Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P12743

- RL7A_HALMA

UniProt

P12743 - RL7A_HALMA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

50S ribosomal protein L7Ae

Gene

rpl7ae

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.Curated

GO - Molecular functioni

  1. ribonuclease P activity Source: UniProtKB-HAMAP
  2. rRNA binding Source: UniProtKB-KW
  3. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. ribosome biogenesis Source: InterPro
  2. translation Source: UniProtKB-HAMAP
  3. tRNA 5'-leader removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-95-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L7AeUniRule annotation
Alternative name(s):
Hs6
Ribosomal protein L8eUniRule annotation
Gene namesi
Name:rpl7aeUniRule annotation
Ordered Locus Names:rrnAC0103
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
ProteomesiUP000001169: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 12011950S ribosomal protein L7AePRO_0000136790Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Interacts with protein L15e. Probably part of the RNase P complex.2 Publications

Protein-protein interaction databases

STRINGi272569.rrnAC0103.

Structurei

Secondary structure

1
120
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 2616Combined sources
Beta strandi30 – 334Combined sources
Helixi34 – 4310Combined sources
Beta strandi49 – 535Combined sources
Helixi58 – 603Combined sources
Turni61 – 633Combined sources
Helixi64 – 696Combined sources
Turni70 – 723Combined sources
Beta strandi75 – 795Combined sources
Helixi81 – 877Combined sources
Beta strandi95 – 1017Combined sources
Helixi103 – 1053Combined sources
Helixi106 – 11813Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40E2-120[»]
1JJ2X-ray2.40F2-120[»]
1K73X-ray3.01H2-120[»]
1K8AX-ray3.00H2-120[»]
1K9MX-ray3.00H2-120[»]
1KC8X-ray3.01H2-120[»]
1KD1X-ray3.00H2-120[»]
1KQSX-ray3.10F2-120[»]
1M1KX-ray3.20H2-120[»]
1M90X-ray2.80H2-120[»]
1N8RX-ray3.00H2-120[»]
1NJIX-ray3.00H2-120[»]
1Q7YX-ray3.20H2-120[»]
1Q81X-ray2.95H2-120[»]
1Q82X-ray2.98H2-120[»]
1Q86X-ray3.00H2-120[»]
1QVFX-ray3.10F2-120[»]
1QVGX-ray2.90F2-120[»]
1S72X-ray2.40F1-120[»]
1VQ4X-ray2.70F1-120[»]
1VQ5X-ray2.60F1-120[»]
1VQ6X-ray2.70F1-120[»]
1VQ7X-ray2.50F1-120[»]
1VQ8X-ray2.20F1-120[»]
1VQ9X-ray2.40F1-120[»]
1VQKX-ray2.30F1-120[»]
1VQLX-ray2.30F1-120[»]
1VQMX-ray2.30F1-120[»]
1VQNX-ray2.40F1-120[»]
1VQOX-ray2.20F1-120[»]
1VQPX-ray2.25F1-120[»]
1W2BX-ray3.50F2-120[»]
1YHQX-ray2.40F1-120[»]
1YI2X-ray2.65F1-120[»]
1YIJX-ray2.60F1-120[»]
1YITX-ray2.80F1-120[»]
1YJ9X-ray2.90F1-120[»]
1YJNX-ray3.00F1-120[»]
1YJWX-ray2.90F1-120[»]
2OTJX-ray2.90F1-120[»]
2OTLX-ray2.70F1-120[»]
2QA4X-ray3.00F1-120[»]
2QEXX-ray2.90F1-120[»]
3CC2X-ray2.40F1-120[»]
3CC4X-ray2.70F1-120[»]
3CC7X-ray2.70F1-120[»]
3CCEX-ray2.75F1-120[»]
3CCJX-ray2.70F1-120[»]
3CCLX-ray2.90F1-120[»]
3CCMX-ray2.55F1-120[»]
3CCQX-ray2.90F1-120[»]
3CCRX-ray3.00F1-120[»]
3CCSX-ray2.95F1-120[»]
3CCUX-ray2.80F1-120[»]
3CCVX-ray2.90F1-120[»]
3CD6X-ray2.75F1-120[»]
3CMAX-ray2.80F1-120[»]
3CMEX-ray2.95F1-120[»]
3CPWX-ray2.70F1-120[»]
3CXCX-ray3.00F2-120[»]
3G4SX-ray3.20F2-120[»]
3G6EX-ray2.70F2-120[»]
3G71X-ray2.85F2-120[»]
3I55X-ray3.11F1-120[»]
3I56X-ray2.90F1-120[»]
3OW2X-ray2.70F2-120[»]
4ADXelectron microscopy6.60F1-120[»]
4HUBX-ray2.40F1-120[»]
ProteinModelPortaliP12743.
SMRiP12743. Positions 2-120.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12743.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L7Ae family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1358.
HOGENOMiHOG000055225.
KOiK02936.
OMAiDEDNCEL.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
