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P12762

- ALDH2_HORSE

UniProt

P12762 - ALDH2_HORSE

Protein

Aldehyde dehydrogenase, mitochondrial

Gene

ALDH2

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei169 – 1691Transition state stabilizerBy similarity
    Active sitei268 – 2681Proton acceptorPROSITE-ProRule annotation
    Active sitei302 – 3021NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi245 – 2506NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    GO - Biological processi

    1. ethanol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    SABIO-RKP12762.
    UniPathwayiUPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase, mitochondrial (EC:1.2.1.3)
    Alternative name(s):
    ALDH class 2
    ALDH-E2
    ALDHI
    Gene namesi
    Name:ALDH2
    OrganismiEquus caballus (Horse)
    Taxonomic identifieri9796 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
    ProteomesiUP000002281: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Aldehyde dehydrogenase, mitochondrialPRO_0000056467Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei35 – 351N6-acetyllysineBy similarity
    Modified residuei56 – 561N6-acetyllysineBy similarity
    Modified residuei142 – 1421N6-acetyllysineBy similarity
    Modified residuei358 – 3581N6-acetyllysineBy similarity
    Modified residuei366 – 3661N6-acetyllysineBy similarity
    Modified residuei409 – 4091N6-acetyllysineBy similarity
    Modified residuei411 – 4111N6-acetyllysineBy similarity
    Modified residuei424 – 4241N6-acetyllysineBy similarity
    Modified residuei434 – 4341N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiP12762.

    Interactioni

    Subunit structurei

    Homotetramer.

    Protein-protein interaction databases

    STRINGi9796.ENSECAP00000015826.

    Structurei

    3D structure databases

    ProteinModelPortaliP12762.
    SMRiP12762. Positions 6-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    HOVERGENiHBG000097.
    InParanoidiP12762.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P12762-1 [UniParc]FASTAAdd to Basket

    « Hide

    AAAATQAVPA PNQQPEVFYN QIFINNEWHD AVSKKTFPTV NPSTGEVICQ    50
    VAAGDKEDVD RAVKAARAAF QLGSPWRRMD ASDRGRLLNR LADLIERDRT 100
    YLAALETLDN GKPYVISYLV DLDMVLKCLR YYAGWADKYH GKTIPIDGDF 150
    FSYTRHEPVG VCGQIIPWNF PLLMQAAKLG PALATGNVVV MKVAEQTPLT 200
    ALYVANLTKE AGFPPGVVNV VPGFGPTAGA AIASHEDVDK VAFTGSTEVG 250
    HLIQVAAGRS NLKKVTLELG GKSPNIIVSD ADMDWAVEQA HFALFFNQGQ 300
    CCGAGSRTFV QEDVYAEFVE RSVARAKSRV VGNPFDSQTE QGPQVDETQF 350
    NKVLGYIKSG KEEGAKLLCG GGAAADRGYF IQPTVFGDVQ DGMTIAKEEI 400
    FGPVMQILKF KTIEEVVGRA NNSKYGLAAA VFTKDLDKAN YLSQALQAGT 450
    VWINCYDVFG AQSPFGGYKM SGNGRELGEY GLQAYTEVKT VTIKVPQKNS 500
    Length:500
    Mass (Da):54,166
    Last modified:October 1, 1989 - v1
    Checksum:i7F95364A73383B24
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1 – 11A → L.
    Natural varianti1 – 11A → S.

    Sequence databases

    PIRiS00364.

    Cross-referencesi

    Sequence databases

    PIRi S00364.

    3D structure databases

    ProteinModelPortali P12762.
    SMRi P12762. Positions 6-500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9796.ENSECAP00000015826.

    Proteomic databases

    PRIDEi P12762.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    HOVERGENi HBG000097.
    InParanoidi P12762.

    Enzyme and pathway databases

    UniPathwayi UPA00780 ; UER00768 .
    SABIO-RK P12762.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mitochondrial aldehyde dehydrogenase from horse liver. Correlations of the same species variants for both the cytosolic and the mitochondrial forms of an enzyme."
      Johansson J., von Bahr-Lindstroem H., Jeck R., Woenckhaus C., Joernvall H.
      Eur. J. Biochem. 172:527-533(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiALDH2_HORSE
    AccessioniPrimary (citable) accession number: P12762
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3