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P12755

- SKI_HUMAN

UniProt

P12755 - SKI_HUMAN

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Protein

Ski oncogene

Gene
SKI
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling.1 Publication

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. histone deacetylase inhibitor activity Source: BHF-UCL
  3. protein binding Source: UniProtKB
  4. protein domain specific binding Source: UniProtKB
  5. protein kinase binding Source: UniProtKB
  6. repressing transcription factor binding Source: UniProtKB
  7. SMAD binding Source: UniProtKB
  8. transcription corepressor activity Source: UniProtKB
  9. ubiquitin protein ligase binding Source: UniProtKB
  10. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. anterior/posterior axis specification Source: BHF-UCL
  2. BMP signaling pathway Source: Reactome
  3. bone morphogenesis Source: BHF-UCL
  4. camera-type eye development Source: BHF-UCL
  5. camera-type eye morphogenesis Source: BHF-UCL
  6. cell motility Source: BHF-UCL
  7. cell proliferation Source: BHF-UCL
  8. embryonic limb morphogenesis Source: BHF-UCL
  9. face morphogenesis Source: BHF-UCL
  10. gene expression Source: Reactome
  11. lens morphogenesis in camera-type eye Source: BHF-UCL
  12. myelination in peripheral nervous system Source: BHF-UCL
  13. myotube differentiation Source: UniProtKB
  14. negative regulation of activin receptor signaling pathway Source: UniProtKB
  15. negative regulation of BMP signaling pathway Source: UniProtKB
  16. negative regulation of cell proliferation Source: UniProtKB
  17. negative regulation of fibroblast proliferation Source: BHF-UCL
  18. negative regulation of osteoblast differentiation Source: UniProtKB
  19. negative regulation of Schwann cell proliferation Source: MGI
  20. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  21. negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
  22. neural tube closure Source: BHF-UCL
  23. nose morphogenesis Source: BHF-UCL
  24. olfactory bulb development Source: BHF-UCL
  25. palate development Source: BHF-UCL
  26. positive regulation of DNA binding Source: UniProtKB
  27. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  28. positive regulation of Wnt signaling pathway Source: BHF-UCL
  29. protein homotrimerization Source: UniProtKB
  30. regulation of apoptotic process Source: BHF-UCL
  31. retina development in camera-type eye Source: BHF-UCL
  32. skeletal muscle fiber development Source: BHF-UCL
  33. SMAD protein signal transduction Source: UniProtKB
  34. somatic stem cell maintenance Source: BHF-UCL
  35. transcription, DNA-templated Source: BHF-UCL
  36. transcription initiation from RNA polymerase II promoter Source: Reactome
  37. transforming growth factor beta receptor signaling pathway Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_12034. Signaling by BMP.
REACT_121111. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
SignaLinkiP12755.

Names & Taxonomyi

Protein namesi
Recommended name:
Ski oncogene
Alternative name(s):
Proto-oncogene c-Ski
Gene namesi
Name:SKI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10896. SKI.

Subcellular locationi

GO - Cellular componenti

  1. centrosome Source: MGI
  2. cytoplasm Source: BHF-UCL
  3. nuclear body Source: UniProtKB
  4. nucleoplasm Source: Reactome
  5. nucleus Source: UniProtKB
  6. PML body Source: UniProtKB
  7. protein complex Source: MGI
  8. transcriptional repressor complex Source: BHF-UCL
  9. transcription factor complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

Orphaneti1606. 1p36 deletion syndrome.
2462. Shprintzen-Goldberg syndrome.
PharmGKBiPA35796.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 728728Ski oncogenePRO_0000129382Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei480 – 4801Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP12755.
PaxDbiP12755.
PRIDEiP12755.

PTM databases

PhosphoSiteiP12755.

Expressioni

Gene expression databases

ArrayExpressiP12755.
BgeeiP12755.
CleanExiHS_SKI.
GenevestigatoriP12755.

Organism-specific databases

HPAiCAB010449.

Interactioni

Subunit structurei

Interacts with SMAD2, SMAD3 and SMAD4. Interacts with HIPK2. Part of a complex with HIPK2 and SMAD1/2/3. Interacts with PRDM16 and SMAD3; the interaction with PRDM16 promotes the recruitment SMAD3-HDAC1 complex on the promoter of TGF-beta target genes.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Fam89bQ9QUI16EBI-347281,EBI-6503100From a different organism.
NCOR1O753762EBI-347281,EBI-347233
Ncor1Q609745EBI-347281,EBI-349004From a different organism.
SIN3AQ96ST33EBI-347281,EBI-347218
SMAD3P840222EBI-347281,EBI-347161
SMAD4Q134854EBI-347281,EBI-347263

Protein-protein interaction databases

BioGridi112388. 45 interactions.
DIPiDIP-31514N.
IntActiP12755. 11 interactions.
MINTiMINT-269973.
STRINGi9606.ENSP00000367797.

Structurei

Secondary structure

1
728
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi101 – 1055
Beta strandi108 – 1158
Beta strandi118 – 1225
Helixi123 – 1275
Turni128 – 1336
Helixi136 – 14510
Helixi155 – 1639
Beta strandi175 – 1784
Helixi179 – 19012
Beta strandi219 – 2224
Beta strandi228 – 2325
Helixi234 – 2363
Beta strandi245 – 2473
Turni248 – 2503
Helixi256 – 2594
Beta strandi269 – 2757
Helixi278 – 2803
Helixi281 – 2844
Helixi296 – 31015

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MR1X-ray2.85C/D219-313[»]
1SBXX-ray1.65A91-192[»]
ProteinModelPortaliP12755.
SMRiP12755. Positions 91-192, 218-312.

Miscellaneous databases

EvolutionaryTraceiP12755.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili536 – 710175 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the SKI family.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG82850.
HOGENOMiHOG000039989.
HOVERGENiHBG006599.
InParanoidiP12755.
OMAiARQIRVC.
OrthoDBiEOG72RN0F.
PhylomeDBiP12755.
TreeFamiTF324133.

Family and domain databases

Gene3Di3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProiIPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028760. Ski.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view]
PANTHERiPTHR10005. PTHR10005. 1 hit.
PTHR10005:SF15. PTHR10005:SF15. 1 hit.
PfamiPF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view]
SMARTiSM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.

Sequencei

Sequence statusi: Complete.

P12755-1 [UniParc]FASTAAdd to Basket

« Hide

MEAAAGGRGC FQPHPGLQKT LEQFHLSSMS SLGGPAAFSA RWAQEAYKKE    50
SAKEAGAAAV PAPVPAATEP PPVLHLPAIQ PPPPVLPGPF FMPSDRSTER 100
CETVLEGETI SCFVVGGEKR LCLPQILNSV LRDFSLQQIN AVCDELHIYC 150
SRCTADQLEI LKVMGILPFS APSCGLITKT DAERLCNALL YGGAYPPPCK 200
KELAASLALG LELSERSVRV YHECFGKCKG LLVPELYSSP SAACIQCLDC 250
RLMYPPHKFV VHSHKALENR TCHWGFDSAN WRAYILLSQD YTGKEEQARL 300
GRCLDDVKEK FDYGNKYKRR VPRVSSEPPA SIRPKTDDTS SQSPAPSEKD 350
KPSSWLRTLA GSSNKSLGCV HPRQRLSAFR PWSPAVSASE KELSPHLPAL 400
IRDSFYSYKS FETAVAPNVA LAPPAQQKVV SSPPCAAAVS RAPEPLATCT 450
QPRKRKLTVD TPGAPETLAP VAAPEEDKDS EAEVEVESRE EFTSSLSSLS 500
SPSFTSSSSA KDLGSPGARA LPSAVPDAAA PADAPSGLEA ELEHLRQALE 550
GGLDTKEAKE KFLHEVVKMR VKQEEKLSAA LQAKRSLHQE LEFLRVAKKE 600
KLREATEAKR NLRKEIERLR AENEKKMKEA NESRLRLKRE LEQARQARVC 650
DKGCEAGRLR AKYSAQIEDL QVKLQHAEAD REQLRADLLR EREAREHLEK 700
VVKELQEQLW PRARPEAAGS EGAAELEP 728
Length:728
Mass (Da):80,005
Last modified:October 1, 1989 - v1
Checksum:i9B78C4840A28C2DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15218 mRNA. Translation: CAA33288.1.
AL590822 Genomic DNA. No translation available.
CCDSiCCDS39.1.
PIRiS06053. TVHUSK.
RefSeqiNP_003027.1. NM_003036.3.
UniGeneiHs.656507.

Genome annotation databases

EnsembliENST00000378536; ENSP00000367797; ENSG00000157933.
GeneIDi6497.
KEGGihsa:6497.
UCSCiuc001aja.4. human.

Polymorphism databases

DMDMi134517.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15218 mRNA. Translation: CAA33288.1 .
AL590822 Genomic DNA. No translation available.
CCDSi CCDS39.1.
PIRi S06053. TVHUSK.
RefSeqi NP_003027.1. NM_003036.3.
UniGenei Hs.656507.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1MR1 X-ray 2.85 C/D 219-313 [» ]
1SBX X-ray 1.65 A 91-192 [» ]
ProteinModelPortali P12755.
SMRi P12755. Positions 91-192, 218-312.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112388. 45 interactions.
DIPi DIP-31514N.
IntActi P12755. 11 interactions.
MINTi MINT-269973.
STRINGi 9606.ENSP00000367797.

PTM databases

PhosphoSitei P12755.

Polymorphism databases

DMDMi 134517.

Proteomic databases

MaxQBi P12755.
PaxDbi P12755.
PRIDEi P12755.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000378536 ; ENSP00000367797 ; ENSG00000157933 .
GeneIDi 6497.
KEGGi hsa:6497.
UCSCi uc001aja.4. human.

Organism-specific databases

CTDi 6497.
GeneCardsi GC01P002173.
GeneReviewsi SKI.
HGNCi HGNC:10896. SKI.
HPAi CAB010449.
MIMi 164780. gene.
neXtProti NX_P12755.
Orphaneti 1606. 1p36 deletion syndrome.
2462. Shprintzen-Goldberg syndrome.
PharmGKBi PA35796.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG82850.
HOGENOMi HOG000039989.
HOVERGENi HBG006599.
InParanoidi P12755.
OMAi ARQIRVC.
OrthoDBi EOG72RN0F.
PhylomeDBi P12755.
TreeFami TF324133.

Enzyme and pathway databases

Reactomei REACT_12034. Signaling by BMP.
REACT_121111. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
SignaLinki P12755.

Miscellaneous databases

ChiTaRSi SKI. human.
EvolutionaryTracei P12755.
GeneWikii SKI_protein.
GenomeRNAii 6497.
NextBioi 25255.
PROi P12755.
SOURCEi Search...

Gene expression databases

ArrayExpressi P12755.
Bgeei P12755.
CleanExi HS_SKI.
Genevestigatori P12755.

Family and domain databases

Gene3Di 3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProi IPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028760. Ski.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view ]
PANTHERi PTHR10005. PTHR10005. 1 hit.
PTHR10005:SF15. PTHR10005:SF15. 1 hit.
Pfami PF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view ]
SMARTi SM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of human cDNA clones of ski and the ski-related gene, sno."
    Nomura N., Sasamoto S., Ishii S., Date T., Matsui M., Ishizaki R.
    Nucleic Acids Res. 17:5489-5500(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation."
    Harada J., Kokura K., Kanei-Ishii C., Nomura T., Khan M.M., Kim Y., Ishii S.
    J. Biol. Chem. 278:38998-39005(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HIPK2; SMAD2; SMAD3 AND SMAD4.
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: FUNCTION, INTERACTION WITH PRDM16 AND SMAD3.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiSKI_HUMAN
AccessioniPrimary (citable) accession number: P12755
Secondary accession number(s): Q5SYT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: September 3, 2014
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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