HAMAPiMF_00326. Ribosomal_L7Ae_Arch.
InterProiIPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR018492. Ribosomal_L7Ae/L8/Nhp2.
IPR022481. Ribosomal_L7Ae_arc.
IPR004037. Ribosomal_L7Ae_CS.
IPR000948. Ribosomal_L7Ae_prok.
[Graphical view]
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
PRINTSiPR00881. L7ARS6FAMILY.
PR00884. RIBOSOMALHS6.
SUPFAMiSSF55315. SSF55315. 1 hit.
TIGRFAMsiTIGR03677. rpl7ae. 1 hit.
PROSITEiPS01082. RIBOSOMAL_L7AE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12743-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVYVDFDVP ADLEDDALEA LEVARDTGAV KKGTNETTKS IERGSAELVF
60 70 80 90 100
VAEDVQPEEI VMHIPELADE KGVPFIFVEQ QDDLGHAAGL EVGSAAAAVT
110 120
DAGEADADVE DIADKVEELR
Length:120
Mass (Da):12,782
Last modified:January 23, 2007 - v4
Checksum:i96132F5CB51840A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1118EADADVED → AAATV AA sequence (PubMed:3315748)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596297 Genomic DNA. Translation: AAV45179.1.
PIRiS00182. R5HSS6.
RefSeqiYP_134885.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV45179; AAV45179; rrnAC0103.
GeneIDi3130242.
KEGGihma:rrnAC0103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY596297 Genomic DNA. Translation: AAV45179.1 .
PIRi S00182. R5HSS6.
RefSeqi YP_134885.1. NC_006396.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FFK X-ray 2.40 E 2-120 [» ]
1JJ2 X-ray 2.40 F 2-120 [» ]
1K73 X-ray 3.01 H 2-120 [» ]
1K8A X-ray 3.00 H 2-120 [» ]
1K9M X-ray 3.00 H 2-120 [» ]
1KC8 X-ray 3.01 H 2-120 [» ]
1KD1 X-ray 3.00 H 2-120 [» ]
1KQS X-ray 3.10 F 2-120 [» ]
1M1K X-ray 3.20 H 2-120 [» ]
1M90 X-ray 2.80 H 2-120 [» ]
1N8R X-ray 3.00 H 2-120 [» ]
1NJI X-ray 3.00 H 2-120 [» ]
1Q7Y X-ray 3.20 H 2-120 [» ]
1Q81 X-ray 2.95 H 2-120 [» ]
1Q82 X-ray 2.98 H 2-120 [» ]
1Q86 X-ray 3.00 H 2-120 [» ]
1QVF X-ray 3.10 F 2-120 [» ]
1QVG X-ray 2.90 F 2-120 [» ]
1S72 X-ray 2.40 F 1-120 [» ]
1VQ4 X-ray 2.70 F 1-120 [» ]
1VQ5 X-ray 2.60 F 1-120 [» ]
1VQ6 X-ray 2.70 F 1-120 [» ]
1VQ7 X-ray 2.50 F 1-120 [» ]
1VQ8 X-ray 2.20 F 1-120 [» ]
1VQ9 X-ray 2.40 F 1-120 [» ]
1VQK X-ray 2.30 F 1-120 [» ]
1VQL X-ray 2.30 F 1-120 [» ]
1VQM X-ray 2.30 F 1-120 [» ]
1VQN X-ray 2.40 F 1-120 [» ]
1VQO X-ray 2.20 F 1-120 [» ]
1VQP X-ray 2.25 F 1-120 [» ]
1W2B X-ray 3.50 F 2-120 [» ]
1YHQ X-ray 2.40 F 1-120 [» ]
1YI2 X-ray 2.65 F 1-120 [» ]
1YIJ X-ray 2.60 F 1-120 [» ]
1YIT X-ray 2.80 F 1-120 [» ]
1YJ9 X-ray 2.90 F 1-120 [» ]
1YJN X-ray 3.00 F 1-120 [» ]
1YJW X-ray 2.90 F 1-120 [» ]
2OTJ X-ray 2.90 F 1-120 [» ]
2OTL X-ray 2.70 F 1-120 [» ]
2QA4 X-ray 3.00 F 1-120 [» ]
2QEX X-ray 2.90 F 1-120 [» ]
3CC2 X-ray 2.40 F 1-120 [» ]
3CC4 X-ray 2.70 F 1-120 [» ]
3CC7 X-ray 2.70 F 1-120 [» ]
3CCE X-ray 2.75 F 1-120 [» ]
3CCJ X-ray 2.70 F 1-120 [» ]
3CCL X-ray 2.90 F 1-120 [» ]
3CCM X-ray 2.55 F 1-120 [» ]
3CCQ X-ray 2.90 F 1-120 [» ]
3CCR X-ray 3.00 F 1-120 [» ]
3CCS X-ray 2.95 F 1-120 [» ]
3CCU X-ray 2.80 F 1-120 [» ]
3CCV X-ray 2.90 F 1-120 [» ]
3CD6 X-ray 2.75 F 1-120 [» ]
3CMA X-ray 2.80 F 1-120 [» ]
3CME X-ray 2.95 F 1-120 [» ]
3CPW X-ray 2.70 F 1-120 [» ]
3CXC X-ray 3.00 F 2-120 [» ]
3G4S X-ray 3.20 F 2-120 [» ]
3G6E X-ray 2.70 F 2-120 [» ]
3G71 X-ray 2.85 F 2-120 [» ]
3I55 X-ray 3.11 F 1-120 [» ]
3I56 X-ray 2.90 F 1-120 [» ]
3OW2 X-ray 2.70 F 2-120 [» ]
4ADX electron microscopy 6.60 F 1-120 [» ]
4HUB X-ray 2.40 F 1-120 [» ]
ProteinModelPortali P12743.
SMRi P12743. Positions 2-120.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272569.rrnAC0103.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV45179 ; AAV45179 ; rrnAC0103 .
GeneIDi 3130242.
KEGGi hma:rrnAC0103.

