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P12748 (LUXC_ALIFS) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acyl-CoA reductase

EC=1.2.1.50
Gene names
Name:luxC
OrganismAliivibrio fischeri (Vibrio fischeri)
Taxonomic identifier668 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.

Catalytic activity

A long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH.

Pathway

Lipid metabolism; fatty acid reduction for biolumincescence.

Sequence similarities

Belongs to the LuxC family.

Ontologies

Keywords
   Biological processLuminescence
   LigandNADP
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processbioluminescence

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionacyl-CoA dehydrogenase activity

Inferred from electronic annotation. Source: InterPro

long-chain-fatty-acyl-CoA reductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479Acyl-CoA reductase
PRO_0000220201

Sequences

Sequence LengthMass (Da)Tools
P12748 [UniParc].

Last modified March 15, 2004. Version 3.
Checksum: 10FD9567E5026340

FASTA47954,578
        10         20         30         40         50         60 
MNKCIPMIIN GMIQDFDNYA YKEVKLNNDN RVKLSVITES SVSKTLNIKD RINLNLNQIV 

        70         80         90        100        110        120 
NFLYTVGQRW KSEEYNRRRT YIRELKTYLG YSDEMARLEA NWIAMLLCSK SALYDIVNYD 

       130        140        150        160        170        180 
LGSIHVLDEW LPRGDCYVKA QPKGVSVHLL AGNVPLSGVT SILRAILTKN ECIIKTSSSD 

       190        200        210        220        230        240 
PFTANALVSS FIDVNADHPI TKSMSVMYWP HDEDMTLSQR IMNHADVVIA WGGDEAIKWA 

       250        260        270        280        290        300 
VKYSPPHVDI LKFGPKKSLS IIEAPKDIEA AAMGVAHDIC FYDQQACFST QDVYYIGDNL 

       310        320        330        340        350        360 
PLFLNELEKQ LDRYAKILPK GSNSFDEKAA FTLTEKESLF AGYEVRKGDK QAWLIVVSPT 

       370        380        390        400        410        420 
NSFGNQPLSR SVYVHQVSDI KEIIPFVNKN RTQTVSIYPW EASLKYRDKL ARSGVERIVE 

       430        440        450        460        470 
SGMNNIFRVG GAHDSLSPLQ YLVRFVSHER PFNYTTKDVA VEIEQTRYLE EDKFLVFVP 

« Hide

References

[1]"Vibrio fischeri Lux operon SalI digest."
Knight T., Papadakis N.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: MJ-1.
[2]"Nucleotide sequence of the regulatory locus controlling expression of bacterial genes for bioluminescence."
Engebrecht J., Silverman M.
Nucleic Acids Res. 15:10455-10467(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-81.
[3]"Nucleotide sequence of the luxR and luxI genes and structure of the primary regulatory region of the lux regulon of Vibrio fischeri ATCC 7744."
Devine J.H., Countryman C., Baldwin T.O.
Biochemistry 27:837-842(1988)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
Strain: ATCC 7744 / DSM 507 / NCIMB 1281 / 398.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF170104 Genomic DNA. Translation: AAD48475.1.
M19039 Genomic DNA. Translation: AAA27553.1.
Y00509 Genomic DNA. Translation: CAA68563.1.
PIRS06862.

3D structure databases

ProteinModelPortalP12748.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00569.

Family and domain databases

Gene3D3.40.605.10. 1 hit.
InterProIPR008670. Acyl-CoA_reduct_LuxC.
IPR016161. Ald_DH/histidinol_DH.
IPR016162. Ald_DH_N.
[Graphical view]
PfamPF05893. LuxC. 1 hit.
[Graphical view]
PIRSFPIRSF009414. LuxC. 1 hit.
SUPFAMSSF53720. SSF53720. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLUXC_ALIFS
AccessionPrimary (citable) accession number: P12748
Secondary accession number(s): Q9S3Z3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: March 15, 2004
Last modified: December 11, 2013
This is version 72 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways