P12757 (SKIL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ski-like protein

Alternative name(s):
Ski-related oncogene
Ski-related protein

Gene names

Name:	SKIL
Synonyms:	SNO

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	684 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May have regulatory role in cell division or differentiation in response to extracellular signals.
Subunit structure	Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1. Ref.7 Ref.8
Tissue specificity	Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle. Ref.6
Sequence similarities	Belongs to the SKI family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	blastocyst formation Inferred from electronic annotation. Source: Compara cell cycle arrest Inferred from electronic annotation. Source: Compara lens fiber cell differentiation Inferred from electronic annotation. Source: Compara lymphocyte homeostasis Inferred from electronic annotation. Source: Compara negative regulation of cell differentiation Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 10531062PubMed 16966324PubMed 17469184. Source: UniProtKB negative regulation of transforming growth factor beta receptor signaling pathway Inferred from direct assay PubMed 17469184PubMed 19383336. Source: UniProtKB positive regulation of axonogenesis Inferred from mutant phenotype PubMed 16675394. Source: UniProtKB protein heterotrimerization Inferred from direct assay PubMed 8514802. Source: UniProtKB protein homotrimerization Inferred from direct assay PubMed 8514802. Source: UniProtKB regulation of apoptotic process Inferred from Biological aspect of Ancestor. Source: RefGenome response to antibiotic Inferred from expression pattern PubMed 15967445. Source: UniProtKB response to growth factor stimulus Inferred from direct assay PubMed 19383336. Source: UniProtKB skeletal muscle tissue development Inferred from direct assay PubMed 17202138. Source: UniProtKB transcription initiation from RNA polymerase II promoter Traceable author statement. Source: Reactome transforming growth factor beta receptor signaling pathway Traceable author statement. Source: Reactome
Cellular_component	PML body Inferred from direct assay PubMed 19383336. Source: UniProtKB cytoplasm Inferred from direct assay PubMed 16109768PubMed 19538364. Source: UniProtKB nucleoplasm Traceable author statement. Source: Reactome
Molecular_function	chromatin binding Inferred from electronic annotation. Source: Compara nucleotide binding Inferred from electronic annotation. Source: InterPro protein complex binding Inferred from direct assay PubMed 18334480. Source: UniProtKB transcription corepressor activity Inferred from direct assay PubMed 10531062. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Ncor1	Q60974	2	EBI-2902468,EBI-349004	From a different organism.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform SNON (identifier: P12757-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform SNOA (identifier: P12757-2)

The sequence of this isoform differs from the canonical sequence as follows:
     367-415: TDAPSGMELQ...DKVVAPNVSL → ASFLYQFLIM...YRLIYLYCSF
     416-684: Missing.

Isoform SNON2 (identifier: P12757-3)

The sequence of this isoform differs from the canonical sequence as follows:
     431-431: S → N
     432-477: Missing.

Isoform SNOI (identifier: P12757-4)

The sequence of this isoform differs from the canonical sequence as follows:
     400-684: Missing.

Isoform 5 (identifier: P12757-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 684

684

Ski-like protein

PRO_0000129387

Regions

Coiled coil

536 – 684

149

Potential

Natural variations

Alternative sequence

1 – 20

20

Missing in isoform 5.

VSP_040099

Alternative sequence

367 – 415

49

TDAPS…PNVSL → ASFLYQFLIMVMVYFEMKIL CLVCNLTCMLNIAHATTTKY RLIYLYCSF in isoform SNOA.

VSP_004392

Alternative sequence

400 – 684

285

Missing in isoform SNOI.

VSP_004393

Alternative sequence

416 – 684

269

Missing in isoform SNOA.

VSP_004394

Alternative sequence

431

1

S → N in isoform SNON2.

VSP_004395

Alternative sequence

432 – 477

46

Missing in isoform SNON2.

VSP_004396

Natural variant

38

1

A → V. Ref.1 Ref.2 Ref.5
Corresponds to variant rs3772173 [ dbSNP | Ensembl ].

VAR_011677

Experimental info

Sequence conflict

13

1

G → R in CAA79636. Ref.6

Secondary structure

1

.

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.

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684

Helix Strand Turn

Details...

