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P12757

- SKIL_HUMAN

UniProt

P12757 - SKIL_HUMAN

Protein

Ski-like protein

Gene

SKIL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    May have regulatory role in cell division or differentiation in response to extracellular signals.

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. protein binding Source: IntAct
    3. protein complex binding Source: UniProtKB
    4. protein domain specific binding Source: UniProtKB
    5. SMAD binding Source: UniProtKB
    6. transcription corepressor activity Source: UniProtKB

    GO - Biological processi

    1. blastocyst formation Source: Ensembl
    2. cell cycle arrest Source: Ensembl
    3. gene expression Source: Reactome
    4. lens fiber cell differentiation Source: Ensembl
    5. lymphocyte homeostasis Source: Ensembl
    6. negative regulation of cell differentiation Source: Ensembl
    7. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    8. negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
    9. positive regulation of axonogenesis Source: Ensembl
    10. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    11. positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
    12. protein heterotrimerization Source: UniProtKB
    13. protein homotrimerization Source: UniProtKB
    14. regulation of apoptotic process Source: RefGenome
    15. response to antibiotic Source: UniProtKB
    16. response to cytokine Source: Ensembl
    17. response to growth factor Source: UniProtKB
    18. skeletal muscle tissue development Source: UniProtKB
    19. spermatogenesis Source: Ensembl
    20. transcription, DNA-templated Source: Reactome
    21. transcription initiation from RNA polymerase II promoter Source: Reactome
    22. transforming growth factor beta receptor signaling pathway Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_121111. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
    SignaLinkiP12757.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ski-like protein
    Alternative name(s):
    Ski-related oncogene
    Ski-related protein
    Gene namesi
    Name:SKIL
    Synonyms:SNO
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:10897. SKIL.

    Subcellular locationi

    GO - Cellular componenti

    1. acrosomal vesicle Source: Ensembl
    2. cytoplasm Source: UniProtKB
    3. nucleoplasm Source: Reactome
    4. nucleus Source: UniProtKB
    5. PML body Source: UniProtKB
    6. protein complex Source: MGI

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35797.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 684684Ski-like proteinPRO_0000129387Add
    BLAST

    Proteomic databases

    MaxQBiP12757.
    PaxDbiP12757.
    PRIDEiP12757.

    PTM databases

    PhosphoSiteiP12757.

    Expressioni

    Tissue specificityi

    Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiP12757.
    BgeeiP12757.
    CleanExiHS_SKIL.
    GenevestigatoriP12757.

    Organism-specific databases

    HPAiHPA008472.

    Interactioni

    Subunit structurei

    Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Ncor1Q609742EBI-2902468,EBI-349004From a different organism.

    Protein-protein interaction databases

    BioGridi112389. 89 interactions.
    DIPiDIP-42138N.
    IntActiP12757. 71 interactions.
    MINTiMINT-1179766.
    STRINGi9606.ENSP00000259119.

    Structurei

    Secondary structure

    1
    684
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi137 – 1393
    Beta strandi145 – 1495
    Beta strandi152 – 1598
    Beta strandi162 – 1665
    Helixi167 – 1726
    Turni173 – 1775
    Helixi180 – 19011
    Helixi199 – 2079
    Beta strandi219 – 2224
    Helixi223 – 23412

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3EQ5X-ray2.45A/B/C/D/E/F/G/H/I/J/K/L137-238[»]
    ProteinModelPortaliP12757.
    SMRiP12757. Positions 141-238, 264-355.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP12757.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili536 – 684149Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SKI family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG82850.
    HOGENOMiHOG000039989.
    HOVERGENiHBG006599.
    InParanoidiP12757.
    OMAiKKEHLDD.
    OrthoDBiEOG72RN0F.
    PhylomeDBiP12757.
    TreeFamiTF324133.

    Family and domain databases

    Gene3Di3.10.260.20. 1 hit.
    3.10.390.10. 1 hit.
    InterProiIPR014890. c-SKI_SMAD4-bd_dom.
    IPR009061. DNA-bd_dom_put.
    IPR010919. SAND_dom-like.
    IPR028373. Ski-rel_Sno.
    IPR003380. Transform_Ski.
    IPR023216. Tscrpt_reg_SKI_SnoN.
    [Graphical view]
    PANTHERiPTHR10005. PTHR10005. 1 hit.
    PTHR10005:SF3. PTHR10005:SF3. 1 hit.
    PfamiPF08782. c-SKI_SMAD_bind. 1 hit.
    PF02437. Ski_Sno. 1 hit.
    [Graphical view]
    SMARTiSM01046. c-SKI_SMAD_bind. 1 hit.
    [Graphical view]
    SUPFAMiSSF46955. SSF46955. 1 hit.
    SSF63763. SSF63763. 1 hit.

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform SNON (identifier: P12757-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MENLQTNFSL VQGSTKKLNG MGDDGSPPAK KMITDIHANG KTINKVPTVK    50
    KEHLDDYGEA PVETDGEHVK RTCTSVPETL HLNPSLKHTL AQFHLSSQSS 100
    LGGPAAFSAR HSQESMSPTV FLPLPSPQVL PGPLLIPSDS STELTQTVLE 150
    GESISCFQVG GEKRLCLPQV LNSVLREFTL QQINTVCDEL YIYCSRCTSD 200
    QLHILKVLGI LPFNAPSCGL ITLTDAQRLC NALLRPRTFP QNGSVLPAKS 250
    SLAQLKETGS AFEVEHECLG KCQGLFAPQF YVQPDAPCIQ CLECCGMFAP 300
    QTFVMHSHRS PDKRTCHWGF ESAKWHCYLH VNQKYLGTPE EKKLKIILEE 350
    MKEKFSMRSG KRNQSKTDAP SGMELQSWYP VIKQEGDHVS QTHSFLHPSY 400
    YLYMCDKVVA PNVSLTSAVS QSKELTKTEA SKSISRQSEK AHSSGKLQKT 450
    VSYPDVSLEE QEKMDLKTSR ELCSRLDASI SNNSTSKRKS ESATCNLVRD 500
    INKVGIGLVA AASSPLLVKD VICEDDKGKI MEEVMRTYLK QQEKLNLILQ 550
    KKQQLQMEVK MLSSSKSMKE LTEEQQNLQK ELESLQNEHA QRMEEFYVEQ 600
    KDLEKKLEQI MKQKCTCDSN LEKDKEAEYA GQLAELRQRL DHAEADRQEL 650
    QDELRQEREA RQKLEMMIKE LKLQILKSSK TAKE 684
    Length:684
    Mass (Da):76,976
    Last modified:November 30, 2010 - v2
    Checksum:i6A04D4ECEC214CF1
    GO
    Isoform SNOA (identifier: P12757-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         367-415: TDAPSGMELQ...DKVVAPNVSL → ASFLYQFLIM...YRLIYLYCSF
         416-684: Missing.

    Show »
    Length:415
    Mass (Da):46,335
    Checksum:iA2F3E39AE47BB69E
    GO
    Isoform SNON2 (identifier: P12757-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         431-431: S → N
         432-477: Missing.

    Show »
    Length:638
    Mass (Da):71,767
    Checksum:i3963A1976EF1673C
    GO
    Isoform SNOI (identifier: P12757-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         400-684: Missing.

    Show »
    Length:399
    Mass (Da):44,203
    Checksum:i0AFD7E54B7AB5139
    GO
    Isoform 5 (identifier: P12757-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-20: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:664
    Mass (Da):74,784
    Checksum:iA9B843A38DAF1ED5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti13 – 131G → R in CAA79636. (PubMed:8233802)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti38 – 381A → V.3 Publications
    Corresponds to variant rs3772173 [ dbSNP | Ensembl ].
    VAR_011677

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2020Missing in isoform 5. 1 PublicationVSP_040099Add
    BLAST
    Alternative sequencei367 – 41549TDAPS…PNVSL → ASFLYQFLIMVMVYFEMKIL CLVCNLTCMLNIAHATTTKY RLIYLYCSF in isoform SNOA. 1 PublicationVSP_004392Add
    BLAST
    Alternative sequencei400 – 684285Missing in isoform SNOI. 1 PublicationVSP_004393Add
    BLAST
    Alternative sequencei416 – 684269Missing in isoform SNOA. 1 PublicationVSP_004394Add
    BLAST
    Alternative sequencei431 – 4311S → N in isoform SNON2. 1 PublicationVSP_004395
    Alternative sequencei432 – 47746Missing in isoform SNON2. 1 PublicationVSP_004396Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15219 mRNA. Translation: CAA33289.1.
    X15217 mRNA. Translation: CAA33287.1.
    U70730 mRNA. Translation: AAB65850.1.
    AK300053 mRNA. Translation: BAG61862.1.
    AC073288 Genomic DNA. No translation available.
    BC059386 mRNA. Translation: AAH59386.1.
    Z19588 mRNA. Translation: CAA79636.1.
    CCDSiCCDS33890.1. [P12757-1]
    CCDS46953.1. [P12757-3]
    CCDS46954.1. [P12757-5]
    PIRiS06052. TVHUSN.
    S06054. TVHUSA.
    RefSeqiNP_001138569.1. NM_001145097.2. [P12757-3]
    NP_001138570.1. NM_001145098.2. [P12757-5]
    NP_001234937.1. NM_001248008.1. [P12757-1]
    NP_005405.2. NM_005414.4. [P12757-1]
    XP_005247778.1. XM_005247721.1. [P12757-1]
    XP_006713798.1. XM_006713735.1. [P12757-1]
    UniGeneiHs.536655.
    Hs.581632.

    Genome annotation databases

    EnsembliENST00000259119; ENSP00000259119; ENSG00000136603. [P12757-1]
    ENST00000413427; ENSP00000400193; ENSG00000136603. [P12757-3]
    ENST00000426052; ENSP00000406520; ENSG00000136603. [P12757-5]
    ENST00000458537; ENSP00000415243; ENSG00000136603. [P12757-1]
    GeneIDi6498.
    KEGGihsa:6498.
    UCSCiuc003fgu.3. human. [P12757-1]
    uc003fgv.3. human. [P12757-3]

    Polymorphism databases

    DMDMi313104010.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15219 mRNA. Translation: CAA33289.1 .
    X15217 mRNA. Translation: CAA33287.1 .
    U70730 mRNA. Translation: AAB65850.1 .
    AK300053 mRNA. Translation: BAG61862.1 .
    AC073288 Genomic DNA. No translation available.
    BC059386 mRNA. Translation: AAH59386.1 .
    Z19588 mRNA. Translation: CAA79636.1 .
    CCDSi CCDS33890.1. [P12757-1 ]
    CCDS46953.1. [P12757-3 ]
    CCDS46954.1. [P12757-5 ]
    PIRi S06052. TVHUSN.
    S06054. TVHUSA.
    RefSeqi NP_001138569.1. NM_001145097.2. [P12757-3 ]
    NP_001138570.1. NM_001145098.2. [P12757-5 ]
    NP_001234937.1. NM_001248008.1. [P12757-1 ]
    NP_005405.2. NM_005414.4. [P12757-1 ]
    XP_005247778.1. XM_005247721.1. [P12757-1 ]
    XP_006713798.1. XM_006713735.1. [P12757-1 ]
    UniGenei Hs.536655.
    Hs.581632.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3EQ5 X-ray 2.45 A/B/C/D/E/F/G/H/I/J/K/L 137-238 [» ]
    ProteinModelPortali P12757.
    SMRi P12757. Positions 141-238, 264-355.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112389. 89 interactions.
    DIPi DIP-42138N.
    IntActi P12757. 71 interactions.
    MINTi MINT-1179766.
    STRINGi 9606.ENSP00000259119.

    PTM databases

    PhosphoSitei P12757.

    Polymorphism databases

    DMDMi 313104010.

    Proteomic databases

    MaxQBi P12757.
    PaxDbi P12757.
    PRIDEi P12757.

    Protocols and materials databases

    DNASUi 6498.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259119 ; ENSP00000259119 ; ENSG00000136603 . [P12757-1 ]
    ENST00000413427 ; ENSP00000400193 ; ENSG00000136603 . [P12757-3 ]
    ENST00000426052 ; ENSP00000406520 ; ENSG00000136603 . [P12757-5 ]
    ENST00000458537 ; ENSP00000415243 ; ENSG00000136603 . [P12757-1 ]
    GeneIDi 6498.
    KEGGi hsa:6498.
    UCSCi uc003fgu.3. human. [P12757-1 ]
    uc003fgv.3. human. [P12757-3 ]

    Organism-specific databases

    CTDi 6498.
    GeneCardsi GC03P170075.
    HGNCi HGNC:10897. SKIL.
    HPAi HPA008472.
    MIMi 165340. gene.
    neXtProti NX_P12757.
    PharmGKBi PA35797.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG82850.
    HOGENOMi HOG000039989.
    HOVERGENi HBG006599.
    InParanoidi P12757.
    OMAi KKEHLDD.
    OrthoDBi EOG72RN0F.
    PhylomeDBi P12757.
    TreeFami TF324133.

    Enzyme and pathway databases

    Reactomei REACT_121111. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
    SignaLinki P12757.

    Miscellaneous databases

    EvolutionaryTracei P12757.
    GeneWikii SKIL.
    GenomeRNAii 6498.
    NextBioi 25259.
    PROi P12757.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P12757.
    Bgeei P12757.
    CleanExi HS_SKIL.
    Genevestigatori P12757.

    Family and domain databases

    Gene3Di 3.10.260.20. 1 hit.
    3.10.390.10. 1 hit.
    InterProi IPR014890. c-SKI_SMAD4-bd_dom.
    IPR009061. DNA-bd_dom_put.
    IPR010919. SAND_dom-like.
    IPR028373. Ski-rel_Sno.
    IPR003380. Transform_Ski.
    IPR023216. Tscrpt_reg_SKI_SnoN.
    [Graphical view ]
    PANTHERi PTHR10005. PTHR10005. 1 hit.
    PTHR10005:SF3. PTHR10005:SF3. 1 hit.
    Pfami PF08782. c-SKI_SMAD_bind. 1 hit.
    PF02437. Ski_Sno. 1 hit.
    [Graphical view ]
    SMARTi SM01046. c-SKI_SMAD_bind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46955. SSF46955. 1 hit.
    SSF63763. SSF63763. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of human cDNA clones of ski and the ski-related gene, sno."
      Nomura N., Sasamoto S., Ishii S., Date T., Matsui M., Ishizaki R.
      Nucleic Acids Res. 17:5489-5500(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SNON AND SNOA), VARIANT VAL-38.
      Tissue: Umbilical vein endothelial cell.
    2. "Proto-oncogene Sno expression, alternative isoforms and immediate early serum response."
      Pearson-White S.H., Crittenden R.
      Nucleic Acids Res. 25:2930-2937(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SNON2), VARIANT VAL-38.
      Tissue: Kidney.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    4. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SNON), VARIANT VAL-38.
      Tissue: Placenta.
    6. "SnoI, a novel alternatively spliced isoform of the ski proto-oncogene homolog, sno."
      Pearson-White S.
      Nucleic Acids Res. 21:4632-4638(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-684 (ISOFORM SNOI), TISSUE SPECIFICITY.
      Tissue: Myoblast.
    7. "Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)."
      Komuro A., Imamura T., Saitoh M., Yoshida Y., Yamori T., Miyazono K., Miyazawa K.
      Oncogene 23:6914-6923(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH WWP1.
    8. "Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation."
      Levy L., Howell M., Das D., Harkin S., Episkopou V., Hill C.S.
      Mol. Cell. Biol. 27:6068-6083(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RNF111.

    Entry informationi

    Entry nameiSKIL_HUMAN
    AccessioniPrimary (citable) accession number: P12757
    Secondary accession number(s): A6NGT1
    , B4DT50, O00464, P12756, Q07501
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 138 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3