Reviewed, UniProtKB/Swiss-Prot P12748 (LUXC_VIBFI)

Names and origin

Protein names

Recommended name:
    Acyl-CoA reductase
    EC=1.2.1.50

Gene names

Name:

luxC

Organism

Vibrio fischeri

Taxonomic identifier

668 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Aliivibrio

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.
Catalytic activity	A long-chain aldehyde + CoA + NADP(+) = a long-chain acyl-CoA + NADPH.
Pathway	Lipid metabolism; bioluminescent fatty acid reduction.
Sequence similarities	Belongs to the luxC family.

Ontologies

Keywords
Biological process	Luminescence
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	bioluminescence Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	acyl-CoA reductase activity Inferred from electronic annotation. Source: InterPro long-chain-fatty-acyl-CoA reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	Acyl-CoA reductase		PRO_0000220201

Sequences

	Sequence		Length	Mass (Da)
	P12748-1 [UniParc]. Last modified March 15, 2004. Version 3. Checksum: 10FD9567E5026340	FASTA	479	54,578
	10 20 30 40 50 60 MNKCIPMIIN GMIQDFDNYA YKEVKLNNDN RVKLSVITES SVSKTLNIKD RINLNLNQIV 70 80 90 100 110 120 NFLYTVGQRW KSEEYNRRRT YIRELKTYLG YSDEMARLEA NWIAMLLCSK SALYDIVNYD 130 140 150 160 170 180 LGSIHVLDEW LPRGDCYVKA QPKGVSVHLL AGNVPLSGVT SILRAILTKN ECIIKTSSSD 190 200 210 220 230 240 PFTANALVSS FIDVNADHPI TKSMSVMYWP HDEDMTLSQR IMNHADVVIA WGGDEAIKWA 250 260 270 280 290 300 VKYSPPHVDI LKFGPKKSLS IIEAPKDIEA AAMGVAHDIC FYDQQACFST QDVYYIGDNL 310 320 330 340 350 360 PLFLNELEKQ LDRYAKILPK GSNSFDEKAA FTLTEKESLF AGYEVRKGDK QAWLIVVSPT 370 380 390 400 410 420 NSFGNQPLSR SVYVHQVSDI KEIIPFVNKN RTQTVSIYPW EASLKYRDKL ARSGVERIVE 430 440 450 460 470 SGMNNIFRVG GAHDSLSPLQ YLVRFVSHER PFNYTTKDVA VEIEQTRYLE EDKFLVFVP

References

[1]	"Vibrio fischeri Lux operon SalI digest." Knight T., Papadakis N. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: MJ-1.
[2]	"Nucleotide sequence of the regulatory locus controlling expression of bacterial genes for bioluminescence." Engebrecht J., Silverman M. Nucleic Acids Res. 15:10455-10467(1987) [PubMed: 3697093] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-81.
[3]	"Nucleotide sequence of the luxR and luxI genes and structure of the primary regulatory region of the lux regulon of Vibrio fischeri ATCC 7744." Devine J.H., Countryman C., Baldwin T.O. Biochemistry 27:837-842(1988) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20. Strain: ATCC 7744 / NCIMB 1281.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF170104 Genomic DNA. Translation: AAD48475.1. M19039 Genomic DNA. Translation: AAA27553.1. Y00509 Genomic DNA. Translation: CAA68563.1.
PIR	S06862.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR008670. LuxC. [Graphical view]
Pfam	PF05893. LuxC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LUXC_VIBFI

Accession

Primary (citable) accession number: P12748
Secondary accession number(s): Q9S3Z3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
Last sequence update:	March 15, 2004
Last modified:	November 25, 2008
This is version 50 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)