P12784 (ACP_RHOSH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl carrier protein
Short name=ACP

Gene names

Name:

acpP

Organism

Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides)

Taxonomic identifier

1063 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length	70 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Carrier of the growing fatty acid chain in fatty acid biosynthesis. HAMAP MF_01217
Pathway	Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01217
Subcellular location	Cytoplasm By similarity HAMAP MF_01217.
Post-translational modification	4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group. HAMAP MF_01217
Sequence similarities	Contains 1 acyl carrier domain.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Ligand	Phosphopantetheine
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1 Ref.2
	Chain	2 – 70	69	Acyl carrier protein HAMAP MF_01217		PRO_0000180178
Amino acid modifications
	Modified residue	37	1	O-(pantetheine 4'-phosphoryl)serine HAMAP MF_01217

Sequences

	Sequence		Length	Mass (Da)
	P12784 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 43B91A72EFC4F936	FASTA	70	7,673
	10 20 30 40 50 60 MSDIADRVKK IVVEHLGVEE EKVTETTSFI DDLGADSLDT VELVMAFEEE FGIEIPDDAA 70 ETIQTFGDAP

References

[1]	"Isolation and characterization of the constitutive acyl carrier protein from Rhizobium meliloti." Platt M.K., Miller K.J., Lane W.S., Kennedy E.P. J. Bacteriol. 172:5440-5444(1990) [PubMed: 2144277] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-70.
[2]	"Purification and characterization of Rhodobacter sphaeroides acyl carrier protein." Cooper C.L., Boyce S.G., Lueking D.R. Biochemistry 26:2740-2746(1987) [PubMed: 3496918] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-47.
+	Additional computationally mapped references.

Cross-references

Sequence databases
PIR	B36728.
3D structure databases
ProteinModelPortal	P12784.
SMR	P12784. Positions 4-68.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_01217. Acyl_carrier. [Tree]
InterPro	IPR003231. Acyl_carrier. IPR009081. Acyl_carrier_prot-like. IPR006163. Phsphopanteth-bd. IPR006162. PPantetheine_attach_site. [Graphical view]
Gene3D	G3DSA:1.10.1200.10. ACP_like. 1 hit.
Pfam	PF00550. PP-binding. 1 hit. [Graphical view]
ProDom	PD000887. PD000887. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF47336. ACP_like. 1 hit.
TIGRFAMs	TIGR00517. Acyl_carrier. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 1 hit. PS00012. PHOSPHOPANTETHEINE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACP_RHOSH

Accession

Primary (citable) accession number: P12784

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	January 23, 2007
Last modified:	October 19, 2011
This is version 73 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program