Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P12762

- ALDH2_HORSE

UniProt

P12762 - ALDH2_HORSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Aldehyde dehydrogenase, mitochondrial

Gene

ALDH2

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei169 – 1691Transition state stabilizerBy similarity
Active sitei268 – 2681Proton acceptorPROSITE-ProRule annotation
Active sitei302 – 3021NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi245 – 2506NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

GO - Biological processi

  1. ethanol catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

SABIO-RKP12762.
UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase, mitochondrial (EC:1.2.1.3)
Alternative name(s):
ALDH class 2
ALDH-E2
ALDHI
Gene namesi
Name:ALDH2
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
ProteomesiUP000002281: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Aldehyde dehydrogenase, mitochondrialPRO_0000056467Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-acetyllysineBy similarity
Modified residuei56 – 561N6-acetyllysineBy similarity
Modified residuei142 – 1421N6-acetyllysineBy similarity
Modified residuei358 – 3581N6-acetyllysineBy similarity
Modified residuei366 – 3661N6-acetyllysineBy similarity
Modified residuei409 – 4091N6-acetyllysineBy similarity
Modified residuei411 – 4111N6-acetyllysineBy similarity
Modified residuei424 – 4241N6-acetyllysineBy similarity
Modified residuei434 – 4341N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP12762.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi9796.ENSECAP00000015826.

Structurei

3D structure databases

ProteinModelPortaliP12762.
SMRiP12762. Positions 6-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiP12762.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12762-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
AAAATQAVPA PNQQPEVFYN QIFINNEWHD AVSKKTFPTV NPSTGEVICQ
60 70 80 90 100
VAAGDKEDVD RAVKAARAAF QLGSPWRRMD ASDRGRLLNR LADLIERDRT
110 120 130 140 150
YLAALETLDN GKPYVISYLV DLDMVLKCLR YYAGWADKYH GKTIPIDGDF
160 170 180 190 200
FSYTRHEPVG VCGQIIPWNF PLLMQAAKLG PALATGNVVV MKVAEQTPLT
210 220 230 240 250
ALYVANLTKE AGFPPGVVNV VPGFGPTAGA AIASHEDVDK VAFTGSTEVG
260 270 280 290 300
HLIQVAAGRS NLKKVTLELG GKSPNIIVSD ADMDWAVEQA HFALFFNQGQ
310 320 330 340 350
CCGAGSRTFV QEDVYAEFVE RSVARAKSRV VGNPFDSQTE QGPQVDETQF
360 370 380 390 400
NKVLGYIKSG KEEGAKLLCG GGAAADRGYF IQPTVFGDVQ DGMTIAKEEI
410 420 430 440 450
FGPVMQILKF KTIEEVVGRA NNSKYGLAAA VFTKDLDKAN YLSQALQAGT
460 470 480 490 500
VWINCYDVFG AQSPFGGYKM SGNGRELGEY GLQAYTEVKT VTIKVPQKNS
Length:500
Mass (Da):54,166
Last modified:October 1, 1989 - v1
Checksum:i7F95364A73383B24
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1 – 11A → L.
Natural varianti1 – 11A → S.

Sequence databases

PIRiS00364.

Cross-referencesi

Sequence databases

PIRi S00364.

3D structure databases

ProteinModelPortali P12762.
SMRi P12762. Positions 6-500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9796.ENSECAP00000015826.

Proteomic databases

PRIDEi P12762.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
HOVERGENi HBG000097.
InParanoidi P12762.

Enzyme and pathway databases

UniPathwayi UPA00780 ; UER00768 .
SABIO-RK P12762.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mitochondrial aldehyde dehydrogenase from horse liver. Correlations of the same species variants for both the cytosolic and the mitochondrial forms of an enzyme."
    Johansson J., von Bahr-Lindstroem H., Jeck R., Woenckhaus C., Joernvall H.
    Eur. J. Biochem. 172:527-533(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.

Entry informationi

Entry nameiALDH2_HORSE
AccessioniPrimary (citable) accession number: P12762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3