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Reviewed, UniProtKB/Swiss-Prot P12748 (LUXC_VIBFI)

Last modified November 25, 2008. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Acyl-CoA reductase
    EC=1.2.1.50
Gene names
Name: luxC
OrganismVibrio fischeri
Taxonomic identifier668 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.

Catalytic activity

A long-chain aldehyde + CoA + NADP(+) = a long-chain acyl-CoA + NADPH.

Pathway

Lipid metabolism; bioluminescent fatty acid reduction.

Sequence similarities

Belongs to the luxC family.

Ontologies

Keywords

   Biological processLuminescence
   LigandNADP
   Molecular functionOxidoreductase

Gene Ontology (GO)

   Biological processbioluminescence

Inferred from electronic annotation. Source: InterPro

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionacyl-CoA reductase activity

Inferred from electronic annotation. Source: InterPro

long-chain-fatty-acyl-CoA reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479Acyl-CoA reductase
PRO_0000220201

Sequences

Sequence LengthMass (Da)Tools
P12748-1 [UniParc].

Last modified March 15, 2004. Version 3.
Checksum: 10FD9567E5026340

FASTA47954,578
        10         20         30         40         50         60 
MNKCIPMIIN GMIQDFDNYA YKEVKLNNDN RVKLSVITES SVSKTLNIKD RINLNLNQIV 

        70         80         90        100        110        120 
NFLYTVGQRW KSEEYNRRRT YIRELKTYLG YSDEMARLEA NWIAMLLCSK SALYDIVNYD 

       130        140        150        160        170        180 
LGSIHVLDEW LPRGDCYVKA QPKGVSVHLL AGNVPLSGVT SILRAILTKN ECIIKTSSSD 

       190        200        210        220        230        240 
PFTANALVSS FIDVNADHPI TKSMSVMYWP HDEDMTLSQR IMNHADVVIA WGGDEAIKWA 

       250        260        270        280        290        300 
VKYSPPHVDI LKFGPKKSLS IIEAPKDIEA AAMGVAHDIC FYDQQACFST QDVYYIGDNL 

       310        320        330        340        350        360 
PLFLNELEKQ LDRYAKILPK GSNSFDEKAA FTLTEKESLF AGYEVRKGDK QAWLIVVSPT 

       370        380        390        400        410        420 
NSFGNQPLSR SVYVHQVSDI KEIIPFVNKN RTQTVSIYPW EASLKYRDKL ARSGVERIVE 

       430        440        450        460        470 
SGMNNIFRVG GAHDSLSPLQ YLVRFVSHER PFNYTTKDVA VEIEQTRYLE EDKFLVFVP 

« Hide

References

[1]"Vibrio fischeri Lux operon SalI digest."
Knight T., Papadakis N.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: MJ-1.
[2]"Nucleotide sequence of the regulatory locus controlling expression of bacterial genes for bioluminescence."
Engebrecht J., Silverman M.
Nucleic Acids Res. 15:10455-10467(1987) [PubMed: 3697093] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-81.
[3]"Nucleotide sequence of the luxR and luxI genes and structure of the primary regulatory region of the lux regulon of Vibrio fischeri ATCC 7744."
Devine J.H., Countryman C., Baldwin T.O.
Biochemistry 27:837-842(1988)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-20.
Strain: ATCC 7744 / NCIMB 1281.

Cross-references

Sequence databases

AF170104 Genomic DNA. Translation: AAD48475.1.
M19039 Genomic DNA. Translation: AAA27553.1.
Y00509 Genomic DNA. Translation: CAA68563.1.
PIRS06862.

3D structure databases

ModBaseSearch...

Family and domain databases

InterProIPR008670. LuxC.
[Graphical view]
PfamPF05893. LuxC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLUXC_VIBFI
AccessionPrimary (citable) accession number: P12748
Secondary accession number(s): Q9S3Z3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: March 15, 2004
Last modified: November 25, 2008
This is version 50 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents