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Protein

Long-chain acyl-protein thioester reductase

Gene

luxC

Organism
Aliivibrio fischeri (Vibrio fischeri)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.By similarity

Catalytic activityi

A long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH.By similarity

Pathwayi: fatty acid reduction for biolumincescence

This protein is involved in the pathway fatty acid reduction for biolumincescence, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid reduction for biolumincescence and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

  • bioluminescence Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Luminescence

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00569.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain acyl-protein thioester reductaseCurated (EC:1.2.1.50By similarity)
Alternative name(s):
Acyl-CoA reductase
Gene namesi
Name:luxC
OrganismiAliivibrio fischeri (Vibrio fischeri)
Taxonomic identifieri668 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002202011 – 479Long-chain acyl-protein thioester reductaseAdd BLAST479

Structurei

3D structure databases

ProteinModelPortaliP12748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxC family.Curated

Family and domain databases

Gene3Di3.40.605.10. 1 hit.
InterProiIPR008670. Acyl-CoA_reduct_LuxC.
IPR016161. Ald_DH/histidinol_DH.
IPR016162. Ald_DH_N.
[Graphical view]
PfamiPF05893. LuxC. 1 hit.
[Graphical view]
PIRSFiPIRSF009414. LuxC. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.

Sequencei

Sequence statusi: Complete.

P12748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKCIPMIIN GMIQDFDNYA YKEVKLNNDN RVKLSVITES SVSKTLNIKD
60 70 80 90 100
RINLNLNQIV NFLYTVGQRW KSEEYNRRRT YIRELKTYLG YSDEMARLEA
110 120 130 140 150
NWIAMLLCSK SALYDIVNYD LGSIHVLDEW LPRGDCYVKA QPKGVSVHLL
160 170 180 190 200
AGNVPLSGVT SILRAILTKN ECIIKTSSSD PFTANALVSS FIDVNADHPI
210 220 230 240 250
TKSMSVMYWP HDEDMTLSQR IMNHADVVIA WGGDEAIKWA VKYSPPHVDI
260 270 280 290 300
LKFGPKKSLS IIEAPKDIEA AAMGVAHDIC FYDQQACFST QDVYYIGDNL
310 320 330 340 350
PLFLNELEKQ LDRYAKILPK GSNSFDEKAA FTLTEKESLF AGYEVRKGDK
360 370 380 390 400
QAWLIVVSPT NSFGNQPLSR SVYVHQVSDI KEIIPFVNKN RTQTVSIYPW
410 420 430 440 450
EASLKYRDKL ARSGVERIVE SGMNNIFRVG GAHDSLSPLQ YLVRFVSHER
460 470
PFNYTTKDVA VEIEQTRYLE EDKFLVFVP
Length:479
Mass (Da):54,578
Last modified:March 15, 2004 - v3
Checksum:i10FD9567E5026340
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170104 Genomic DNA. Translation: AAD48475.1.
M19039 Genomic DNA. Translation: AAA27553.1.
Y00509 Genomic DNA. Translation: CAA68563.1.
PIRiS06862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170104 Genomic DNA. Translation: AAD48475.1.
M19039 Genomic DNA. Translation: AAA27553.1.
Y00509 Genomic DNA. Translation: CAA68563.1.
PIRiS06862.

3D structure databases

ProteinModelPortaliP12748.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00569.

Family and domain databases

Gene3Di3.40.605.10. 1 hit.
InterProiIPR008670. Acyl-CoA_reduct_LuxC.
IPR016161. Ald_DH/histidinol_DH.
IPR016162. Ald_DH_N.
[Graphical view]
PfamiPF05893. LuxC. 1 hit.
[Graphical view]
PIRSFiPIRSF009414. LuxC. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLUXC_ALIFS
AccessioniPrimary (citable) accession number: P12748
Secondary accession number(s): Q9S3Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: March 15, 2004
Last modified: November 2, 2016
This is version 75 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.