Helix

137 – 139

3

Beta strand

145 – 149

5

Beta strand

152 – 159

8

Beta strand

162 – 166

5

Helix

167 – 172

6

Turn

173 – 177

5

Helix

180 – 190

11

Helix

199 – 207

9

Beta strand

219 – 222

4

Helix

223 – 234

12

Sequences

	Sequence		Length	Mass (Da)
	Isoform SNON [UniParc]. Last modified November 30, 2010. Version 2. Checksum: 6A04D4ECEC214CF1	FASTA	684	76,976
	10 20 30 40 50 60 MENLQTNFSL VQGSTKKLNG MGDDGSPPAK KMITDIHANG KTINKVPTVK KEHLDDYGEA 70 80 90 100 110 120 PVETDGEHVK RTCTSVPETL HLNPSLKHTL AQFHLSSQSS LGGPAAFSAR HSQESMSPTV 130 140 150 160 170 180 FLPLPSPQVL PGPLLIPSDS STELTQTVLE GESISCFQVG GEKRLCLPQV LNSVLREFTL 190 200 210 220 230 240 QQINTVCDEL YIYCSRCTSD QLHILKVLGI LPFNAPSCGL ITLTDAQRLC NALLRPRTFP 250 260 270 280 290 300 QNGSVLPAKS SLAQLKETGS AFEVEHECLG KCQGLFAPQF YVQPDAPCIQ CLECCGMFAP 310 320 330 340 350 360 QTFVMHSHRS PDKRTCHWGF ESAKWHCYLH VNQKYLGTPE EKKLKIILEE MKEKFSMRSG 370 380 390 400 410 420 KRNQSKTDAP SGMELQSWYP VIKQEGDHVS QTHSFLHPSY YLYMCDKVVA PNVSLTSAVS 430 440 450 460 470 480 QSKELTKTEA SKSISRQSEK AHSSGKLQKT VSYPDVSLEE QEKMDLKTSR ELCSRLDASI 490 500 510 520 530 540 SNNSTSKRKS ESATCNLVRD INKVGIGLVA AASSPLLVKD VICEDDKGKI MEEVMRTYLK 550 560 570 580 590 600 QQEKLNLILQ KKQQLQMEVK MLSSSKSMKE LTEEQQNLQK ELESLQNEHA QRMEEFYVEQ 610 620 630 640 650 660 KDLEKKLEQI MKQKCTCDSN LEKDKEAEYA GQLAELRQRL DHAEADRQEL QDELRQEREA 670 680 RQKLEMMIKE LKLQILKSSK TAKE
	Isoform SNOA [UniParc]. Checksum: A2F3E39AE47BB69E	FASTA	415	46,335
	10 20 30 40 50 60 MENLQTNFSL VQGSTKKLNG MGDDGSPPAK KMITDIHANG KTINKVPTVK KEHLDDYGEA 70 80 90 100 110 120 PVETDGEHVK RTCTSVPETL HLNPSLKHTL AQFHLSSQSS LGGPAAFSAR HSQESMSPTV 130 140 150 160 170 180 FLPLPSPQVL PGPLLIPSDS STELTQTVLE GESISCFQVG GEKRLCLPQV LNSVLREFTL 190 200 210 220 230 240 QQINTVCDEL YIYCSRCTSD QLHILKVLGI LPFNAPSCGL ITLTDAQRLC NALLRPRTFP 250 260 270 280 290 300 QNGSVLPAKS SLAQLKETGS AFEVEHECLG KCQGLFAPQF YVQPDAPCIQ CLECCGMFAP 310 320 330 340 350 360 QTFVMHSHRS PDKRTCHWGF ESAKWHCYLH VNQKYLGTPE EKKLKIILEE MKEKFSMRSG 370 380 390 400 410 KRNQSKASFL YQFLIMVMVY FEMKILCLVC NLTCMLNIAH ATTTKYRLIY LYCSF
	Isoform SNON2 [UniParc]. Checksum: 3963A1976EF1673C	FASTA	638	71,767
	10 20 30 40 50 60 MENLQTNFSL VQGSTKKLNG MGDDGSPPAK KMITDIHANG KTINKVPTVK KEHLDDYGEA 70 80 90 100 110 120 PVETDGEHVK RTCTSVPETL HLNPSLKHTL AQFHLSSQSS LGGPAAFSAR HSQESMSPTV 130 140 150 160 170 180 FLPLPSPQVL PGPLLIPSDS STELTQTVLE GESISCFQVG GEKRLCLPQV LNSVLREFTL 190 200 210 220 230 240 QQINTVCDEL YIYCSRCTSD QLHILKVLGI LPFNAPSCGL ITLTDAQRLC NALLRPRTFP 250 260 270 280 290 300 QNGSVLPAKS SLAQLKETGS AFEVEHECLG KCQGLFAPQF YVQPDAPCIQ CLECCGMFAP 310 320 330 340 350 360 QTFVMHSHRS PDKRTCHWGF ESAKWHCYLH VNQKYLGTPE EKKLKIILEE MKEKFSMRSG 370 380 390 400 410 420 KRNQSKTDAP SGMELQSWYP VIKQEGDHVS QTHSFLHPSY YLYMCDKVVA PNVSLTSAVS 430 440 450 460 470 480 QSKELTKTEA NASISNNSTS KRKSESATCN LVRDINKVGI GLVAAASSPL LVKDVICEDD 490 500 510 520 530 540 KGKIMEEVMR TYLKQQEKLN LILQKKQQLQ MEVKMLSSSK SMKELTEEQQ NLQKELESLQ 550 560 570 580 590 600 NEHAQRMEEF YVEQKDLEKK LEQIMKQKCT CDSNLEKDKE AEYAGQLAEL RQRLDHAEAD 610 620 630 RQELQDELRQ EREARQKLEM MIKELKLQIL KSSKTAKE
	Isoform SNOI [UniParc]. Checksum: 0AFD7E54B7AB5139	FASTA	399	44,203
