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P12743

- RL7A_HALMA

UniProt

P12743 - RL7A_HALMA

Protein

50S ribosomal protein L7Ae

Gene

rpl7ae

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.Curated

    GO - Molecular functioni

    1. ribonuclease P activity Source: UniProtKB-HAMAP
    2. rRNA binding Source: UniProtKB-KW
    3. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. ribosome biogenesis Source: InterPro
    2. translation Source: UniProtKB-HAMAP
    3. tRNA 5'-leader removal Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciHMAR272569:GJDH-95-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    50S ribosomal protein L7AeUniRule annotation
    Alternative name(s):
    Hs6
    Ribosomal protein L8eUniRule annotation
    Gene namesi
    Name:rpl7aeUniRule annotation
    Ordered Locus Names:rrnAC0103
    OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
    Taxonomic identifieri272569 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
    ProteomesiUP000001169: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 12011950S ribosomal protein L7AePRO_0000136790Add
    BLAST

    Interactioni

    Subunit structurei

    Part of the 50S ribosomal subunit. Interacts with protein L15e. Probably part of the RNase P complex.2 Publications

    Protein-protein interaction databases

    STRINGi272569.rrnAC0103.

    Structurei

    Secondary structure

    1
    120
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi11 – 2616
    Beta strandi30 – 334
    Helixi34 – 4310
    Beta strandi49 – 535
    Helixi58 – 603
    Turni61 – 633
    Helixi64 – 696
    Turni70 – 723
    Beta strandi75 – 795
    Helixi81 – 877
    Beta strandi95 – 1017
    Helixi103 – 1053
    Helixi106 – 11813

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FFKX-ray2.40E2-120[»]
    1JJ2X-ray2.40F2-120[»]
    1K73X-ray3.01H2-120[»]
    1K8AX-ray3.00H2-120[»]
    1K9MX-ray3.00H2-120[»]
    1KC8X-ray3.01H2-120[»]
    1KD1X-ray3.00H2-120[»]
    1KQSX-ray3.10F2-120[»]
    1M1KX-ray3.20H2-120[»]
    1M90X-ray2.80H2-120[»]
    1N8RX-ray3.00H2-120[»]
    1NJIX-ray3.00H2-120[»]
    1Q7YX-ray3.20H2-120[»]
    1Q81X-ray2.95H2-120[»]
    1Q82X-ray2.98H2-120[»]
    1Q86X-ray3.00H2-120[»]
    1QVFX-ray3.10F2-120[»]
    1QVGX-ray2.90F2-120[»]
    1S72X-ray2.40F1-120[»]
    1VQ4X-ray2.70F1-120[»]
    1VQ5X-ray2.60F1-120[»]
    1VQ6X-ray2.70F1-120[»]
    1VQ7X-ray2.50F1-120[»]
    1VQ8X-ray2.20F1-120[»]
    1VQ9X-ray2.40F1-120[»]
    1VQKX-ray2.30F1-120[»]
    1VQLX-ray2.30F1-120[»]
    1VQMX-ray2.30F1-120[»]
    1VQNX-ray2.40F1-120[»]
    1VQOX-ray2.20F1-120[»]
    1VQPX-ray2.25F1-120[»]
    1W2BX-ray3.50F2-120[»]
    1YHQX-ray2.40F1-120[»]
    1YI2X-ray2.65F1-120[»]
    1YIJX-ray2.60F1-120[»]
    1YITX-ray2.80F1-120[»]
    1YJ9X-ray2.90F1-120[»]
    1YJNX-ray3.00F1-120[»]
    1YJWX-ray2.90F1-120[»]
    2OTJX-ray2.90F1-120[»]
    2OTLX-ray2.70F1-120[»]
    2QA4X-ray3.00F1-120[»]
    2QEXX-ray2.90F1-120[»]
    3CC2X-ray2.40F1-120[»]
    3CC4X-ray2.70F1-120[»]
    3CC7X-ray2.70F1-120[»]
    3CCEX-ray2.75F1-120[»]
    3CCJX-ray2.70F1-120[»]
    3CCLX-ray2.90F1-120[»]
    3CCMX-ray2.55F1-120[»]
    3CCQX-ray2.90F1-120[»]
    3CCRX-ray3.00F1-120[»]
    3CCSX-ray2.95F1-120[»]
    3CCUX-ray2.80F1-120[»]
    3CCVX-ray2.90F1-120[»]
    3CD6X-ray2.75F1-120[»]
    3CMAX-ray2.80F1-120[»]
    3CMEX-ray2.95F1-120[»]
    3CPWX-ray2.70F1-120[»]
    3CXCX-ray3.00F2-120[»]
    3G4SX-ray3.20F2-120[»]
    3G6EX-ray2.70F2-120[»]
    3G71X-ray2.85F2-120[»]
    3I55X-ray3.11F1-120[»]
    3I56X-ray2.90F1-120[»]
    3OW2X-ray2.70F2-120[»]
    4ADXelectron microscopy6.60F1-120[»]
    4HUBX-ray2.40F1-120[»]
    ProteinModelPortaliP12743.
    SMRiP12743. Positions 2-120.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP12743.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L7Ae family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1358.
    HOGENOMiHOG000055225.
    KOiK02936.
    OMAiDEDNCEL.

