Reviewed, UniProtKB/Swiss-Prot P12762 (ALDH2_HORSE)

Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase, mitochondrial
    EC=1.2.1.3
Alternative name(s):
    ALDH class 2
    ALDHI
    ALDH-E2

Gene names

Name:

ALDH2

Organism

Equus caballus (Horse)

Taxonomic identifier

9796 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD(+) + H(2)O = an acid + NADH.
Pathway	Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Subunit structure	Homotetramer.
Subcellular location	Mitochondrion matrix.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Aldehyde dehydrogenase, mitochondrial		PRO_0000056467
Regions
	Nucleotide binding	245 – 250	6	NAD By similarity
Sites
	Active site	268	1	Proton acceptor By similarity
	Active site	302	1	Nucleophile By similarity
	Site	169	1	Transition state stabilizer By similarity
Natural variations
	Natural variant	1	1	A → L
	Natural variant	1	1	A → S

Sequences

	Sequence		Length	Mass (Da)
	P12762-1 [UniParc]. Last modified October 1, 1989. Version 1. Checksum: 7F95364A73383B24	FASTA	500	54,166
	10 20 30 40 50 60 AAAATQAVPA PNQQPEVFYN QIFINNEWHD AVSKKTFPTV NPSTGEVICQ VAAGDKEDVD 70 80 90 100 110 120 RAVKAARAAF QLGSPWRRMD ASDRGRLLNR LADLIERDRT YLAALETLDN GKPYVISYLV 130 140 150 160 170 180 DLDMVLKCLR YYAGWADKYH GKTIPIDGDF FSYTRHEPVG VCGQIIPWNF PLLMQAAKLG 190 200 210 220 230 240 PALATGNVVV MKVAEQTPLT ALYVANLTKE AGFPPGVVNV VPGFGPTAGA AIASHEDVDK 250 260 270 280 290 300 VAFTGSTEVG HLIQVAAGRS NLKKVTLELG GKSPNIIVSD ADMDWAVEQA HFALFFNQGQ 310 320 330 340 350 360 CCGAGSRTFV QEDVYAEFVE RSVARAKSRV VGNPFDSQTE QGPQVDETQF NKVLGYIKSG 370 380 390 400 410 420 KEEGAKLLCG GGAAADRGYF IQPTVFGDVQ DGMTIAKEEI FGPVMQILKF KTIEEVVGRA 430 440 450 460 470 480 NNSKYGLAAA VFTKDLDKAN YLSQALQAGT VWINCYDVFG AQSPFGGYKM SGNGRELGEY 490 500 GLQAYTEVKT VTIKVPQKNS

References

[1]

"Mitochondrial aldehyde dehydrogenase from horse liver. Correlations of the same species variants for both the cytosolic and the mitochondrial forms of an enzyme." Johansson J., von Bahr-Lindstroem H., Jeck R., Woenckhaus C., Joernvall H. Eur. J. Biochem. 172:527-533(1988) [PubMed: 3350012] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	S00364.
3D structure databases
HSSP	HSSP built from PDB template 1O01 based on UniProtKB P05091.
SMR	P12762. Positions 7-500.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P12762.
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH2_HORSE

Accession

Primary (citable) accession number: P12762

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	October 1, 1989
Last modified:	November 4, 2008
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)