Phylogenomic databases

eggNOGi COG1358.
HOGENOMi HOG000055225.
KOi K02936.
OMAi DEDNCEL.

Enzyme and pathway databases

BioCyci HMAR272569:GJDH-95-MONOMER.

Miscellaneous databases

EvolutionaryTracei P12743.

Family and domain databases

Gene3Di 3.30.1330.30. 1 hit.
HAMAPi MF_00326. Ribosomal_L7Ae_Arch.
InterProi IPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR018492. Ribosomal_L7Ae/L8/Nhp2.
IPR022481. Ribosomal_L7Ae_arc.
IPR004037. Ribosomal_L7Ae_CS.
IPR000948. Ribosomal_L7Ae_prok.
[Graphical view ]
Pfami PF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view ]
PRINTSi PR00881. L7ARS6FAMILY.
PR00884. RIBOSOMALHS6.
SUPFAMi SSF55315. SSF55315. 1 hit.
TIGRFAMsi TIGR03677. rpl7ae. 1 hit.
PROSITEi PS01082. RIBOSOMAL_L7AE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  2. "Primary structures of three highly acidic ribosomal proteins S6, S12 and S15 from the archaebacterium Halobacterium marismortui."
    Kimura J., Arndt E., Kimura M.
    FEBS Lett. 224:65-70(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-120.
  3. "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
    Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
    Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  4. "The structural basis of ribosome activity in peptide bond synthesis."
    Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
    Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  5. "A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
    Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
    Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  6. "The kink-turn: a new RNA secondary structure motif."
    Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
    EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  7. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
    Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
    Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  8. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  9. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
    Hansen J.L., Moore P.B., Steitz T.A.
    J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  10. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
    Schmeing T.M., Moore P.B., Steitz T.A.
    RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
  11. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
    Gabdulkhakov A., Nikonov S., Garber M.
    Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.

Entry informationi

Entry nameiRL7A_HALMA
AccessioniPrimary (citable) accession number: P12743
Secondary accession number(s): Q5V5M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 121 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be a protein from the small subunit of the ribosome.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3