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P12788

- TRY4_RAT

UniProt

P12788 - TRY4_RAT

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Protein

Trypsin-4

Gene

Try4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactori

Ca2+By similarityNote: Binds 1 Ca(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641Charge relay systemBy similarity
Metal bindingi76 – 761CalciumBy similarity
Metal bindingi78 – 781Calcium; via carbonyl oxygenBy similarity
Metal bindingi81 – 811Calcium; via carbonyl oxygenBy similarity
Metal bindingi86 – 861CalciumBy similarity
Active sitei108 – 1081Charge relay systemBy similarity
Sitei195 – 1951Required for specificityBy similarity
Active sitei201 – 2011Charge relay systemBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. digestion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Keywords - Ligandi

Calcium, Metal-binding

Protein family/group databases

MEROPSiS01.183.

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin-4 (EC:3.4.21.4)
Alternative name(s):
Pretrypsinogen IV
Trypsin IV
Gene namesi
Name:Try4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi708585. LOC286960.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Add
BLAST
Propeptidei16 – 238Activation peptidePRO_0000028213
Chaini24 – 247224Trypsin-4PRO_0000028214Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 161PROSITE-ProRule annotation
Disulfide bondi49 ↔ 65PROSITE-ProRule annotation
Disulfide bondi133 ↔ 234PROSITE-ProRule annotation
Disulfide bondi140 ↔ 207PROSITE-ProRule annotation
Disulfide bondi172 ↔ 186PROSITE-ProRule annotation
Disulfide bondi197 ↔ 221PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiP12788.
PRIDEiP12788.

Expressioni

Inductioni

By CCK.

Gene expression databases

GenevestigatoriP12788.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017852.

Structurei

3D structure databases

ProteinModelPortaliP12788.
SMRiP12788. Positions 24-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 245222Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
GeneTreeiENSGT00760000118862.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP12788.
KOiK01312.
OMAiWIQETIT.
OrthoDBiEOG75B84T.
PhylomeDBiP12788.
TreeFamiTF331065.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12788-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKISIFFAFL GAAVALPVND DDKIVGGYTC PKHLVPYQVS LHDGISHQCG
60 70 80 90 100
GSLISDQWVL SAAHCYKRKL QVRLGEHNIH VLEGGEQFID AEKIIRHPEY
110 120 130 140 150
NKDTLDNDIM LIKLKSPAVL NSQVSTVSLP RSCASTDAQC LVSGWGNTVS
160 170 180 190 200
IGGKYPALLQ CLEAPVLSAS SCKKSYPGQI TSNMFCLGFL EGGKDSCDGD
210 220 230 240
SGGPVVCNGE IQGIVSWGSV CAMRGKPGVY TKVCNYLSWI QETMANN
Length:247
Mass (Da):26,573
Last modified:October 1, 1989 - v1
Checksum:iAE987B9D32D58F93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15679 mRNA. Translation: CAA33718.1.
PIRiS05494.
RefSeqiNP_775423.1. NM_173301.1.
UniGeneiRn.10387.

Genome annotation databases

EnsembliENSRNOT00000017852; ENSRNOP00000017852; ENSRNOG00000013245.
GeneIDi286960.
KEGGirno:286960.
UCSCiRGD:708585. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15679 mRNA. Translation: CAA33718.1 .
PIRi S05494.
RefSeqi NP_775423.1. NM_173301.1.
UniGenei Rn.10387.

3D structure databases

ProteinModelPortali P12788.
SMRi P12788. Positions 24-247.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000017852.

Protein family/group databases

MEROPSi S01.183.

Proteomic databases

PaxDbi P12788.
PRIDEi P12788.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000017852 ; ENSRNOP00000017852 ; ENSRNOG00000013245 .
GeneIDi 286960.
KEGGi rno:286960.
UCSCi RGD:708585. rat.

Organism-specific databases

RGDi 708585. LOC286960.

Phylogenomic databases

eggNOGi COG5640.
GeneTreei ENSGT00760000118862.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P12788.
KOi K01312.
OMAi WIQETIT.
OrthoDBi EOG75B84T.
PhylomeDBi P12788.
TreeFami TF331065.

Miscellaneous databases

NextBioi 625158.

Gene expression databases

Genevestigatori P12788.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A fourth trypsinogen (P23) in the rat pancreas induced by CCK."
    Luetcke H.A., Rausch U., Vasiloudes P., Scheele G.A., Kern H.F.
    Nucleic Acids Res. 17:6736-6736(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Pancreas.

Entry informationi

Entry nameiTRY4_RAT
AccessioniPrimary (citable) accession number: P12788
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 26, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3