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Protein

Cytochrome P450 2B5

Gene

CYP2B5

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi436Iron (heme axial ligand)1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2B5 (EC:1.14.14.1)
Alternative name(s):
CYPIIB5
Cytochrome P450 form HP1
Cytochrome P450 type B2
Gene namesi
Name:CYP2B5
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000516821 – 491Cytochrome P450 2B5Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei128Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

By phenobarbital.

Structurei

3D structure databases

ProteinModelPortaliP12789.
SMRiP12789.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
HOVERGENiHBG015789.
InParanoidiP12789.
KOiK07412.

Family and domain databases

InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

P12789-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFSLLLLLA FLAGLLLLLF RGHPKAHGRL PPGPPPLPVL GNLLQMDRKG
60 70 80 90 100
LLRSFLRLRE KYGDVFTVYL GSRPVVVLCG TDAIREALVD QAEAFSGRGK
110 120 130 140 150
IAVVDPIFQG YGVFFANGEH WRALRRFSLA TMRDFGMGKR SVEERIQEEA
160 170 180 190 200
RCLVEELRKS KGALLDNTLL FHSVTSNIIC SIVFGKRFDY KDPVFLRLLD
210 220 230 240 250
LFFQSFSLIS SFSSQVFELF PGFLKHFPGT HRQIYRNLQE INTFIGQTVE
260 270 280 290 300
KHRATLDPSN PRDFIDVYLL RMEKDKSDPS SEFHHRNLIL TVLTLFFAGT
310 320 330 340 350
ETTSTTLRYG FLLMLKYPHV TERVQKEIEQ VIGSHRPPAL DDRAKMPYTD
360 370 380 390 400
AVIHEIQRLG DLVPFGAPHM VTKDTQFRGY VIPKNTEVFP VLSSALHDPR
410 420 430 440 450
YFETPNTFNP GHFLDADGAL KRNEGFMPFS LGKRICLGEG IARTELFLFF
460 470 480 490
TTILQNFSIA SPVPPEDIDL TPRESGVGNV PPSYQIRFLA R
Length:491
Mass (Da):55,770
Last modified:October 1, 1989 - v1
Checksum:iABE2B978B8408DCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20855 mRNA. Translation: AAA31223.1.
S78830 mRNA. Translation: AAB35177.1.
PIRiD27717.
S31278.
RefSeqiNP_001164601.1. NM_001171130.1.
UniGeneiOcu.1858.
Ocu.6935.
Ocu.7479.

Genome annotation databases

GeneIDi100328947.
KEGGiocu:100328947.

Similar proteinsi

Entry informationi

Entry nameiCP2B5_RABIT
AccessioniPrimary (citable) accession number: P12789
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: August 30, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families