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P12789 (CP2B5_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2B5

EC=1.14.14.1
Alternative name(s):
CYPIIB5
Cytochrome P450 form HP1
Cytochrome P450 type B2
Gene names
Name:CYP2B5
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By phenobarbital.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Cytochrome P450 2B5
PRO_0000051682

Sites

Metal binding4361Iron (heme axial ligand)

Amino acid modifications

Modified residue1281Phosphoserine; by PKA By similarity

Sequences

Sequence LengthMass (Da)Tools
P12789 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: ABE2B978B8408DCF

FASTA49155,770
        10         20         30         40         50         60 
MEFSLLLLLA FLAGLLLLLF RGHPKAHGRL PPGPPPLPVL GNLLQMDRKG LLRSFLRLRE 

        70         80         90        100        110        120 
KYGDVFTVYL GSRPVVVLCG TDAIREALVD QAEAFSGRGK IAVVDPIFQG YGVFFANGEH 

       130        140        150        160        170        180 
WRALRRFSLA TMRDFGMGKR SVEERIQEEA RCLVEELRKS KGALLDNTLL FHSVTSNIIC 

       190        200        210        220        230        240 
SIVFGKRFDY KDPVFLRLLD LFFQSFSLIS SFSSQVFELF PGFLKHFPGT HRQIYRNLQE 

       250        260        270        280        290        300 
INTFIGQTVE KHRATLDPSN PRDFIDVYLL RMEKDKSDPS SEFHHRNLIL TVLTLFFAGT 

       310        320        330        340        350        360 
ETTSTTLRYG FLLMLKYPHV TERVQKEIEQ VIGSHRPPAL DDRAKMPYTD AVIHEIQRLG 

       370        380        390        400        410        420 
DLVPFGAPHM VTKDTQFRGY VIPKNTEVFP VLSSALHDPR YFETPNTFNP GHFLDADGAL 

       430        440        450        460        470        480 
KRNEGFMPFS LGKRICLGEG IARTELFLFF TTILQNFSIA SPVPPEDIDL TPRESGVGNV 

       490 
PPSYQIRFLA R 

« Hide

References

[1]"Primary structures of multiple forms of cytochrome P-450 isozyme 2 derived from rabbit pulmonary and hepatic cDNAs."
Gasser R., Negishi M., Philpot R.M.
Mol. Pharmacol. 33:22-30(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Rabbit liver cytochrome P-450 2B5: high-level expression of the full-length protein in Escherichia coli, purification, and catalytic activity."
Lehnerer M., Schulze J., Petzold A., Bernhardt R., Hlavica P.
Biochim. Biophys. Acta 1245:107-115(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-56.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M20855 mRNA. Translation: AAA31223.1.
S78830 mRNA. Translation: AAB35177.1.
PIRD27717.
S31278.
RefSeqNP_001164601.1. NM_001171130.1.
UniGeneOcu.6935.

3D structure databases

ProteinModelPortalP12789.
SMRP12789. Positions 28-491.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100328947.

Organism-specific databases

CTD100328947.

Phylogenomic databases

eggNOGCOG2124.
HOVERGENHBG015789.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2B5_RABIT
AccessionPrimary (citable) accession number: P12789
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: December 11, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families