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P12757

- SKIL_HUMAN

UniProt

P12757 - SKIL_HUMAN

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Protein

Ski-like protein

Gene

SKIL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May have regulatory role in cell division or differentiation in response to extracellular signals.

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. protein complex binding Source: UniProtKB
  3. protein domain specific binding Source: UniProtKB
  4. SMAD binding Source: UniProtKB
  5. transcription corepressor activity Source: UniProtKB

GO - Biological processi

  1. blastocyst formation Source: Ensembl
  2. cell cycle arrest Source: Ensembl
  3. gene expression Source: Reactome
  4. lens fiber cell differentiation Source: Ensembl
  5. lymphocyte homeostasis Source: Ensembl
  6. negative regulation of cell differentiation Source: Ensembl
  7. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  8. negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
  9. positive regulation of axonogenesis Source: Ensembl
  10. positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  11. positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  12. protein heterotrimerization Source: UniProtKB
  13. protein homotrimerization Source: UniProtKB
  14. regulation of apoptotic process Source: RefGenome
  15. response to antibiotic Source: UniProtKB
  16. response to cytokine Source: Ensembl
  17. response to growth factor Source: UniProtKB
  18. skeletal muscle tissue development Source: UniProtKB
  19. spermatogenesis Source: Ensembl
  20. transcription, DNA-templated Source: Reactome
  21. transcription initiation from RNA polymerase II promoter Source: Reactome
  22. transforming growth factor beta receptor signaling pathway Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_121111. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
SignaLinkiP12757.

Names & Taxonomyi

Protein namesi
Recommended name:
Ski-like protein
Alternative name(s):
Ski-related oncogene
Ski-related protein
Gene namesi
Name:SKIL
Synonyms:SNO
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:10897. SKIL.

Subcellular locationi

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. cytoplasm Source: UniProtKB
  3. nucleoplasm Source: Reactome
  4. nucleus Source: UniProtKB
  5. PML body Source: UniProtKB
  6. protein complex Source: MGI
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35797.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 684684Ski-like proteinPRO_0000129387Add
BLAST

Proteomic databases

MaxQBiP12757.
PaxDbiP12757.
PRIDEiP12757.

PTM databases

PhosphoSiteiP12757.

Expressioni

Tissue specificityi

Isoform SNON and isoform SNOA are widely expressed. Highest expression is found in skeletal muscle, followed by placenta and lung. Lowest expression in heart, brain and pancreas. Isoform SNOI expression is restricted to skeletal muscle.1 Publication

Gene expression databases

BgeeiP12757.
CleanExiHS_SKIL.
ExpressionAtlasiP12757. baseline and differential.
GenevestigatoriP12757.

Organism-specific databases

HPAiHPA008472.

Interactioni

Subunit structurei

Interacts with SMAD2, SMAD3 and RNF111. Isoform 1 interacts with WWP1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Ncor1Q609742EBI-2902468,EBI-349004From a different organism.

Protein-protein interaction databases

BioGridi112389. 92 interactions.
DIPiDIP-42138N.
IntActiP12757. 71 interactions.
MINTiMINT-1179766.
STRINGi9606.ENSP00000259119.

Structurei

Secondary structure

1
684
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi137 – 1393Combined sources
Beta strandi145 – 1495Combined sources
Beta strandi152 – 1598Combined sources
Beta strandi162 – 1665Combined sources
Helixi167 – 1726Combined sources
Turni173 – 1775Combined sources
Helixi180 – 19011Combined sources
Helixi199 – 2079Combined sources
Beta strandi219 – 2224Combined sources
Helixi223 – 23412Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EQ5X-ray2.45A/B/C/D/E/F/G/H/I/J/K/L137-238[»]
ProteinModelPortaliP12757.
SMRiP12757. Positions 141-238, 264-355.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12757.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili536 – 684149Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the SKI family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG82850.
GeneTreeiENSGT00530000063040.
HOGENOMiHOG000039989.
HOVERGENiHBG006599.
InParanoidiP12757.
KOiK18499.
OMAiKKEHLDD.
OrthoDBiEOG72RN0F.
PhylomeDBiP12757.
TreeFamiTF324133.

Family and domain databases

Gene3Di3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProiIPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028373. Ski-rel_Sno.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view]
PANTHERiPTHR10005. PTHR10005. 1 hit.
PTHR10005:SF3. PTHR10005:SF3. 1 hit.
PfamiPF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view]
SMARTiSM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform SNON (identifier: P12757-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENLQTNFSL VQGSTKKLNG MGDDGSPPAK KMITDIHANG KTINKVPTVK
60 70 80 90 100
KEHLDDYGEA PVETDGEHVK RTCTSVPETL HLNPSLKHTL AQFHLSSQSS
110 120 130 140 150
LGGPAAFSAR HSQESMSPTV FLPLPSPQVL PGPLLIPSDS STELTQTVLE
160 170 180 190 200
GESISCFQVG GEKRLCLPQV LNSVLREFTL QQINTVCDEL YIYCSRCTSD
210 220 230 240 250
QLHILKVLGI LPFNAPSCGL ITLTDAQRLC NALLRPRTFP QNGSVLPAKS
260 270 280 290 300
SLAQLKETGS AFEVEHECLG KCQGLFAPQF YVQPDAPCIQ CLECCGMFAP
310 320 330 340 350
QTFVMHSHRS PDKRTCHWGF ESAKWHCYLH VNQKYLGTPE EKKLKIILEE
360 370 380 390 400
MKEKFSMRSG KRNQSKTDAP SGMELQSWYP VIKQEGDHVS QTHSFLHPSY
410 420 430 440 450
YLYMCDKVVA PNVSLTSAVS QSKELTKTEA SKSISRQSEK AHSSGKLQKT
460 470 480 490 500
VSYPDVSLEE QEKMDLKTSR ELCSRLDASI SNNSTSKRKS ESATCNLVRD
510 520 530 540 550
INKVGIGLVA AASSPLLVKD VICEDDKGKI MEEVMRTYLK QQEKLNLILQ
560 570 580 590 600
KKQQLQMEVK MLSSSKSMKE LTEEQQNLQK ELESLQNEHA QRMEEFYVEQ
610 620 630 640 650
KDLEKKLEQI MKQKCTCDSN LEKDKEAEYA GQLAELRQRL DHAEADRQEL
660 670 680
QDELRQEREA RQKLEMMIKE LKLQILKSSK TAKE
Length:684
Mass (Da):76,976
Last modified:November 30, 2010 - v2
Checksum:i6A04D4ECEC214CF1
GO
Isoform SNOA (identifier: P12757-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     367-415: TDAPSGMELQ...DKVVAPNVSL → ASFLYQFLIM...YRLIYLYCSF
     416-684: Missing.

Show »
Length:415
Mass (Da):46,335
Checksum:iA2F3E39AE47BB69E
GO
Isoform SNON2 (identifier: P12757-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     431-431: S → N
     432-477: Missing.

Show »
Length:638
Mass (Da):71,767
Checksum:i3963A1976EF1673C
GO
Isoform SNOI (identifier: P12757-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     400-684: Missing.

Show »
Length:399
Mass (Da):44,203
Checksum:i0AFD7E54B7AB5139
GO
Isoform 5 (identifier: P12757-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Note: No experimental confirmation available.

Show »
Length:664
Mass (Da):74,784
Checksum:iA9B843A38DAF1ED5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131G → R in CAA79636. (PubMed:8233802)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti38 – 381A → V.3 Publications
Corresponds to variant rs3772173 [ dbSNP | Ensembl ].
VAR_011677

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2020Missing in isoform 5. 1 PublicationVSP_040099Add
BLAST
Alternative sequencei367 – 41549TDAPS…PNVSL → ASFLYQFLIMVMVYFEMKIL CLVCNLTCMLNIAHATTTKY RLIYLYCSF in isoform SNOA. 1 PublicationVSP_004392Add
BLAST
Alternative sequencei400 – 684285Missing in isoform SNOI. 1 PublicationVSP_004393Add
BLAST
Alternative sequencei416 – 684269Missing in isoform SNOA. 1 PublicationVSP_004394Add
BLAST
Alternative sequencei431 – 4311S → N in isoform SNON2. 1 PublicationVSP_004395
Alternative sequencei432 – 47746Missing in isoform SNON2. 1 PublicationVSP_004396Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15219 mRNA. Translation: CAA33289.1.
X15217 mRNA. Translation: CAA33287.1.
U70730 mRNA. Translation: AAB65850.1.
AK300053 mRNA. Translation: BAG61862.1.
AC073288 Genomic DNA. No translation available.
BC059386 mRNA. Translation: AAH59386.1.
Z19588 mRNA. Translation: CAA79636.1.
CCDSiCCDS33890.1. [P12757-1]
CCDS46953.1. [P12757-3]
CCDS46954.1. [P12757-5]
PIRiS06052. TVHUSN.
S06054. TVHUSA.
RefSeqiNP_001138569.1. NM_001145097.2. [P12757-3]
NP_001138570.1. NM_001145098.2. [P12757-5]
NP_001234937.1. NM_001248008.1. [P12757-1]
NP_005405.2. NM_005414.4. [P12757-1]
XP_005247778.1. XM_005247721.1. [P12757-1]
XP_006713798.1. XM_006713735.1. [P12757-1]
UniGeneiHs.536655.
Hs.581632.

Genome annotation databases

EnsembliENST00000259119; ENSP00000259119; ENSG00000136603. [P12757-1]
ENST00000413427; ENSP00000400193; ENSG00000136603. [P12757-3]
ENST00000426052; ENSP00000406520; ENSG00000136603. [P12757-5]
ENST00000458537; ENSP00000415243; ENSG00000136603. [P12757-1]
GeneIDi6498.
KEGGihsa:6498.
UCSCiuc003fgu.3. human. [P12757-1]
uc003fgv.3. human. [P12757-3]

Polymorphism databases

DMDMi313104010.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15219 mRNA. Translation: CAA33289.1 .
X15217 mRNA. Translation: CAA33287.1 .
U70730 mRNA. Translation: AAB65850.1 .
AK300053 mRNA. Translation: BAG61862.1 .
AC073288 Genomic DNA. No translation available.
BC059386 mRNA. Translation: AAH59386.1 .
Z19588 mRNA. Translation: CAA79636.1 .
CCDSi CCDS33890.1. [P12757-1 ]
CCDS46953.1. [P12757-3 ]
CCDS46954.1. [P12757-5 ]
PIRi S06052. TVHUSN.
S06054. TVHUSA.
RefSeqi NP_001138569.1. NM_001145097.2. [P12757-3 ]
NP_001138570.1. NM_001145098.2. [P12757-5 ]
NP_001234937.1. NM_001248008.1. [P12757-1 ]
NP_005405.2. NM_005414.4. [P12757-1 ]
XP_005247778.1. XM_005247721.1. [P12757-1 ]
XP_006713798.1. XM_006713735.1. [P12757-1 ]
UniGenei Hs.536655.
Hs.581632.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3EQ5 X-ray 2.45 A/B/C/D/E/F/G/H/I/J/K/L 137-238 [» ]
ProteinModelPortali P12757.
SMRi P12757. Positions 141-238, 264-355.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112389. 92 interactions.
DIPi DIP-42138N.
IntActi P12757. 71 interactions.
MINTi MINT-1179766.
STRINGi 9606.ENSP00000259119.

PTM databases

PhosphoSitei P12757.

Polymorphism databases

DMDMi 313104010.

Proteomic databases

MaxQBi P12757.
PaxDbi P12757.
PRIDEi P12757.

Protocols and materials databases

DNASUi 6498.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000259119 ; ENSP00000259119 ; ENSG00000136603 . [P12757-1 ]
ENST00000413427 ; ENSP00000400193 ; ENSG00000136603 . [P12757-3 ]
ENST00000426052 ; ENSP00000406520 ; ENSG00000136603 . [P12757-5 ]
ENST00000458537 ; ENSP00000415243 ; ENSG00000136603 . [P12757-1 ]
GeneIDi 6498.
KEGGi hsa:6498.
UCSCi uc003fgu.3. human. [P12757-1 ]
uc003fgv.3. human. [P12757-3 ]

Organism-specific databases

CTDi 6498.
GeneCardsi GC03P170075.
HGNCi HGNC:10897. SKIL.
HPAi HPA008472.
MIMi 165340. gene.
neXtProti NX_P12757.
PharmGKBi PA35797.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG82850.
GeneTreei ENSGT00530000063040.
HOGENOMi HOG000039989.
HOVERGENi HBG006599.
InParanoidi P12757.
KOi K18499.
OMAi KKEHLDD.
OrthoDBi EOG72RN0F.
PhylomeDBi P12757.
TreeFami TF324133.

Enzyme and pathway databases

Reactomei REACT_121111. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
SignaLinki P12757.

Miscellaneous databases

ChiTaRSi SKIL. human.
EvolutionaryTracei P12757.
GeneWikii SKIL.
GenomeRNAii 6498.
NextBioi 25259.
PROi P12757.
SOURCEi Search...

Gene expression databases

Bgeei P12757.
CleanExi HS_SKIL.
ExpressionAtlasi P12757. baseline and differential.
Genevestigatori P12757.

Family and domain databases

Gene3Di 3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProi IPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028373. Ski-rel_Sno.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view ]
PANTHERi PTHR10005. PTHR10005. 1 hit.
PTHR10005:SF3. PTHR10005:SF3. 1 hit.
Pfami PF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view ]
SMARTi SM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of human cDNA clones of ski and the ski-related gene, sno."
    Nomura N., Sasamoto S., Ishii S., Date T., Matsui M., Ishizaki R.
    Nucleic Acids Res. 17:5489-5500(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SNON AND SNOA), VARIANT VAL-38.
    Tissue: Umbilical vein endothelial cell.
  2. "Proto-oncogene Sno expression, alternative isoforms and immediate early serum response."
    Pearson-White S.H., Crittenden R.
    Nucleic Acids Res. 25:2930-2937(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SNON2), VARIANT VAL-38.
    Tissue: Kidney.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SNON), VARIANT VAL-38.
    Tissue: Placenta.
  6. "SnoI, a novel alternatively spliced isoform of the ski proto-oncogene homolog, sno."
    Pearson-White S.
    Nucleic Acids Res. 21:4632-4638(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 13-684 (ISOFORM SNOI), TISSUE SPECIFICITY.
    Tissue: Myoblast.
  7. "Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)."
    Komuro A., Imamura T., Saitoh M., Yoshida Y., Yamori T., Miyazono K., Miyazawa K.
    Oncogene 23:6914-6923(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WWP1.
  8. "Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation."
    Levy L., Howell M., Das D., Harkin S., Episkopou V., Hill C.S.
    Mol. Cell. Biol. 27:6068-6083(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RNF111.

Entry informationi

Entry nameiSKIL_HUMAN
AccessioniPrimary (citable) accession number: P12757
Secondary accession number(s): A6NGT1
, B4DT50, O00464, P12756, Q07501
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: November 30, 2010
Last modified: November 26, 2014
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

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