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Protein

Neuromedin-U

Gene

Nmu

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates muscle contractions of specific regions of the gastrointestinal tract. In rat, NMU stimulates contractions of stomach circular muscle.

GO - Molecular functioni

  • neuromedin U receptor binding Source: MGI

GO - Biological processi

  • eating behavior Source: RGD
  • gastric acid secretion Source: RGD
  • neuropeptide signaling pathway Source: MGI
  • photoperiodism Source: RGD
  • positive regulation of hormone secretion Source: RGD
  • positive regulation of smooth muscle contraction Source: RGD
  • positive regulation of synaptic transmission Source: RGD
  • sensory perception of pain Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U
Cleaved into the following chain:
Neuromedin-U-23
Short name:
NmU-23
Gene namesi
Name:Nmu
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi68388. Nmu.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • terminal bouton Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3737Sequence analysisAdd
BLAST
Propeptidei38 – 10568PRO_0000019780Add
BLAST
Propeptidei106 – 14035PRO_0000262499Add
BLAST
Propeptidei141 – 1433PRO_0000262500
Peptidei144 – 16623Neuromedin-U-23PRO_0000019781Add
BLAST
Propeptidei170 – 1745PRO_0000019782

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei166 – 1661Asparagine amide1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP12760.
PRIDEiP12760.

Expressioni

Tissue specificityi

Expressed throughout the gastrointestinal tract with highest levels in the duodenum and jejunum. Low levels in spinal cord, hypothalamus, and stomach.1 Publication

Gene expression databases

GenevisibleiP12760. RN.

Interactioni

GO - Molecular functioni

  • neuromedin U receptor binding Source: MGI

Protein-protein interaction databases

BioGridi248921. 2 interactions.
STRINGi10116.ENSRNOP00000002941.

Family & Domainsi

Sequence similaritiesi

Belongs to the NmU family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZAW. Eukaryota.
ENOG41120HH. LUCA.
GeneTreeiENSGT00510000048726.
HOGENOMiHOG000113806.
HOVERGENiHBG000378.
InParanoidiP12760.
KOiK05249.
OMAiFQSPFAS.
OrthoDBiEOG7SJD6G.
PhylomeDBiP12760.
TreeFamiTF338319.

Family and domain databases

InterProiIPR018070. Neuromedin-U_amidation-site.
IPR008200. NMU_C.
[Graphical view]
PfamiPF02070. NMU. 1 hit.
[Graphical view]
SMARTiSM00084. NMU. 1 hit.
[Graphical view]
PROSITEiPS00967. NMU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12760-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRAANRRPG LSAGQLAAAT ASPLLSLLLL LACCADACRG TPISPQRLPP
60 70 80 90 100
EQELQLWNEI PEACASFLSV DSQPQASVAL RKLCRVLMEI FQKPQEQTEK
110 120 130 140 150
DNAKRFLFHY SKTQKLGNSN VVSSVVHPLL QLVPQLHERR MKRYKVNEYQ
160 170
GPVAPSGGFF LFRPRNGKRS TSFI
Length:174
Mass (Da):19,403
Last modified:February 1, 1994 - v2
Checksum:i674CF5A2846FF3FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94555 mRNA. Translation: AAA41717.1.
AF222764
, AF222755, AF222756, AF222759, AF222760, AF222761, AF222762, AF222763 Genomic DNA. Translation: AAF64427.1.
PIRiA45356.
RefSeqiNP_071575.1. NM_022239.2.
UniGeneiRn.47720.

Genome annotation databases

EnsembliENSRNOT00000002941; ENSRNOP00000002941; ENSRNOG00000002164.
GeneIDi63887.
KEGGirno:63887.
UCSCiRGD:68388. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94555 mRNA. Translation: AAA41717.1.
AF222764
, AF222755, AF222756, AF222759, AF222760, AF222761, AF222762, AF222763 Genomic DNA. Translation: AAF64427.1.
PIRiA45356.
RefSeqiNP_071575.1. NM_022239.2.
UniGeneiRn.47720.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248921. 2 interactions.
STRINGi10116.ENSRNOP00000002941.

Proteomic databases

PaxDbiP12760.
PRIDEiP12760.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002941; ENSRNOP00000002941; ENSRNOG00000002164.
GeneIDi63887.
KEGGirno:63887.
UCSCiRGD:68388. rat.

Organism-specific databases

CTDi10874.
RGDi68388. Nmu.

Phylogenomic databases

eggNOGiENOG410IZAW. Eukaryota.
ENOG41120HH. LUCA.
GeneTreeiENSGT00510000048726.
HOGENOMiHOG000113806.
HOVERGENiHBG000378.
InParanoidiP12760.
KOiK05249.
OMAiFQSPFAS.
OrthoDBiEOG7SJD6G.
PhylomeDBiP12760.
TreeFamiTF338319.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

NextBioi612526.
PROiP12760.

Gene expression databases

GenevisibleiP12760. RN.

Family and domain databases

InterProiIPR018070. Neuromedin-U_amidation-site.
IPR008200. NMU_C.
[Graphical view]
PfamiPF02070. NMU. 1 hit.
[Graphical view]
SMARTiSM00084. NMU. 1 hit.
[Graphical view]
PROSITEiPS00967. NMU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of complementary DNA encoding the rat neuromedin U precursor."
    Lo G., Legon S., Austin C., Wallis S., Wang Z., Bloom S.R.
    Mol. Endocrinol. 6:1538-1544(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
  2. "Molecular cloning, characterization and chromosomal localization of the rat neuromedin U (NmU) gene."
    Sharma S.K., Lo G., Szpirer C., Bloom S.R.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
  3. "Isolation and structural determination of rat neuromedin U."
    Minamino N., Kangawa K., Honzawa M., Matsuo H.
    Biochem. Biophys. Res. Commun. 156:355-360(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 144-166.
    Tissue: Small intestine.
  4. Cited for: PROTEIN SEQUENCE OF 144-166.
  5. "Distribution and developmental pattern of neuromedin U expression in the rat gastrointestinal tract."
    Austin C., Oka M., Nandha K.A., Legon S., Khandan-Nia N., Lo G., Bloom S.R.
    J. Mol. Endocrinol. 12:257-263(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Identification of neuromedin S and its possible role in the mammalian circadian oscillator system."
    Mori K., Miyazato M., Ida T., Murakami N., Serino R., Ueta Y., Kojima M., Kangawa K.
    EMBO J. 24:325-335(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING.

Entry informationi

Entry nameiNMU_RAT
AccessioniPrimary (citable) accession number: P12760
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: February 1, 1994
Last modified: November 11, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.