	10 20 30 40 50 60 MENLQTNFSL VQGSTKKLNG MGDDGSPPAK KMITDIHANG KTINKVPTVK KEHLDDYGEA 70 80 90 100 110 120 PVETDGEHVK RTCTSVPETL HLNPSLKHTL AQFHLSSQSS LGGPAAFSAR HSQESMSPTV 130 140 150 160 170 180 FLPLPSPQVL PGPLLIPSDS STELTQTVLE GESISCFQVG GEKRLCLPQV LNSVLREFTL 190 200 210 220 230 240 QQINTVCDEL YIYCSRCTSD QLHILKVLGI LPFNAPSCGL ITLTDAQRLC NALLRPRTFP 250 260 270 280 290 300 QNGSVLPAKS SLAQLKETGS AFEVEHECLG KCQGLFAPQF YVQPDAPCIQ CLECCGMFAP 310 320 330 340 350 360 QTFVMHSHRS PDKRTCHWGF ESAKWHCYLH VNQKYLGTPE EKKLKIILEE MKEKFSMRSG 370 380 390 KRNQSKTDAP SGMELQSWYP VIKQEGDHVS QTHSFLHPS
	Isoform 5 [UniParc]. Checksum: A9B843A38DAF1ED5	FASTA	664	74,784
	10 20 30 40 50 60 MGDDGSPPAK KMITDIHANG KTINKVPTVK KEHLDDYGEA PVETDGEHVK RTCTSVPETL 70 80 90 100 110 120 HLNPSLKHTL AQFHLSSQSS LGGPAAFSAR HSQESMSPTV FLPLPSPQVL PGPLLIPSDS 130 140 150 160 170 180 STELTQTVLE GESISCFQVG GEKRLCLPQV LNSVLREFTL QQINTVCDEL YIYCSRCTSD 190 200 210 220 230 240 QLHILKVLGI LPFNAPSCGL ITLTDAQRLC NALLRPRTFP QNGSVLPAKS SLAQLKETGS 250 260 270 280 290 300 AFEVEHECLG KCQGLFAPQF YVQPDAPCIQ CLECCGMFAP QTFVMHSHRS PDKRTCHWGF 310 320 330 340 350 360 ESAKWHCYLH VNQKYLGTPE EKKLKIILEE MKEKFSMRSG KRNQSKTDAP SGMELQSWYP 370 380 390 400 410 420 VIKQEGDHVS QTHSFLHPSY YLYMCDKVVA PNVSLTSAVS QSKELTKTEA SKSISRQSEK 430 440 450 460 470 480 AHSSGKLQKT VSYPDVSLEE QEKMDLKTSR ELCSRLDASI SNNSTSKRKS ESATCNLVRD 490 500 510 520 530 540 INKVGIGLVA AASSPLLVKD VICEDDKGKI MEEVMRTYLK QQEKLNLILQ KKQQLQMEVK 550 560 570 580 590 600 MLSSSKSMKE LTEEQQNLQK ELESLQNEHA QRMEEFYVEQ KDLEKKLEQI MKQKCTCDSN 610 620 630 640 650 660 LEKDKEAEYA GQLAELRQRL DHAEADRQEL QDELRQEREA RQKLEMMIKE LKLQILKSSK TAKE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of human cDNA clones of ski and the ski-related gene, sno." Nomura N., Sasamoto S., Ishii S., Date T., Matsui M., Ishizaki R. Nucleic Acids Res. 17:5489-5500(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SNON AND SNOA), VARIANT VAL-38. Tissue: Umbilical vein endothelial cell.
[2]	"Proto-oncogene Sno expression, alternative isoforms and immediate early serum response." Pearson-White S.H., Crittenden R. Nucleic Acids Res. 25:2930-2937(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SNON2), VARIANT VAL-38. Tissue: Kidney.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
[4]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SNON), VARIANT VAL-38. Tissue: Placenta.
[6]	"SnoI, a novel alternatively spliced isoform of the ski proto-oncogene homolog, sno." Pearson-White S. Nucleic Acids Res. 21:4632-4638(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-684 (ISOFORM SNOI), TISSUE SPECIFICITY. Tissue: Myoblast.
[7]	"Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)." Komuro A., Imamura T., Saitoh M., Yoshida Y., Yamori T., Miyazono K., Miyazawa K. Oncogene 23:6914-6923(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH WWP1.
[8]	"Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation." Levy L., Howell M., Das D., Harkin S., Episkopou V., Hill C.S. Mol. Cell. Biol. 27:6068-6083(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH RNF111.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X15219 mRNA. Translation: CAA33289.1.
X15217 mRNA. Translation: CAA33287.1.
U70730 mRNA. Translation: AAB65850.1.
AK300053 mRNA. Translation: BAG61862.1.
AC073288 Genomic DNA. No translation available.
BC059386 mRNA. Translation: AAH59386.1.
Z19588 mRNA. Translation: CAA79636.1.

IPI

IPI00025468.
IPI00216658.
IPI00216661.
IPI00867624.
IPI00953209.

PIR

TVHUSN. S06052.
TVHUSA. S06054.

RefSeq

NP_001138569.1. NM_001145097.2.
NP_001138570.1. NM_001145098.2.
NP_001234937.1. NM_001248008.1.
NP_005405.2. NM_005414.4.

UniGene

Hs.536655.
Hs.581632.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3EQ5	X-ray	2.45	A/B/C/D/E/F/G/H/I/J/K/L	137-238	[»]

ProteinModelPortal

P12757.

SMR

P12757. Positions 141-238, 264-355.

ModBase

Search...

Protein-protein interaction databases

IntAct

P12757. 5 interactions.

MINT

MINT-1179766.

STRING

9606.ENSP00000259119.

PTM databases

PhosphoSite

P12757.

Polymorphism databases

DMDM

134594.

Proteomic databases

PaxDb

P12757.

PRIDE

P12757.

Protocols and materials databases

DNASU

6498.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000259119; ENSP00000259119; ENSG00000136603.
ENST00000413427; ENSP00000400193; ENSG00000136603.
ENST00000426052; ENSP00000406520; ENSG00000136603.
ENST00000458537; ENSP00000415243; ENSG00000136603.

GeneID

6498.

KEGG

hsa:6498.

UCSC

uc003fgu.3. human.
uc003fgv.3. human.

Organism-specific databases

CTD

6498.

GeneCards

GC03P170075.

HGNC

HGNC:10897. SKIL.

HPA

HPA008472.

MIM

165340. gene.

neXtProt

NX_P12757.

PharmGKB

PA35797.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG82850.

HOGENOM

HOG000039989.

HOVERGEN

HBG006599.

InParanoid

P12757.

OMA

KKEHLDD.

OrthoDB

EOG4229J8.

Enzyme and pathway databases

Pathway_Interaction_DB

smad2_3nuclearpathway. Regulation of nuclear SMAD2/3 signaling.
tgfbrpathway. TGF-beta receptor signaling.

Reactome

REACT_111102. Signal Transduction.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpress

P12757.

Bgee

P12757.

CleanEx

HS_SKIL.

Genevestigator

P12757.

GermOnline

ENSG00000136603. Homo sapiens.

Family and domain databases

Gene3D

3.10.260.20. 1 hit.
3.10.390.10. 1 hit.

InterPro

IPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view]

PANTHER

PTHR10005. PTHR10005. 1 hit.

Pfam

PF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view]

SMART

SM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view]

SUPFAM

SSF46955. Putativ_DNA_bind. 1 hit.
SSF63763. SAND_like. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P12757.

GenomeRNAi

6498.

NextBio

25259.

SOURCE

Search...

Entry information

Entry name

SKIL_HUMAN

Accession

Primary (citable) accession number: P12757
Secondary accession number(s): A6NGT1 , B4DT50, O00464, P12756, Q07501

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	November 30, 2010
Last modified:	May 1, 2013
This is version 123 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.