    Family and domain databases

    Gene3Di3.30.1330.30. 1 hit.
    HAMAPiMF_00326. Ribosomal_L7Ae_Arch.
    InterProiIPR029064. L30e-like.
    IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
    IPR018492. Ribosomal_L7Ae/L8/Nhp2.
    IPR022481. Ribosomal_L7Ae_arc.
    IPR004037. Ribosomal_L7Ae_CS.
    IPR000948. Ribosomal_L7Ae_prok.
    [Graphical view]
    PfamiPF01248. Ribosomal_L7Ae. 1 hit.
    [Graphical view]
    PRINTSiPR00881. L7ARS6FAMILY.
    PR00884. RIBOSOMALHS6.
    SUPFAMiSSF55315. SSF55315. 1 hit.
    TIGRFAMsiTIGR03677. rpl7ae. 1 hit.
    PROSITEiPS01082. RIBOSOMAL_L7AE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P12743-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVYVDFDVP ADLEDDALEA LEVARDTGAV KKGTNETTKS IERGSAELVF    50
    VAEDVQPEEI VMHIPELADE KGVPFIFVEQ QDDLGHAAGL EVGSAAAAVT 100
    DAGEADADVE DIADKVEELR 120
    Length:120
    Mass (Da):12,782
    Last modified:January 23, 2007 - v4
    Checksum:i96132F5CB51840A0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti104 – 1118EADADVED → AAATV AA sequence (PubMed:3315748)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. Translation: AAV45179.1.
    PIRiS00182. R5HSS6.
    RefSeqiYP_134885.1. NC_006396.1.

    Genome annotation databases

    EnsemblBacteriaiAAV45179; AAV45179; rrnAC0103.
    GeneIDi3130242.
    KEGGihma:rrnAC0103.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY596297 Genomic DNA. Translation: AAV45179.1 .
    PIRi S00182. R5HSS6.
    RefSeqi YP_134885.1. NC_006396.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FFK X-ray 2.40 E 2-120 [» ]
    1JJ2 X-ray 2.40 F 2-120 [» ]
    1K73 X-ray 3.01 H 2-120 [» ]
    1K8A X-ray 3.00 H 2-120 [» ]
    1K9M X-ray 3.00 H 2-120 [» ]
    1KC8 X-ray 3.01 H 2-120 [» ]
    1KD1 X-ray 3.00 H 2-120 [» ]
    1KQS X-ray 3.10 F 2-120 [» ]
    1M1K X-ray 3.20 H 2-120 [» ]
    1M90 X-ray 2.80 H 2-120 [» ]
    1N8R X-ray 3.00 H 2-120 [» ]
    1NJI X-ray 3.00 H 2-120 [» ]
    1Q7Y X-ray 3.20 H 2-120 [» ]
    1Q81 X-ray 2.95 H 2-120 [» ]
    1Q82 X-ray 2.98 H 2-120 [» ]
    1Q86 X-ray 3.00 H 2-120 [» ]
    1QVF X-ray 3.10 F 2-120 [» ]
    1QVG X-ray 2.90 F 2-120 [» ]
    1S72 X-ray 2.40 F 1-120 [» ]
    1VQ4 X-ray 2.70 F 1-120 [» ]
    1VQ5 X-ray 2.60 F 1-120 [» ]
    1VQ6 X-ray 2.70 F 1-120 [» ]
    1VQ7 X-ray 2.50 F 1-120 [» ]
    1VQ8 X-ray 2.20 F 1-120 [» ]
    1VQ9 X-ray 2.40 F 1-120 [» ]
    1VQK X-ray 2.30 F 1-120 [» ]
    1VQL X-ray 2.30 F 1-120 [» ]
    1VQM X-ray 2.30 F 1-120 [» ]
    1VQN X-ray 2.40 F 1-120 [» ]
    1VQO X-ray 2.20 F 1-120 [» ]
    1VQP X-ray 2.25 F 1-120 [» ]
    1W2B X-ray 3.50 F 2-120 [» ]
    1YHQ X-ray 2.40 F 1-120 [» ]
    1YI2 X-ray 2.65 F 1-120 [» ]
    1YIJ X-ray 2.60 F 1-120 [» ]
    1YIT X-ray 2.80 F 1-120 [» ]
    1YJ9 X-ray 2.90 F 1-120 [» ]
    1YJN X-ray 3.00 F 1-120 [» ]
    1YJW X-ray 2.90 F 1-120 [» ]
    2OTJ X-ray 2.90 F 1-120 [» ]
    2OTL X-ray 2.70 F 1-120 [» ]
    2QA4 X-ray 3.00 F 1-120 [» ]
    2QEX X-ray 2.90 F 1-120 [» ]
    3CC2 X-ray 2.40 F 1-120 [» ]
    3CC4 X-ray 2.70 F 1-120 [» ]
    3CC7 X-ray 2.70 F 1-120 [» ]
    3CCE X-ray 2.75 F 1-120 [» ]
    3CCJ X-ray 2.70 F 1-120 [» ]
    3CCL X-ray 2.90 F 1-120 [» ]
    3CCM X-ray 2.55 F 1-120 [» ]
    3CCQ X-ray 2.90 F 1-120 [» ]
    3CCR X-ray 3.00 F 1-120 [» ]
    3CCS X-ray 2.95 F 1-120 [» ]
    3CCU X-ray 2.80 F 1-120 [» ]
    3CCV X-ray 2.90 F 1-120 [» ]
    3CD6 X-ray 2.75 F 1-120 [» ]
    3CMA X-ray 2.80 F 1-120 [» ]
    3CME X-ray 2.95 F 1-120 [» ]
    3CPW X-ray 2.70 F 1-120 [» ]
    3CXC X-ray 3.00 F 2-120 [» ]
    3G4S X-ray 3.20 F 2-120 [» ]
    3G6E X-ray 2.70 F 2-120 [» ]
    3G71 X-ray 2.85 F 2-120 [» ]
    3I55 X-ray 3.11 F 1-120 [» ]
    3I56 X-ray 2.90 F 1-120 [» ]
    3OW2 X-ray 2.70 F 2-120 [» ]
    4ADX electron microscopy 6.60 F 1-120 [» ]
    4HUB X-ray 2.40 F 1-120 [» ]
    ProteinModelPortali P12743.
    SMRi P12743. Positions 2-120.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272569.rrnAC0103.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAV45179 ; AAV45179 ; rrnAC0103 .
    GeneIDi 3130242.
    KEGGi hma:rrnAC0103.

    Phylogenomic databases

    eggNOGi COG1358.
    HOGENOMi HOG000055225.
    KOi K02936.
    OMAi DEDNCEL.

    Enzyme and pathway databases

    BioCyci HMAR272569:GJDH-95-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P12743.

    Family and domain databases

    Gene3Di 3.30.1330.30. 1 hit.
    HAMAPi MF_00326. Ribosomal_L7Ae_Arch.
    InterProi IPR029064. L30e-like.
    IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
    IPR018492. Ribosomal_L7Ae/L8/Nhp2.
    IPR022481. Ribosomal_L7Ae_arc.
    IPR004037. Ribosomal_L7Ae_CS.
    IPR000948. Ribosomal_L7Ae_prok.
    [Graphical view ]
    Pfami PF01248. Ribosomal_L7Ae. 1 hit.
    [Graphical view ]
    PRINTSi PR00881. L7ARS6FAMILY.
    PR00884. RIBOSOMALHS6.
    SUPFAMi SSF55315. SSF55315. 1 hit.
    TIGRFAMsi TIGR03677. rpl7ae. 1 hit.
    PROSITEi PS01082. RIBOSOMAL_L7AE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    2. "Primary structures of three highly acidic ribosomal proteins S6, S12 and S15 from the archaebacterium Halobacterium marismortui."
      Kimura J., Arndt E., Kimura M.
      FEBS Lett. 224:65-70(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-120.
    3. "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
      Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
      Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    4. "The structural basis of ribosome activity in peptide bond synthesis."
      Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
      Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    5. "A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
      Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
      Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    6. "The kink-turn: a new RNA secondary structure motif."
      Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
      EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    7. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
      Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
      Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    8. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    9. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
      Hansen J.L., Moore P.B., Steitz T.A.
      J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
      Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
    10. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
      Schmeing T.M., Moore P.B., Steitz T.A.
      RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
    11. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
      Gabdulkhakov A., Nikonov S., Garber M.
      Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.

    Entry informationi

    Entry nameiRL7A_HALMA
    AccessioniPrimary (citable) accession number: P12743
    Secondary accession number(s): Q5V5M3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1989
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 120 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Was originally thought to be a protein from the small subunit of the ribosome.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3