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Protein

Alpha-2-HS-glycoprotein

Gene

AHSG

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Suggested to have lymphocyte stimulating properties, lipid binding capability and to bind thyroid hormone.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Mineral balance

Enzyme and pathway databases

ReactomeiR-BTA-114608. Platelet degranulation.
R-BTA-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiI25.020.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-2-HS-glycoprotein
Alternative name(s):
Asialofetuin
Fetuin-A
Gene namesi
Name:AHSG
Synonyms:FETUA
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: GO_Central
  • extracellular exosome Source: Ensembl
  • extracellular matrix Source: GO_Central
  • extracellular membrane-bounded organelle Source: AgBase
  • plasma membrane Source: AgBase
  • vesicle Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 182 PublicationsAdd BLAST18
ChainiPRO_000000888519 – 359Alpha-2-HS-glycoproteinAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 350PROSITE-ProRule annotation
Disulfide bondi89 ↔ 100PROSITE-ProRule annotation
GlycosylationiCAR_00006199N-linked (GlcNAc...)4 Publications1
Disulfide bondi114 ↔ 132PROSITE-ProRule annotation
Modified residuei134PhosphoserineBy similarity1
Modified residuei135PhosphoserineBy similarity1
Modified residuei138Phosphoserine2 Publications1
Disulfide bondi146 ↔ 149PROSITE-ProRule annotation
GlycosylationiCAR_000062156N-linked (GlcNAc...)4 Publications1
GlycosylationiCAR_000063176N-linked (GlcNAc...)4 Publications1
Disulfide bondi208 ↔ 219PROSITE-ProRule annotation
Disulfide bondi230 ↔ 248PROSITE-ProRule annotation
Glycosylationi271O-linked (GalNAc...)3 Publications1
Glycosylationi280O-linked (GalNAc...)3 Publications1
Glycosylationi282O-linked (GalNAc...)3 Publications1
Glycosylationi296O-linked (GalNAc...)3 Publications1
Modified residuei314PhosphothreonineBy similarity1
Modified residuei316PhosphoserineBy similarity1
Modified residuei320Phosphoserine1 Publication1
Modified residuei323Phosphoserine1 Publication1
Modified residuei325Phosphoserine1 Publication1
Glycosylationi334O-linked (GalNAc...)1 Publication1
Glycosylationi341O-linked (GalNAc...); partial4 Publications1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei143 – 144Cleavage; by trypsinSequence analysis2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP12763.
PeptideAtlasiP12763.
PRIDEiP12763.

PTM databases

iPTMnetiP12763.
UniCarbKBiP12763.

Miscellaneous databases

PMAP-CutDBP12763.

Expressioni

Tissue specificityi

Liver and bone.

Gene expression databases

BgeeiENSBTAG00000000522.
ExpressionAtlasiP12763. baseline and differential.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LGALS3P179312EBI-9396660,EBI-1170392From a different organism.

Protein-protein interaction databases

IntActiP12763. 1 interactor.
STRINGi9913.ENSBTAP00000000673.

Structurei

3D structure databases

ProteinModelPortaliP12763.
SMRiP12763.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 133Cystatin fetuin-A-type 1PROSITE-ProRule annotationAdd BLAST107
Domaini144 – 256Cystatin fetuin-A-type 2PROSITE-ProRule annotationAdd BLAST113

Sequence similaritiesi

Belongs to the fetuin family.PROSITE-ProRule annotation
Contains 2 cystatin fetuin-A-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IK8F. Eukaryota.
ENOG4111RIP. LUCA.
GeneTreeiENSGT00530000063413.
HOGENOMiHOG000290189.
HOVERGENiHBG051607.
InParanoidiP12763.
OMAiRAHYDLR.
OrthoDBiEOG091G0FHG.
TreeFamiTF333729.

Family and domain databases

CDDicd00042. CY. 2 hits.
InterProiIPR000010. Cystatin_dom.
IPR025760. Cystatin_Fetuin_A.
IPR001363. Prot_inh_fetuin_CS.
[Graphical view]
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 2 hits.
[Graphical view]
PROSITEiPS51529. CYSTATIN_FETUIN_A. 2 hits.
PS01254. FETUIN_1. 1 hit.
PS01255. FETUIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12763-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSFVLLFCL AQLWGCHSIP LDPVAGYKEP ACDDPDTEQA ALAAVDYINK
60 70 80 90 100
HLPRGYKHTL NQIDSVKVWP RRPTGEVYDI EIDTLETTCH VLDPTPLANC
110 120 130 140 150
SVRQQTQHAV EGDCDIHVLK QDGQFSVLFT KCDSSPDSAE DVRKLCPDCP
160 170 180 190 200
LLAPLNDSRV VHAVEVALAT FNAESNGSYL QLVEISRAQF VPLPVSVSVE
210 220 230 240 250
FAVAATDCIA KEVVDPTKCN LLAEKQYGFC KGSVIQKALG GEDVRVTCTL
260 270 280 290 300
FQTQPVIPQP QPDGAEAEAP SAVPDAAGPT PSAAGPPVAS VVVGPSVVAV
310 320 330 340 350
PLPLHRAHYD LRHTFSGVAS VESSSGEAFH VGKTPIVGQP SIPGGPVRLC

PGRIRYFKI
Length:359
Mass (Da):38,419
Last modified:August 1, 1990 - v2
Checksum:iED8F685C44CCE49B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57 – 58KH → VK AA sequence (PubMed:6165360).Curated2
Sequence conflicti72R → Q AA sequence (PubMed:2436943).Curated1
Sequence conflicti106T → H AA sequence (PubMed:2436943).Curated1
Sequence conflicti116 – 121IHVLKQ → FSVVKL AA sequence (PubMed:2436943).Curated6
Sequence conflicti186S → R AA sequence (PubMed:2447075).Curated1
Sequence conflicti195V → P AA sequence (PubMed:2436943).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16577 mRNA. Translation: CAA34596.1.
BC147948 mRNA. Translation: AAI47949.1.
PIRiA35714.
RefSeqiNP_776409.1. NM_173984.3.
UniGeneiBt.23250.

Genome annotation databases

EnsembliENSBTAT00000000673; ENSBTAP00000000673; ENSBTAG00000000522.
GeneIDi280988.
KEGGibta:280988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16577 mRNA. Translation: CAA34596.1.
BC147948 mRNA. Translation: AAI47949.1.
PIRiA35714.
RefSeqiNP_776409.1. NM_173984.3.
UniGeneiBt.23250.

3D structure databases

ProteinModelPortaliP12763.
SMRiP12763.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP12763. 1 interactor.
STRINGi9913.ENSBTAP00000000673.

Protein family/group databases

MEROPSiI25.020.

PTM databases

iPTMnetiP12763.
UniCarbKBiP12763.

Proteomic databases

PaxDbiP12763.
PeptideAtlasiP12763.
PRIDEiP12763.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000000673; ENSBTAP00000000673; ENSBTAG00000000522.
GeneIDi280988.
KEGGibta:280988.

Organism-specific databases

CTDi197.

Phylogenomic databases

eggNOGiENOG410IK8F. Eukaryota.
ENOG4111RIP. LUCA.
GeneTreeiENSGT00530000063413.
HOGENOMiHOG000290189.
HOVERGENiHBG051607.
InParanoidiP12763.
OMAiRAHYDLR.
OrthoDBiEOG091G0FHG.
TreeFamiTF333729.

Enzyme and pathway databases

ReactomeiR-BTA-114608. Platelet degranulation.
R-BTA-6798695. Neutrophil degranulation.

Miscellaneous databases

PMAP-CutDBP12763.

Gene expression databases

BgeeiENSBTAG00000000522.
ExpressionAtlasiP12763. baseline and differential.

Family and domain databases

CDDicd00042. CY. 2 hits.
InterProiIPR000010. Cystatin_dom.
IPR025760. Cystatin_Fetuin_A.
IPR001363. Prot_inh_fetuin_CS.
[Graphical view]
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
SMARTiSM00043. CY. 2 hits.
[Graphical view]
PROSITEiPS51529. CYSTATIN_FETUIN_A. 2 hits.
PS01254. FETUIN_1. 1 hit.
PS01255. FETUIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFETUA_BOVIN
AccessioniPrimary (citable) accession number: P12763
Secondary accession number(s): A6QLF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: August 1, 1990
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.