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P12757

- SKIL_HUMAN

UniProt

P12757 - SKIL_HUMAN

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Protein

Ski-like protein

Gene
SKIL, SNO
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May have regulatory role in cell division or differentiation in response to extracellular signals.

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. protein binding Source: IntAct
  3. protein complex binding Source: UniProtKB
  4. protein domain specific binding Source: UniProtKB
  5. SMAD binding Source: UniProtKB
  6. transcription corepressor activity Source: UniProtKB

GO - Biological processi

  1. blastocyst formation Source: Ensembl
  2. cell cycle arrest Source: Ensembl
  3. gene expression Source: Reactome
  4. lens fiber cell differentiation Source: Ensembl
  5. lymphocyte homeostasis Source: Ensembl
  6. negative regulation of cell differentiation Source: Ensembl
  7. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  8. negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
  9. positive regulation of axonogenesis Source: Ensembl
  10. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  11. positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  12. protein heterotrimerization Source: UniProtKB
  13. protein homotrimerization Source: UniProtKB
  14. regulation of apoptotic process Source: RefGenome
  15. response to antibiotic Source: UniProtKB
  16. response to cytokine Source: Ensembl
  17. response to growth factor Source: UniProtKB
  18. skeletal muscle tissue development Source: UniProtKB
  19. spermatogenesis Source: Ensembl
  20. transcription, DNA-templated Source: Reactome
  21. transcription initiation from RNA polymerase II promoter Source: Reactome
  22. transforming growth factor beta receptor signaling pathway Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_121111. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
SignaLinkiP12757.

Names & Taxonomyi

Protein namesi
Recommended name:
Ski-like protein
Alternative name(s):
Ski-related oncogene
Ski-related protein
Gene namesi
Name:SKIL
Synonyms:SNO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:10897. SKIL.

Subcellular locationi

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. cytoplasm Source: UniProtKB
  3. nucleoplasm Source: Reactome
  4. nucleus Source: UniProtKB
  5. PML body Source: UniProtKB
  6. protein complex Source: MGI
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35797.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 684684Ski-like proteinPRO_0000129387Add
BLAST

Proteomic databases

MaxQBiP12757.
PaxDbiP12757.
PRIDEiP12757.

PTM databases

PhosphoSiteiP12757.

Expressioni

Tissue specificityi

Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle.1 Publication

Gene expression databases

ArrayExpressiP12757.
BgeeiP12757.
CleanExiHS_SKIL.
GenevestigatoriP12757.

Organism-specific databases

HPAiHPA008472.

Interactioni

Subunit structurei

Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Ncor1Q609742EBI-2902468,EBI-349004From a different organism.

Protein-protein interaction databases

BioGridi112389. 89 interactions.
DIPiDIP-42138N.
IntActiP12757. 71 interactions.
MINTiMINT-1179766.
STRINGi9606.ENSP00000259119.

Structurei

Secondary structure

1
684
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi137 – 1393
Beta strandi145 – 1495
Beta strandi152 – 1598
Beta strandi162 – 1665
Helixi167 – 1726
Turni173 – 1775
Helixi180 – 19011
Helixi199 – 2079
Beta strandi219 – 2224
Helixi223 – 23412

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EQ5X-ray2.45A/B/C/D/E/F/G/H/I/J/K/L137-238[»]
ProteinModelPortaliP12757.
SMRiP12757. Positions 141-238, 264-355.

Miscellaneous databases

EvolutionaryTraceiP12757.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili536 – 684149 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the SKI family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG82850.
HOGENOMiHOG000039989.
HOVERGENiHBG006599.
InParanoidiP12757.
OMAiKKEHLDD.
OrthoDBiEOG72RN0F.
PhylomeDBiP12757.
TreeFamiTF324133.

