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Protein

Phosphoglycerate kinase, cytosolic

Gene
N/A
Organism
Triticum aestivum (Wheat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase, cytosolic
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Pyruvate kinase, Pyruvate kinase, Pyruvate kinase (TRAES_3BF026900020CFD_c1), Pyruvate kinase, Pyruvate kinase (TRAES_3BF028500040CFD_c1), Pyruvate kinase, Pyruvate kinase, Pyruvate kinase, Pyruvate kinase, Pyruvate kinase, Pyruvate kinase
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41SubstrateBy similarity1
Binding sitei122SubstrateBy similarity1
Binding sitei155SubstrateBy similarity1
Binding sitei206ATPBy similarity1
Binding sitei297ATP; via carbonyl oxygenBy similarity1
Binding sitei328ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi357 – 360ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase, cytosolic (EC:2.7.2.3)
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeTriticinaeTriticum
Proteomesi
  • UP000019116 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001458721 – 401Phosphoglycerate kinase, cytosolicAdd BLAST401

Proteomic databases

PRIDEiP12783.

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP12783.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 27Substrate bindingBy similarity3
Regioni64 – 67Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12783-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKRSVGTL GEADLKGKKV FVRADLNVPL DDAQKITDDT RIRASIPTIK
60 70 80 90 100
YLLEKGAKVI LASHLGRPKG VTPKFSLKPL VARLSELLGL EVVMAPDCIG
110 120 130 140 150
EEVEKLAAAL PDGGVLLLEN VRFYKEEEKN DPEFAKKLAS VADLYVNDAF
160 170 180 190 200
GTAHRAHAST EGVTKFLRPS VAGFLMQKEL DYLVGAVANP KKPFAAIVGG
210 220 230 240 250
SKVSSKIGVI ESLLAKVDIL ILGGGMIFTF YKAQGLAVGK SLVEEDKLEL
260 270 280 290 300
ATSLIETAKS KGVKLLLPTD VVVADKFAAD AESKIVPATA IPDGWMGLDV
310 320 330 340 350
GPDSIKTFAE ALDTTKTVIW NGPMGVFEFE KFAAGTDAIA KQLAELTGKG
360 370 380 390 400
VTTIIGGGDS VAAVEKAGLA DKMSHISTGG GASLELLEGK PLPGVLALDE

A
Length:401
Mass (Da):42,122
Last modified:October 1, 1989 - v1
Checksum:iDF35346175CEB3F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15232 mRNA. Translation: CAA33302.1.
PIRiS05966. TVWTGY.
UniGeneiTa.54263.

Genome annotation databases

EnsemblPlantsiTRIAE_CS42_6BS_TGACv1_513938_AA1652520.2; TRIAE_CS42_6BS_TGACv1_513938_AA1652520.2; TRIAE_CS42_6BS_TGACv1_513938_AA1652520.
GrameneiTRIAE_CS42_6BS_TGACv1_513938_AA1652520.2; TRIAE_CS42_6BS_TGACv1_513938_AA1652520.2; TRIAE_CS42_6BS_TGACv1_513938_AA1652520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15232 mRNA. Translation: CAA33302.1.
PIRiS05966. TVWTGY.
UniGeneiTa.54263.

3D structure databases

ProteinModelPortaliP12783.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP12783.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiTRIAE_CS42_6BS_TGACv1_513938_AA1652520.2; TRIAE_CS42_6BS_TGACv1_513938_AA1652520.2; TRIAE_CS42_6BS_TGACv1_513938_AA1652520.
GrameneiTRIAE_CS42_6BS_TGACv1_513938_AA1652520.2; TRIAE_CS42_6BS_TGACv1_513938_AA1652520.2; TRIAE_CS42_6BS_TGACv1_513938_AA1652520.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGKY_WHEAT
AccessioniPrimary (citable) accession number: P12783
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: November 30, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.