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P12748

- LUXC_ALIFS

UniProt

P12748 - LUXC_ALIFS

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Protein

Acyl-CoA reductase

Gene

luxC

Organism
Aliivibrio fischeri (Vibrio fischeri)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.

Catalytic activityi

A long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH.

Pathwayi

GO - Molecular functioni

  1. acyl-CoA dehydrogenase activity Source: InterPro
  2. long-chain-fatty-acyl-CoA reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. bioluminescence Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Luminescence

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00569.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA reductase (EC:1.2.1.50)
Gene namesi
Name:luxC
OrganismiAliivibrio fischeri (Vibrio fischeri)
Taxonomic identifieri668 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479Acyl-CoA reductasePRO_0000220201Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP12748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxC family.Curated

Family and domain databases

Gene3Di3.40.605.10. 1 hit.
InterProiIPR008670. Acyl-CoA_reduct_LuxC.
IPR016161. Ald_DH/histidinol_DH.
IPR016162. Ald_DH_N.
[Graphical view]
PfamiPF05893. LuxC. 1 hit.
[Graphical view]
PIRSFiPIRSF009414. LuxC. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.

Sequencei

Sequence statusi: Complete.

P12748-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKCIPMIIN GMIQDFDNYA YKEVKLNNDN RVKLSVITES SVSKTLNIKD
60 70 80 90 100
RINLNLNQIV NFLYTVGQRW KSEEYNRRRT YIRELKTYLG YSDEMARLEA
110 120 130 140 150
NWIAMLLCSK SALYDIVNYD LGSIHVLDEW LPRGDCYVKA QPKGVSVHLL
160 170 180 190 200
AGNVPLSGVT SILRAILTKN ECIIKTSSSD PFTANALVSS FIDVNADHPI
210 220 230 240 250
TKSMSVMYWP HDEDMTLSQR IMNHADVVIA WGGDEAIKWA VKYSPPHVDI
260 270 280 290 300
LKFGPKKSLS IIEAPKDIEA AAMGVAHDIC FYDQQACFST QDVYYIGDNL
310 320 330 340 350
PLFLNELEKQ LDRYAKILPK GSNSFDEKAA FTLTEKESLF AGYEVRKGDK
360 370 380 390 400
QAWLIVVSPT NSFGNQPLSR SVYVHQVSDI KEIIPFVNKN RTQTVSIYPW
410 420 430 440 450
EASLKYRDKL ARSGVERIVE SGMNNIFRVG GAHDSLSPLQ YLVRFVSHER
460 470
PFNYTTKDVA VEIEQTRYLE EDKFLVFVP
Length:479
Mass (Da):54,578
Last modified:March 15, 2004 - v3
Checksum:i10FD9567E5026340
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF170104 Genomic DNA. Translation: AAD48475.1.
M19039 Genomic DNA. Translation: AAA27553.1.
Y00509 Genomic DNA. Translation: CAA68563.1.
PIRiS06862.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF170104 Genomic DNA. Translation: AAD48475.1 .
M19039 Genomic DNA. Translation: AAA27553.1 .
Y00509 Genomic DNA. Translation: CAA68563.1 .
PIRi S06862.

3D structure databases

ProteinModelPortali P12748.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00569 .

Family and domain databases

Gene3Di 3.40.605.10. 1 hit.
InterProi IPR008670. Acyl-CoA_reduct_LuxC.
IPR016161. Ald_DH/histidinol_DH.
IPR016162. Ald_DH_N.
[Graphical view ]
Pfami PF05893. LuxC. 1 hit.
[Graphical view ]
PIRSFi PIRSF009414. LuxC. 1 hit.
SUPFAMi SSF53720. SSF53720. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Vibrio fischeri Lux operon SalI digest."
    Knight T., Papadakis N.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: MJ-1.
  2. "Nucleotide sequence of the regulatory locus controlling expression of bacterial genes for bioluminescence."
    Engebrecht J., Silverman M.
    Nucleic Acids Res. 15:10455-10467(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-81.
  3. "Nucleotide sequence of the luxR and luxI genes and structure of the primary regulatory region of the lux regulon of Vibrio fischeri ATCC 7744."
    Devine J.H., Countryman C., Baldwin T.O.
    Biochemistry 27:837-842(1988)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
    Strain: ATCC 7744 / DSM 507 / NCIMB 1281 / 398.

Entry informationi

Entry nameiLUXC_ALIFS
AccessioniPrimary (citable) accession number: P12748
Secondary accession number(s): Q9S3Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: March 15, 2004
Last modified: October 1, 2014
This is version 73 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3