Family and domain databases

Gene3Di3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProiIPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028373. Ski-rel_Sno.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view]
PANTHERiPTHR10005. PTHR10005. 1 hit.
PTHR10005:SF3. PTHR10005:SF3. 1 hit.
PfamiPF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view]
SMARTiSM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform SNON (identifier: P12757-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MENLQTNFSL VQGSTKKLNG MGDDGSPPAK KMITDIHANG KTINKVPTVK    50
KEHLDDYGEA PVETDGEHVK RTCTSVPETL HLNPSLKHTL AQFHLSSQSS 100
LGGPAAFSAR HSQESMSPTV FLPLPSPQVL PGPLLIPSDS STELTQTVLE 150
GESISCFQVG GEKRLCLPQV LNSVLREFTL QQINTVCDEL YIYCSRCTSD 200
QLHILKVLGI LPFNAPSCGL ITLTDAQRLC NALLRPRTFP QNGSVLPAKS 250
SLAQLKETGS AFEVEHECLG KCQGLFAPQF YVQPDAPCIQ CLECCGMFAP 300
QTFVMHSHRS PDKRTCHWGF ESAKWHCYLH VNQKYLGTPE EKKLKIILEE 350
MKEKFSMRSG KRNQSKTDAP SGMELQSWYP VIKQEGDHVS QTHSFLHPSY 400
YLYMCDKVVA PNVSLTSAVS QSKELTKTEA SKSISRQSEK AHSSGKLQKT 450
VSYPDVSLEE QEKMDLKTSR ELCSRLDASI SNNSTSKRKS ESATCNLVRD 500
INKVGIGLVA AASSPLLVKD VICEDDKGKI MEEVMRTYLK QQEKLNLILQ 550
KKQQLQMEVK MLSSSKSMKE LTEEQQNLQK ELESLQNEHA QRMEEFYVEQ 600
KDLEKKLEQI MKQKCTCDSN LEKDKEAEYA GQLAELRQRL DHAEADRQEL 650
QDELRQEREA RQKLEMMIKE LKLQILKSSK TAKE 684
Length:684
Mass (Da):76,976
Last modified:November 30, 2010 - v2
Checksum:i6A04D4ECEC214CF1
GO
Isoform SNOA (identifier: P12757-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     367-415: TDAPSGMELQ...DKVVAPNVSL → ASFLYQFLIM...YRLIYLYCSF
     416-684: Missing.

Show »
Length:415
Mass (Da):46,335
Checksum:iA2F3E39AE47BB69E
GO
Isoform SNON2 (identifier: P12757-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-431: S → N
     432-477: Missing.

Show »
Length:638
Mass (Da):71,767
Checksum:i3963A1976EF1673C
GO
Isoform SNOI (identifier: P12757-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     400-684: Missing.

Show »
Length:399
Mass (Da):44,203
Checksum:i0AFD7E54B7AB5139
GO
Isoform 5 (identifier: P12757-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Note: No experimental confirmation available.

Show »
Length:664
Mass (Da):74,784
Checksum:iA9B843A38DAF1ED5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti38 – 381A → V.3 Publications
Corresponds to variant rs3772173 [ dbSNP | Ensembl ].
VAR_011677

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2020Missing in isoform 5. VSP_040099Add
BLAST
Alternative sequencei367 – 41549TDAPS…PNVSL → ASFLYQFLIMVMVYFEMKIL CLVCNLTCMLNIAHATTTKY RLIYLYCSF in isoform SNOA. VSP_004392Add
BLAST
Alternative sequencei400 – 684285Missing in isoform SNOI. VSP_004393Add
BLAST
Alternative sequencei416 – 684269Missing in isoform SNOA. VSP_004394Add
BLAST
Alternative sequencei431 – 4311S → N in isoform SNON2. VSP_004395
Alternative sequencei432 – 47746Missing in isoform SNON2. VSP_004396Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131G → R in CAA79636. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15219 mRNA. Translation: CAA33289.1.
X15217 mRNA. Translation: CAA33287.1.
U70730 mRNA. Translation: AAB65850.1.
AK300053 mRNA. Translation: BAG61862.1.
AC073288 Genomic DNA. No translation available.
BC059386 mRNA. Translation: AAH59386.1.
Z19588 mRNA. Translation: CAA79636.1.
CCDSiCCDS33890.1. [P12757-1]
CCDS46953.1. [P12757-3]
CCDS46954.1. [P12757-5]
PIRiS06052. TVHUSN.
S06054. TVHUSA.
RefSeqiNP_001138569.1. NM_001145097.2. [P12757-3]
NP_001138570.1. NM_001145098.2. [P12757-5]
NP_001234937.1. NM_001248008.1. [P12757-1]
NP_005405.2. NM_005414.4. [P12757-1]
XP_005247778.1. XM_005247721.1. [P12757-1]
XP_006713798.1. XM_006713735.1. [P12757-1]
UniGeneiHs.536655.
Hs.581632.

Genome annotation databases

EnsembliENST00000259119; ENSP00000259119; ENSG00000136603. [P12757-1]
ENST00000413427; ENSP00000400193; ENSG00000136603. [P12757-3]
ENST00000426052; ENSP00000406520; ENSG00000136603. [P12757-5]
ENST00000458537; ENSP00000415243; ENSG00000136603. [P12757-1]
GeneIDi6498.
KEGGihsa:6498.
UCSCiuc003fgu.3. human. [P12757-1]
uc003fgv.3. human. [P12757-3]

Polymorphism databases

DMDMi313104010.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15219 mRNA. Translation: CAA33289.1 .
X15217 mRNA. Translation: CAA33287.1 .
U70730 mRNA. Translation: AAB65850.1 .
AK300053 mRNA. Translation: BAG61862.1 .
AC073288 Genomic DNA. No translation available.
BC059386 mRNA. Translation: AAH59386.1 .
Z19588 mRNA. Translation: CAA79636.1 .
CCDSi CCDS33890.1. [P12757-1 ]
CCDS46953.1. [P12757-3 ]
CCDS46954.1. [P12757-5 ]
PIRi S06052. TVHUSN.
S06054. TVHUSA.
RefSeqi NP_001138569.1. NM_001145097.2. [P12757-3 ]
NP_001138570.1. NM_001145098.2. [P12757-5 ]
NP_001234937.1. NM_001248008.1. [P12757-1 ]
NP_005405.2. NM_005414.4. [P12757-1 ]
XP_005247778.1. XM_005247721.1. [P12757-1 ]
XP_006713798.1. XM_006713735.1. [P12757-1 ]
UniGenei Hs.536655.
Hs.581632.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3EQ5 X-ray 2.45 A/B/C/D/E/F/G/H/I/J/K/L 137-238 [» ]
ProteinModelPortali P12757.
SMRi P12757. Positions 141-238, 264-355.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112389. 89 interactions.
DIPi DIP-42138N.
IntActi P12757. 71 interactions.
MINTi MINT-1179766.
STRINGi 9606.ENSP00000259119.

PTM databases

PhosphoSitei P12757.

Polymorphism databases

DMDMi 313104010.

Proteomic databases

MaxQBi P12757.
PaxDbi P12757.
PRIDEi P12757.

Protocols and materials databases

DNASUi 6498.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000259119 ; ENSP00000259119 ; ENSG00000136603 . [P12757-1 ]
ENST00000413427 ; ENSP00000400193 ; ENSG00000136603 . [P12757-3 ]
ENST00000426052 ; ENSP00000406520 ; ENSG00000136603 . [P12757-5 ]
ENST00000458537 ; ENSP00000415243 ; ENSG00000136603 . [P12757-1 ]
GeneIDi 6498.
KEGGi hsa:6498.
UCSCi uc003fgu.3. human. [P12757-1 ]
uc003fgv.3. human. [P12757-3 ]

Organism-specific databases

CTDi 6498.
GeneCardsi GC03P170075.
HGNCi HGNC:10897. SKIL.
HPAi HPA008472.
MIMi 165340. gene.
neXtProti NX_P12757.
PharmGKBi PA35797.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG82850.
HOGENOMi HOG000039989.
HOVERGENi HBG006599.
InParanoidi P12757.
OMAi KKEHLDD.
OrthoDBi EOG72RN0F.
PhylomeDBi P12757.
TreeFami TF324133.

Enzyme and pathway databases

Reactomei REACT_121111. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
SignaLinki P12757.

Miscellaneous databases

EvolutionaryTracei P12757.
GeneWikii SKIL.
GenomeRNAii 6498.
NextBioi 25259.
PROi P12757.
SOURCEi Search...

Gene expression databases

ArrayExpressi P12757.
Bgeei P12757.
CleanExi HS_SKIL.
Genevestigatori P12757.

Family and domain databases

Gene3Di 3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProi IPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028373. Ski-rel_Sno.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view ]
PANTHERi PTHR10005. PTHR10005. 1 hit.
PTHR10005:SF3. PTHR10005:SF3. 1 hit.
Pfami PF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view ]
SMARTi SM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of human cDNA clones of ski and the ski-related gene, sno."
    Nomura N., Sasamoto S., Ishii S., Date T., Matsui M., Ishizaki R.
    Nucleic Acids Res. 17:5489-5500(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SNON AND SNOA), VARIANT VAL-38.
    Tissue: Umbilical vein endothelial cell.
  2. "Proto-oncogene Sno expression, alternative isoforms and immediate early serum response."
    Pearson-White S.H., Crittenden R.
    Nucleic Acids Res. 25:2930-2937(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SNON2), VARIANT VAL-38.
    Tissue: Kidney.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SNON), VARIANT VAL-38.
    Tissue: Placenta.
  6. "SnoI, a novel alternatively spliced isoform of the ski proto-oncogene homolog, sno."
    Pearson-White S.
    Nucleic Acids Res. 21:4632-4638(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-684 (ISOFORM SNOI), TISSUE SPECIFICITY.
    Tissue: Myoblast.
  7. "Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)."
    Komuro A., Imamura T., Saitoh M., Yoshida Y., Yamori T., Miyazono K., Miyazawa K.
    Oncogene 23:6914-6923(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WWP1.
  8. "Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation."
    Levy L., Howell M., Das D., Harkin S., Episkopou V., Hill C.S.
    Mol. Cell. Biol. 27:6068-6083(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RNF111.

Entry informationi

Entry nameiSKIL_HUMAN
AccessioniPrimary (citable) accession number: P12757
Secondary accession number(s): A6NGT1
, B4DT50, O00464, P12756, Q07501
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: November 30, 2010
Last modified: September 3, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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