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P12734

- RL21_HALMA

UniProt

P12734 - RL21_HALMA

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Protein

50S ribosomal protein L21e

Gene
rpl21e, rrnAC0260
Organism
Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

This is one of 5 proteins that mediate the attachment of the 5S rRNA onto the large ribosomal subunit, stabilizing the orientation of adjacent RNA domains.UniRule annotation

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-KW
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciHMAR272569:GJDH-236-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L21e
Alternative name(s):
Hl31
Gene namesi
Name:rpl21e
Ordered Locus Names:rrnAC0260
OrganismiHaloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (Halobacterium marismortui)
Taxonomic identifieri272569 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHaloarcula
ProteomesiUP000001169: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 969550S ribosomal protein L21eUniRule annotationPRO_0000149686Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Interacts with protein L18 and binds the 5S rRNA. Has been cross-linked to L18.9 Publications

Protein-protein interaction databases

STRINGi272569.rrnAC0260.

Structurei

Secondary structure

1
96
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni7 – 104
Turni12 – 154
Helixi19 – 213
Helixi28 – 314
Beta strandi39 – 424
Helixi55 – 573
Beta strandi61 – 688
Beta strandi71 – 788
Beta strandi81 – 877
Helixi89 – 913
Beta strandi92 – 943

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FFKX-ray2.40N2-96[»]
1JJ2X-ray2.40P2-96[»]
1K73X-ray3.01R2-96[»]
1K8AX-ray3.00R2-96[»]
1K9MX-ray3.00R2-96[»]
1KC8X-ray3.01R2-96[»]
1KD1X-ray3.00R2-96[»]
1KQSX-ray3.10P2-96[»]
1M1KX-ray3.20R2-96[»]
1M90X-ray2.80R2-96[»]
1N8RX-ray3.00R2-96[»]
1NJIX-ray3.00R2-96[»]
1Q7YX-ray3.20R2-96[»]
1Q81X-ray2.95R2-96[»]
1Q82X-ray2.98R2-96[»]
1Q86X-ray3.00R2-96[»]
1QVFX-ray3.10P2-96[»]
1QVGX-ray2.90P2-96[»]
1S72X-ray2.40Q1-96[»]
1VQ4X-ray2.70Q1-96[»]
1VQ5X-ray2.60Q1-96[»]
1VQ6X-ray2.70Q1-96[»]
1VQ7X-ray2.50Q1-96[»]
1VQ8X-ray2.20Q1-96[»]
1VQ9X-ray2.40Q1-96[»]
1VQKX-ray2.30Q1-96[»]
1VQLX-ray2.30Q1-96[»]
1VQMX-ray2.30Q1-96[»]
1VQNX-ray2.40Q1-96[»]
1VQOX-ray2.20Q1-96[»]
1VQPX-ray2.25Q1-96[»]
1W2BX-ray3.50P2-96[»]
1YHQX-ray2.40Q1-96[»]
1YI2X-ray2.65Q1-96[»]
1YIJX-ray2.60Q1-96[»]
1YITX-ray2.80Q1-96[»]
1YJ9X-ray2.90Q1-96[»]
1YJNX-ray3.00Q1-96[»]
1YJWX-ray2.90Q1-96[»]
2OTJX-ray2.90Q1-96[»]
2OTLX-ray2.70Q1-96[»]
2QA4X-ray3.00Q1-96[»]
2QEXX-ray2.90Q1-96[»]
3CC2X-ray2.40Q1-96[»]
3CC4X-ray2.70Q1-96[»]
3CC7X-ray2.70Q1-96[»]
3CCEX-ray2.75Q1-96[»]
3CCJX-ray2.70Q1-96[»]
3CCLX-ray2.90Q1-96[»]
3CCMX-ray2.55Q1-96[»]
3CCQX-ray2.90Q1-96[»]
3CCRX-ray3.00Q1-96[»]
3CCSX-ray2.95Q1-96[»]
3CCUX-ray2.80Q1-96[»]
3CCVX-ray2.90Q1-96[»]
3CD6X-ray2.75Q1-96[»]
3CMAX-ray2.80Q1-96[»]
3CMEX-ray2.95Q1-96[»]
3CPWX-ray2.70P1-96[»]
3CXCX-ray3.00P2-96[»]
3G4SX-ray3.20Q2-96[»]
3G6EX-ray2.70Q2-96[»]
3G71X-ray2.85Q2-96[»]
3I55X-ray3.11Q1-96[»]
3I56X-ray2.90Q1-96[»]
3OW2X-ray2.70P2-96[»]
4ADXelectron microscopy6.60Q1-96[»]
4HUBX-ray2.40Q1-96[»]
ProteinModelPortaliP12734.
SMRiP12734. Positions 2-96.

