Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P12755

- SKI_HUMAN

UniProt

P12755 - SKI_HUMAN

Protein

Ski oncogene

Gene

SKI

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 1 (01 Oct 1989)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling.1 Publication

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. histone deacetylase inhibitor activity Source: BHF-UCL
    3. protein binding Source: UniProtKB
    4. protein domain specific binding Source: UniProtKB
    5. protein kinase binding Source: UniProtKB
    6. repressing transcription factor binding Source: UniProtKB
    7. SMAD binding Source: UniProtKB
    8. transcription corepressor activity Source: UniProtKB
    9. ubiquitin protein ligase binding Source: UniProtKB
    10. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. anterior/posterior axis specification Source: BHF-UCL
    2. BMP signaling pathway Source: Reactome
    3. bone morphogenesis Source: BHF-UCL
    4. camera-type eye development Source: BHF-UCL
    5. camera-type eye morphogenesis Source: BHF-UCL
    6. cell motility Source: BHF-UCL
    7. cell proliferation Source: BHF-UCL
    8. embryonic limb morphogenesis Source: BHF-UCL
    9. face morphogenesis Source: BHF-UCL
    10. gene expression Source: Reactome
    11. lens morphogenesis in camera-type eye Source: BHF-UCL
    12. myelination in peripheral nervous system Source: BHF-UCL
    13. myotube differentiation Source: UniProtKB
    14. negative regulation of activin receptor signaling pathway Source: UniProtKB
    15. negative regulation of BMP signaling pathway Source: UniProtKB
    16. negative regulation of cell proliferation Source: UniProtKB
    17. negative regulation of fibroblast proliferation Source: BHF-UCL
    18. negative regulation of osteoblast differentiation Source: UniProtKB
    19. negative regulation of Schwann cell proliferation Source: MGI
    20. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    21. negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
    22. neural tube closure Source: BHF-UCL
    23. nose morphogenesis Source: BHF-UCL
    24. olfactory bulb development Source: BHF-UCL
    25. palate development Source: BHF-UCL
    26. positive regulation of DNA binding Source: UniProtKB
    27. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    28. positive regulation of Wnt signaling pathway Source: BHF-UCL
    29. protein homotrimerization Source: UniProtKB
    30. regulation of apoptotic process Source: BHF-UCL
    31. retina development in camera-type eye Source: BHF-UCL
    32. skeletal muscle fiber development Source: BHF-UCL
    33. SMAD protein signal transduction Source: UniProtKB
    34. somatic stem cell maintenance Source: BHF-UCL
    35. transcription, DNA-templated Source: BHF-UCL
    36. transcription initiation from RNA polymerase II promoter Source: Reactome
    37. transforming growth factor beta receptor signaling pathway Source: BHF-UCL

    Enzyme and pathway databases

    ReactomeiREACT_12034. Signaling by BMP.
    REACT_121111. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
    SignaLinkiP12755.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ski oncogene
    Alternative name(s):
    Proto-oncogene c-Ski
    Gene namesi
    Name:SKI
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:10896. SKI.

    Subcellular locationi

    GO - Cellular componenti

    1. centrosome Source: MGI
    2. cytoplasm Source: BHF-UCL
    3. nuclear body Source: UniProtKB
    4. nucleoplasm Source: Reactome
    5. nucleus Source: UniProtKB
    6. PML body Source: UniProtKB
    7. protein complex Source: MGI
    8. transcriptional repressor complex Source: BHF-UCL
    9. transcription factor complex Source: BHF-UCL

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Shprintzen-Goldberg craniosynostosis syndrome (SGS) [MIM:182212]: A very rare syndrome characterized by a marfanoid habitus, craniosynostosis, characteristic dysmorphic facial features, skeletal and cardiovascular abnormalities, mental retardation, developmental delay and learning disabilities.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211L → R in SGS. 1 Publication
    VAR_071170
    Natural varianti31 – 311S → L in SGS. 1 Publication
    VAR_071171
    Natural varianti32 – 321L → P in SGS. 1 Publication
    VAR_071172
    Natural varianti32 – 321L → V in SGS. 2 Publications
    VAR_071173
    Natural varianti34 – 341G → C in SGS. 2 Publications
    VAR_071174
    Natural varianti34 – 341G → D in SGS. 1 Publication
    VAR_071175
    Natural varianti34 – 341G → S in SGS. 2 Publications
    VAR_071176
    Natural varianti34 – 341G → V in SGS. 1 Publication
    VAR_071177
    Natural varianti35 – 351P → Q in SGS. 1 Publication
    VAR_071178
    Natural varianti35 – 351P → S in SGS. 2 Publications
    VAR_071179
    Natural varianti94 – 974Missing in SGS.
    VAR_071180
    Natural varianti95 – 973Missing in SGS.
    VAR_071181
    Natural varianti116 – 1161G → E in SGS. 1 Publication
    VAR_071182
    Natural varianti117 – 1171G → R in SGS. 1 Publication
    VAR_071183

