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Protein

Neuromedin-U

Gene

Nmu

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates muscle contractions of specific regions of the gastrointestinal tract. In rat, NMU stimulates contractions of stomach circular muscle.

GO - Molecular functioni

  • neuromedin U receptor binding Source: MGI
  • type 1 neuromedin U receptor binding Source: UniProtKB
  • type 2 neuromedin U receptor binding Source: UniProtKB

GO - Biological processi

  • eating behavior Source: RGD
  • energy homeostasis Source: UniProtKB
  • gastric acid secretion Source: RGD
  • negative regulation of eating behavior Source: UniProtKB
  • negative regulation of feeding behavior Source: UniProtKB
  • negative regulation of gastric acid secretion Source: UniProtKB
  • negative regulation of gastric emptying Source: UniProtKB
  • neuropeptide signaling pathway Source: MGI
  • photoperiodism Source: RGD
  • positive regulation of blood pressure in other organism Source: UniProtKB
  • positive regulation of cytosolic calcium ion concentration Source: UniProtKB
  • positive regulation of heart rate Source: UniProtKB
  • positive regulation of heat generation Source: UniProtKB
  • positive regulation of hormone secretion Source: RGD
  • positive regulation of prolactin secretion Source: UniProtKB
  • positive regulation of sensory perception of pain Source: UniProtKB
  • positive regulation of smooth muscle contraction Source: UniProtKB
  • positive regulation of stomach fundus smooth muscle contraction Source: UniProtKB
  • positive regulation of synaptic transmission Source: RGD
  • regulation of circadian sleep/wake cycle, sleep Source: UniProtKB
  • regulation of grooming behavior Source: UniProtKB
  • sensory perception of pain Source: RGD
  • temperature homeostasis Source: Ensembl

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-416476 G alpha (q) signalling events
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U
Cleaved into the following chain:
Neuromedin-U-23
Short name:
NmU-23
Gene namesi
Name:Nmu
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi68388 Nmu

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
PropeptideiPRO_000001978038 – 105Add BLAST68
PropeptideiPRO_0000262499106 – 140Add BLAST35
PropeptideiPRO_0000262500141 – 1433
PeptideiPRO_0000019781144 – 166Neuromedin-U-23Add BLAST23
PropeptideiPRO_0000019782170 – 1745

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei166Asparagine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP12760
PRIDEiP12760

Expressioni

Tissue specificityi

Expressed throughout the gastrointestinal tract with highest levels in the duodenum and jejunum. Low levels in spinal cord, hypothalamus, and stomach.1 Publication

Gene expression databases

BgeeiENSRNOG00000002164
GenevisibleiP12760 RN

Interactioni

GO - Molecular functioni

  • neuromedin U receptor binding Source: MGI
  • type 1 neuromedin U receptor binding Source: UniProtKB
  • type 2 neuromedin U receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi248921, 2 interactors
STRINGi10116.ENSRNOP00000002941

Family & Domainsi

Sequence similaritiesi

Belongs to the NmU family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZAW Eukaryota
ENOG41120HH LUCA
GeneTreeiENSGT00510000048726
HOGENOMiHOG000113806
HOVERGENiHBG000378
InParanoidiP12760
KOiK05249
OMAiLWNEIDD
OrthoDBiEOG091G0V1C
PhylomeDBiP12760
TreeFamiTF338319

Family and domain databases

InterProiView protein in InterPro
IPR018070 Neuromedin-U_amidation-site
IPR008200 NMU_C
PfamiView protein in Pfam
PF02070 NMU, 1 hit
SMARTiView protein in SMART
SM00084 NMU, 1 hit
PROSITEiView protein in PROSITE
PS00967 NMU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12760-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRAANRRPG LSAGQLAAAT ASPLLSLLLL LACCADACRG TPISPQRLPP
60 70 80 90 100
EQELQLWNEI PEACASFLSV DSQPQASVAL RKLCRVLMEI FQKPQEQTEK
110 120 130 140 150
DNAKRFLFHY SKTQKLGNSN VVSSVVHPLL QLVPQLHERR MKRYKVNEYQ
160 170
GPVAPSGGFF LFRPRNGKRS TSFI
Length:174
Mass (Da):19,403
Last modified:February 1, 1994 - v2
Checksum:i674CF5A2846FF3FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94555 mRNA Translation: AAA41717.1
AF222764
, AF222755, AF222756, AF222759, AF222760, AF222761, AF222762, AF222763 Genomic DNA Translation: AAF64427.1
PIRiA45356
RefSeqiNP_071575.1, NM_022239.2
UniGeneiRn.47720

Genome annotation databases

EnsembliENSRNOT00000002941; ENSRNOP00000002941; ENSRNOG00000002164
GeneIDi63887
KEGGirno:63887
UCSCiRGD:68388 rat

Similar proteinsi

Entry informationi

Entry nameiNMU_RAT
AccessioniPrimary (citable) accession number: P12760
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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