELRKS KGALLDNTLL FHSVTSNIIC SIVFGKRFDY KDPVFLRLLD 200
LFFQSFSLIS SFSSQVFELF PGFLKHFPGT HRQIYRNLQE INTFIGQTVE 250
KHRATLDPSN PRDFIDVYLL RMEKDKSDPS SEFHHRNLIL TVLTLFFAGT 300
ETTSTTLRYG FLLMLKYPHV TERVQKEIEQ VIGSHRPPAL DDRAKMPYTD 350
AVIHEIQRLG DLVPFGAPHM VTKDTQFRGY VIPKNTEVFP VLSSALHDPR 400
YFETPNTFNP GHFLDADGAL KRNEGFMPFS LGKRICLGEG IARTELFLFF 450
TTILQNFSIA SPVPPEDIDL TPRESGVGNV PPSYQIRFLA R 491
Length:491
Mass (Da):55,770
Last modified:October 1, 1989 - v1
Checksum:iABE2B978B8408DCF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M20855 mRNA. Translation: AAA31223.1.
S78830 mRNA. Translation: AAB35177.1.
PIRiD27717.
S31278.
RefSeqiNP_001164601.1. NM_001171130.1.
UniGeneiOcu.6935.

Genome annotation databases

GeneIDi100328947.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M20855 mRNA. Translation: AAA31223.1 .
S78830 mRNA. Translation: AAB35177.1 .
PIRi D27717.
S31278.
RefSeqi NP_001164601.1. NM_001171130.1.
UniGenei Ocu.6935.

3D structure databases

ProteinModelPortali P12789.
SMRi P12789. Positions 28-491.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100328947.

Organism-specific databases

CTDi 100328947.

Phylogenomic databases

eggNOGi COG2124.
HOVERGENi HBG015789.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary structures of multiple forms of cytochrome P-450 isozyme 2 derived from rabbit pulmonary and hepatic cDNAs."
    Gasser R., Negishi M., Philpot R.M.
    Mol. Pharmacol. 33:22-30(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Rabbit liver cytochrome P-450 2B5: high-level expression of the full-length protein in Escherichia coli, purification, and catalytic activity."
    Lehnerer M., Schulze J., Petzold A., Bernhardt R., Hlavica P.
    Biochim. Biophys. Acta 1245:107-115(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-56.

Entry informationi

Entry nameiCP2B5_RABIT
AccessioniPrimary (citable) accession number: P12789
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: December 11, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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