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Protein

50S ribosomal protein L4

Gene

rpl4

Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly (By similarity).By similarity
Makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit.
Forms part of the polypeptide exit tunnel, in which it helps forms a bend with protein L22. Contacts the macrolide antibiotic spiramycin in the polypeptide exit tunnel.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L4
Alternative name(s):
Hl6
Hmal4
Gene namesi
Name:rpl4
Ordered Locus Names:rrnAC1610
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHaloarculaceaeHaloarcula
Proteomesi
  • UP000001169 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001293291 – 24650S ribosomal protein L4Add BLAST246

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Interacts weakly with proteins L18e, L24 and L37e. Has been cross-linked to L18e.2 Publications

Protein-protein interaction databases

STRINGi272569.rrnAC1610

Structurei

Secondary structure

1246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Turni8 – 10Combined sources3
Beta strandi12 – 17Combined sources6
Helixi20 – 23Combined sources4
Helixi28 – 41Combined sources14
Turni50 – 54Combined sources5
Beta strandi63 – 66Combined sources4
Beta strandi71 – 73Combined sources3
Beta strandi94 – 96Combined sources3
Helixi104 – 117Combined sources14
Helixi121 – 127Combined sources7
Beta strandi137 – 140Combined sources4
Helixi142 – 146Combined sources5
Helixi150 – 159Combined sources10
Helixi164 – 168Combined sources5
Helixi178 – 182Combined sources5
Beta strandi193 – 199Combined sources7
Turni202 – 206Combined sources5
Beta strandi211 – 214Combined sources4
Turni215 – 217Combined sources3
Helixi220 – 223Combined sources4
Helixi225 – 227Combined sources3
Beta strandi233 – 236Combined sources4
Helixi237 – 242Combined sources6
Helixi243 – 245Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40C1-246[»]
1JJ2X-ray2.40C1-246[»]
1K73X-ray3.01E1-246[»]
1K8AX-ray3.00E1-246[»]
1K9MX-ray3.00E1-246[»]
1KC8X-ray3.01E1-246[»]
1KD1X-ray3.00E1-246[»]
1KQSX-ray3.10C1-246[»]
1M1KX-ray3.20E1-246[»]
1M90X-ray2.80E1-246[»]
1ML5electron microscopy14.00f1-246[»]
1N8RX-ray3.00E1-246[»]
1NJIX-ray3.00E1-246[»]
1Q7YX-ray3.20E1-246[»]
1Q81X-ray2.95E1-246[»]
1Q82X-ray2.98E1-246[»]
1Q86X-ray3.00E1-246[»]
1QVFX-ray3.10C1-246[»]
1QVGX-ray2.90C1-246[»]
1S72X-ray2.40C1-246[»]
1VQ4X-ray2.70C1-246[»]
1VQ5X-ray2.60C1-246[»]
1VQ6X-ray2.70C1-246[»]
1VQ7X-ray2.50C1-246[»]
1VQ8X-ray2.20C1-246[»]
1VQ9X-ray2.40C1-246[»]
1VQKX-ray2.30C1-246[»]
1VQLX-ray2.30C1-246[»]
1VQMX-ray2.30C1-246[»]
1VQNX-ray2.40C1-246[»]
1VQOX-ray2.20C1-246[»]
1VQPX-ray2.25C1-246[»]
1W2BX-ray3.50C1-246[»]
1YHQX-ray2.40C1-246[»]
1YI2X-ray2.65C1-246[»]
1YIJX-ray2.60C1-246[»]
1YITX-ray2.80C1-246[»]
1YJ9X-ray2.90C1-246[»]
1YJNX-ray3.00C1-246[»]
1YJWX-ray2.90C1-246[»]
2OTJX-ray2.90C1-246[»]
2OTLX-ray2.70C1-246[»]
2QA4X-ray3.00C1-246[»]
2QEXX-ray2.90C1-246[»]
3CC2X-ray2.40C1-246[»]
3CC4X-ray2.70C1-246[»]
3CC7X-ray2.70C1-246[»]
3CCEX-ray2.75C1-246[»]
3CCJX-ray2.70C1-246[»]
3CCLX-ray2.90C1-246[»]
3CCMX-ray2.55C1-246[»]
3CCQX-ray2.90C1-246[»]
3CCRX-ray3.00C1-246[»]
3CCSX-ray2.95C1-246[»]
3CCUX-ray2.80C1-246[»]
3CCVX-ray2.90C1-246[»]
3CD6X-ray2.75C1-246[»]
3CMAX-ray2.80C1-246[»]
3CMEX-ray2.95C1-246[»]
3CPWX-ray2.70C1-246[»]
3CXCX-ray3.00C1-246[»]
3G4SX-ray3.20C1-246[»]
3G6EX-ray2.70C1-246[»]
3G71X-ray2.85C1-246[»]
3I55X-ray3.11C1-246[»]
3I56X-ray2.90C1-246[»]
3OW2X-ray2.70C1-246[»]
4ADXelectron microscopy6.60C1-246[»]
4V4RX-ray5.90F1-246[»]
4V4SX-ray6.76F1-246[»]
4V4TX-ray6.46F1-246[»]
4V9FX-ray2.40C1-246[»]
ProteinModelPortaliP12735
SMRiP12735
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12735

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG04071 Archaea
COG0088 LUCA
HOGENOMiHOG000107332
KOiK02930
OMAiGRGKMRN
OrthoDBiPOG093Z07B4

Family and domain databases

Gene3Di3.40.1370.10, 1 hit
HAMAPiMF_01328_A Ribosomal_L4_A, 1 hit
InterProiView protein in InterPro
IPR002136 Ribosomal_L4/L1e
IPR013000 Ribosomal_L4/L1e_euk/arc_CS
IPR023574 Ribosomal_L4_dom_sf
IPR019970 Ribosomall_L4
PfamiView protein in Pfam
PF00573 Ribosomal_L4, 1 hit
SUPFAMiSSF52166 SSF52166, 1 hit
TIGRFAMsiTIGR03672 rpl4p_arch, 1 hit
PROSITEiView protein in PROSITE
PS00939 RIBOSOMAL_L1E, 1 hit

Sequencei

Sequence statusi: Complete.

P12735-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQATIYDLDG NTDGEVDLPD VFETPVRSDL IGKAVRAAQA NRKQDYGSDE
60 70 80 90 100
YAGLRTPAES FGSGRGQAHV PKQDGRARRV PQAVKGRSAH PPKTEKDRSL
110 120 130 140 150
DLNDKERQLA VRSALAATAD ADLVADRGHE FDRDEVPVVV SDDFEDLVKT
160 170 180 190 200
QEVVSLLEAL DVHADIDRAD ETKIKAGQGS ARGRKYRRPA SILFVTSDEP
210 220 230 240
STAARNLAGA DVATASEVNT EDLAPGGAPG RLTVFTESAL AEVAER
Length:246
Mass (Da):26,420
Last modified:January 4, 2005 - v4
Checksum:i4BCA2FE20EE24EDF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154V → K AA sequence (PubMed:3196689).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05222 Genomic DNA Translation: AAA86860.1
AY596297 Genomic DNA Translation: AAV46527.1
PIRiD35063 R5HS6H
RefSeqiWP_004957420.1, NC_006396.1

Genome annotation databases

EnsemblBacteriaiAAV46527; AAV46527; rrnAC1610
GeneIDi3128386
KEGGihma:rrnAC1610
PATRICifig|272569.17.peg.2300

Similar proteinsi

Entry informationi

Entry nameiRL4_HALMA
AccessioniPrimary (citable) accession number: P12735
Secondary accession number(s): Q5V1S5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 4, 2005
Last modified: May 23, 2018
This is version 134 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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