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Protein

Transcriptional activator protein LuxR

Gene

luxR

Organism
Aliivibrio fischeri (Vibrio fischeri)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator of the bioluminescence operon. Binds to the OHHL autoinducer.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi200 – 21920H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Luminescence, Quorum sensing, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator protein LuxR
Gene namesi
Name:luxR
OrganismiAliivibrio fischeri (Vibrio fischeri)
Taxonomic identifieri668 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeAliivibrio

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL5351.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 250250Transcriptional activator protein LuxRPRO_0000184161Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiP12746. 1 interaction.

Chemistry

BindingDBiP12746.

Structurei

3D structure databases

ProteinModelPortaliP12746.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini176 – 24166HTH luxR-typePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 2010Arg/Lys-rich (basic)
Compositional biasi64 – 674Arg/Lys-rich (basic)
Compositional biasi104 – 11411Lys-rich (basic)Add
BLAST

Sequence similaritiesi

Contains 1 HTH luxR-type DNA-binding domain.PROSITE-ProRule annotation

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.30.450.80. 1 hit.
InterProiIPR016032. Sig_transdc_resp-reg_C-effctor.
IPR005143. TF_LuxR_autoind-bd_dom.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03472. Autoind_bind. 1 hit.
PF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF75516. SSF75516. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P12746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNINADDTY RIINKIKACR SNNDINQCLS DMTKMVHCEY YLLAIIYPHS
60 70 80 90 100
MVKSDISILD NYPKKWRQYY DDANLIKYDP IVDYSNSNHS PINWNIFENN
110 120 130 140 150
AVNKKSPNVI KEAKTSGLIT GFSFPIHTAN NGFGMLSFAH SEKDNYIDSL
160 170 180 190 200
FLHACMNIPL IVPSLVDNYR KINIANNKSN NDLTKREKEC LAWACEGKSS
210 220 230 240 250
WDISKILGCS ERTVTFHLTN AQMKLNTTNR CQSISKAILT GAIDCPYFKN
Length:250
Mass (Da):28,556
Last modified:February 1, 1994 - v3
Checksum:iBDB636192F5E1C64
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 233SNN → AY in CAA68561 (PubMed:3697093).Curated
Sequence conflicti42 – 421L → LT in CAA68561 (PubMed:3697093).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31N → D in strain: ATCC 7744.
Natural varianti115 – 1151T → S in strain: ATCC 7744.
Natural varianti211 – 2111E → K in strain: ATCC 7744.
Natural varianti250 – 2501N → S in strain: ATCC 7744.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25751 Genomic DNA. Translation: AAA27540.1.
M19039 Genomic DNA. Translation: AAA27551.1.
M25752 Genomic DNA. Translation: AAA27541.1.
AF170104 Genomic DNA. Translation: AAD48473.1.
Y00509 Genomic DNA. Translation: CAA68561.1.
PIRiB33538.
S06314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25751 Genomic DNA. Translation: AAA27540.1.
M19039 Genomic DNA. Translation: AAA27551.1.
M25752 Genomic DNA. Translation: AAA27541.1.
AF170104 Genomic DNA. Translation: AAD48473.1.
Y00509 Genomic DNA. Translation: CAA68561.1.
PIRiB33538.
S06314.

3D structure databases

ProteinModelPortaliP12746.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP12746. 1 interaction.

Chemistry

BindingDBiP12746.
ChEMBLiCHEMBL5351.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
3.30.450.80. 1 hit.
InterProiIPR016032. Sig_transdc_resp-reg_C-effctor.
IPR005143. TF_LuxR_autoind-bd_dom.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03472. Autoind_bind. 1 hit.
PF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF75516. SSF75516. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLUXR_ALIFS
AccessioniPrimary (citable) accession number: P12746
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: February 1, 1994
Last modified: September 7, 2016
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.