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Reviewed, UniProtKB/Swiss-Prot P12755 (SKI_HUMAN)

Last modified June 16, 2009. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Ski oncogene
Alternative name(s):
    C-ski
Gene names
Name: SKI
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length728 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage.

Subunit structure

Interacts with SMAD2, SMAD3 and SMAD4. Interacts with HIPK2. Part of a complex with HIPK2 and SMAD1/2/3. Ref.3

Subcellular location

Nucleus.

Sequence similarities

Belongs to the SKI family.

Ontologies

Keywords
   Cellular componentNucleus
   DiseaseProto-oncogene
   DomainCoiled coil
Repeat
   Technical term3D-structure
Gene Ontology (GO)
   Biological processBMP signaling pathway

Inferred from Experiment. Source: Reactome

cell differentiation

Non-traceable author statement. Source: UniProtKB

   Cellular componentnucleoplasm

Inferred from Experiment. Source: Reactome

   Molecular functionnucleotide binding

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 728728Ski oncogene
PRO_0000129382

Regions

Coiled coil536 – 710175 Potential

Secondary structure

.................................. 728
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P12755-1 [UniParc].

Last modified October 1, 1989. Version 1.
Checksum: 9B78C4840A28C2DA

FASTA72880,005
        10         20         30         40         50         60 
MEAAAGGRGC FQPHPGLQKT LEQFHLSSMS SLGGPAAFSA RWAQEAYKKE SAKEAGAAAV 

        70         80         90        100        110        120 
PAPVPAATEP PPVLHLPAIQ PPPPVLPGPF FMPSDRSTER CETVLEGETI SCFVVGGEKR 

       130        140        150        160        170        180 
LCLPQILNSV LRDFSLQQIN AVCDELHIYC SRCTADQLEI LKVMGILPFS APSCGLITKT 

       190        200        210        220        230        240 
DAERLCNALL YGGAYPPPCK KELAASLALG LELSERSVRV YHECFGKCKG LLVPELYSSP 

       250        260        270        280        290        300 
SAACIQCLDC RLMYPPHKFV VHSHKALENR TCHWGFDSAN WRAYILLSQD YTGKEEQARL 

       310        320        330        340        350        360 
GRCLDDVKEK FDYGNKYKRR VPRVSSEPPA SIRPKTDDTS SQSPAPSEKD KPSSWLRTLA 

       370        380        390        400        410        420 
GSSNKSLGCV HPRQRLSAFR PWSPAVSASE KELSPHLPAL IRDSFYSYKS FETAVAPNVA 

       430        440        450        460        470        480 
LAPPAQQKVV SSPPCAAAVS RAPEPLATCT QPRKRKLTVD TPGAPETLAP VAAPEEDKDS 

       490        500        510        520        530        540 
EAEVEVESRE EFTSSLSSLS SPSFTSSSSA KDLGSPGARA LPSAVPDAAA PADAPSGLEA 

       550        560        570        580        590        600 
ELEHLRQALE GGLDTKEAKE KFLHEVVKMR VKQEEKLSAA LQAKRSLHQE LEFLRVAKKE 

       610        620        630        640        650        660 
KLREATEAKR NLRKEIERLR AENEKKMKEA NESRLRLKRE LEQARQARVC DKGCEAGRLR 

       670        680        690        700        710        720 
AKYSAQIEDL QVKLQHAEAD REQLRADLLR EREAREHLEK VVKELQEQLW PRARPEAAGS 


EGAAELEP 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of human cDNA clones of ski and the ski-related gene, sno."
Nomura N., Sasamoto S., Ishii S., Date T., Matsui M., Ishizaki R.
Nucleic Acids Res. 17:5489-5500(1989) [PubMed: 2762147] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed: 16710414] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation."
Harada J., Kokura K., Kanei-Ishii C., Nomura T., Khan M.M., Kim Y., Ishii S.
J. Biol. Chem. 278:38998-39005(2003) [PubMed: 12874272] [Abstract]
Cited for: INTERACTION WITH HIPK2; SMAD2; SMAD3 AND SMAD4.
+Additional computationally mapped references.

Cross-references

Sequence databases

X15218 mRNA. Translation: CAA33288.1.
AL590822 Genomic DNA. Translation: CAI12482.1.
IPIIPI00220921.
PIRTVHUSK. S06053.
RefSeqNP_003027.1.
UniGeneHs.663133

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1MR1X-ray2.85C/D219-313[»]
1SBXX-ray1.65A91-192[»]
ModBaseSearch...

Protein-protein interaction databases

IntActP12755. 4 interactions.

Proteomic databases

PRIDEP12755.

Genome annotation databases

EnsemblENSG00000157933. Homo sapiens. [Contig view]
GeneID6497.
KEGGhsa:6497.

Organism-specific databases

GeneCardsGC01P002173.
H-InvDBHIX0028862.
HGNCHGNC:10896. SKI.
HPACAB010449.
MIM164780. gene.
PharmGKBPA35796.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP12755.
HOVERGENP12755.
OMAP12755. NKYKRKA.

Enzyme and pathway databases

Pathway_Interaction_DBbmppathway. BMP receptor signaling.
smad2_3nuclearpathway. Regulation of nuclear SMAD2/3 signaling.
ReactomeREACT_12034. Signaling by BMP.
REACT_6844. Signaling by TGF beta.

Gene expression databases

ArrayExpressP12755.
BgeeP12755.
CleanExHS_SKI.
GermOnlineENSG00000157933. Homo sapiens.

Family and domain databases

InterProIPR014890. c-SKI_SMAD_bd.
IPR010919. SAND-like.
IPR003380. Transform_Ski.
[Graphical view]
Gene3DG3DSA:3.10.390.10. SAND. 1 hit.
G3DSA:3.10.260.20. Transform_Ski. 1 hit.
PfamPF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio25255.
SOURCESearch...

Entry information

Entry nameSKI_HUMAN
AccessionPrimary (citable) accession number: P12755
Secondary accession number(s): Q5SYT7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: June 16, 2009
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents