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Protein

Cytochrome c oxidase subunit 5A, mitochondrial

Gene

Cox5a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-5628897. TP53 Regulates Metabolic Genes.
R-MMU-611105. Respiratory electron transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 5A, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide Va
Gene namesi
Name:Cox5a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88474. Cox5a.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
  • myelin sheath Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3737MitochondrionAdd
BLAST
Chaini38 – 146109Cytochrome c oxidase subunit 5A, mitochondrialPRO_0000006101Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831N6-acetyllysineCombined sources
Modified residuei109 – 1091N6-acetyllysineCombined sources
Modified residuei137 – 1371PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP12787.
MaxQBiP12787.
PaxDbiP12787.
PRIDEiP12787.
TopDownProteomicsiP12787.

2D gel databases

SWISS-2DPAGEP12787.
UCD-2DPAGEP12787.

PTM databases

iPTMnetiP12787.
PhosphoSiteiP12787.

Expressioni

Gene expression databases

BgeeiP12787.
CleanExiMM_COX5A.
GenevisibleiP12787. MM.

Interactioni

Protein-protein interaction databases

BioGridi198841. 4 interactions.
IntActiP12787. 6 interactions.
MINTiMINT-1839581.
STRINGi10090.ENSMUSP00000000090.

Structurei

3D structure databases

ProteinModelPortaliP12787.
SMRiP12787. Positions 42-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4077. Eukaryota.
ENOG4111MPD. LUCA.
GeneTreeiENSGT00390000001424.
HOGENOMiHOG000160656.
HOVERGENiHBG051088.
InParanoidiP12787.
KOiK02264.
OMAiSARCYSH.
OrthoDBiEOG74J99R.
PhylomeDBiP12787.
TreeFamiTF105062.

Family and domain databases

Gene3Di1.25.40.40. 1 hit.
InterProiIPR003204. Cyt_c_oxidase_su5A/6.
[Graphical view]
PANTHERiPTHR14200. PTHR14200. 1 hit.
PfamiPF02284. COX5A. 1 hit.
[Graphical view]
SUPFAMiSSF48479. SSF48479. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAAALRRCT AAAAARGLLH PASAPSPAAA VCSIRCYSHG SHETDEEFDA
60 70 80 90 100
RWVTYFNKPD IDAWELRKGM NTLVGYDLVP EPKIIDAALR ACRRLNDFAS
110 120 130 140
AVRILEVVKD KAGPHKEIYP YVIQELRPTL NELGISTPEE LGLDKV
Length:146
Mass (Da):16,101
Last modified:February 5, 2008 - v2
Checksum:i8F6AFF91B5C6160F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111Missing in CAA34085 (PubMed:2550898).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15963 mRNA. Translation: CAA34085.1.
AK018723 mRNA. Translation: BAB31369.1.
BC034302 mRNA. Translation: AAH34302.1.
CCDSiCCDS23223.1.
PIRiS05495.
RefSeqiNP_031773.2. NM_007747.2.
UniGeneiMm.273403.

Genome annotation databases

EnsembliENSMUST00000000090; ENSMUSP00000000090; ENSMUSG00000000088.
GeneIDi12858.
KEGGimmu:12858.
UCSCiuc009puz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15963 mRNA. Translation: CAA34085.1.
AK018723 mRNA. Translation: BAB31369.1.
BC034302 mRNA. Translation: AAH34302.1.
CCDSiCCDS23223.1.
PIRiS05495.
RefSeqiNP_031773.2. NM_007747.2.
UniGeneiMm.273403.

3D structure databases

ProteinModelPortaliP12787.
SMRiP12787. Positions 42-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198841. 4 interactions.
IntActiP12787. 6 interactions.
MINTiMINT-1839581.
STRINGi10090.ENSMUSP00000000090.

PTM databases

iPTMnetiP12787.
PhosphoSiteiP12787.

2D gel databases

SWISS-2DPAGEP12787.
UCD-2DPAGEP12787.

Proteomic databases

EPDiP12787.
MaxQBiP12787.
PaxDbiP12787.
PRIDEiP12787.
TopDownProteomicsiP12787.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000090; ENSMUSP00000000090; ENSMUSG00000000088.
GeneIDi12858.
KEGGimmu:12858.
UCSCiuc009puz.1. mouse.

Organism-specific databases

CTDi9377.
MGIiMGI:88474. Cox5a.

Phylogenomic databases

eggNOGiKOG4077. Eukaryota.
ENOG4111MPD. LUCA.
GeneTreeiENSGT00390000001424.
HOGENOMiHOG000160656.
HOVERGENiHBG051088.
InParanoidiP12787.
KOiK02264.
OMAiSARCYSH.
OrthoDBiEOG74J99R.
PhylomeDBiP12787.
TreeFamiTF105062.

Enzyme and pathway databases

ReactomeiR-MMU-5628897. TP53 Regulates Metabolic Genes.
R-MMU-611105. Respiratory electron transport.

Miscellaneous databases

NextBioi282416.
PROiP12787.
SOURCEiSearch...

Gene expression databases

BgeeiP12787.
CleanExiMM_COX5A.
GenevisibleiP12787. MM.

Family and domain databases

Gene3Di1.25.40.40. 1 hit.
InterProiIPR003204. Cyt_c_oxidase_su5A/6.
[Graphical view]
PANTHERiPTHR14200. PTHR14200. 1 hit.
PfamiPF02284. COX5A. 1 hit.
[Graphical view]
SUPFAMiSSF48479. SSF48479. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of cDNA encoding mouse cytochrome c oxidase subunit Va."
    Ayane M., Nielson P.J., Koehler G.
    Nucleic Acids Res. 17:6723-6723(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Bone marrow.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary tumor.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 69-83 AND 95-103, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  6. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-83 AND LYS-109, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCOX5A_MOUSE
AccessioniPrimary (citable) accession number: P12787
Secondary accession number(s): Q9D2W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: February 5, 2008
Last modified: May 11, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.