Miscellaneous databases

EvolutionaryTraceiP12734.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2139.
HOGENOMiHOG000106438.
KOiK02889.
OMAiPRFHGRT.

Family and domain databases

Gene3Di2.30.30.70. 1 hit.
HAMAPiMF_00369. Ribosomal_L21e.
InterProiIPR001147. Ribosomal_L21e.
IPR022856. Ribosomal_L21e_arc.
IPR018259. Ribosomal_L21e_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PfamiPF01157. Ribosomal_L21e. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01171. RIBOSOMAL_L21E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12734-1 [UniParc]FASTAAdd to Basket

« Hide

MPSSNGPLEG TRGKLKNKPR DRGTSPPQRA VEEFDDGEKV HLKIDPSVPN   50
GRFHPRFDGQ TGTVEGKQGD AYKVDIVDGG KEKTIIVTAA HLRRQE 96
Length:96
Mass (Da):10,548
Last modified:January 23, 2007 - v2
Checksum:iDE6DE036844EF1F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY596297 Genomic DNA. Translation: AAV45317.1.
PIRiS00370. R5HS31.
RefSeqiYP_135023.1. NC_006396.1.

Genome annotation databases

EnsemblBacteriaiAAV45317; AAV45317; rrnAC0260.
GeneIDi3129654.
KEGGihma:rrnAC0260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY596297 Genomic DNA. Translation: AAV45317.1 .
PIRi S00370. R5HS31.
RefSeqi YP_135023.1. NC_006396.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FFK X-ray 2.40 N 2-96 [» ]
1JJ2 X-ray 2.40 P 2-96 [» ]
1K73 X-ray 3.01 R 2-96 [» ]
1K8A X-ray 3.00 R 2-96 [» ]
1K9M X-ray 3.00 R 2-96 [» ]
1KC8 X-ray 3.01 R 2-96 [» ]
1KD1 X-ray 3.00 R 2-96 [» ]
1KQS X-ray 3.10 P 2-96 [» ]
1M1K X-ray 3.20 R 2-96 [» ]
1M90 X-ray 2.80 R 2-96 [» ]
1N8R X-ray 3.00 R 2-96 [» ]
1NJI X-ray 3.00 R 2-96 [» ]
1Q7Y X-ray 3.20 R 2-96 [» ]
1Q81 X-ray 2.95 R 2-96 [» ]
1Q82 X-ray 2.98 R 2-96 [» ]
1Q86 X-ray 3.00 R 2-96 [» ]
1QVF X-ray 3.10 P 2-96 [» ]
1QVG X-ray 2.90 P 2-96 [» ]
1S72 X-ray 2.40 Q 1-96 [» ]
1VQ4 X-ray 2.70 Q 1-96 [» ]
1VQ5 X-ray 2.60 Q 1-96 [» ]
1VQ6 X-ray 2.70 Q 1-96 [» ]
1VQ7 X-ray 2.50 Q 1-96 [» ]
1VQ8 X-ray 2.20 Q 1-96 [» ]
1VQ9 X-ray 2.40 Q 1-96 [» ]
1VQK X-ray 2.30 Q 1-96 [» ]
1VQL X-ray 2.30 Q 1-96 [» ]
1VQM X-ray 2.30 Q 1-96 [» ]
1VQN X-ray 2.40 Q 1-96 [» ]
1VQO X-ray 2.20 Q 1-96 [» ]
1VQP X-ray 2.25 Q 1-96 [» ]
1W2B X-ray 3.50 P 2-96 [» ]
1YHQ X-ray 2.40 Q 1-96 [» ]
1YI2 X-ray 2.65 Q 1-96 [» ]
1YIJ X-ray 2.60 Q 1-96 [» ]
1YIT X-ray 2.80 Q 1-96 [» ]
1YJ9 X-ray 2.90 Q 1-96 [» ]
1YJN X-ray 3.00 Q 1-96 [» ]
1YJW X-ray 2.90 Q 1-96 [» ]
2OTJ X-ray 2.90 Q 1-96 [» ]
2OTL X-ray 2.70 Q 1-96 [» ]
2QA4 X-ray 3.00 Q 1-96 [» ]
2QEX X-ray 2.90 Q 1-96 [» ]
3CC2 X-ray 2.40 Q 1-96 [» ]
3CC4 X-ray 2.70 Q 1-96 [» ]
3CC7 X-ray 2.70 Q 1-96 [» ]
3CCE X-ray 2.75 Q 1-96 [» ]
3CCJ X-ray 2.70 Q 1-96 [» ]
3CCL X-ray 2.90 Q 1-96 [» ]
3CCM X-ray 2.55 Q 1-96 [» ]
3CCQ X-ray 2.90 Q 1-96 [» ]
3CCR X-ray 3.00 Q 1-96 [» ]
3CCS X-ray 2.95 Q 1-96 [» ]
3CCU X-ray 2.80 Q 1-96 [» ]
3CCV X-ray 2.90 Q 1-96 [» ]
3CD6 X-ray 2.75 Q 1-96 [» ]
3CMA X-ray 2.80 Q 1-96 [» ]
3CME X-ray 2.95 Q 1-96 [» ]
3CPW X-ray 2.70 P 1-96 [» ]
3CXC X-ray 3.00 P 2-96 [» ]
3G4S X-ray 3.20 Q 2-96 [» ]
3G6E X-ray 2.70 Q 2-96 [» ]
3G71 X-ray 2.85 Q 2-96 [» ]
3I55 X-ray 3.11 Q 1-96 [» ]
3I56 X-ray 2.90 Q 1-96 [» ]
3OW2 X-ray 2.70 P 2-96 [» ]
4ADX electron microscopy 6.60 Q 1-96 [» ]
4HUB X-ray 2.40 Q 1-96 [» ]
ProteinModelPortali P12734.
SMRi P12734. Positions 2-96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272569.rrnAC0260.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAV45317 ; AAV45317 ; rrnAC0260 .
GeneIDi 3129654.
KEGGi hma:rrnAC0260.

