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Protein

Alpha-2-HS-glycoprotein

Gene

AHSG

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Suggested to have lymphocyte stimulating properties, lipid binding capability and to bind thyroid hormone.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processMineral balance

Enzyme and pathway databases

ReactomeiR-BTA-114608 Platelet degranulation
R-BTA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-BTA-6798695 Neutrophil degranulation
R-BTA-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI25.020

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2-HS-glycoprotein
Alternative name(s):
Asialofetuin
Fetuin-A
Gene namesi
Name:AHSG
Synonyms:FETUA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Organism-specific databases

VGNCiVGNC:25756 AHSG

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 182 PublicationsAdd BLAST18
ChainiPRO_000000888519 – 359Alpha-2-HS-glycoproteinAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 350PROSITE-ProRule annotation
Disulfide bondi89 ↔ 100PROSITE-ProRule annotation
GlycosylationiCAR_00006199N-linked (GlcNAc...) asparagine4 Publications1
Disulfide bondi114 ↔ 132PROSITE-ProRule annotation
Modified residuei134PhosphoserineBy similarity1
Modified residuei135PhosphoserineBy similarity1
Modified residuei138Phosphoserine2 Publications1
Disulfide bondi146 ↔ 149PROSITE-ProRule annotation
GlycosylationiCAR_000062156N-linked (GlcNAc...) asparagine4 Publications1
GlycosylationiCAR_000063176N-linked (GlcNAc...) asparagine4 Publications1
Disulfide bondi208 ↔ 219PROSITE-ProRule annotation
Disulfide bondi230 ↔ 248PROSITE-ProRule annotation
Glycosylationi271O-linked (GalNAc...) serine3 Publications1
Glycosylationi280O-linked (GalNAc...) threonine3 Publications1
Glycosylationi282O-linked (GalNAc...) serine3 Publications1
Glycosylationi296O-linked (GalNAc...) serine3 Publications1
Modified residuei314PhosphothreonineBy similarity1
Modified residuei316PhosphoserineBy similarity1
Modified residuei320Phosphoserine1 Publication1
Modified residuei323Phosphoserine1 Publication1
Modified residuei325Phosphoserine1 Publication1
Glycosylationi334O-linked (GalNAc...) threonine1 Publication1
Glycosylationi341O-linked (GalNAc...) serine; partial4 Publications1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei143 – 144Cleavage; by trypsinSequence analysis2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP12763
PeptideAtlasiP12763
PRIDEiP12763

PTM databases

GlyConnecti22
iPTMnetiP12763
UniCarbKBiP12763

Miscellaneous databases

PMAP-CutDBiP12763

Expressioni

Tissue specificityi

Liver and bone.

Gene expression databases

BgeeiENSBTAG00000000522
ExpressionAtlasiP12763 baseline and differential

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LGALS3P179312EBI-9396660,EBI-1170392From Homo sapiens.

Protein-protein interaction databases

IntActiP12763, 2 interactors
STRINGi9913.ENSBTAP00000000673

Structurei

3D structure databases

ProteinModelPortaliP12763
SMRiP12763
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 133Cystatin fetuin-A-type 1PROSITE-ProRule annotationAdd BLAST107
Domaini144 – 256Cystatin fetuin-A-type 2PROSITE-ProRule annotationAdd BLAST113

Sequence similaritiesi

Belongs to the fetuin family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IK8F Eukaryota
ENOG4111RIP LUCA
GeneTreeiENSGT00530000063413
HOGENOMiHOG000290189
HOVERGENiHBG051607
InParanoidiP12763
OMAiETTCHVL
OrthoDBiEOG091G0FHG
TreeFamiTF333729

Family and domain databases

CDDicd00042 CY, 2 hits
InterProiView protein in InterPro
IPR000010 Cystatin_dom
IPR025760 Cystatin_Fetuin_A
IPR001363 Prot_inh_fetuin_CS
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
SMARTiView protein in SMART
SM00043 CY, 2 hits
PROSITEiView protein in PROSITE
PS51529 CYSTATIN_FETUIN_A, 2 hits
PS01254 FETUIN_1, 1 hit
PS01255 FETUIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12763-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSFVLLFCL AQLWGCHSIP LDPVAGYKEP ACDDPDTEQA ALAAVDYINK
60 70 80 90 100
HLPRGYKHTL NQIDSVKVWP RRPTGEVYDI EIDTLETTCH VLDPTPLANC
110 120 130 140 150
SVRQQTQHAV EGDCDIHVLK QDGQFSVLFT KCDSSPDSAE DVRKLCPDCP
160 170 180 190 200
LLAPLNDSRV VHAVEVALAT FNAESNGSYL QLVEISRAQF VPLPVSVSVE
210 220 230 240 250
FAVAATDCIA KEVVDPTKCN LLAEKQYGFC KGSVIQKALG GEDVRVTCTL
260 270 280 290 300
FQTQPVIPQP QPDGAEAEAP SAVPDAAGPT PSAAGPPVAS VVVGPSVVAV
310 320 330 340 350
PLPLHRAHYD LRHTFSGVAS VESSSGEAFH VGKTPIVGQP SIPGGPVRLC

PGRIRYFKI
Length:359
Mass (Da):38,419
Last modified:August 1, 1990 - v2
Checksum:iED8F685C44CCE49B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57 – 58KH → VK AA sequence (PubMed:6165360).Curated2
Sequence conflicti72R → Q AA sequence (PubMed:2436943).Curated1
Sequence conflicti106T → H AA sequence (PubMed:2436943).Curated1
Sequence conflicti116 – 121IHVLKQ → FSVVKL AA sequence (PubMed:2436943).Curated6
Sequence conflicti186S → R AA sequence (PubMed:2447075).Curated1
Sequence conflicti195V → P AA sequence (PubMed:2436943).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16577 mRNA Translation: CAA34596.1
BC147948 mRNA Translation: AAI47949.1
PIRiA35714
RefSeqiNP_776409.1, NM_173984.3
UniGeneiBt.23250

Genome annotation databases

EnsembliENSBTAT00000000673; ENSBTAP00000000673; ENSBTAG00000000522
GeneIDi280988
KEGGibta:280988

Similar proteinsi

Entry informationi

Entry nameiFETUA_BOVIN
AccessioniPrimary (citable) accession number: P12763
Secondary accession number(s): A6QLF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: August 1, 1990
Last modified: May 23, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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