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P12788

- TRY4_RAT

UniProt

P12788 - TRY4_RAT

Protein

Trypsin-4

Gene

Try4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei64 – 641Charge relay systemBy similarity
    Metal bindingi76 – 761CalciumBy similarity
    Metal bindingi78 – 781Calcium; via carbonyl oxygenBy similarity
    Metal bindingi81 – 811Calcium; via carbonyl oxygenBy similarity
    Metal bindingi86 – 861CalciumBy similarity
    Active sitei108 – 1081Charge relay systemBy similarity
    Sitei195 – 1951Required for specificityBy similarity
    Active sitei201 – 2011Charge relay systemBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. digestion Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Digestion

    Keywords - Ligandi

    Calcium, Metal-binding

    Protein family/group databases

    MEROPSiS01.183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trypsin-4 (EC:3.4.21.4)
    Alternative name(s):
    Pretrypsinogen IV
    Trypsin IV
    Gene namesi
    Name:Try4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi708585. LOC286960.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Add
    BLAST
    Propeptidei16 – 238Activation peptidePRO_0000028213
    Chaini24 – 247224Trypsin-4PRO_0000028214Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 161PROSITE-ProRule annotation
    Disulfide bondi49 ↔ 65PROSITE-ProRule annotation
    Disulfide bondi133 ↔ 234PROSITE-ProRule annotation
    Disulfide bondi140 ↔ 207PROSITE-ProRule annotation
    Disulfide bondi172 ↔ 186PROSITE-ProRule annotation
    Disulfide bondi197 ↔ 221PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Proteomic databases

    PaxDbiP12788.
    PRIDEiP12788.

    Expressioni

    Inductioni

    By CCK.

    Gene expression databases

    GenevestigatoriP12788.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000017852.

    Structurei

    3D structure databases

    ProteinModelPortaliP12788.
    SMRiP12788. Positions 24-247.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 245222Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00740000115192.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP12788.
    KOiK01312.
    OMAiWIQETIT.
    OrthoDBiEOG75B84T.
    PhylomeDBiP12788.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12788-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKISIFFAFL GAAVALPVND DDKIVGGYTC PKHLVPYQVS LHDGISHQCG    50
    GSLISDQWVL SAAHCYKRKL QVRLGEHNIH VLEGGEQFID AEKIIRHPEY 100
    NKDTLDNDIM LIKLKSPAVL NSQVSTVSLP RSCASTDAQC LVSGWGNTVS 150
    IGGKYPALLQ CLEAPVLSAS SCKKSYPGQI TSNMFCLGFL EGGKDSCDGD 200
    SGGPVVCNGE IQGIVSWGSV CAMRGKPGVY TKVCNYLSWI QETMANN 247
    Length:247
    Mass (Da):26,573
    Last modified:October 1, 1989 - v1
    Checksum:iAE987B9D32D58F93
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15679 mRNA. Translation: CAA33718.1.
    PIRiS05494.
    RefSeqiNP_775423.1. NM_173301.1.
    UniGeneiRn.10387.

    Genome annotation databases

    EnsembliENSRNOT00000017852; ENSRNOP00000017852; ENSRNOG00000013245.
    GeneIDi286960.
    KEGGirno:286960.
    UCSCiRGD:708585. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15679 mRNA. Translation: CAA33718.1 .
    PIRi S05494.
    RefSeqi NP_775423.1. NM_173301.1.
    UniGenei Rn.10387.

    3D structure databases

    ProteinModelPortali P12788.
    SMRi P12788. Positions 24-247.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000017852.

    Protein family/group databases

    MEROPSi S01.183.

    Proteomic databases

    PaxDbi P12788.
    PRIDEi P12788.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000017852 ; ENSRNOP00000017852 ; ENSRNOG00000013245 .
    GeneIDi 286960.
    KEGGi rno:286960.
    UCSCi RGD:708585. rat.

    Organism-specific databases

    RGDi 708585. LOC286960.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00740000115192.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P12788.
    KOi K01312.
    OMAi WIQETIT.
    OrthoDBi EOG75B84T.
    PhylomeDBi P12788.
    TreeFami TF331065.

    Miscellaneous databases

    NextBioi 625158.

    Gene expression databases

    Genevestigatori P12788.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A fourth trypsinogen (P23) in the rat pancreas induced by CCK."
      Luetcke H.A., Rausch U., Vasiloudes P., Scheele G.A., Kern H.F.
      Nucleic Acids Res. 17:6736-6736(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Pancreas.

    Entry informationi

    Entry nameiTRY4_RAT
    AccessioniPrimary (citable) accession number: P12788
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3