    Keywords - Diseasei

    Craniosynostosis, Disease mutation, Proto-oncogene

    Organism-specific databases

    MIMi182212. phenotype.
    Orphaneti1606. 1p36 deletion syndrome.
    2462. Shprintzen-Goldberg syndrome.
    PharmGKBiPA35796.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 728728Ski oncogenePRO_0000129382Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei480 – 4801Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP12755.
    PaxDbiP12755.
    PRIDEiP12755.

    PTM databases

    PhosphoSiteiP12755.

    Expressioni

    Gene expression databases

    ArrayExpressiP12755.
    BgeeiP12755.
    CleanExiHS_SKI.
    GenevestigatoriP12755.

    Organism-specific databases

    HPAiCAB010449.

    Interactioni

    Subunit structurei

    Interacts with SMAD2, SMAD3 and SMAD4. Interacts with HIPK2. Part of a complex with HIPK2 and SMAD1/2/3. Interacts with PRDM16 and SMAD3; the interaction with PRDM16 promotes the recruitment SMAD3-HDAC1 complex on the promoter of TGF-beta target genes.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Fam89bQ9QUI16EBI-347281,EBI-6503100From a different organism.
    NCOR1O753762EBI-347281,EBI-347233
    Ncor1Q609745EBI-347281,EBI-349004From a different organism.
    SIN3AQ96ST33EBI-347281,EBI-347218
    SMAD3P840222EBI-347281,EBI-347161
    SMAD4Q134854EBI-347281,EBI-347263

    Protein-protein interaction databases

    BioGridi112388. 45 interactions.
    DIPiDIP-31514N.
    IntActiP12755. 11 interactions.
    MINTiMINT-269973.
    STRINGi9606.ENSP00000367797.

    Structurei

    Secondary structure

    1
    728
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi101 – 1055
    Beta strandi108 – 1158
    Beta strandi118 – 1225
    Helixi123 – 1275
    Turni128 – 1336
    Helixi136 – 14510
    Helixi155 – 1639
    Beta strandi175 – 1784
    Helixi179 – 19012
    Beta strandi219 – 2224
    Beta strandi228 – 2325
    Helixi234 – 2363
    Beta strandi245 – 2473
    Turni248 – 2503
    Helixi256 – 2594
    Beta strandi269 – 2757
    Helixi278 – 2803
    Helixi281 – 2844
    Helixi296 – 31015

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1MR1X-ray2.85C/D219-313[»]
    1SBXX-ray1.65A91-192[»]
    ProteinModelPortaliP12755.
    SMRiP12755. Positions 91-192, 218-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP12755.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili536 – 710175Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SKI family.Curated

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG82850.
    HOGENOMiHOG000039989.
    HOVERGENiHBG006599.
    InParanoidiP12755.
    OMAiARQIRVC.
    OrthoDBiEOG72RN0F.
    PhylomeDBiP12755.
    TreeFamiTF324133.

    Family and domain databases

    Gene3Di3.10.260.20. 1 hit.
    3.10.390.10. 1 hit.
    InterProiIPR014890. c-SKI_SMAD4-bd_dom.
    IPR009061. DNA-bd_dom_put.
    IPR010919. SAND_dom-like.
    IPR028760. Ski.
    IPR003380. Transform_Ski.
    IPR023216. Tscrpt_reg_SKI_SnoN.
    [Graphical view]
    PANTHERiPTHR10005. PTHR10005. 1 hit.
    PTHR10005:SF15. PTHR10005:SF15. 1 hit.
    PfamiPF08782. c-SKI_SMAD_bind. 1 hit.
    PF02437. Ski_Sno. 1 hit.
    [Graphical view]
    SMARTiSM01046. c-SKI_SMAD_bind. 1 hit.
    [Graphical view]
    SUPFAMiSSF46955. SSF46955. 1 hit.
    SSF63763. SSF63763. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P12755-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAAAGGRGC FQPHPGLQKT LEQFHLSSMS SLGGPAAFSA RWAQEAYKKE    50
    SAKEAGAAAV PAPVPAATEP PPVLHLPAIQ PPPPVLPGPF FMPSDRSTER 100
    CETVLEGETI SCFVVGGEKR LCLPQILNSV LRDFSLQQIN AVCDELHIYC 150
    SRCTADQLEI LKVMGILPFS APSCGLITKT DAERLCNALL YGGAYPPPCK 200
    KELAASLALG LELSERSVRV YHECFGKCKG LLVPELYSSP SAACIQCLDC 250
    RLMYPPHKFV VHSHKALENR TCHWGFDSAN WRAYILLSQD YTGKEEQARL 300
    GRCLDDVKEK FDYGNKYKRR VPRVSSEPPA SIRPKTDDTS SQSPAPSEKD 350
    KPSSWLRTLA GSSNKSLGCV HPRQRLSAFR PWSPAVSASE KELSPHLPAL 400
    IRDSFYSYKS FETAVAPNVA LAPPAQQKVV SSPPCAAAVS RAPEPLATCT 450
    QPRKRKLTVD TPGAPETLAP VAAPEEDKDS EAEVEVESRE EFTSSLSSLS 500
    SPSFTSSSSA KDLGSPGARA LPSAVPDAAA PADAPSGLEA ELEHLRQALE 550
    GGLDTKEAKE KFLHEVVKMR VKQEEKLSAA LQAKRSLHQE LEFLRVAKKE 600
    KLREATEAKR NLRKEIERLR AENEKKMKEA NESRLRLKRE LEQARQARVC 650
    DKGCEAGRLR AKYSAQIEDL QVKLQHAEAD REQLRADLLR EREAREHLEK 700
    VVKELQEQLW PRARPEAAGS EGAAELEP 728
    Length:728
    Mass (Da):80,005
    Last modified:October 1, 1989 - v1
    Checksum:i9B78C4840A28C2DA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211L → R in SGS. 1 Publication
    VAR_071170
    Natural varianti31 – 311S → L in SGS. 1 Publication
    VAR_071171
    Natural varianti32 – 321L → P in SGS. 1 Publication
    VAR_071172
    Natural varianti32 – 321L → V in SGS. 2 Publications
    VAR_071173
    Natural varianti34 – 341G → C in SGS. 2 Publications
    VAR_071174
    Natural varianti34 – 341G → D in SGS. 1 Publication
    VAR_071175
    Natural varianti34 – 341G → S in SGS. 2 Publications
    VAR_071176
    Natural varianti34 – 341G → V in SGS. 1 Publication
    VAR_071177
    Natural varianti35 – 351P → Q in SGS. 1 Publication
    VAR_071178
    Natural varianti35 – 351P → S in SGS. 2 Publications
    VAR_071179
    Natural varianti94 – 974Missing in SGS.
    VAR_071180
    Natural varianti95 – 973Missing in SGS.
    VAR_071181
    Natural varianti116 – 1161G → E in SGS. 1 Publication
    VAR_071182
    Natural varianti117 – 1171G → R in SGS. 1 Publication
    VAR_071183

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15218 mRNA. Translation: CAA33288.1.
    AL590822 Genomic DNA. No translation available.
    CCDSiCCDS39.1.
    PIRiS06053. TVHUSK.
    RefSeqiNP_003027.1. NM_003036.3.
    UniGeneiHs.656507.

    Genome annotation databases

    EnsembliENST00000378536; ENSP00000367797; ENSG00000157933.
    GeneIDi6497.
    KEGGihsa:6497.
    UCSCiuc001aja.4. human.

    Polymorphism databases

    DMDMi134517.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15218 mRNA. Translation: CAA33288.1 .
    AL590822 Genomic DNA. No translation available.
    CCDSi CCDS39.1.
    PIRi S06053. TVHUSK.
    RefSeqi NP_003027.1. NM_003036.3.
    UniGenei Hs.656507.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1MR1 X-ray 2.85 C/D 219-313 [» ]
    1SBX X-ray 1.65 A 91-192 [» ]
    ProteinModelPortali P12755.
    SMRi P12755. Positions 91-192, 218-312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112388. 45 interactions.
    DIPi DIP-31514N.
    IntActi P12755. 11 interactions.
    MINTi MINT-269973.
    STRINGi 9606.ENSP00000367797.

    PTM databases

    PhosphoSitei P12755.

    Polymorphism databases

    DMDMi 134517.

    Proteomic databases

    MaxQBi P12755.
    PaxDbi P12755.
    PRIDEi P12755.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378536 ; ENSP00000367797 ; ENSG00000157933 .
    GeneIDi 6497.
    KEGGi hsa:6497.
    UCSCi uc001aja.4. human.

    Organism-specific databases

    CTDi 6497.
    GeneCardsi GC01P002173.
    GeneReviewsi SKI.
    HGNCi HGNC:10896. SKI.
    HPAi CAB010449.
    MIMi 164780. gene.
    182212. phenotype.
    neXtProti NX_P12755.
    Orphaneti 1606. 1p36 deletion syndrome.
    2462. Shprintzen-Goldberg syndrome.
    PharmGKBi PA35796.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG82850.
    HOGENOMi HOG000039989.
    HOVERGENi HBG006599.
    InParanoidi P12755.
    OMAi ARQIRVC.
    OrthoDBi EOG72RN0F.
    PhylomeDBi P12755.
    TreeFami TF324133.

    Enzyme and pathway databases

    Reactomei REACT_12034. Signaling by BMP.
    REACT_121111. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
    SignaLinki P12755.

    Miscellaneous databases

    ChiTaRSi SKI. human.
    EvolutionaryTracei P12755.
    GeneWikii SKI_protein.
    GenomeRNAii 6497.
    NextBioi 25255.
    PROi P12755.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P12755.
    Bgeei P12755.
    CleanExi HS_SKI.
    Genevestigatori P12755.

    Family and domain databases

    Gene3Di 3.10.260.20. 1 hit.
    3.10.390.10. 1 hit.
    InterProi IPR014890. c-SKI_SMAD4-bd_dom.
    IPR009061. DNA-bd_dom_put.
    IPR010919. SAND_dom-like.
    IPR028760. Ski.
    IPR003380. Transform_Ski.
    IPR023216. Tscrpt_reg_SKI_SnoN.
    [Graphical view ]
    PANTHERi PTHR10005. PTHR10005. 1 hit.
    PTHR10005:SF15. PTHR10005:SF15. 1 hit.
    Pfami PF08782. c-SKI_SMAD_bind. 1 hit.
    PF02437. Ski_Sno. 1 hit.
    [Graphical view ]
    SMARTi SM01046. c-SKI_SMAD_bind. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46955. SSF46955. 1 hit.
    SSF63763. SSF63763. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of human cDNA clones of ski and the ski-related gene, sno."
      Nomura N., Sasamoto S., Ishii S., Date T., Matsui M., Ishizaki R.
      Nucleic Acids Res. 17:5489-5500(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Requirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activation."
      Harada J., Kokura K., Kanei-Ishii C., Nomura T., Khan M.M., Kim Y., Ishii S.
      J. Biol. Chem. 278:38998-39005(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HIPK2; SMAD2; SMAD3 AND SMAD4.
    4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Cited for: FUNCTION, INTERACTION WITH PRDM16 AND SMAD3.
    6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    7. Cited for: VARIANTS SGS LEU-31; VAL-32; PRO-32; CYS-34; VAL-34; SER-34; GLN-35; SER-35; 94-SER--SER-97 DEL AND 95-ASP--SER-97 DEL.
    8. Cited for: VARIANTS SGS ARG-21; VAL-32; ASP-34; CYS-34; SER-34; SER-35; 95-ASP--SER-97 DEL; GLU-116 AND ARG-117.

    Entry informationi

    Entry nameiSKI_HUMAN
    AccessioniPrimary (citable) accession number: P12755
    Secondary accession number(s): Q5SYT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 145 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3