ID   ALLS_DIPPU              Reviewed;         370 AA.
AC   P12764; P12765; P12766; P12767; P22410;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   21-SEP-2011, entry version 58.
DE   RecName: Full=Allatostatins;
DE   Contains:
DE     RecName: Full=Allatostatin-1;
DE              Short=AST1;
DE   Contains:
DE     RecName: Full=Allatostatin-2;
DE              Short=AST2;
DE     AltName: Full=ASA5;
DE     AltName: Full=ASB2;
DE   Contains:
DE     RecName: Full=Allatostatin-3;
DE              Short=AST3;
DE   Contains:
DE     RecName: Full=Allatostatin-4;
DE              Short=AST4;
DE     AltName: Full=ASA7;
DE   Contains:
DE     RecName: Full=Allatostatin-5;
DE              Short=AST5;
DE     AltName: Full=ASA4;
DE   Contains:
DE     RecName: Full=Allatostatin-6;
DE              Short=AST6;
DE   Contains:
DE     RecName: Full=Allatostatin-7;
DE              Short=AST7;
DE     AltName: Full=ASA1;
DE   Contains:
DE     RecName: Full=Allatostatin-8;
DE              Short=AST8;
DE     AltName: Full=ASA3;
DE   Contains:
DE     RecName: Full=Allatostatin-9;
DE              Short=AST9;
DE     AltName: Full=ASA2;
DE   Contains:
DE     RecName: Full=Allatostatin-10;
DE              Short=AST10;
DE   Contains:
DE     RecName: Full=Allatostatin-11;
DE              Short=AST11;
DE     AltName: Full=ASA6;
DE   Contains:
DE     RecName: Full=Allatostatin-12;
DE              Short=AST12;
DE   Contains:
DE     RecName: Full=Allatostatin-13;
DE              Short=AST13;
DE   Flags: Precursor;
OS   Diploptera punctata (Pacific beetle cockroach).
OC   Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Orthopteroidea; Dictyoptera; Blattodea; Blaberoidea;
OC   Blaberidae; Diplopterinae; Diploptera.
OX   NCBI_TaxID=6984;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   MEDLINE=94022263; PubMed=8415611; DOI=10.1073/pnas.90.19.8807;
RA   Donly B.C., Ding Q., Tobe S.S., Bendena W.G.;
RT   "Molecular cloning of the gene for the allatostatin family of
RT   neuropeptides from the cockroach Diploptera punctata.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:8807-8811(1993).
RN   [2]
RP   PROTEIN SEQUENCE OF 154-161; 176-188; 192-200 AND 204-213.
RC   TISSUE=Brain;
RX   MEDLINE=89345592; PubMed=2762309; DOI=10.1073/pnas.86.15.5997;
RA   Woodhead A.P., Stay B., Seidel S.L., Khan M.A., Tobe S.S.;
RT   "Primary structure of four allatostatins: neuropeptide inhibitors of
RT   juvenile hormone synthesis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:5997-6001(1989).
RN   [3]
RP   PROTEIN SEQUENCE OF 77-94.
RC   TISSUE=Brain;
RX   MEDLINE=91172818; PubMed=2006179; DOI=10.1073/pnas.88.6.2412;
RA   Pratt G.E., Farnsworth D.E., Fok K.F., Siegel N.R., McCormack A.L.,
RA   Shabanowitz J., Hunt D.F., Feyereisen R.;
RT   "Identity of a second type of allatostatin from cockroach brains: an
RT   octadecapeptide amide with a tyrosine-rich address sequence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:2412-2416(1991).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 77-189.
RX   MEDLINE=95083607; PubMed=7991553; DOI=10.1073/pnas.91.25.11894;
RA   Reichwald K., Unnithan G.C., Davis N.T., Agricola H., Feyereisen R.;
RT   "Expression of the allatostatin gene in endocrine cells of the
RT   cockroach midgut.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:11894-11898(1994).
RN   [5]
RP   PROTEIN SEQUENCE OF 176-188 (AST7).
RC   TISSUE=Brain;
RX   MEDLINE=89392029; PubMed=2783135; DOI=10.1016/0006-291X(89)91111-X;
RA   Pratt G.E., Farnsworth D.E., Siegel N.R., Fok K.F., Feyereisen R.;
RT   "Identification of an allatostatin from adult Diploptera punctata.";
RL   Biochem. Biophys. Res. Commun. 163:1243-1247(1989).
RN   [6]
RP   STRUCTURE BY NMR OF 154-161 AND 192-200, FUNCTION, AND AMIDATION AT
RP   LEU-161 AND LEU-200.
RX   PubMed=18191874; DOI=10.1016/j.peptides.2007.11.016;
RA   Banerjee M., Meyerowitz E., Huang C., Mohanty S.;
RT   "Probing the conformation and dynamics of allatostatin neuropeptides:
RT   a structural model for functional differences.";
RL   Peptides 29:375-385(2008).
CC   -!- FUNCTION: Neuropeptide inhibitors of juvenile hormone synthesis
CC       and gut muscle contraction.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Brain, suboesophageal ganglion and corpus
CC       allatum.
CC   -!- SIMILARITY: Belongs to the allatostatin family.
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DR   EMBL; U00444; AAA18260.1; -; mRNA.
DR   EMBL; S74578; AAB32720.2; -; mRNA.
DR   PIR; A48252; A48252.
DR   PDB; 2JQS; NMR; -; A=154-161.
DR   PDB; 2JQU; NMR; -; A=192-200.
DR   PDBsum; 2JQS; -.
DR   PDBsum; 2JQU; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR010276; Allatostatin.
DR   Pfam; PF05953; Allatostatin; 13.
PE   1: Evidence at protein level;
KW   3D-structure; Amidation; Cleavage on pair of basic residues;
KW   Direct protein sequencing; Neuropeptide; Secreted; Signal.
FT   SIGNAL        1     27       Potential.
FT   PROPEP       28     65
FT                                /FTId=PRO_0000001129.
FT   PEPTIDE      68     73       Allatostatin-1.
FT                                /FTId=PRO_0000001130.
FT   PEPTIDE      77     94       Allatostatin-2.
FT                                /FTId=PRO_0000001131.
FT   PEPTIDE      98    105       Allatostatin-3.
FT                                /FTId=PRO_0000001132.
FT   PEPTIDE     109    117       Allatostatin-4.
FT                                /FTId=PRO_0000001133.
FT   PROPEP      121    151
FT                                /FTId=PRO_0000001134.
FT   PEPTIDE     154    161       Allatostatin-5.
FT                                /FTId=PRO_0000001135.
FT   PEPTIDE     165    172       Allatostatin-6.
FT                                /FTId=PRO_0000001136.
FT   PEPTIDE     176    188       Allatostatin-7.
FT                                /FTId=PRO_0000001137.
FT   PEPTIDE     192    200       Allatostatin-8.
FT                                /FTId=PRO_0000001138.
FT   PEPTIDE     204    213       Allatostatin-9.
FT                                /FTId=PRO_0000001139.
FT   PEPTIDE     217    232       Allatostatin-10.
FT                                /FTId=PRO_0000001140.
FT   PROPEP      236    251
FT                                /FTId=PRO_0000001141.
FT   PEPTIDE     254    264       Allatostatin-11.
FT                                /FTId=PRO_0000001142.
FT   PROPEP      268    345
FT                                /FTId=PRO_0000001143.
FT   PEPTIDE     348    353       Allatostatin-12.
FT                                /FTId=PRO_0000001144.
FT   PEPTIDE     357    364       Allatostatin-13.
FT                                /FTId=PRO_0000001145.
FT   PROPEP      368    370
FT                                /FTId=PRO_0000001146.
FT   MOD_RES      73     73       Leucine amide.
FT   MOD_RES      94     94       Leucine amide.
FT   MOD_RES     105    105       Leucine amide.
FT   MOD_RES     117    117       Leucine amide.
FT   MOD_RES     161    161       Leucine amide.
FT   MOD_RES     172    172       Leucine amide.
FT   MOD_RES     188    188       Leucine amide.
FT   MOD_RES     200    200       Leucine amide.
FT   MOD_RES     213    213       Leucine amide.
FT   MOD_RES     232    232       Leucine amide.
FT   MOD_RES     264    264       Leucine amide.
FT   MOD_RES     353    353       Leucine amide.
FT   MOD_RES     364    364       Isoleucine amide.
FT   HELIX       157    159
FT   STRAND      194    198
SQ   SEQUENCE   370 AA;  41562 MW;  A5AA8E7C13DE8ED9 CRC64;
     MSGPRTCFCL PSALVLVLLS LSTSALGTAP EPSGVHEESP AGGGTDLLPH PEDLSASDNP
     DLEFVKRLYD FGLGKRAYSY VSEYKRLPVY NFGLGKRSKM YGFGLGKRDG RMYSFGLGKR
     DYDYYGEEDE DDQQAIGDED IEESDVGDLM DKRDRLYSFG LGKRARPYSF GLGKRAPSGA
     QRLYGFGLGK RGGSLYSFGL GKRGDGRLYA FGLGKRPVNS GRSSGSRFNF GLGKRSDDID
     FRELEEKFAE DKRYPQEHRF SFGLGKREVE PSELEAVRNE EKDNSSVHDK KNNTNDMHSG
     ERIKRSLHYP FGIRKLESSY DLNSASSLNS EENDDITPEE FSRMVRRPFN FGLGKRIPMY
     DFGIGKRSER
//