Phylogenomic databases

eggNOGi COG2139.
HOGENOMi HOG000106438.
KOi K02889.
OMAi PRFHGRT.

Enzyme and pathway databases

BioCyci HMAR272569:GJDH-236-MONOMER.

Miscellaneous databases

EvolutionaryTracei P12734.

Family and domain databases

Gene3Di 2.30.30.70. 1 hit.
HAMAPi MF_00369. Ribosomal_L21e.
InterProi IPR001147. Ribosomal_L21e.
IPR022856. Ribosomal_L21e_arc.
IPR018259. Ribosomal_L21e_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view ]
Pfami PF01157. Ribosomal_L21e. 1 hit.
[Graphical view ]
SUPFAMi SSF50104. SSF50104. 1 hit.
PROSITEi PS01171. RIBOSOMAL_L21E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  2. "Complete amino acid sequences of the ribosomal proteins L25, L29 and L31 from the archaebacterium Halobacterium marismortui."
    Hatakeyama T., Kimura M.
    Eur. J. Biochem. 172:703-711(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-96.
  3. "Localization of proteins HL29 and HL31 from Haloarcula marismortui within the 50 S ribosomal subunit by chemical crosslinking."
    Bergmann U., Wittmann-Liebold B.
    J. Mol. Biol. 232:693-700(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: CROSS-LINKING TO L18.
  4. "The complete atomic structure of the large ribosomal subunit at 2.4 A resolution."
    Ban N., Nissen P., Hansen J., Moore P.B., Steitz T.A.
    Science 289:905-920(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  5. "The structural basis of ribosome activity in peptide bond synthesis."
    Nissen P., Hansen J., Ban N., Moore P.B., Steitz T.A.
    Science 289:920-930(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  6. "A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits."
    Schmeing T.M., Seila A.C., Hansen J.L., Freeborn B., Soukup J.K., Scaringe S.A., Strobel S.A., Moore P.B., Steitz T.A.
    Nat. Struct. Biol. 9:225-230(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  7. "The kink-turn: a new RNA secondary structure motif."
    Klein D.J., Schmeing T.M., Moore P.B., Steitz T.A.
    EMBO J. 20:4214-4221(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  8. "The structures of four macrolide antibiotics bound to the large ribosomal subunit."
    Hansen J.L., Ippolito J.A., Ban N., Nissen P., Moore P.B., Steitz T.A.
    Mol. Cell 10:117-128(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FOUR MACROLIDE ANTIBIOTICS.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  9. Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  10. "Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit."
    Hansen J.L., Moore P.B., Steitz T.A.
    J. Mol. Biol. 330:1061-1075(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS AT THE PEPTIDYL TRANSFERASE CENTER.
    Strain: ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809.
  11. "Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit."
    Schmeing T.M., Moore P.B., Steitz T.A.
    RNA 9:1345-1352(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF THE 50S SUBUNIT WITH TWO DIFFERENT E SITE SUBSTRATES.
  12. "Revisiting the Haloarcula marismortui 50S ribosomal subunit model."
    Gabdulkhakov A., Nikonov S., Garber M.
    Acta Crystallogr. D 69:997-1004(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF THE 50S SUBUNIT.

Entry informationi

Entry nameiRL21_HALMA
AccessioniPrimary (citable) accession number: P12734
Secondary accession number(s): Q5V585
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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