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P12786 (COX1_PEA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COX1
Synonyms:COXI
Encoded onMitochondrion
OrganismPisum sativum (Garden pea)
Taxonomic identifier3888 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeFabeaePisum

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 527527Cytochrome c oxidase subunit 1
PRO_0000183384

Regions

Transmembrane18 – 3821Helical; Potential
Transmembrane59 – 7921Helical; Potential
Transmembrane103 – 12321Helical; Potential
Transmembrane149 – 16921Helical; Potential
Transmembrane193 – 21321Helical; Potential
Transmembrane246 – 26621Helical; Potential
Transmembrane269 – 28921Helical; Potential
Transmembrane312 – 33221Helical; Potential
Transmembrane339 – 35921Helical; Potential
Transmembrane375 – 39521Helical; Potential
Transmembrane414 – 43421Helical; Potential
Transmembrane447 – 46721Helical; Potential

Sites

Metal binding641Iron (heme A axial ligand) Probable
Metal binding2431Copper B Probable
Metal binding2471Copper B Probable
Metal binding2921Copper B Probable
Metal binding2931Copper B Probable
Metal binding3781Iron (heme A3 axial ligand) Probable
Metal binding3801Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link243 ↔ 2471'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
P12786 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: B904E54385836CDE

FASTA52757,509
        10         20         30         40         50         60 
MTNPVRWLFS TNHKDIGTLY FIFGAIAGVM GTCFSVLIRM ELARPGDQIL GGNHQLYNVL 

        70         80         90        100        110        120 
ITAHAFFMIF FMVMPAMIGG SGNWSVPILI GAPDMAFPRL NNISFWLLPP SLLLLLSSAL 

       130        140        150        160        170        180 
VEVGSGTGWT VYPPLSGITS HSGGAVDSAI SSLHLSGVSS ILGSINFLTT ISNMRGPGMT 

       190        200        210        220        230        240 
MHRSPLFVWS VPVTAFPLLL SLPVLAGAIT MLLTDRNFNT TFSDPAGGGD PILYQHLFRF 

       250        260        270        280        290        300 
FGHPEVYIPI LPGSGIISHI VSTFSGKPVF GYLGMVYAMI SIGVLGFLVW AHHMFTVGLD 

       310        320        330        340        350        360 
VDTRAYFTAA TMIIAVPTGI KIFSWIATMW GGSIQYKTPM LFAVGFIFLF TIGGLTGIVP 

       370        380        390        400        410        420 
ANSGLDIALH DTYYVVAHFH YVLSMGAVFA LFAGFHYWVG KIFGRTYPET LGKIHFWITF 

       430        440        450        460        470        480 
FGVNLTLFPM HFLGLSGMPR RIPDYPDAYA GWNALSSFGS YISVVGIRRF FVVVTITSSS 

       490        500        510        520 
GNNITRANIP WAVEQNSTTL EWLVQSPPAF HTFGELPAIK ETKSYVK 

« Hide

References

[1]"Isolation and nucleotide sequence of the pea cytochrome oxidase subunit I gene."
Kemmerer E.C., Kao T., Deng G., Wu R.
Plant Mol. Biol. 13:121-124(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14409 Genomic DNA. Translation: CAA32581.1.
PIRS05290.

3D structure databases

ProteinModelPortalP12786.
SMRP12786. Positions 6-515.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_PEA
AccessionPrimary (citable) accession number: P12786
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways